Quick Details ProName: Estradiol hot sales CasNo: 50-28-2 Molecular Formula: C18H24O2 Appearance: White powder Application: Pharmaceuticals DeliveryTime: Within 15 workdays after payment PackAge: accordi
Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the busine
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Items Standards Results Appearance Almost white crystal or crystalline powder Conforms
Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:-20°C Package:1kg/foil bag; 1kg/tin ; 25
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inquiryEplerenone CAS No.:107724-20-9 Name: Eplerenone Synonyms Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester Molecular Structure Molecular Formula: C24H30O6 Molecular Weig
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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Name:Eplerenone The alias:Eplerenone for system suitability CAS NO:107724-20-9 EINECS NO:600-850-8 Molecular formula:C24H30O6 Molecular weight:414.49 Product Quality 12 years of chemical raw materials Mature operation of the industry Sys
Cas:107724-20-9
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inquiryProduct Name: Eplerenone Synonyms: pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;EPLERENONE 98%;EPLERENONE USP STANDARD;Elperenone;EplerenoneC24H3006;pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hyd
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu
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Cas:107724-20-9
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inquiryName Eplerenone Synonyms Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester Molecular Formula
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:107724-20-9
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:107724-20-9
Min.Order:10 Gram
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:107724-20-9
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Type:Trading Company
inquiryProduct Name: Eplerenone Synonyms: plerenone;(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:107724-20-9
Min.Order:1 Gram
FOB Price: $10.5 / 12.3
Type:Trading Company
inquiryEplerenone CAS: 107724-20-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:107724-20-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
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Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:107724-20-9
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:107724-20-9
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe
Cas:107724-20-9
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiry17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
eplerenone
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 0 - 15℃; for 24h; pH=9; | 98% |
With trichloroacetamide; dihydrogen peroxide; potassium acetate In dichloromethane at 10 - 15℃; for 0.75h; Temperature; | 91.3% |
With potassium phosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 20℃; | 85.3% |
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
eplerenone
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; dihydrogen peroxide | 82% |
Multi-step reaction with 2 steps 1: potassium formate; formic acid / acetic anhydride / 100 °C 2: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme |
methanol
4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
sodium methylate
eplerenone
Conditions | Yield |
---|---|
Stage #1: methanol; 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate for 20.25h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; water Heating / reflux; Stage #3: With dipotassium hydrogenphosphate; formic acid; dihydrogen peroxide; potassium formate; acetic anhydride; methanesulfonyl chloride; triethylamine; trichloroacetonitrile more than 3 stages; | 27.1% |
Stage #1: methanol; 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate at 67℃; for 16 - 20h; Stage #2: With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 0.75h; Stage #3: With dipotassium hydrogenphosphate; formic acid; dihydrogen peroxide; potassium formate; acetic anhydride; trichloroacetonitrile more than 3 stages; | 7.2 g |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 24h; Heating / reflux; | 20% |
Δ9(11)-canrenone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 82 g / AlEt3 / hexane; tetrahydrofuran / 0.5 h / Heating 2: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C 3: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C 4: 2.7 g / CH2Cl2; diethyl ether / 0.17 h 5: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C View Scheme | |
Multi-step reaction with 5 steps 1.1: boron trifluoride diethyl etherate / tetrahydrofuran / -10 °C 2.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran; water / 35 °C 3.1: ozone / dichloromethane; isopropyl alcohol / -20 °C 3.2: 20 °C 4.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C 5.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C View Scheme |
C23H30O4
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C 2: 2.7 g / CH2Cl2; diethyl ether / 0.17 h 3: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C View Scheme |
17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C 2: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C 3: 2.7 g / CH2Cl2; diethyl ether / 0.17 h 4: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C View Scheme |
17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2.7 g / CH2Cl2; diethyl ether / 0.17 h 2: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C View Scheme |
Conditions | Yield |
---|---|
for 23.5h; Heating / reflux; |
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
E
eplerenone
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetonitrile In dichloromethane; water at 8 - 10℃; for 23h; | A n/a B 123 mg C n/a D 46.7 mg E 3.16 g |
eplerenone
11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 1.2: 4 h 2.1: potassium carbonate / 0 - 20 °C 3.1: triethylamine / dichloromethane / 0 °C 4.1: potassium formate; formic acid / acetic anhydride / 100 °C 5.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C 1.2: 4 h 2.1: potassium carbonate / acetone / 0 - 20 °C 3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 4.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere 5.1: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9 View Scheme |
11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: potassium formate; formic acid / acetic anhydride / 100 °C 6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme |
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 °C 2: potassium formate; formic acid / acetic anhydride / 100 °C 3: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sulfuryl dichloride; 1H-imidazole / tetrahydrofuran / 1.5 h / -10 - 20 °C 2: trichloroacetamide; disodium hydrogenphosphate; dihydrogen peroxide / dichloromethane / 18 h / 15 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 2: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere 3: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9 View Scheme |
9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / 0 - 20 °C 2: triethylamine / dichloromethane / 0 °C 3: potassium formate; formic acid / acetic anhydride / 100 °C 4: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate / acetone / 0 - 20 °C 2: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere 4: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9 View Scheme |
11α-hydroxyl canrenone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: potassium formate; formic acid / acetic anhydride / 100 °C 6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: potassium formate; formic acid / acetic anhydride / 100 °C 6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 2.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C 3.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 3.2: 4 h 4.1: potassium carbonate / 0 - 20 °C 5.1: triethylamine / dichloromethane / 0 °C 6.1: potassium formate; formic acid / acetic anhydride / 100 °C 7.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 - 100 °C 2.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / acetone / 0 - 20 °C 4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 5.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere 6.1: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9 View Scheme |
9(11)-encanrenone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -25 - -20 °C / Inert atmosphere 2: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere 3: ozone / -50 °C 4: trichloroacetamide; potassium phosphate; dihydrogen peroxide / dichloromethane / 20 °C View Scheme |
17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere 2: ozone / -50 °C 3: trichloroacetamide; potassium phosphate; dihydrogen peroxide / dichloromethane / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran; water / 35 °C 2.1: ozone / dichloromethane; isopropyl alcohol / -20 °C 2.2: 20 °C 3.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C 4.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C View Scheme |
eplerenone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ozone / dichloromethane; isopropyl alcohol / -20 °C 1.2: 20 °C 2.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C 3.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C View Scheme |
eplerenone
Conditions | Yield |
---|---|
Stage #1: eplerenone With sodium hydroxide In water; acetonitrile at 25 - 90℃; for 66.67h; Heating / reflux; Stage #2: With sulfuric acid In water; acetonitrile | 67% |
Multi-step reaction with 2 steps 1: lithium hydroxide / water / 48 h 2: hydrogenchloride / water View Scheme |
eplerenone
Conditions | Yield |
---|---|
With sodium methylate In methanol for 24h; Reflux; | A 49% B 0.55 g |
eplerenone
Conditions | Yield |
---|---|
With potassium hydroxide In 1,4-dioxane; water at 25 - 70℃; for 6h; | 0.55 g |
eplerenone
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 70℃; for 0.666667h; |
eplerenone
Conditions | Yield |
---|---|
With sodium methylate In methanol at 50 - 65℃; for 16.5h; Heating / reflux; | 400 mg |
orthoformic acid triethyl ester
eplerenone
Conditions | Yield |
---|---|
Stage #1: orthoformic acid triethyl ester; eplerenone; toluene-4-sulfonic acid In ethanol at 20℃; for 0.5h; Stage #2: With pyridine; sodium acetate In ethanol | 33.8 g |
eplerenone
C47H42O10
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium hydroxide / water / 48 h 2: hydrogenchloride / water 3: dmap; dicyclohexyl-carbodiimide View Scheme |
eplerenone
C23H30O7
Conditions | Yield |
---|---|
With lithium hydroxide In water for 48h; |
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