Add time:07/14/2019         Source:sciencedirect.com

Seven A2-binding peptides were tested by the HLA class I α-chain refolding assay previously described for their direct binding to HLA class I α chains derived from a panel of 18 HLA-homozygous B-cell lines of various HLA specificities, including four A2 subtypes: A∗0201, A∗0204, A∗0205, and A∗0206. All but one test peptide possessed the major anchor residue motifs, L-V, L-L, or I-L, of A2(A∗0201)/A2(A∗0205)-binding peptides or the closely related motifs, I–V or V-V. This cell panel analysis confirmed the high A2 allele specificity of the test peptides, but also revealed the existence of a broad cross-binding within the A2 subgroup. Most peptides bound to the α chains of the A2 subtypes tested, although their binding patterns showed differences. Furthermore, the A2-binding peptides carrying the I–V or V-V motif were found to cross-react also outside of the A2 subtypes, probably with A24, A26, A28, and A29. Other A-locus allelic products, A1, A3, A11, A30, and A31, and the B-locus allelic products carried by the cells tested were essentially negative, although a few exceptions were seen.

We also recommend Trading Suppliers and Manufacturers of A2-binding peptide (cas 119425-35-3). Pls Click Website Link as below: cas 119425-35-3 suppliers