Ixazomib CAS No.:1072833-77-2 Name: Ixazomib Synonyms: MLN 2238; B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid Molecular Structure Molecular Fo
Cas:1072833-77-2
Min.Order:1 Kilogram
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1072833-77-2
Min.Order:1 Gram
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Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing ne
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:1072833-77-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:1072833-77-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1072833-77-2
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:1072833-77-2
Min.Order:10 Gram
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inquiry(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid CAS:1072833-77-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical inter
Cas:1072833-77-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se
Cas:1072833-77-2
Min.Order:0 Metric Ton
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1072833-77-2
Min.Order:100 Milligram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:1072833-77-2
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:1072833-77-2
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
Product name: Ixazomib CAS No.:1072833-77-2 Molecule Formula:C14H19BCl2N2O4 Molecule Weight:361.00 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:1072833-77-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:1072833-77-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:1072833-77-2
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Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:1072833-77-2
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:1072833-77-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryOur company advantages: 1 The highest quality with the competitive price. 2、 Professional human services. 3、 The fastest and safest delivery service. 4、Our old customers all around the world. 5、 The high purity products. 6、We have a suf
Cas:1072833-77-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
Cas:1072833-77-2
Min.Order:0
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Type:Lab/Research institutions
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:1072833-77-2
Min.Order:1 Kilogram
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Type:Other
inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
Cas:1072833-77-2
Min.Order:0
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Type:Lab/Research institutions
inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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factory?direct?sale Application:healing drugs
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20℃; | 93% |
dihydroxy-methyl-borane
2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide
Ixazomib
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20℃; for 40h; | 92% |
2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide
boric acid
Ixazomib
Conditions | Yield |
---|---|
With hydrogenchloride In di-isopropyl ether at 20℃; for 5h; | 86.5% |
2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide
Ixazomib
Conditions | Yield |
---|---|
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; hexane; water | 76.5% |
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; hexane at 20℃; | 63% |
N-(fluoren-9-ylmethoxycarbonyl)glycine
2,5-dichlorobenzoic acid
Ixazomib
Conditions | Yield |
---|---|
Stage #1: C23H27BNO5Pol With piperidine In N,N-dimethyl-formamide for 0.333333h; 1-glycerol polystyrene resin; Stage #2: N-(fluoren-9-ylmethoxycarbonyl)glycine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 2h; 1-glycerol polystyrene resin; Stage #3: 2,5-dichlorobenzoic acid Further stages; | 49% |
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethyl acetate / 12 h / 120 °C 2: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C View Scheme | |
Stage #1: (R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide With boron trichloride In dichloromethane at -78℃; Inert atmosphere; Stage #2: With methanol for 0.166667h; | 23.0 mg |
Ixazomib
Conditions | Yield |
---|---|
With hydrogenchloride; water In ethyl acetate at 20℃; for 0.5h; |
2,5-dichlorobenzoic acid
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h 1.2: 12 h / 20 °C 2.1: lithium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C 3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / 20 °C 4.1: ethyl acetate / 12 h / 120 °C 5.1: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C 1.2: 0.5 h 1.3: 20 °C 2.1: lithium hydroxide monohydrate / methanol; water / 2 h 3.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C 3.2: 0.5 h 4.1: Dihydroxy-isobutyl-boran; hydrogenchloride / methanol; water; hexane View Scheme | |
Multi-step reaction with 5 steps 1: acetonitrile / 1 h / 20 °C / Inert atmosphere 2: sodium hydroxide; water / 1 h / 0 - 10 °C 3: acetonitrile / 20 - 30 °C 4: 1 h / 0 - 10 °C 5: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C View Scheme |
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C 2: benzotriazol-1-ol; dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / 20 °C 3: ethyl acetate / 12 h / 120 °C 4: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium hydroxide monohydrate / methanol; water / 2 h 2.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C 2.2: 0.5 h 3.1: Dihydroxy-isobutyl-boran; hydrogenchloride / methanol; water; hexane View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water; acetone / 2 h / 0 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C 3: hydrogenchloride / water; acetone / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water; acetone / 2 h / 0 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C 3: hydrogenchloride / water; acetone / 40 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium hydroxide monohydrate / methanol; water / 3 h / 20 °C / Cooling with ice 2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.67 h / -5 °C 2.2: 6.67 h / 20 °C 3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane / 20 °C View Scheme |
2-[(2,5-dichlorobenzoyl)amino]acetic acid
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / 20 °C 2: ethyl acetate / 12 h / 120 °C 3: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C 1.2: 0.5 h 2.1: Dihydroxy-isobutyl-boran; hydrogenchloride / methanol; water; hexane View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile / 20 - 30 °C 2: 1 h / 0 - 10 °C 3: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C View Scheme |
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1 h / 0 - 10 °C 2: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C View Scheme |
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide; water / 1 h / 0 - 10 °C 2: acetonitrile / 20 - 30 °C 3: 1 h / 0 - 10 °C 4: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C View Scheme |
Ixazomib
2,2'-iminobis[ethanol]
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Product distribution / selectivity; | 100% |
Ixazomib
citric acid
Conditions | Yield |
---|---|
In acetone at 20℃; for 0.5h; | 95% |
In ethyl acetate at 60℃; for 0.5h; |
Ixazomib
citric acid
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Conditions | Yield |
---|---|
In ethyl acetate at 60 - 74℃; for 3h; | 94% |
Ixazomib
2,2'-iminobis[ethanol]
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 74℃; for 3h; | 85.4% |
In ethyl acetate at 60 - 74℃; for 3h; | 557 mg |
Ixazomib
Conditions | Yield |
---|---|
In dimethyl sulfoxide; toluene for 18h; Reflux; | 83.4% |
Conditions | Yield |
---|---|
In chloroform-d1 | 67% |
N-Methyldiethanolamine
Ixazomib
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; | 66% |
Ixazomib
diisopropanolamine
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; | 64% |
Ixazomib
(R)-Mandelic Acid
2-chloro-5-chloro-N-[2-({(1R)-3-methyl-1-[(5R)-4-oxo-5-phenyl-1,3,2-dioxaborolan-2-yl]butyl}amino)-2-oxoethyl]benzamide
Conditions | Yield |
---|---|
In ethyl acetate for 0.666667h; | 57% |
Ixazomib
Conditions | Yield |
---|---|
With dimethylsulfoxide-d6; water-d2; potassium carbonate In tetrahydrofuran at 65℃; for 5h; | 55.6% |
With water-d2; sodium methylate at 0℃; for 72h; | 630 mg |
triethanolamine
Ixazomib
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 74℃; for 3h; | 53.3% |
Ixazomib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water-d2; sodium methylate / 72 h / 0 °C 2: ethyl acetate / 48 h / 40 °C View Scheme |
Conditions | Yield |
---|---|
In acetic acid butyl ester at 90℃; for 14h; | 51 mg |
Conditions | Yield |
---|---|
In acetic acid butyl ester at 90℃; for 14h; | 53 mg |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; |
Ixazomib
Ixazomib
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