Add time:07/20/2019         Source:sciencedirect.com

Improvement in the stability of the 9-chloroacridine stock solution has been made in the colorimetric method for primary aromatic amines based on the reaction between the acridine and an amine. The improved procedure has been applied to some local anesthetics and local anesthetic mixtures. It has been found to be comparable in sensitivity to other local anesthetic determinations, particularly the popular diazotization-coupling procedures. Quantitative data from several systems reveal that use of this procedure permits the determination of local anesthetics in the presence of various drugs and other local anesthetics. Comparative analyses were performed with the method of Bratton and Marshall on procaine, metabutethamine, and nesacaine hydrochlorides.

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