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An iridium-catalyzed annulation between 1,2-diarylethanone and 3-Aminopropanol (cas 156-87-6) was developed, leading to site specific 2,3-diarylpyridines in moderate yields. 3-Aminopropanol served as both a four-atom component and solvent during this procedure, releasing water as a clean by-product. The reaction may proceed with sequential imine formation, alcohol oxidation and intramolecular cyclization by Knoevenagel reaction.
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