Add time:09/29/2019 Source:infona.pl
Cobalt is an essential metal that is required for the generation of vitamin B12. However, exposure to excess cobalt for a prolonged period may adversely affect the human body, causing hepatotoxicity, pulmonary fibrosis, and neurotoxicity. 3-AMINOTRIAZOLE (cas 155-25-9) (3-AT) is a catalase inhibitor that is often used to examine the cellular role of catalase. In the present study, we showed that 3-AT treatment significantly reduced cobalt (II) chloride (CoCl2)-induced cytotoxicity in HepG2 cells by suppressing the expression and activation of apoptotic markers, caspase-3 and poly adenosine diphosphate ribose polymerase (PARP). Mechanistically, 3-AT treatment attenuated CoCl2-induced accumulation of reactive oxygen species (ROS) and expression of RO S-responsive genes. Furthermore, the CoCl2-induced mitochondrial membrane potential (Δψm) shift and mitochondrial damage were attenuated by 3-AT. Taken together, these findings suggest that 3-AT alleviates CoCl2-induced cytotoxicity by reducing ROS generation and protecting against mitochondrial damage.
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