Add time:07/20/2019         Source:sciencedirect.com

In an attempt to understand the preferential action of 5-aza-2'-deoxycytidine against the lymphatic system, metabolic conversions of the tritiated drug in mouse liver and spleen in vivo and in vitro were followed. Simultaneously, the degradation of the drug resulting in the formation of N-amidino-N′-deoxy-β-D-ribofuranosy was investigated. In the spleen the drug is extensively phosphorylated and incorporated into DNA; however, in the liver and other non-lymphatic tissues its utilization is limited. The analogue affects the formation of DNA in the spleen without concomitantly interfering with the level of cyclic AMP.

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