Add time:09/28/2019 Source:infona.pl
Recently, 1-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)-4-(2-methoxyphenyl)piperazine (1) was reported as a highly selective and potent 5-HT 1A R ligand. In the present work we adopted an in-parallel synthetic strategy to rapidly explore a new set of arylpiperazine (7–32) that is structurally related to 1. The compounds were tested for binding affinity and functional activity at 5-HT 1A R and α
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