Product Name

  • Name

    Eplerenone

  • EINECS 600-850-8
  • CAS No. 107724-20-9
  • Article Data12
  • CAS DataBase
  • Density 1.31 g/cm3
  • Solubility
  • Melting Point 241-243 °C
  • Formula C24H30O6
  • Boiling Point 597.933 °C at 760 mmHg
  • Molecular Weight 414.499
  • Flash Point 259.474 °C
  • Transport Information
  • Appearance White solid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 107724-20-9 (Eplerenone)
  • Hazard Symbols
  • Synonyms Pregn-4-ene-7,21-dicarboxylic acid,9,11-epoxy-17-hydroxy-3-oxo-,?- lactone,methyl ester,(7R,11R,17R)-;9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester;Cgp 30083;Epoxymexrenone;SC-66110;Inspra;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-;Eplerenone(& the intermediates);Inspra (TN);Pregn-4-ene-7,21-dicarboxylic acid,9,11-epoxy-17-hydroxy-3-oxo-γ,-lactone,methyl ester,(7a,11a,17a);Pregn-4-ene-7,21-dicarboxylic acid,9,11-epoxy-17-hydroxy-3-oxo-,?- lactone,methyl ester,(7R,11R,17R)-;
  • PSA 82.20000
  • LogP 3.12450

Synthetic route

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 0 - 15℃; for 24h; pH=9;98%
With trichloroacetamide; dihydrogen peroxide; potassium acetate In dichloromethane at 10 - 15℃; for 0.75h; Temperature;91.3%
With potassium phosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 20℃;85.3%
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
192704-58-8

methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; dihydrogen peroxide82%
Multi-step reaction with 2 steps
1: potassium formate; formic acid / acetic anhydride / 100 °C
2: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
methanol
67-56-1

methanol

4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
192704-54-4

4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile

sodium methylate
124-41-4

sodium methylate

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Stage #1: methanol; 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate for 20.25h; Heating / reflux;
Stage #2: With hydrogenchloride In methanol; water Heating / reflux;
Stage #3: With dipotassium hydrogenphosphate; formic acid; dihydrogen peroxide; potassium formate; acetic anhydride; methanesulfonyl chloride; triethylamine; trichloroacetonitrile more than 3 stages;		27.1%
Stage #1: methanol; 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate at 67℃; for 16 - 20h;
Stage #2: With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 0.75h;
Stage #3: With dipotassium hydrogenphosphate; formic acid; dihydrogen peroxide; potassium formate; acetic anhydride; trichloroacetonitrile more than 3 stages;		7.2 g
...Expand
methanol
67-56-1

methanol

C24H27NO5

C24H27NO5

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 24h; Heating / reflux;20%
Δ9(11)-canrenone
95716-71-5

Δ9(11)-canrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 82 g / AlEt3 / hexane; tetrahydrofuran / 0.5 h / Heating
2: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C
3: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
4: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
5: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / tetrahydrofuran / -10 °C
2.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran; water / 35 °C
3.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
3.2: 20 °C
4.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
5.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C
View Scheme
C23H30O4
188988-15-0

C23H30O4

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
2: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
3: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
95716-72-6

17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C
2: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
3: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
4: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
95716-74-8

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
2: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
methanol
67-56-1

methanol

C24H27NO5

C24H27NO5

sodium methylate
124-41-4

sodium methylate

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
for 23.5h; Heating / reflux;
...Expand
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

A

7-methyl hydrogen 17-hydroxy-3,12-dioxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 17-hydroxy-3,12-dioxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

B

7-methyl hydrogen 12α,17-dihydroxy-3-oxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 12α,17-dihydroxy-3-oxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

C

7-methyl hydrogen 4α,5α:9α,11α-diepoxy,17-hydroxy-3-oxo-17α-pregnane-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 4α,5α:9α,11α-diepoxy,17-hydroxy-3-oxo-17α-pregnane-7α,21-dicarboxylate, γ-lactone

D

7-methyl hydrogen 9α,11β,17-trihydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 9α,11β,17-trihydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

E

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetonitrile In dichloromethane; water at 8 - 10℃; for 23h;A n/a
B 123 mg
C n/a
D 46.7 mg
E 3.16 g
...Expand
C23H28O6

C23H28O6

eplerenone
107724-20-9

eplerenone

11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
1398078-03-9

11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
1.2: 4 h
2.1: potassium carbonate / 0 - 20 °C
3.1: triethylamine / dichloromethane / 0 °C
4.1: potassium formate; formic acid / acetic anhydride / 100 °C
5.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C
1.2: 4 h
2.1: potassium carbonate / acetone / 0 - 20 °C
3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
4.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
5.1: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
1398078-09-5

11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
192704-56-6

11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0 °C
2: potassium formate; formic acid / acetic anhydride / 100 °C
3: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sulfuryl dichloride; 1H-imidazole / tetrahydrofuran / 1.5 h / -10 - 20 °C
2: trichloroacetamide; disodium hydrogenphosphate; dihydrogen peroxide / dichloromethane / 18 h / 15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
2: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
3: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone
209253-72-5

9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / 0 - 20 °C
2: triethylamine / dichloromethane / 0 °C
3: potassium formate; formic acid / acetic anhydride / 100 °C
4: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 0 - 20 °C
2: triethylamine / dichloromethane / 3 h / 0 - 20 °C
3: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
4: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
11α-hydroxyl canrenone
192569-17-8

11α-hydroxyl canrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C
2.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C
3.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
3.2: 4 h
4.1: potassium carbonate / 0 - 20 °C
5.1: triethylamine / dichloromethane / 0 °C
6.1: potassium formate; formic acid / acetic anhydride / 100 °C
7.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 - 100 °C
2.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / acetone / 0 - 20 °C
4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
5.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
6.1: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
9(11)-encanrenone
41850-21-9

9(11)-encanrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -25 - -20 °C / Inert atmosphere
2: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere
3: ozone / -50 °C
4: trichloroacetamide; potassium phosphate; dihydrogen peroxide / dichloromethane / 20 °C
View Scheme
17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
610785-40-5

17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere
2: ozone / -50 °C
3: trichloroacetamide; potassium phosphate; dihydrogen peroxide / dichloromethane / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran; water / 35 °C
2.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
2.2: 20 °C
3.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
4.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C
View Scheme
7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
1.2: 20 °C
2.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
3.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C
View Scheme
eplerenone
107724-20-9

eplerenone

9,11α-epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, γ-lactone

9,11α-epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, γ-lactone

Conditions
ConditionsYield
Stage #1: eplerenone With sodium hydroxide In water; acetonitrile at 25 - 90℃; for 66.67h; Heating / reflux;
Stage #2: With sulfuric acid In water; acetonitrile		67%
Multi-step reaction with 2 steps
1: lithium hydroxide / water / 48 h
2: hydrogenchloride / water
View Scheme
eplerenone
107724-20-9

eplerenone

A

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

B

9,11α-epoxy-7-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11α-epoxy-7-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

Conditions
ConditionsYield
With sodium methylate In methanol for 24h; Reflux;A 49%
B 0.55 g
eplerenone
107724-20-9

eplerenone

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, dipotassium salt

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, dipotassium salt

Conditions
ConditionsYield
With potassium hydroxide In 1,4-dioxane; water at 25 - 70℃; for 6h;0.55 g
eplerenone
107724-20-9

eplerenone

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, disodium salt

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, disodium salt

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 70℃; for 0.666667h;
eplerenone
107724-20-9

eplerenone

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

Conditions
ConditionsYield
With sodium methylate In methanol at 50 - 65℃; for 16.5h; Heating / reflux;400 mg
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

eplerenone
107724-20-9

eplerenone

7-methyl hydrogen 9,11α-epoxy-3-ethoxy-17-hydroxy-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 9,11α-epoxy-3-ethoxy-17-hydroxy-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

Conditions
ConditionsYield
Stage #1: orthoformic acid triethyl ester; eplerenone; toluene-4-sulfonic acid In ethanol at 20℃; for 0.5h;
Stage #2: With pyridine; sodium acetate In ethanol		33.8 g
eplerenone
107724-20-9

eplerenone

C47H42O10
1621954-04-8

C47H42O10

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium hydroxide / water / 48 h
2: hydrogenchloride / water
3: dmap; dicyclohexyl-carbodiimide
View Scheme
eplerenone
107724-20-9

eplerenone

C23H30O7
1621954-05-9

C23H30O7

Conditions
ConditionsYield
With lithium hydroxide In water for 48h;

Eplerenone Specification

1. Introduction of Eplerenone

Eplerenone, with its systematic name of Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate, is one kind of white crystalline powder. Its Classification Code are including Aldosterone antagonist; Aldosterone antagonists; Antihypertensive; Hormone Antagonists; Hormones, Hormone Substitutes, and Hormone Antagonists.

2. Properties of Eplerenone

Eplerenone has the following datas: (1)Index of Refraction: 1.587; (2)Molar Refractivity: 106.122 cm3; (3)Molar Volume: 315.658 cm3; (4)Surface Tension: 53.062 dyne/cm; (5)Density: 1.313 g/cm3; (6)Flash Point: 259.474 °C; (7)Enthalpy of Vaporization: 89.051 kJ/mol; (8)Boiling Point: 597.933 °C at 760 mmHg; (9)Vapour Pressure: 0 mmHg at 25 °C; (10)Melting Point: 241-243 °C.

3. Use of Eplerenone

Eplerenone is an aldosterone antagonist used as an adjunct in the management of chronic heart failure. Eplerenone is used alone or in combination with other medications to treat high blood pressure.Common adverse drug reactions associated with the use of Eplerenone include: hyperkalaemia, hypotension, dizziness, altered renal function, and increased creatinine concentration.

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