Add time:07/17/2019 Source:sciencedirect.com
A one-pot procedure for the synthesis of 5-benzoyl-8H-phthalazino[1,2-b]quinazolin-8-ones is achieved by an iodine-catalyzed reaction of 2-aminobenzohydrazides and 2-alkynylbenzaldehydes in good yields. The salient feature of this strategy is a domino type process including a condensation, addition, hydroamination, and a noteworthy benzyl automatic oxidation by oxygen under metal-catalyst-free conditions.
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