Add time:07/16/2019         Source:sciencedirect.com

The metabolism and excretion of orally administered or injected n-butyl 4-hydroxy-3,5-di[25I]iodobenzoate has been studied in man, the rhesus, cynomolgus, squirrel and capuchin monkeys and the rat and rabbit. These species excreted most (about 80 per cent of dose) of the radioactivity in the urine over a period of 3 days except in the case of the squirrel and capuchin monkeys and the rat which excreted considerable amounts (17–30 per cent of dose) in the faeces. Four metabolites were characterized by thin-layer chromatography, gas-liquid chromatography-mass spectral analysis and by reverse isotope dilution and these were: 4-hydroxy-3,5-diiodobenzoic acid and its glycine conjugate and a product of O-methylation, namely, 3,5-diiodoanisic acid and its glycine derivative. There is a marked species difference in the excretion of 3,5-diiodoanisic acid for this metabolite was found only in the urine of the human subjects and the new and old World primate species and not in the rat and rabbit which excreted only 4-hydroxy-3,5-diiodobenzoic acid and its glycine conjugate. The excretion of the O-methylation product, 3,5-diiodoanisic acid, may be a further example of a metabolic reaction which is restricted in its occurrence to man and sub-human primates.

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