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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(6-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID

Cas:1072946-50-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1072946-50-9 CAS NO.1072946-50-9

Cas:1072946-50-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(6-Chloro-2-methoxy-3-pyridinyl)boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

1072946-50-9

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SAGECHEM LIMITED

laboratory Application:Synthetic building block

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

6-Chloro-2-methoxypyridine-3-boronic acid 1072946-50-9

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

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Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

6-Chloro-2-methoxypyridine-3-boronic acid 1072946-50-9

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

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Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

(6-Chloro-2-methoxypyridin-3-yl)boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Other

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

B-(6-chloro-2-methoxy-3-pyridinyl)-Boronic acid

Cas:1072946-50-9

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

1072946-50-9 CAS NO.1072946-50-9

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ENAO Chemical Co, Limited

For quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,

(6-Chloro-2-methoxypyridin-3-yl)boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Chemlin Chemical Co., Ltd.

Compound sourcing ServicesAgency of testing serviceFactory audit serviceFounded in Dec. 1999, Nanjing Chemlin Chemical Industrial Co.,Ltd(CHEMLIN) has been covering the business scope from trading of chemicals to custom-synthesis & Manufacturing. Co

1072946-50-9

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Forever Synthesis Co.,Ltd.

As a professional chemical R&D and synthesis supplier, Shanghai Forever Synthesis Co.,Ltd. is specialized R&D and synthesizing APIs and Impurities. Besides, we value more special service, that is, to customize chemical synthesis according to client’s

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the 6-Chloro-2-methoxypyridine-3-boronic acid, CAS:1072946-50-9 with the most competitive

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GZ HONESTCHEM CO., LTD

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Nanjing Raymon Biotech Co., Ltd.

6-Chloro-2-methoxypyridine-3-boronic acid Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like DHL or Fedx. Port:Shanghai/S

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Pure Chemistry Scientific Inc.

1072946-50-9 Application:6-Chloro-2-methoxypyridine-3-boronic acid

6-Chloro-2-methoxypyridine-3-boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

B-(6-chloro-2-methoxy-3-pyridinyl)Boronic acid

Cas:1072946-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2,5-dibromo-3-nitro-pyridine
15862-37-0

2,5-dibromo-3-nitro-pyridine

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

5-bromo-6’-chloro-2’-methoxy-3-nitro-2,3’-bipyridine

5-bromo-6’-chloro-2’-methoxy-3-nitro-2,3’-bipyridine

Conditions
ConditionsYield
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran at 80℃; Suzuki Coupling; Inert atmosphere; Sealed tube;78%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-2-methoxypyridine
17228-64-7

6-chloro-2-methoxypyridine

Conditions
ConditionsYield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water In toluene at 90℃; for 3h; Microwave irradiation; Green chemistry;72%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine
1562338-65-1

6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(6-chloro-2-methoxypyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(6-chloro-2-methoxypyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 90℃; for 16h;55%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-3-iodo-2-methoxypyridine
1261769-34-9

6-chloro-3-iodo-2-methoxypyridine

Conditions
ConditionsYield
With N-iodo-succinimide at 90℃; for 0.0833333h; Microwave irradiation;51%
(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
1007882-59-8

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C18H23ClN4O3
1255936-29-8

C18H23ClN4O3

Conditions
ConditionsYield
Stage #1: (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium carbonate In 1,2-dimethoxyethane; water for 1.16667h;
Stage #1: (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium acetate In 1,2-dimethoxyethane; water for 1.16667h; Inert atmosphere;
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

2-chloro-6-methoxypyridine-5-d

2-chloro-6-methoxypyridine-5-d

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water / toluene / 3 h / 90 °C / Microwave irradiation; Green chemistry
2: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water-d2 / toluene; tetrahydrofuran / 2 h / 90 °C / Microwave irradiation
View Scheme
(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
1007882-59-8

(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C18H23ClN4O3
1255936-29-8

C18H23ClN4O3

Conditions
ConditionsYield
Stage #1: (S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester With palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium carbonate In 1,2-dimethoxyethane; water at 100℃; for 1.16667h;
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one

Conditions
ConditionsYield
With pyridine; copper diacetate In acetonitrile for 6h; Molecular sieve; Reflux;0.075 g
With pyridine; copper diacetate In acetonitrile for 6h; Molecular sieve; Reflux;0.075 g
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-thione

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-thione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 6 h / Molecular sieve; Reflux
2: Lawessons reagent / toluene / 5 h / Reflux
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

3-[(2-amino-6-methylphenyl)methyloxy]-1-(2-methoxy-6-chloropyridin-3-yl)pyrazole

3-[(2-amino-6-methylphenyl)methyloxy]-1-(2-methoxy-6-chloropyridin-3-yl)pyrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 6 h / Molecular sieve; Reflux
2: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

11-chloro-8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}ethan-1-one

1-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
5.2: 1.5 h
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

2-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}propan-2-ol

2-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
5.2: 1.5 h
6.1: cerium(III) chloride / tetrahydrofuran / 0.02 h / 20 °C
6.2: 0.17 h
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-N-methyl-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-N-[2-(methylamino)ethyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine

8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-N-methyl-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-N-[2-(methylamino)ethyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5: triethylamine / 0.5 h / Microwave irradiation
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-methanesulfonyl-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-methanesulfonyl-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
5: copper(II) bis(trifluoromethanesulfonate); N,N`-dimethylethylenediamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-(4,4-difluoropiperidin-l-yl)-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-(4,4-difluoropiperidin-l-yl)-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
5: palladium diacetate; ruphos; sodium t-butanolate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

A

(R)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

(R)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

B

(S)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

(S)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5.2: 2 h / 20 °C
6.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

3-bromo-7-chloro-9-methoxy-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

3-bromo-7-chloro-9-methoxy-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

(S)-3-bromo-7-chloro-9-methoxy-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

(S)-3-bromo-7-chloro-9-methoxy-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-chloro-8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C30H27(2)H3F2N6O2

C30H27(2)H3F2N6O2

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5.2: 2 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-[2-methoxy-6-(1H-pyrazol-4-yl)pyridin-3-yl]-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine hydrochloride

6-[2-methoxy-6-(1H-pyrazol-4-yl)pyridin-3-yl]-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
3: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-(2-methoxy-6-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)pyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(2-methoxy-6-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)pyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-6-(1H-pyrazol-4-yl)pyridin-2-ol hydrochloride

3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-6-(1H-pyrazol-4-yl)pyridin-2-ol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
3: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

(S)-tert-butyl 4-bromo-2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-1H-imidazole-1-carboxylate

(S)-tert-butyl 4-bromo-2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-1H-imidazole-1-carboxylate

(S)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-4-(6-chloro-2-methoxypyridin-3-yl)-l H-imidazole-1-carboxylate

(S)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-4-(6-chloro-2-methoxypyridin-3-yl)-l H-imidazole-1-carboxylate

Conditions
ConditionsYield
With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In tetrahydrofuran; water at 20 - 60℃; for 2h;

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