Add time:07/19/2019         Source:sciencedirect.com

The dissimilar antibiotics Saramycetin (cas 11130-70-4) and prasinomycin are capable of self-association in aqueous solvents between pH 3 and 12. Saramycetin, with a monomeric molecular weight (M.W.) of approximately 2,100 daltons, forms a 55,000-dalton aggregate. A 1,050-dalton fragment of saramycetin, isolated after mild acid hydrolysis, aggregates to an apparent M.W. of 29,000 daltons. Both aggregates are disrupted by such hydrophobic bond-breaking agents as ethanol, urea, and formamide.Prasinomycin, with a monomeric M.W. of 1,700 daltons, forms a 30,000-dalton aggregate. Maintenance of the aggregate must be by lipid-lipid hydrophobic bonding, because: (1) a 1,400-dalton fragment, which lacks a 350-dalton lipid side chain, does not aggregate; (2) the ability of an alcohol to disrupt the aggregate increases with its hydrocarbon content; and (3) the hydrophobic bond-breaking solvent systems of formamide or guanidinium chloride, in aqueous buffer, disrupt the aggregate to monomer.

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