Add time:09/29/2019         Source:infona.pl

The construction and electrochemical response characteristics of poly(vinyl chloride) (PVC), membrane sensors for determination of FLUPHENAZINE HYDROCHLORIDE (cas 146-56-5) and nortriptyline hydrochloride are described. The method is based on the formation of the ion-pair complexes between the two drugs cations and sodium tetraphenylborate (NaTPB) or tetrakis (4-chlorophenyl) borate (KtpClPB). Four poly(vinyl chloride) sensors were fabricated. For fluphenazine HCl sensors 1 and 3 were prepared using NaTPB and KtpClPB, respectively. For nortriptyline HCl sensors 2 and 4 were prepared using NaTPB and KtpClPB, respectively. They show linear responses for both drugs over the concentration ranges of 10 - 3 -10 - 5 , 10 - 2 -10 - 5 , 10 - 3 -10 - 5 and 10 - 2 -10 - 5 M with cationic slopes of 58.9, 52.5, 59.3 and 54.3mV per concentration decade, for sensors 1-4, respectively. The direct potentiometric determination of fluphenazine and nortriptyline hydrochlorides in their pure forms using the proposed sensors gave recoveries of 98.8+/-0.9, 99.0+/-0.9, 98.7+/-0.8 and 99.4+/-0.8% for sensors 1-4, respectively. This is compared reasonably with the data obtained using the British Pharmacopoeial method (1993). Sensors 1-4 were also used for determination of both drugs in their pharmaceutical dosage forms and in the presence of their degradates. It is noteworthy to mention that tetrakis (4-chlorophenyl) borate affects significantly the life time of the fabricated sensors of both drugs.

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