Add time:07/18/2019         Source:sciencedirect.com

Mice were examined for carcinogenic effects of 4-nitro and 4-hydroxylamino-quinoline 1-oxide derivatives which were substituted by an additional group or atom such as a methyl-, halogeno- or nitro-group. It became evident from the carcinogenicity-structure relationship that carcinogenesis of this class of compounds requires the presence of a nitro group at position-4 and an oxide group at position-1 of the quinoline nucleus. However, the proximate structure in the carcinogenic action must be the 4-hydroxylaminoquinoline 1-oxide structure which is formed from the 4-nitro derivatives by metabolic reduction.

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