Add time:07/19/2019         Source:sciencedirect.com

The enzymes involved in the activation of the O-phosphate of p-hydroxyaniline mustard in cells in culture have been studied. The results are consistent with the view that the cytotoxic action of the drug against HeLa cells is dependent on the activity of alkaline phosphatase, of the carcinoplacental type, located in the cell membrane. The drug was shown to be a substrate for each of the isoenzymes of HeLa alkaline phosphatase. The importance of extracellular phosphatase in drug activation was also established.

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