Phentermine is an indirect-acting, sympathomimetic amine used in the treatment of obesity. A central nervous system stimulant, phentermine increases heart rate and blood pressure and decreases appetite. It can induce physical and psychological dependence. It is used alone or in combination with ...
Women presenting to the cardiac catheterization laboratory with normal coronary arteries without significant atherosclerotic disease is a common presentation. In such patients, it is important to maintain a wide differential and consider alternate diagnoses. We present two cases of women present...
BackgroundTo evaluate effectiveness, safety, and costs of Lorcaserin vs. phentermine among obese non–surgical and surgical patients (post bariatric surgery).
N-t-Butyl α-chlorophosphonamidates (4) undergo methoxide-induced rearrangement to give products (6 and 7) in which either the P-N or P-C bond has been broken. This implies the intermediacy of a cyclic azaphosphiridine oxide 5.
The condensation of resorcinol or methylresorcinol with methylaminoacetaldehyde dimethyl acetal in an acid medium results in the formation of 2,2-bis[(2,4-dihydroxyaryl)ethyl]methylamine hydrochlorides
Complexes of copper, nickel, cobalt, palladium, and platinum with pyrazine-2,5-dicarboxylic acid have been prepared and characterized as potential semiconductors. All. however, showed power resisti- titles >1012 ohm.
A new series of 3,6-dimethyl-pyrazine-2,5-dicarboxylic acid derivatives were synthesized and both their gelation abilities and thermotropic properties were studied. These compounds are efficient organogelators and easily form stable gels in many organic solvents. Moreover, they are room temperat...
A series of new low molecular organogelators (LMOGs) with thermotropic mesophase were synthesized via the reaction of 3,6-dimethyl-pyrazine-2,5-dicarboxylic acid with p-alkoxyl anilines. These compounds readily formed stable gels in a variety of organic solvents and their self-assembly behavior,...
Methods based on reversed-phase liquid chromatography with UV detection of 4-nitrobenzoyl- or 3,5-dinitrobenzoyl azide derivatives lack in accuracy and stability of derivatives to be applied for azide determination in pharmaceutical protein samples with high sodium chloride concentrations. This ...
The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using α-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. ...
A high performance liquid chromatographic method (HPLC) for the simultaneous determination of 4-nonylphenol, bisphenol A, 17α-ethinylestradiol and three endogenic estrogens including 17α-estradiol, 17β-estradiol, estriol in urine sample, based on precolumn derivatization with p-nitrobenzoyl c...
A new visible-light-mediated radical cyclization of alkynoates with acyl chlorides is described for the one-pot construction of diverse 3-acylcoumarins with high efficiency and selectivity. This method is successful by sequential difunctionalization of an alkynes CC triple bond with the CCl bond...
1,2-Naphthoquinone thiosemicarbazone has been immobilized on derivatised silica gel and used for the preconcentration of copper from large sample volumes. 1,2-Naphthoquinone thiosemicarbazone has very attractive cation-binding properties and the immobilization technique has resulted in the prepa...
Chamaecin (2-hydroxy-4-isopropylbenzaldehyde) was synthesized and tested for its tyrosinase inhibitory activity. It partially inhibits the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) catalyzed by mushroom tyrosinase with an IC50 of 2.3 μM. The inhibition kinetics analyzed by Dixon plots ...
CO bond formation between terminal alkenes/benzyl alcohols as an arylcarboxy surrogate and carbonyl compounds in a biodegradable deep eutectic solvent (DES) based on choline chloride and urea was performed. By employment of TBAI as catalyst and TBHP as oxidant, various derivatives of carbonyl co...
The 4-chlorobenzoyl-CoA dehalogenase catalyzes the hydrolytic dechlorination of 4-chlorobenzoyl-CoA via a two-step mechanism, namely nucleophilic aromatic substitution and ester hydrolysis. The mutation of an active-site Histidine residue has been shown to reduce the catalytic activity in both t...
The chlorine kinetic isotope effect (KIE) on the dehalogenation of 4-chlorobenzoyl-CoA catalyzed by 4-chlorobenzoyl-CoA dehalogenase has been measured at room temperature and optimal pH. The measured value of 37k = 1.0090 ± 0.0006 is larger than the KIEs recently measured for haloalkane and flu...
An efficient synthesis of new A-2, A-3, and A-4 analogues from amlodipine (A-1) has been achieved. All synthesized compounds were investigated by elemental analysis, FTIR, EIMS, and 1H NMR techniques. Crystal structures of A-2 and A-3 were determined by single crystal X-ray diffraction method. C...
Allosteric enhancers for the A1 adenosine receptor represent a novel and unique drug design strategy to augment the response to endogenous adenosine in a site- and event-specific manner. We have previously investigated a detailed structure–activity relationship study around a wide series of 2-a...
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