Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:460-00-4
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inquiryItems Standard Result Appearance Colorless,transparent liquid Complies Content% ≥99.90
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:4-Bromofluorobenzene CAS NO:460-00-4 Grade:Medical scientific research and export Molecular formula:C2H2BrF Molecular weight:124.9397 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability
Cas:460-00-4
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inquiryProduct Description Name 4-Bromofluorobenzene CAS 460-00-4 Assay 99% Appearance
Cas:460-00-4
Min.Order:1 Kilogram
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inquiry460-00-4 4-Bromofluorobenzene 1.Large qty in stock 2.High quality 3.Lowest price 4.Best service Our Advantage 1. Risk-free guarantee,15days refund 2. Most of the products in stock,can ship within 7days after the order 3. Stable
Cas:460-00-4
Min.Order:1 Liter
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:460-00-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t
Cas:460-00-4
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inquiryIdentification Product name: 4-Bromofluorobenzene Product name: 4-Bromofluorobenzene Molecular formula: C6H4BrF Molecular weight: 175.00 St
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:460-00-4
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Type:Trading Company
inquiry4-Bromofluorobenzene CAS:460-00-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm
Cas:460-00-4
Min.Order:1 Gram
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:460-00-4
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:460-00-4
Min.Order:1 Kilogram
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inquiry4-Bromofluorobenzene CAS: 460-00-4 Specification mp −16 °c(lit.) bp 150 °c(lit.) density 1.593 g/ml at 25 °c(lit.) refractive index n20/d 1.527(lit.) fp 140 °f
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:460-00-4
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:460-00-4
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:460-00-4
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:460-00-4
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Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With carbon dioxide; bromine at 40℃; under 187519 Torr; for 2h; Supercritical conditions; Green chemistry; | 100% |
With N-Bromosuccinimide; boron trifluoride at 20℃; for 1h; | 96% |
With tribromo-isocyanuric acid In trifluoroacetic acid at 20℃; for 0.5h; | 74% |
Conditions | Yield |
---|---|
With boron tribromide; dimethyl sulfoxide at 80℃; for 1h; | 99% |
Conditions | Yield |
---|---|
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride; diphenylzinc In toluene at 80℃; for 20h; Product distribution / selectivity; Sealed vial; | 95% |
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride In toluene at 23 - 80℃; for 18.5h; Inert atmosphere; | 88 %Spectr. |
Conditions | Yield |
---|---|
With dibenzo-18-crown-6; N,N,N,N,-tetramethylethylenediamine; potassium bromide; copper(I) bromide; copper(ll) bromide In acetonitrile at 20℃; for 1h; Sandmeyer Reaction; | 94% |
With (triphenylphosphine)gold(I) chloride; sodium bromide In acetonitrile at 50℃; for 5h; Sandmeyer Reaction; | 81 %Spectr. |
With Bromotrichloromethane; tetrabutylammonium perchlorate In N,N-dimethyl-formamide at 20℃; for 3h; Sandmeyer Reaction; Electrochemical reaction; | 37 %Spectr. |
With lithium bromide In acetonitrile at 20℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Time; Sandmeyer Reaction; Inert atmosphere; | 96 %Spectr. |
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With tetrafluoroboric acid diethyl ether In tetradecafluorohexane at 100℃; for 1h; Balz-Schiemann reaction; Autoclave; solid phase reaction; | 88% |
Conditions | Yield |
---|---|
Stage #1: 4-fluoroaniline With boron trifluoride diethyl etherate; lithium bromide In acetonitrile at 0℃; for 0.166667h; Stage #2: With tert.-butylnitrite In acetonitrile at 0 - 20℃; for 1h; | 82% |
Stage #1: 4-fluoroaniline With Bromotrichloromethane; sodium nitrite In dichloromethane; water at 23℃; for 0.0833333h; Stage #2: With acetic acid In dichloromethane; water at 23℃; for 1h; | 51% |
Conditions | Yield |
---|---|
Stage #1: 1.4-dibromobenzene With n-butyllithium In tetrahydrofuran; hexane at 0℃; Flow reactor; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; hexane at 0℃; Flow reactor; | 78% |
Conditions | Yield |
---|---|
Stage #1: 1.4-dibromobenzene With n-butyllithium In tetrahydrofuran; hexane at 0℃; Flow reactor; Stage #2: With 2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide In tetrahydrofuran; hexane at 0℃; Flow reactor; | A 13% B 76% |
Conditions | Yield |
---|---|
Stage #1: 4-Bromophenylboronic acid With sodium hydroxide In methanol at 23℃; for 0.25h; Inert atmosphere; Stage #2: With silver trifluoromethanesulfonate In methanol at 0℃; for 0.5h; Inert atmosphere; Stage #3: With Selectfluor In acetone at 23℃; for 1h; Inert atmosphere; Molecular sieve; regiospecific reaction; | 73% |
With cesium fluoroxysulphate In methanol at 0℃; for 24h; | 20 % Spectr. |
Multi-step reaction with 2 steps 1: diethyl ether / 20 °C / Inert atmosphere; Molecular sieve 2: silver fluoride; (tBuCN)2Cu*OTf; 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate / tetrahydrofuran / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: methanol; water / 14 h / 23 °C 2: 2,2':6,2''-terpyridine; [(terpy)Pd(MeCN)][BF4]2; sodium fluoride; 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) / acetonitrile / 15 h / 40 °C View Scheme | |
Stage #1: 4-Bromophenylboronic acid With C27H23N4O6PdS; potassium carbonate In methanol; benzene at 23℃; for 3.5h; Stage #2: With Selectfluor In acetonitrile at 50℃; for 0.5h; | 12.8 mg |
Pd(C5H5N)(C13H8N2SO2C6H4NO2)(C6H4Br)
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
Stage #1: Pd(C5H5N)(C13H8N2SO2C6H4NO2)(C6H4Br) With Selectfluor In acetonitrile at 50℃; for 0.5h; Stage #2: With pyridine In acetonitrile at 23℃; Product distribution / selectivity; | 73% |
Conditions | Yield |
---|---|
With tert.-butylnitrite; boron trifluoride diethyl etherate In various solvent(s) at 100 - 110℃; for 2h; Balz-Schiemann reaction; | 54% |
With tert.-butylnitrite; boron trifluoride diethyl etherate In 1,2-dichloro-benzene at 100 - 115℃; for 1.08333h; Balz-Schiemann Reaction; | 54% |
Stage #1: 4-bromo-aniline With tetrafluoroboric acid; 1-ethyl-3-methylimidazolium tetrafluoroborate; sodium nitrite at 0 - 20℃; for 12.5h; Stage #2: at 90℃; Balz-Schiemann reaction; | 100 % Spectr. |
Stage #1: 4-bromo-aniline With lithium tetrafluoroborate; tert.-butylnitrite; boron trifluoride diethyl etherate In acetonitrile at 0℃; for 0.0833333h; Balz-Schiemann Reaction; Flow reactor; Stage #2: In toluene; acetonitrile at 120℃; for 1h; Solvent; Reagent/catalyst; Balz-Schiemann Reaction; Flow reactor; |
(N,N′-di-tert-butyl-2,11-diaza[3.3](2,6)pyridinophane)Ni(PhF)Br
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With ferrocenium hexafluorophosphate In [D3]acetonitrile at -50 - 20℃; for 0.0833333h; Glovebox; Schlenk technique; Inert atmosphere; | 36% |
Conditions | Yield |
---|---|
With lead(IV) acetate; trifluoroacetic acid; potassium bromide at 25℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With manganese triacetate; trifluoroacetic acid; potassium bromide for 72h; Product distribution; Ambient temperature; Co(CH3COO)3, 67percent aq. CF3COOH, 15 - 10 h; | |
With potassium nitrate; potassium bromide In water; trifluoroacetic acid at 20℃; for 10h; Product distribution; under argon; |
fluorobenzene
A
o-fluorobromobenzene
B
2,4-dibromo-1-fluorobenzene
C
2,4,6-Tribromofluorobenzene
D
1-Fluoro-1,2,3,4,5,6-hexabromocyclohexane
E
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With bromine In trichlorofluoromethane for 42h; Irradiation; other compounds: o-, m-, p-difluorobenzene; |
fluorobenzene
A
o-fluorobromobenzene
B
2,4-dibromo-1-fluorobenzene
C
1-Fluoro-1,2,3,4,5,6-hexabromocyclohexane
D
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With bromine In trichlorofluoromethane for 42h; Irradiation; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; |
bromobenzene
A
o-fluorobromobenzene
B
3-fluorobromobenzene
C
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With fluorine In trichlorofluoromethane at -78℃; for 1h; | A 23 % Chromat. B 17 % Chromat. C 60 % Chromat. |
With fluorine In trichlorofluoromethane at -78℃; for 1h; Rate constant; Product distribution; competitive reaction with benzene; | A 23 % Chromat. B 17 % Chromat. C 60 % Chromat. |
With xenon difluoride; boron trifluoride diethyl etherate In acetonitrile at -35 - 20℃; for 2.5h; Inert atmosphere; Overall yield = 56 %; |
4-bromobenzenediazonium tetrafluoroborate
A
bromochlorobenzene
B
bromobenzene
C
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With 18-crown-6 ether; 1,2-dichloro-ethane at 50℃; Rate constant; | A 11.1 % Chromat. B 82.3 % Chromat. C 6.6 % Chromat. |
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With meta-dinitrobenzene; cesium fluoroxysulphate In acetonitrile Ambient temperature; | 15 % Spectr. |
Conditions | Yield |
---|---|
With bromobenzene; Cu-HZSM-5 zeolite at 399.9℃; Mechanism; | 9.7 % Chromat. |
4-bromobenzenediazonium tetrafluoroborate
A
bromochlorobenzene
B
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
In dichloromethane for 336h; Schiemann reaction; Heating; | A 5 % Chromat. B 30 % Chromat. |
1-Bromo-4-fluorobenzene
fluorobenzene
bromine
A
o-fluorobromobenzene
B
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
at 100℃; |
carbon disulfide
fluorobenzene
bromine
A
o-fluorobromobenzene
B
3-fluorobromobenzene
C
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
at 55℃; Product distribution; |
tetrachloromethane
fluorobenzene
A
o-fluorobromobenzene
B
3-fluorobromobenzene
C
4-fluoro-1-iodobenzene
D
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
Product distribution; |
fluorobenzene
A
1,2,-dibromo-4-fluorobenzene
B
2,4-dibromo-1-fluorobenzene
C
1-Bromo-4-fluorobenzene
fluorobenzene
A
o-fluorobromobenzene
B
3-fluorobromobenzene
C
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With bromine at 25℃; for 16h; Irradiation; Yield given; |
Conditions | Yield |
---|---|
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium methylate In methanol; acetonitrile at 40℃; for 4h; | 99 % Chromat. |
Conditions | Yield |
---|---|
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium methylate In methanol; acetonitrile at 40℃; | 97 % Chromat. |
bromobenzene
A
o-fluorobromobenzene
B
2-bromo-1-oxypentafluorosulfanylbenzene
C
4-bromo-1-oxypentafluorosulfanylbenzene
R
3-fluorobromobenzene
S
1,3-dibromobenzene
T
1.4-dibromobenzene
U
1-Bromo-4-fluorobenzene
V
1,2-dibromobenzene
Conditions | Yield |
---|---|
With bis(pentafluorosulfur) peroxide at 100℃; for 17h; |
2,4-dimethylbenzaldehyde
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With iodine; magnesium In tetrahydrofuran | 100% |
With iodine; magnesium In tetrahydrofuran | 100% |
With iodine; magnesium In tetrahydrofuran | 100% |
1-Bromo-4-fluorobenzene
cyclohexylmagnesium bromide
1-cyclohexyl-4-fluorobenzene
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-4-fluorobenzene With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II) In tetrahydrofuran for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Stage #2: cyclohexylmagnesium bromide With lithium bromide In tetrahydrofuran at 20℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique; | 100% |
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 120℃; Inert atmosphere; | 100% |
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 12h; Schlenk technique; Inert atmosphere; | 100% |
Norbornan-2-on
1-Bromo-4-fluorobenzene
2-(4-fluorophenyl)bicyclo[2.2.1]heptan-2-ol
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-4-fluorobenzene With iodine; magnesium In tetrahydrofuran at 0℃; for 4h; Stage #2: Norbornan-2-on In tetrahydrofuran at 0 - 20℃; Stage #3: With water In tetrahydrofuran | 99% |
With magnesium | |
Stage #1: 1-Bromo-4-fluorobenzene With iodine; magnesium In tetrahydrofuran Cooling with ice; Inert atmosphere; Stage #2: Norbornan-2-on In tetrahydrofuran at 20℃; Inert atmosphere; Stage #3: With hydrogenchloride In tetrahydrofuran; water pH=7; |
Conditions | Yield |
---|---|
With (1E,2E)-N1,N2-bis(2,6-dimethylphenyl)ethane-1,2-diimine; nickel dibromide; zinc In tetrahydrofuran at 70℃; for 10h; Inert atmosphere; | 99% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride In dimethyl sulfoxide at 120℃; for 10h; | 98% |
With potassium phosphate In ethanol; water at 80℃; for 20h; | 97% |
Conditions | Yield |
---|---|
With Br(1-)*C28H29BrN5O2Pd(1+); potassium carbonate In methanol; water at 100℃; for 3h; Suzuki-Miyaura coupling; | 99% |
With potassium phosphate In methanol at 60℃; for 1.5h; Suzuki coupling; | 99% |
With 0.42C23H20N4O4*2Cl(1-)*Zn(2+)*10.16H2O*0.58Pd(2+)*0.58C23H20N4O4(1-); potassium carbonate In toluene at 70℃; for 5h; Suzuki-Miyaura Coupling; | 99% |
4-methylphenylboronic acid
1-Bromo-4-fluorobenzene
4-methyl-4'-fluorobiphenyl
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene for 0.25h; Suzuki Coupling; Inert atmosphere; Stage #2: 4-methylphenylboronic acid In ethanol; water; toluene at 80℃; for 48h; Suzuki Coupling; Inert atmosphere; | 99% |
With 3,5-di-tert-butyl-2-hydroxybenzaldehyde; potassium carbonate; palladium dichloride In ethanol; water at 20℃; for 2h; Suzuki-Miyaura Coupling; | 99% |
With tetrabutylammonium acetate; polyurea-encapsulated Pd(OAc)2 In various solvent(s) at 100℃; Suzuki reaction; | 98% |
4-methoxyphenylboronic acid
1-Bromo-4-fluorobenzene
4-(4-fluorophenyl)anisole
Conditions | Yield |
---|---|
With barium hydroxide octahydrate; palladium diacetate; triphenylphosphine In tetrahydrofuran; water at 80℃; for 18h; Inert atmosphere; | 99% |
With caesium carbonate In propan-1-ol; water at 20℃; for 1h; Suzuki-Miyaura Coupling; Inert atmosphere; | 98% |
With palladium diacetate In water; N,N-dimethyl-formamide at 25℃; | 96% |
Conditions | Yield |
---|---|
With potassium phosphate; [Pd(Ph2PCH2CH(CH3)O)2] In tetrahydrofuran; water at 20℃; for 9h; Suzuki cross-coupling reaction; | 99% |
With potassium fluoride; [Ph2P(CH2)2NH2]2PdCl2 In tetrahydrofuran; water at 25 - 27℃; for 7h; Suzuki cross-coupling reaction; | 99% |
3,4-(methylenedioxy)-benzeneboronic acid
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With barium hydroxide octahydrate; palladium diacetate; triphenylphosphine In tetrahydrofuran; water at 60℃; for 16h; Inert atmosphere; | 99% |
With tetra-butylammonium acetate; Pd EnCat-30TM In acetonitrile at 140℃; for 0.25h; Suzuki cross-coupling; microwave irradiation; |
3-chloro-4-fluorophenylboronic acid
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With tetra-butylammonium acetate; Pd EnCat-30TM In ethanol at 120℃; for 0.166667h; Suzuki cross-coupling; microwave irradiation; | 99% |
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1-Bromo-4-fluorobenzene
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane at -50 - 23℃; for 4h; Inert atmosphere; Flow reactor; | 99% |
Stage #1: 1-Bromo-4-fluorobenzene With n-butyllithium In tetrahydrofuran; toluene at -20℃; for 0.5h; Stage #2: 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran; toluene at -20 - 20℃; Further stages.; | 95% |
Stage #1: 1-Bromo-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #2: 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran; hexane at -78℃; Inert atmosphere; | 84% |
With n-butyllithium; Triisopropyl borate In tetrahydrofuran; hexane at -60℃; | 77% |
With n-butyllithium In tetrahydrofuran at -80 - 20℃; for 5h; | 56% |
Trimethyl borate
1-Bromo-4-fluorobenzene
dihydroxy-(5-bromo-2-fluorophenyl)-borane
Conditions | Yield |
---|---|
With acetic acid; lithium diisopropyl amide In tetrahydrofuran; diethyl ether; water | 99% |
1-(2,3-dihydro-1H-naphtho[1,8-de]-1,3,2-diazaborinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene
1-Bromo-4-fluorobenzene
4-(2,3-dihydro-1H-naphtho[1,8-de]-1,3,2-diazaborinyl)-4'-fluoro-1,1'-biphenyl
Conditions | Yield |
---|---|
With sodium hydroxide; bis(tri-tert-butylphosphine)palladium In 1,4-dioxane; water at 60℃; for 4h; Suzuki-Miyaura coupling; | 99% |
4-fluorobenzaldehyde
1-Bromo-4-fluorobenzene
4,4'-difluorobenzhydryl alcohol
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In diethyl ether Stage #2: 4-fluorobenzaldehyde In diethyl ether at -18℃; | 99% |
Stage #1: 1-Bromo-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexanes at -78℃; for 0.35h; Stage #2: 4-fluorobenzaldehyde In tetrahydrofuran; hexanes at -78℃; for 1.25h; Stage #3: With acetic acid In tetrahydrofuran; hexanes | 94% |
Stage #1: 1-Bromo-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 4-fluorobenzaldehyde In tetrahydrofuran; hexane for 0.333333h; Inert atmosphere; Stage #3: With water In tetrahydrofuran; hexane Inert atmosphere; | 92% |
Stage #1: 4-fluorobenzaldehyde; 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran at 20 - 85℃; for 2h; Stage #2: In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | |
Stage #1: 1-Bromo-4-fluorobenzene With magnesium In diethyl ether at 20℃; for 2h; Inert atmosphere; Stage #2: 4-fluorobenzaldehyde In diethyl ether at 20℃; for 2h; Inert atmosphere; |
(2,6-dimethoxyphenyl)boronic acid
1-Bromo-4-fluorobenzene
2,6-dimethoxy-4'-fluorobiphenyl
Conditions | Yield |
---|---|
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); triethylamine In water at 20℃; for 24h; Suzuki-Miyaura reaction; Inert atmosphere; Micellar solution; | 99% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2,5-di(2,4,6-trimethylphenyl)-1,2,5-thiadiazolidine-1-oxide; tetrabutylammomium bromide; sodium acetate In 1-methyl-pyrrolidin-2-one at 200℃; for 0.5h; Heck reaction; Microwave irradiation; | 99% |
With 2,5-di(2,4,6-trimethylphenyl)-1,2,5-thiadiazolidine-1-oxide; tetrabutylammomium bromide; sodium acetate; bis(dibenzylideneacetone)-palladium(0) In 1-methyl-pyrrolidin-2-one at 200℃; for 0.5h; Mizoroki-Heck reaction; Microwave irradiation; | 99% |
With potassium phosphate; C34H46Br4N8Pd2 In N,N-dimethyl-formamide at 110℃; for 4h; Heck Reaction; | 80% |
With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; 1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol In N,N-dimethyl acetamide at 140℃; for 40h; Heck Reaction; Inert atmosphere; |
4-Methoxystyrene
1-Bromo-4-fluorobenzene
1-(4-methoxystyryl)-4-fluorobenzene
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2,5-di(2,4,6-trimethylphenyl)-1,2,5-thiadiazolidine-1-oxide; tetrabutylammomium bromide; sodium acetate In 1-methyl-pyrrolidin-2-one at 200℃; for 0.5h; Heck reaction; Microwave irradiation; | 99% |
With 2,5-di(2,4,6-trimethylphenyl)-1,2,5-thiadiazolidine-1-oxide; tetrabutylammomium bromide; sodium acetate; bis(dibenzylideneacetone)-palladium(0) In 1-methyl-pyrrolidin-2-one at 200℃; for 0.5h; Mizoroki-Heck reaction; Microwave irradiation; | 99% |
With dichloro bis(acetonitrile) palladium(II); 10F6P(1-)*C235H200N20O10(10+); potassium hydroxide In 1-methyl-pyrrolidin-2-one at 160℃; for 5h; Heck Reaction; Inert atmosphere; | 95% |
With potassium phosphate; C34H46Br4N8Pd2 In N,N-dimethyl-formamide at 110℃; for 4h; Heck Reaction; | 73% |
7,8-benzoquinoline
1-Bromo-4-fluorobenzene
10-(4-fluorophenyl)benzo[h]quinoline
Conditions | Yield |
---|---|
With rhodium(II) acetate dimer; 1,3-bis(mesityl)imidazolium chloride; sodium t-butanolate; tricyclohexylphosphine In toluene at 80℃; | 99% |
With iron(III)-acetylacetonate; 1,2-dichloro-2-methylpropane; magnesium; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane at 0℃; for 24h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine In toluene for 3h; Inert atmosphere; Reflux; | 99% |
(5,10,15,20-tetrakis(p-tolyl)porphyrinato)carbonyliridium(III) chloride
1-Bromo-4-fluorobenzene
(p-fluorophenyl)(5,10,15,20-tetrakis(p-tolyl)porphyrinato)iridium(III)
Conditions | Yield |
---|---|
With K2CO3 In benzene mixing Ir complex, Br compd., K2CO3 (20 equiv.), C6H6, 200°C, 20 h; | 99% |
With potassium carbonate In benzene at 200℃; for 20h; Inert atmosphere; Darkness; | 99% |
(5,10,15,20-tetrakis(p-tolyl)porphyrinato)carbonyliridium(III) chloride
1-Bromo-4-fluorobenzene
Conditions | Yield |
---|---|
With potassium carbonate In benzene at 200℃; for 20h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tetrabutylammomium bromide; triethylamine In N,N-dimethyl-formamide at 140℃; for 20h; Reagent/catalyst; Heck Reaction; Sealed tube; Inert atmosphere; Schlenk technique; | 99% |
With bis(η3-allyl-μ-chloropalladium(II)); 6H-dibenzo[d,f-1,3]diazepin-6-ylidene-5,7-dihydro-5,7-diphenylphosphanyl; sodium carbonate In N,N-dimethyl acetamide at 130℃; for 24h; Heck Reaction; Schlenk technique; Inert atmosphere; | 96% |
With bis(η3-allyl-μ-chloropalladium(II)); 6H-dibenzo[d,f-1,3]diazepin-6-ylidene-5,7-dihydro-5,7-diphenylphosphanyl; sodium carbonate In N,N-dimethyl acetamide at 130℃; for 24h; Concentration; Time; Heck Reaction; Inert atmosphere; Schlenk technique; | 96% |
Conditions | Yield |
---|---|
With Potassium phosphate In N,N-dimethyl-formamide at 150℃; for 27h; | 99% |
With potassium phosphate In N,N-dimethyl-formamide at 190℃; for 1h; Microwave irradiation; | 71% |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20 - 130℃; for 5.5h; Cooling with ice; | 13 g |
With potassium phosphate In 1-methyl-pyrrolidin-2-one at 200℃; for 2h; Sealed tube; | |
With potassium phosphate In 1-methyl-pyrrolidin-2-one at 200℃; for 2h; Sealed tube; |
2-Benzylpyridine
1-Bromo-4-fluorobenzene
2-((4-fluorophenyl)(phenyl)methyl)pyridine
Conditions | Yield |
---|---|
With 15-crown-5; NiXantphos; palladium diacetate; sodium hexamethyldisilazane at 23℃; for 12h; Catalytic behavior; Reagent/catalyst; Glovebox; Inert atmosphere; Sealed tube; | 99% |
With bis(1,5-cyclooctadiene)nickel (0); sodium hexamethyldisilazane; nixantphos at 50℃; for 16h; | 83% |
With tris(triphenylphosphine)rhodium(l) chloride; C18H27N2(1+)*Cl(1-); sodium t-butanolate In toluene at 120℃; for 12h; Inert atmosphere; | 63% |
1-Bromo-4-fluorobenzene
1-cyclopentyl-4-fluorobenzene
Conditions | Yield |
---|---|
With Pd-PEPPSI-IPrAn In tetrahydrofuran; 1,4-dioxane at 0 - 20℃; for 0.5h; Negishi Coupling; Schlenk technique; Inert atmosphere; | 99% |
4-Methylthiazole
1-Bromo-4-fluorobenzene
5-(4-fluorophenyl)-4-methylthiazole
Conditions | Yield |
---|---|
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h; | 99% |
With C23H20ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; regioselective reaction; | 94% |
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h; | 83% |
Conditions | Yield |
---|---|
With palladium diacetate; sodium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In water at 80℃; for 4h; Time; Suzuki-Miyaura Coupling; | 99% |
With water; palladium diacetate; sodium carbonate at 80℃; for 2h; Time; Suzuki Coupling; Green chemistry; | 98% |
With [Pd(N-(3-chloro-2-quinoxalinyl)-N'-(2,6-diisopropylphenyl)imidazolium)(PPh3)Cl2]; potassium carbonate In water at 70℃; for 3h; Catalytic behavior; Suzuki-Miyaura Coupling; | 96% |
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