Add time:09/29/2019         Source:infona.pl

Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = Pyrazino[2,3-f][1,10]phenanthroline (cas 217-90-3)) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated.

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