Add time:07/17/2019 Source:sciencedirect.com
A novel spectrofluorimetric method for the determination of Ornidazole (cas 16773-42-5) (ORN) in pure form and dosage forms was developed based on the influence of ORN on the native fluorescence of bovine serum albumin (BSA) in a stimulated physiological environment. The obtained data reveal that the presence of ORN has a strong quenching effect on the fluorescence of BSA through both a dynamic and a static process. The parameters of the binding of ORN to BSA were calculated at different temperatures. Thermodynamic parameters values suggest a role of electrostatic and hydrophobic forces in the binding of ORN to BSA. The investigated method for the determination of ORN is accurate, precise and sensitive with a detection limit of 0.106 μg/mL and a quantification limit of 0.353 μg/mL. The quenching method was applied successfully in the determination of ORN in pure form and dosage forms.
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