Benzo[b]fluoranthene (B[b]F) and benzo[k]fluoranthene (B[k]F) are widespread priority pollutants of polycyclic aromatic hydrocarbons (PAHs), which can react with atmospheric oxidants during transport in the troposphere and lead to the formation of more toxic compounds. At present, the rates of h...
Polycyclic aromatic hydrocarbons (PAHs) are a large family of environmentally prevalent toxic compounds generated from the combustion of organic materials and diesel exhaust. Humans and wild animals are exposed to PAHs mostly through dietary intake of contaminated food. Benzo[b]fluoranthene (B[b...
A new efficient synthesis of indolo[3,2,1-jk]carbazoles by the palladium-catalyzed cyclization of N-(2-bromoaryl)carbazoles is described. The reaction involves intramolecular C–C bond formation, coupled with the cleavage of a C–X bond and a C–H bond on carbazole ring. Substitutions on N-aryl ...
Three novel planarized CPB derivatives (ICzCz, ICzPCz, ICzICz) have been synthesized and characterized concerning applications as host materials for PhOLEDs. The incorporation of fully planar indolo[3,2,1-jk]carbazole (ICz) in the CBP scaffold has been systematically investigated, revealing a si...
From stromata (fruiting bodies) of three xylariaceous fungi belonging to the genus Annulohypoxylon (A. leptascum, A. cf. truncatum and an unidentified Annulohypoxylon sp.), truncatone A (1), three unprecedented derivatives named truncatones B–D (2–4) besides the known 4,5,4′,5′-tetrahydroxy-...
The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a-ep...
3,6,8,11-Tetramethoxybenzo[j]fluoranthene can be made from 1,6-dimethoxynaphthalene in a one-pot ferric chloride oxidation/methanol reduction procedure. The reaction is tolerant of the presence of substituents in the 7-position of the naphthalene nucleus and provides a quick and easy route to th...
Several substituted 7H-pyrido[4,3-c]carbazoles were synthesized from the natural product mukonal and tested for inhibition of HIV replication in H9 lymphocytes. 5-Methoxy-7-methyl-7H-pyrido[4,3-c]carbazole (7) had an EC 5 0 value of 0.0054 μg/mL and the highest therapeutic index (T...
As the sum of benfluron metabolites found was only a part of the total amount applied, a search for undiscovered metabolites was undertaken in the extracts from isolated rat hepatocytes and in the bile and perfusate in the experiments with an isolated perfused rat liver. To identify the metabol...
Benfluron (B) [5-(2-dimethylaminoethoxy)-7H-benzo[c]fluorene-7-one hydrochloride] is a potential antineoplastic agent. In the organism, B undergoes a rapid phase I biotransformation through oxidative and reductive metabolic pathways. The carbonyl reduction of B leads to reduced benfluron, red-B,...
In the present paper, we have described the synthesis and biological activity of the novel derivatives of imidazo[4,5-b]pyridines and triaza-benzo[c]fluorenes (7–21, 24–26, 28–29). A preponderance of these compounds exerted strong cytostatic effects on the panel of seven human tumour cell lin...
The first synthesis of dithieno[3,2-b:2′,3′-d]furan (1) from 3,4-dibromofuran is presented. The stability and reactivity of 1 were investigated in selected substitution and coupling reactions.
The reactive 1:1 intermediate produced in the reaction between dimethyl acetylenedicarboxylate and triphenylphosphine was trapped by ethyl 1H-perimidine-2-carboxylate to yield 5-ethyl 9-methyl 7-oxo-7H-pyrido[1,2,3-cd]perimidine-5,9-dicarboxylate and 5-ethyl 9-methyl 1-[3-methoxy-1-(methoxycarbo...
A new reaction between 2‐aminobenzophenone and thiourea in dimethyl sulfoxide (DMSO) has been developed that primarily affords 4‐phenylquinazoline as a single product. This reaction is also applicable, in general, to the reactions between thiourea and conformation‐restricted β‐amino ketones...
A series of mononuclear complexes of the type, [MLCl2] [M = CoII, NiII, CuII, and ZnII] with a pyrimidene‐type ligand, which was synthesized by the reaction of 2‐furaldehyde and 1, 8‐diaminonaphthalene, was obtained. The ligand and its complexes were characterized by elemental analysis, IR, N...
Growth sequence patterns of molecular clusters have not been well elucidated. To examine structures of planar-molecule clusters, naphthalene, anthracene, phenanthrene, phenalene, naphthacene, and pyrene clusters with up to 10 molecules were theoretically investigated with the all-atom OPLS poten...
Each of the isomers of phenalene, 1H-, 2H-, 3aH-, and 9bH-phenalene, as well as the cation, neutral radical, and anion in the phenalenyl system, have been examined at the Hartree–Fock 6-31G(d) and the density functional B3LYP/6-31G(d) levels of theory. The structures and properties of the phena...
N,N'-Bis(7-amino-2,5-dihydro-1H-cyclopenta[cd]phenalen-5-ylidene)-substituted derivatives of 2,5-diamino-1,3,4-thiadiazole, 2,6-diaminopyridine, and 3,5-diamino-1-phenyl-1,2,4-triazole were synthesized. The products are soluble in water, and they attract interest as potential biologically active...
Fluoreno[1,9,8-abcd]corannulene (4) and difluoreno[1,9,8,7-cdefg;2',1',9',8'-klmno]anthracene (8) have been synthesized by multistage thermal and catalytic dehydrocyclization reactions starting from 4-[9H-fluorenylidene-(9)]-4H-cyclopenta[def]phenanthrene and benzo[p]naphtho[1,8,7-ghi]chrysene, ...
Geometries, ionization potentials (IPs), electron affinities (EAs) and optical properties of two series of π-conjugated oligomers (2,6-(4,4-bis(2-ethylthexyl)-4H-cyclopenta-[def]-phenanthrene)) n CPPn (2,6-(4,4-bis(2-ethylthexyl)-8,9-dihydro-4H-cyclopenta-[def]-phenanthrene)) n ...
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