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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

High purity L-Pyroglutamic acid 98% TOP1 supplier in China

Cas:98-79-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,

L-Pyroglutamic acid manufacturer

Cas:98-79-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chengdu Baishixing Science and Technology Industry Co., Ltd.

1.Doing amino acid for 13 years .The stable process and advanced technology can provide high quality product 2.we can offer you very Competitve price 3.Good after-sale service Test Item Specification

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shanghai Sutong Biotechnology Co.,Ltd

Appearance:white to light yellow crystal powder Package:25kg/drum

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

(S)-(-)-2-Pyrrolidone-5-carboxylic acid / L-Pyroglutamic acid / L-pyr 98-79-3

Cas:98-79-3

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality L-Pyroglutamic Acid supplier in China

Cas:98-79-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to off-white powder White powder Specific rotation -1

High purity Various Specifications (S)-(-)-2-Pyrrolidone-5-carboxylic acid CAS:98-79-3

Cas:98-79-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

L-Pyroglutamic acid with best price and top quality

Cas:98-79-3

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

L-Pyroglutamic acid CAS NO.98-79-3

Cas:98-79-3

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Top quality 99% L-Pyroglutamic Acid / PCA Powder Cas 98-79-3

Cas:98-79-3

Min.Order:1 Kilogram

FOB Price: $29.0 / 39.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

L-Pyroglutamic Acid CAS:98-79-3 Appearance Transparent fine crystal Content ≥99% Use Used in food, medicine, cosmetics and other industries Package 25 kg cardboard barrels HANGZHOU TH

L-Pyroglutamic Acid in China

Cas:98-79-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply L-Pyroglutamic Acid

Cas:98-79-3

Min.Order:1

Negotiable

Type:Other

inquiry

shanghai Tauto Biotech Co., Ltd

20-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2015 quality management system Leader Supplier of Botanical Reference Materials in China 3000 kinds of

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

L-Pyroglutamic Acid manufacturer with low price

Cas:98-79-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% L-Pyroglutamic acid 98-79-3 ISO Producer

Cas:98-79-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:L-pyroglutamic acid CAS:98-79-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

High purity L-Pyroglutamic acid 98% TOP1 supplier in China

Cas:98-79-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Name L-Pyroglutamic acid CAS 98-79-3 Assay 99% Appearance

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

top L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 98-79-3 with best quality

Cas:98-79-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:2-8°C Package:25kg/drum Application:L-Pyroglutamic acid is used in the synthesis of: Nonproteinogenic amino acids such as (3S,4R)-3,4-dimethyl-L-pyroglutamic acid and (3S,4R)-3,4-dimethyl-L-glutamine. Ch

L-Pyroglutamic acid factory price

Cas:98-79-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Off-White crystalline powder Storage:Store in sealed contain

Factory supply Hight quality CAS NO 98-79-3 L-Pyroglutamic Acid Powder

Cas:98-79-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: L-Pyroglutamic acid Molecular Structure: Formula: C5H7NO3 Molecular Weight : 129.11 Synonyms: (5s)-2-oxopyrrolidine-5-carboxylicacid;(s)-5-oxo-2-pyrrolidin

L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

L-Pyroglutamic acid 98-79-3

Cas:98-79-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White crystal powder / Refer to COA Package:Ent

98-79-3 CAS White crystalline powder L-Pyroglutamic acid

Cas:98-79-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

L-Pyroglutamic acid CAS: 98-79-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

L-Pyroglutamic acid CAS: 98-79-3

Cas:98-79-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

L-glutamic acid
56-86-0

L-glutamic acid

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water for 16h; Heating;95%
In water for 16h; Heating;95%
With 1,1'-carbonyldiimidazole In chloroform at 55℃; for 3h; Solvent; Concentration;76.8%
L-N-t-butoxycarbonylpyroglutamic acid
53100-44-0

L-N-t-butoxycarbonylpyroglutamic acid

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With silica gel In dichloromethane for 0.0166667h; Irradiation;91%
With tin(II) trifluoromethanesulfonate In dichloromethane at 20℃; for 2h;87%
tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate
91229-91-3

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 0.333333h; Ambient temperature;90%
L-glutamic acid γ-benzyl ester
1676-73-9

L-glutamic acid γ-benzyl ester

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide at 40℃; for 20h;88.3%
(5S)-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo[3.3.0]octan-4,8-dione
317845-09-3

(5S)-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo[3.3.0]octan-4,8-dione

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water In isopropyl alcohol at 20℃;87%
L-glutamic acid
56-86-0

L-glutamic acid

A

Pyroglutamic acid
149-87-1

Pyroglutamic acid

B

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
at 175℃; under 3750.38 Torr; for 5h; Temperature; Pressure; Autoclave; Large scale;A 15.9%
B 83%
Boc-Gln-OH
13726-85-7

Boc-Gln-OH

trifluoroacetic acid
76-05-1

trifluoroacetic acid

A

L-glutamic acid
56-86-0

L-glutamic acid

B

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
at 20℃; for 0.25h;A 61%
B 18%
tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate
220280-79-5

tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water for 12h; Hydrolysis; cyclization; Heating;45%
L-glutamic acid γ-benzyl ester
1676-73-9

L-glutamic acid γ-benzyl ester

A

benzaldehyde
100-52-7

benzaldehyde

B

benzoic acid
65-85-0

benzoic acid

C

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

D

benzyl alcohol
100-51-6

benzyl alcohol

Conditions
ConditionsYield
With sodium hydroxide; sodium tetrachloropalladate(II) In water Product distribution; Ambient temperature; initial pH:6.8; variation of initial pH and temperature;A 37%
B 4%
C n/a
D 24%
H-Glu(OChp)-OH
107930-17-6

H-Glu(OChp)-OH

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide at 40℃; for 20h;4.1%
D-Glutamic acid
6893-26-1

D-Glutamic acid

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water
(S)-2-Amino-pentanedioic acid 5-ethyl ester
1119-33-1

(S)-2-Amino-pentanedioic acid 5-ethyl ester

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With ammonium hydroxide
diethyl 2-aminopentanedioate
55895-85-7

diethyl 2-aminopentanedioate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water
L-glutamic acid diethyl ester
16450-41-2

L-glutamic acid diethyl ester

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water
N-(benzyloxycarbonyl)-L-glutamic acid anhydride
4124-76-9

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With palladium on activated charcoal; acetic acid Hydrogenation;
L-glutamine
56-85-9

L-glutamine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
at 28℃; for 840h; pH=5.5 (acetate buffer), PhCH3 on surface;
With human blood serum at 24.84℃;
(S)-2-Amino-pentanedioic acid 5-ethyl ester
1119-33-1

(S)-2-Amino-pentanedioic acid 5-ethyl ester

A

ethanol
64-17-5

ethanol

B

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
In water at 40℃; Rate constant; pH 7.6-10.4, μ=0.5 (KCl);
histrelin
76712-82-8

histrelin

A

His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt
134190-11-7

His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt

B

cyclo(-His-Trp)

cyclo(-His-Trp)

C

Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt
134009-09-9

Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt

E

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water at 87℃; for 432h; Product distribution; degradation, var. reaction time, temperature and ph;
N-Acetylpyroglutamic acid
53971-11-2

N-Acetylpyroglutamic acid

A

N-Acetyl-D-pyroglutamic acid
53971-11-2, 56805-18-6, 89885-76-7

N-Acetyl-D-pyroglutamic acid

B

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst;
ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

A

ethanol
64-17-5

ethanol

B

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With water In acetonitrile at 40℃; Rate constant; pH 9.7-10.5, μ=0.5 (KCl);
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Bacillus thermocatenulanatus In water at 40℃; pH=7.20; Enzyme kinetics;
inactive form

inactive form

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
With Quinine
L-glutamic acid
56-86-0

L-glutamic acid

A

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

B

Fmoc-Pro-Rink amide-MBHA resin

Fmoc-Pro-Rink amide-MBHA resin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 67 percent / dimethylsulfoxide / 20 °C
2: 99 percent / SOCl2; DMF / CH2Cl2 / 20 °C
3: 87 percent / H2O / propan-2-ol / 20 °C
View Scheme
(S)-[2,2-bis(trifluoromethyl)-5-oxo-1,3-oxazolidin-4-yl]propionic acid
131021-88-0

(S)-[2,2-bis(trifluoromethyl)-5-oxo-1,3-oxazolidin-4-yl]propionic acid

A

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

B

Fmoc-Pro-Rink amide-MBHA resin

Fmoc-Pro-Rink amide-MBHA resin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / SOCl2; DMF / CH2Cl2 / 20 °C
2: 87 percent / H2O / propan-2-ol / 20 °C
View Scheme
N-Boc-L-proline
15761-39-4

N-Boc-L-proline

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dicyclohexylcarbodiimide, 4-dimethylaminopyridine
2: 95 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 2 h / Ambient temperature
3: 90 percent / CF3COOH / CH2Cl2 / 0.33 h / Ambient temperature
View Scheme
N-BOC-proline tert-butyl ester
91237-84-2

N-BOC-proline tert-butyl ester

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 2 h / Ambient temperature
2: 90 percent / CF3COOH / CH2Cl2 / 0.33 h / Ambient temperature
View Scheme
Cbz-(L)-Glu-OBn
3705-42-8

Cbz-(L)-Glu-OBn

A

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

B

natrium carbonate

natrium carbonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran
2: 76 percent / H2, AcOH / Pd / methanol / 24 h
3: 4.1 percent / Et3N / dimethylformamide; H2O / 20 h / 40 °C
View Scheme
C26H48N6O15
1134188-65-0

C26H48N6O15

A

5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine
1134188-60-5

5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine

B

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Conditions
ConditionsYield
BtrG enzyme In water at 20℃; for 24h; Product distribution / selectivity; HEPES buffer; Enzymatic reaction;
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

methyl (S)-pyroglutamate
4931-66-2

methyl (S)-pyroglutamate

Conditions
ConditionsYield
In diethyl ether100%
With diethyl ether
In methanol; diethyl ether at 0℃; for 0.5h;
methanol
67-56-1

methanol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

methyl (S)-pyroglutamate
4931-66-2

methyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride at 0 - 25℃;100%
With methanesulfonic acid In chloroform; water Reflux;100%
With Dowex-50W (X8-200) resin Inert atmosphere; Reflux;100%
acetic acid tert-butyl ester
540-88-5

acetic acid tert-butyl ester

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

L-t-butyl pyroglutamate
35418-16-7, 85136-12-5

L-t-butyl pyroglutamate

Conditions
ConditionsYield
With perchloric acid In water at 20℃; for 18h;100%
Stage #1: acetic acid tert-butyl ester; L-Pyroglutamic acid With perchloric acid at 20℃; for 48h; Inert atmosphere;
Stage #2: With perchloric acid for 48h; Inert atmosphere;
90%
With perchloric acid at 20℃; for 96h; Inert atmosphere;90%
1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

L-trimethylsilyl pyroglutamate
97717-45-8

L-trimethylsilyl pyroglutamate

Conditions
ConditionsYield
With saccharin for 2.5h; Heating;100%
benzyl chloride
100-44-7

benzyl chloride

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

benzyl (L)-pyroglutamate
94885-52-6

benzyl (L)-pyroglutamate

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at 60℃; for 15h; Temperature; Large scale;100%
With triethylamine In acetone for 168h; Heating;85%
With TEA In acetone85%
2-methyl-1-buten-4-ol
763-32-6

2-methyl-1-buten-4-ol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(5S)-2-pyrrolidone-5-carboxylic acid 3-methyl-3-butenyl ester
865183-91-1

(5S)-2-pyrrolidone-5-carboxylic acid 3-methyl-3-butenyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

2-(trimethylsilyl)ethyl (S)-5-oxopyrrolidine-2-carboxylate

2-(trimethylsilyl)ethyl (S)-5-oxopyrrolidine-2-carboxylate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 130℃; for 2h; Dean-Stark;100%
With toluene-4-sulfonic acid In benzene for 2h; Heating;
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

pyroglutamoyl chloride
55478-53-0

pyroglutamoyl chloride

Conditions
ConditionsYield
Stage #1: L-Pyroglutamic acid With 1,1,1,3,3,3-hexamethyl-disilazane; saccharin for 2.5h; Heating / reflux;
Stage #2: With oxalyl dichloride In dichloromethane at 20℃; Heating / reflux;
100%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester
51693-17-5

(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester

Conditions
ConditionsYield
Stage #1: L-Pyroglutamic acid With thionyl chloride In methanol at 20℃; for 4h;
Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 15h;
Stage #3: p-toluenesulfonyl chloride With dmap; triethylamine In dichloromethane at 20℃; for 16h;
100%
methanesulfonic acid
75-75-2

methanesulfonic acid

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

methyl (S)-pyroglutamate
4931-66-2

methyl (S)-pyroglutamate

Conditions
ConditionsYield
In methanol; chloroform Molecular sieve; Reflux;100%
sodium methylate
124-41-4

sodium methylate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

5-methoxypyrrolidin-2-one

5-methoxypyrrolidin-2-one

Conditions
ConditionsYield
In methanol100%
ethanol
64-17-5

ethanol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

ethyl (S)-pyroglutamate
7149-65-7

ethyl (S)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;99%
With thionyl chloride at 0℃; for 15h;99%
With thionyl chloride at -5 - 20℃; for 10h;98%
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Succinimide
123-56-8

Succinimide

Conditions
ConditionsYield
With ammonium peroxydisulfate; silver nitrate In water at 20℃; for 2h; Reagent/catalyst; Temperature;99%
With iodosylbenzene In dichloromethane for 48h; Ambient temperature;27%
allyl alcohol
107-18-6

allyl alcohol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-allyl 5-oxopyrrolidine-2-carboxylate
4931-79-7

(S)-allyl 5-oxopyrrolidine-2-carboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane99%
With thionyl chloride at 20℃; for 12h;85%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 5℃; Inert atmosphere;
N1-(4,4-difluorocyclohexyl)-4-(3,5-dimethylisoxazol-4-yl)benzene-1,2-diamine

N1-(4,4-difluorocyclohexyl)-4-(3,5-dimethylisoxazol-4-yl)benzene-1,2-diamine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-N-(2-((4,4-difluorocyclohexyl)amino)-5-(3,5-dimethylisoxazol-4-yl)phenyl)-5-oxopyrrolidine-2-carboxamide

(S)-N-(2-((4,4-difluorocyclohexyl)amino)-5-(3,5-dimethylisoxazol-4-yl)phenyl)-5-oxopyrrolidine-2-carboxamide

Conditions
ConditionsYield
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h;99%
tegaserod
1044642-88-7

tegaserod

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

3-(5-methoxy-1H-indol-3-ylmethylene)-N-pentylcarbazimidamide pidolate

3-(5-methoxy-1H-indol-3-ylmethylene)-N-pentylcarbazimidamide pidolate

Conditions
ConditionsYield
In acetone at 25 - 55℃; for 20h;98.3%
isopropyl alcohol
67-63-0

isopropyl alcohol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-isopropyl 5-oxopyrrolidine-2-carboxylate
52989-50-1

(S)-isopropyl 5-oxopyrrolidine-2-carboxylate

Conditions
ConditionsYield
With thionyl chloride at 15℃; for 2h;98.1%
With toluene-4-sulfonic acid for 6h; Haller-Bauer Reaction; 4 A molecular sieve;96%
With toluene-4-sulfonic acid for 6h; Heating / reflux;96%
(1S,2R,5S)-(+)-menthol
15356-60-2

(1S,2R,5S)-(+)-menthol

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-oxopyrrolidine-5-carboxylate
139014-48-5

(S)-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-oxopyrrolidine-5-carboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 23℃; for 24.5h; Inert atmosphere;98%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 20.5h; Inert atmosphere;86%
carboxymethyl-dodecyl-dimethyl-ammonium betaine
683-10-3

carboxymethyl-dodecyl-dimethyl-ammonium betaine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

C16H34NO2(1+)*C5H6NO3(1-)

C16H34NO2(1+)*C5H6NO3(1-)

Conditions
ConditionsYield
In ethanol at 25℃; for 0.5h;98%
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
88150-42-9

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

amlodipine (R)-(+)-pyroglutamate
663180-17-4

amlodipine (R)-(+)-pyroglutamate

Conditions
ConditionsYield
In ethanol at 5 - 20℃; for 1h;97.1%
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

LiOH

LiOH

lithium L-pyroglutamate
38609-04-0

lithium L-pyroglutamate

Conditions
ConditionsYield
In water for 2h; Heating;97%
methyl glyoxylate methyl hemi-acetal
109745-70-2, 19757-97-2

methyl glyoxylate methyl hemi-acetal

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

methyl 2-hydroxy-2-(2-oxoprolin-1-yl)acetate
502481-82-5

methyl 2-hydroxy-2-(2-oxoprolin-1-yl)acetate

Conditions
ConditionsYield
In acetone for 60h; Heating;97%
amlodipine
103129-82-4

amlodipine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-(-)-amlodipine pidolate salt
851447-24-0

(S)-(-)-amlodipine pidolate salt

Conditions
ConditionsYield
In ethanol at 20℃; for 1h;97%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(2S,5R)-6-(sulfoxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
1192500-31-4

(2S,5R)-6-(sulfoxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Conditions
ConditionsYield
Stage #1: L-Pyroglutamic acid With benzyl chloride; triethylamine In chloroform at 0℃; for 3.5h; Reflux;
Stage #2: di-tert-butyl dicarbonate With dmap; triethylamine In ethyl acetate at -25 - 35℃; for 4.91667h;
Stage #3: With pyrographite; sodium sulfate In cyclohexane; water Solvent; Temperature;
96.3%
isobutene
115-11-7

isobutene

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

L-t-butyl pyroglutamate
35418-16-7, 85136-12-5

L-t-butyl pyroglutamate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane96%
With sulfuric acid In dichloromethane at 0 - 20℃; Inert atmosphere;78%
With sulfuric acid In dichloromethane at 25℃; for 48h;65%
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl (L)-pyroglutamate
94885-52-6

benzyl (L)-pyroglutamate

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide for 15h; Ambient temperature;96%
With thionyl chloride at 0 - 20℃;96%
With thionyl chloride; N,N-dimethyl-formamide at 20℃;90%
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate
1189587-53-8

(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate
1189587-54-9

(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0℃; for 8h;96%
febuxostat

febuxostat

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

febuxostat hemipidolate salt

febuxostat hemipidolate salt

Conditions
ConditionsYield
In acetone at 20 - 25℃; for 4h; Solvent;96%
vortioxetine
508233-74-7

vortioxetine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine L-pyroglutamate

1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine L-pyroglutamate

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 60℃; for 2h;96%
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
113994-41-5

2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

amlodipine (S)-(-)-pyroglutamate

amlodipine (S)-(-)-pyroglutamate

Conditions
ConditionsYield
In ethyl acetate at 25℃; for 1h;95.3%
In ethyl acetate at 25℃; for 1h;95.3%
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