Optimization details and limitations of a novel synthetic method of 4-tert-butyl 2-ethyl 3-amino-1-benzyl-5-dialkylamino-1H-pyrrole-2,4-dicarboxylate derivatives are herein disclosed. This synthesis consists of four steps that include a highly selective cyclization, and can be carried out from s...

This work was devoted to investigate the aggregation of methylene blue (MB) with pyrene labeled poly(acrylic acid) (PAA25Py3) by using the measurements of UV–vis absorption, steady-state and time-resolved fluorescence. For comparison, the effect of unlabeled poly(acrylic acid) (PAA25) on the se...

Heteroleptic iridium(III) cyclometalates, [5-(2-MeCB)dfppy]2Ir(LX) (2-MeCB = 2-methyl-o-carboran-1-yl; dfppy = 2-(4,6-difluorophenyl)pyridinato-C2,N; LX = picolinate (5a) or tetrakis(1-pyrazolyl)borate (5b)), with o-carborane at the 5-position of the phenyl ring of the dfppy ligand were prepared...

This study of Chilean cultivation of blue mussel (Mytilus edulis) analyses the relative importance of small-scale producers in the industry and the institutional factors that enabled the current level of development. To these ends, the study incorporates a value chain analysis, a descriptive sta...

A photodetector, based on zinc oxide nanoparticles (ZnO-NPs) is designed and fabricated using the drop casting method. Two glass slides coated with Indium tin oxide (ITO) thin films approximately 2.5 μm thick are used as source and drain electrodes, together with Schottky contacts fabricated wi...

ERCC1/XPF endonuclease plays an important role in multiple DNA repair pathways and stands as a potential prognostic and predictive biomarker for cisplatin-based chemotherapy. Four distinct ERCC1 isoforms arising from alternative splicing have been described (201, 202, 203 and 204) but only the 2...

MicroRNAs (miRNAs) play important roles in mammalian spermatogenesis, which is highly dependent on Sertoli cells. However, the functions and mechanisms of miRNAs in regulating human Sertoli cells remain largely unknown. Here, we report that hsa-miR-202-3p mediates the proliferation, apoptosis, a...

N-carboxymethylchitosan-N-O-sulfate (NCMCS), a sulfated polysaccharide derivative of chitin, inhibited the propagation of the human immunodeficiency virus type 1 (HIV-1) in human CD4+ cells and that of Rauscher murine leukemia virus (RLV) in murine fibroblasts. A dose-dependent inhibition of bot...

Chitosan has been shown to act on the mucosal epithelial barriers mainly when protonated at acidic pH values in which it is soluble. Soluble chitosan is able to improve the permeation and absorption of neutral to cationic macromolecules only, as it forms polyelectrolyte complexes with anionic ma...

Nanoparticles were used to remove the anionic dye Remazol Red 198 (RR198) from aqueous solution by microwave-assisted systems. Adsorption of RR198 on OCh-ML by the microwave-assisted method was investigated with respect to pH, initial dye concentration, temperature, irradiation time, and microwa...

ObjectiveTo compare the anti-adhesion potential of 1% methylene blue (MB) solution and 2% N,O-carboxymethylchitosan (NOCC) gel in a rat uterine horn model.

Magnetic nanoparticles prepared with iron oxides and N-benzyl-O-carboxymethylchitosan, an amphiphilic chitosan derivative, were prepared through the incorporation method and characterized by Fourier infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), transmission electron microscopy...

Magnetic N-benzyl-O-carboxymethylchitosan nanoparticles were synthesized through incorporation and in situ methods and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and magnetization measurements. Indomethacin was incorporated int...

ObjectiveTo examine the logistics, safety, and efficacy of N,O-carboxymethylchitosan (NOCC) in reducing adhesions in women.

IntroductionVon Willebrand disease (vWD) is the second least common hemostatic disorder in Malaysia, and it has a low prevalence. This study examined the underlying platelet thrombogenicity cascades in the presence of different formulations of chitosan-derivatives in vWD patients. This paper aim...

O-Carboxymethylchitosan-N-lauryl/γ-Fe2O3 magnetic nanoparticles (OCh-LM) were synthesized and characterized using FT-IR, TGA, SEM and VSM. The OCh-LM was essentially spherical in shape, with a mean particle size of 11.1 ± 3.4 nm and saturated magnetization of 18.4 emu/g. The nanoparticle was u...

3'-Azido-2',3'-dideoxyuridine (AzddU, CS-87) is a potent inhibitor of human immunodeficiency virus replication in vitro with low bone marrow toxicity. Although AzddU is currently being evaluated in clinical trials, its catabolic disposition is unknown. Pharmacokinetic studies in r...

Nine dimaltoside derivatives of ethane-1,2-diol, propane-1,3-diol, and butane-1,4-diol having the α,α, α,β, and β,β anomeric configurations at the linkage sites have been synthesized. Suitably protected maltosyl halides or a 1-(phenylthio) derivative were condensed with the foregoing diols...

The chromatographic behaviour of 6-O-α-d-glucosyl-, 6-O-α-maltosyl and 6-O-α-maltotriosyl derivatives of α-, β- and γ-cyclodextrin (CD) and of 6,6′''-di-O-α-d-glucosyl-β-CD on three kinds of high-performance liquid chromatographic (HPLC) columns and four kinds of thin-layer ch...

Oxone mediated reaction of imidazo[2,1-b]thiazole, imidazo[1,2-a]pyridine and 1H-pyrazole derivatives with diaryl diselenides is presented here. The methodology represents an efficient and simple protocol for carrying out the selective synthesis of 5-arylselanyl-imidazo[2,1-b]thiazoles, 3-arylse...