As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE EP/USP both ok Appearance:WHITE POWDER Storage:in cool Package:25kg/drum Application:active pharmaceutical ingredient Transportation:as request Port:any
Cas:103129-82-4
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:103129-82-4
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:103129-82-4
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:103129-82-4
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inquiryUnique advantages for (S)-Amlodipine Cas 103129-82-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:Cool dry place Package:1kg/foi
Cas:103129-82-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:103129-82-4
Min.Order:1 Gram
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:103129-82-4
Min.Order:1 Gram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:103129-82-4
Min.Order:5 Kiloliter
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Type:Manufacturers
inquiryOur advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient
Cas:103129-82-4
Min.Order:1 Kilogram
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:103129-82-4
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:103129-82-4
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inquiryLevamlodipine Besylate Synonyms: (S)-Amlodipine;(4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester Cas no :103129-82-4 MF: MF:C20H25ClN2O5 MW: 408.88 Structure
Cas:103129-82-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing w
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Cas:103129-82-4
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:103129-82-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:103129-82-4
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry(S)-Amlodipine CAS:103129-82-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi
Cas:103129-82-4
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:103129-82-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:103129-82-4
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryProduct Name: (S)-Amlodipine Synonyms: 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-;3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1
Cas:103129-82-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:103129-82-4
Min.Order:0 Metric Ton
Negotiable
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inquiryAdvantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit
Cas:103129-82-4
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:103129-82-4
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAppearance/Colour:white crystal powder Vapor Pressure:0mmHg at 25°C Melting Point:102-104°C Refractive Index:1.546 Boiling Point:527.2 °C at 760 mmHg PKA:8.97±0.10(Predicted) Flash Point:272.6 °C PSA:99.88000
Cas:103129-82-4
Min.Order:1 Gram
FOB Price: $6.0
Type:Trading Company
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 20℃; for 0.666667h; | 93.9% |
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 20℃; for 0.5h; | 93% |
amlodipine
Conditions | Yield |
---|---|
With ammonia; water In dichloromethane for 0.5h; Product distribution / selectivity; | 92% |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
Stage #1: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With D-(+)-camphoric acid In isopropyl alcohol at 20℃; for 12.5h; Stage #2: With sodium hydroxide In dichloromethane; water for 1h; Reagent/catalyst; | 90.5% |
With D-tartaric acid In dimethyl sulfoxide; acetone at 20 - 60℃; for 1.5h; Reagent/catalyst; Solvent; | 45.2% |
Stage #1: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With L-Tartaric acid In ISOPROPYLAMIDE at 5℃; for 2h; Resolution of racemate; Stage #2: With sodium hydroxide In dichloromethane; water for 0.666667h; | n/a |
Multi-step reaction with 2 steps 1: water; iso-butanol / 1 h / 50 °C 2: sodium hydroxide / dichloromethane; water / pH 9 View Scheme |
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water pH=9; | 90% |
With sodium hydroxide In dichloromethane; water pH=9; | 90% |
amlodipine
Conditions | Yield |
---|---|
With ammonia; water In dichloromethane for 0.5h; Product distribution / selectivity; | 82% |
D-tartaric acid
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
N,N-dimethyl-formamide
B
amlodipine
Conditions | Yield |
---|---|
In water at 20℃; for 4.5h; Product distribution / selectivity; | A 78.38% B n/a |
amlodipine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water at 5℃; for 0.333333h; | 69% |
(-)-2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; acetonitrile for 1h; | 64% |
2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
With hydrogen; Lindlar's catalyst In ethanol under 775.7 Torr; Yield given; | |
With sodium tetrahydroborate; nickel dichloride In ethanol Ambient temperature; Yield given; |
A
(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
B
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide; water In dichloromethane |
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide In tert-butyl methyl ether at 20 - 25℃; for 0.5h; |
2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) carbonyldiimidazole / 1.) CH2Cl2, reflux, 2.) THF, RT, 1 h 2: NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating 3: H2 / 5percent Pd/CaCO3 / ethanol / 775.7 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 1.) carbonyldiimidazole 2: ethanol / 1 h / Heating 3: 6percent nickel chloride, sodium borohydride / ethanol / Ambient temperature View Scheme |
(+)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating 2: H2 / 5percent Pd/CaCO3 / ethanol / 775.7 Torr View Scheme | |
Multi-step reaction with 2 steps 1: ethanol / 1 h / Heating 2: 6percent nickel chloride, sodium borohydride / ethanol / Ambient temperature View Scheme |
2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate
amlodipine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 41 percent / ethanol / 2 h / Heating 2: 74 percent / aq. NaOH / bis-(2-methoxy-ethyl) ether / 2 h / Ambient temperature 3: 1.) carbonyldiimidazole / 1.) CH2Cl2, reflux, 2.) THF, RT, 1 h 4: NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating 5: H2 / 5percent Pd/CaCO3 / ethanol / 775.7 Torr View Scheme |
2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 74 percent / aq. NaOH / bis-(2-methoxy-ethyl) ether / 2 h / Ambient temperature 2: 1.) carbonyldiimidazole / 1.) CH2Cl2, reflux, 2.) THF, RT, 1 h 3: NaOEt / bis-(2-methoxy-ethyl) ether / 1 h / Heating 4: H2 / 5percent Pd/CaCO3 / ethanol / 775.7 Torr View Scheme |
2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 64 percent / 6.7 M HCl / acetonitrile; dioxane / 1 h View Scheme |
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide In tert-butyl methyl ether; water; isopropyl alcohol | |
With sodium hydroxide In tert-butyl methyl ether; water at 20 - 25℃; for 0.333333 - 0.5h; | |
With sodium hydroxide In n-heptane; tert-butyl methyl ether; water at 20 - 40℃; for 2.5 - 3.5h; |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
amlodipine
Conditions | Yield |
---|---|
Stage #1: L-(+)-tartaric acid; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With sodium hydroxide In water; butanone at 20℃; for 1h; Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; | n/a |
Stage #1: L-(+)-tartaric acid; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With sodium hydroxide In dichloromethane; butanone at 20℃; for 1h; Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; | n/a |
Stage #1: L-(+)-tartaric acid; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With sodium hydroxide In ethyl acetate; butanone at 20℃; for 1h; Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; | n/a |
Stage #1: L-(+)-tartaric acid; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With sodium hydroxide In ethanol; butanone at 20℃; for 1h; Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; | n/a |
Stage #1: L-(+)-tartaric acid; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With sodium hydroxide In acetone; butanone at 20℃; for 1h; Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; | n/a |
amlodipine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water for 0.5h; | n/a |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
A
(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
B
amlodipine
Conditions | Yield |
---|---|
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 0℃; Purification / work up; | |
With isopropylamine; trifluoroacetic acid In methanol; isopropyl alcohol at 35℃; under 103432 Torr; Resolution of racemate; Supercritical conditions; | |
With acetic acid; triethylamine In methanol at 5℃; Reagent/catalyst; Concentration; Temperature; Resolution of racemate; | |
With L-glutamate based immobilized chiral ionic liquid on SBA-15 In methanol Resolution of racemate; |
(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
amlodipine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: calcium hypochlorite / ethyl acetate; water / 20 - 30 °C 2: acetic acid; sodium cyanoborohydride / 2 h / 15 - 25 °C 3: D-tartaric acid / dimethyl sulfoxide; acetone / 1.5 h / 20 - 60 °C View Scheme |
Conditions | Yield |
---|---|
In tert-butyl methyl ether; water; isopropyl alcohol at 0 - 50℃; for 4.5 - 5h; | 98.1% |
In tert-butyl methyl ether; water; isopropyl alcohol at 50℃; for 1h; Product distribution / selectivity; | 98.1% |
In tert-butyl methyl ether; water; isopropyl alcohol at 0 - 50℃; for 4h; Product distribution / selectivity; | 98.1% |
Conditions | Yield |
---|---|
In ethanol at 20℃; for 1h; | 97% |
Conditions | Yield |
---|---|
In ethanol at 20℃; for 1h; | 96% |
2,2-dimethylglutaric acid
amlodipine
Conditions | Yield |
---|---|
In ethanol at 20℃; for 1h; | 96% |
Conditions | Yield |
---|---|
In ethanol; water | 93% |
Conditions | Yield |
---|---|
In ethanol at 25℃; for 2h; Product distribution / selectivity; | 91% |
In water at 25℃; for 2h; Product distribution / selectivity; | 89% |
In ethanol; water | 82.88% |
Conditions | Yield |
---|---|
In ethanol; isopropyl alcohol at 25℃; for 2h; Product distribution / selectivity; | 91% |
In ethanol; isopropyl alcohol at 25℃; for 2h; Product distribution / selectivity; | 91% |
In water for 5h; Product distribution / selectivity; | 89% |
Conditions | Yield |
---|---|
In ethanol; water | 89.2% |
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 20℃; for 0.5h; Product distribution / selectivity; | 89% |
In ethanol; water at 0 - 20℃; | 85% |
In ethanol; water Product distribution / selectivity; | 82.88% |
In ethanol; water at 20℃; for 24h; | 80.2% |
(1S)-10-camphorsulfonic acid
amlodipine
Conditions | Yield |
---|---|
With water In isopropyl alcohol at 20℃; for 1h; | 88% |
(1S)-10-camphorsulfonic acid
amlodipine
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 40℃; Product distribution / selectivity; | 88% |
In tert-butyl methyl ether; isopropyl alcohol at 25℃; for 2h; Product distribution / selectivity; | 84% |
In water at 25℃; for 2h; Product distribution / selectivity; | 83% |
In hexane; tert-butyl methyl ether; isopropyl alcohol at 20℃; for 2h; | 81.5% |
(1S)-10-camphorsulfonic acid
amlodipine
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 40℃; | 88% |
camphor-10-sulfonic acid
amlodipine
Conditions | Yield |
---|---|
With water In isopropyl alcohol at 15 - 20℃; for 5h; | 87.4% |
Conditions | Yield |
---|---|
In methanol at 25℃; for 2h; Product distribution / selectivity; | 85% |
In water at 20 - 25℃; for 2h; Product distribution / selectivity; | 85% |
(R)-10-camphorsulfonic acid
amlodipine
Conditions | Yield |
---|---|
In tert-butyl methyl ether; isopropyl alcohol at 25℃; for 2h; Product distribution / selectivity; | 84% |
In water at 25℃; for 2h; Product distribution / selectivity; | 83% |
In water; isopropyl alcohol at 15 - 20℃; | 62.3% |
2-methylglutaric acid
amlodipine
Conditions | Yield |
---|---|
In ethanol at 20℃; for 1h; | 84% |
Conditions | Yield |
---|---|
In ethanol; water | 82.88% |
Conditions | Yield |
---|---|
In Petroleum ether for 5h; Heating / reflux; | 79.3% |
atorvastatin lactone
amlodipine
Conditions | Yield |
---|---|
In ethanol for 18h; Heating / reflux; | 64% |
(1S)-(-)-camphanic chloride
amlodipine
(-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
Conditions | Yield |
---|---|
With pyridine In dichloromethane for 2h; Ambient temperature; Yields of byproduct given; |
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