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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Exemestane/ LIDE PHARMA- Factory supply / Best price

Cas:107868-30-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are very strong on this product. Package:25kgs net carton drums Application:API Port:SHANGHAI

Exemestane manufacturer 99%

Cas:107868-30-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Mawer Biological Technology Co., Ltd.

Our service: 1.We have experience in exporting Pharmaceutical intermediates . 2.Professional packing with professional materials 3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the trackin

Aromasin/Exemestane

Cas:107868-30-4

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Exemestane

Cas:107868-30-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Exemestane Aromasin Aromatase Raw Powder

Cas:107868-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Keywords Exemestane Aromasin 107868-30-4 Quick Details ProName: Bodybuilding Nutrition Supplement Arom... CasNo: 107868-30-4 Molecular Formula: C20H24O2 Appearance: White Crystalline Powder Application: Muscle Building, fat loss

Bodybuilding Nutrition Supplement Aromasin/exemestane CAS NO.107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

We have GMP.it conforms to USP pending. Appearance:White crystalline powder Storage:room temperature Package:1kg/bag or customer requirements Application:used to treat breast cancer. Transportation:BY SEA AIR EXPRESS(EMS DHL FEDEX TNT) Port:Hangzho

Exemestane 99% USP

Cas:107868-30-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Shanghai Terui OP New Material Technology Co., Ltd.

Superiority We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the

Pharmaceutical Chemical API Exemestane powder cas 107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

FOB Price: $60.0 / 70.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up USP standard Exemestane 107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White crystalline powder White crystalline powder Identification

High purity Exemestane with high quality cas:107868-30-4

Cas:107868-30-4

Min.Order:1 Gram

FOB Price: $3.5 / 4.5

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Exemestone supplier in China

Cas:107868-30-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Certification: ISO, BRC, KOSHER, HALAL Application: meidicine addictive Type: extract Appearance: white Powder Part Used: shrimp shell

Exemestane

Cas:107868-30-4

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Other

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers

Exemestane

Cas:107868-30-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Lab supply 99% Exemestane Powder supplier cas:107868-30-4

Cas:107868-30-4

Min.Order:10 Gram

FOB Price: $6.0 / 10.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Exemestane CAS No.:107868-30-4 Name: Exemestane Synonyms: 6-Methylenandrosta-1,4-diene-3,17-dione; 10,13-Dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene- Molecular Structure Mole

High purity Exemestane CAS No.:107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-Methyleneandrosta-1,4-diene-3,17-dione

Cas:107868-30-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Exemestane 107868-30-4 GMP Manufacturer

Cas:107868-30-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

CHemwill -- Exemestane

Cas:107868-30-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Exemestane CAS NO:107868-30-4 Grade:Medical scientific research and export Molecular formula: C20H24O2 Molecular weight:296.4034 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Dat

Exemestane/ CAS:107868-30-4/Exemestane raw material/ high-quality

Cas:107868-30-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

tianfu-chem_ Exemestane 107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Exemestane CAS 107868-30-4

Cas:107868-30-4

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Antimex Chemical Limied

Exemestane discount wholesale Antimex Group, was founded in 2001,we are specializing in manufacturing & researching, warehouse & logistics of Active pharmaceutical Ingredients, pharmaceutical and chemical raw materials, Veterinary pharm

Exemestane discount wholesale

Cas:107868-30-4

Min.Order:1 Gram

FOB Price: $15.0

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:ln stock Package:1kg/Bottle or at customers reqirement Application:Chemicals Transportation:Express/Sea/Air Port:Any port in China

API Exemestan powder cas 107868-30-4

Cas:107868-30-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

6-Methyleneandrosta-1,4-diene-3,17-dione 107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

An antineoplastic drugs Exemestane CAS:107868-30-4

Cas:107868-30-4

Min.Order:20 Gram

FOB Price: $81.0 / 94.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao white whale Import and Export Co., LTD advantage 1. One of the largest domestic suppliers. 2. Professional laboratory and production base to ensure product stability. 3. Export this product to many countries and regions at the most favora

98% high quality exemestane manufacturer in China CAS NO.107868-30-4

Cas:107868-30-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

1. quality & price we offer high quality and reasonably priced products to our customers 2. payment methord t/t, l/c, paypal, moneygram, westerm union, other 3. service: best service and after-sales service to all clients 4. delivery:

Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

Exemestane/ Aromasin

Cas:107868-30-4

Min.Order:20 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

Exemestane CAS NO.107868-30-4

Cas:107868-30-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Synthetic route

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one
122370-91-6

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With Jones reagent In acetone at -20℃; Jones oxidation; Inert atmosphere;100%
With jones reagent In acetone at -20℃; for 0.25h;85%
With Jones reagent In acetone at 0℃; Product distribution / selectivity;
6α-hydroxymethylandrosta-1,4-diene-3,17-dione
933455-74-4

6α-hydroxymethylandrosta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Stage #1: 6α-hydroxymethylandrosta-1,4-diene-3,17-dione With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 30℃;
Stage #2: With methanol; potassium hydroxide at 40 - 50℃;
90%
17-hydroxyimino-6-methylenandrosta-1,4-diene-3-one

17-hydroxyimino-6-methylenandrosta-1,4-diene-3-one

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water; acetone at 25 - 30℃; for 10h; Solvent; Reagent/catalyst; Temperature; Jones Oxidation; Inert atmosphere;88.2%
6-methylene-androst-4-ene 3,17-dione
19457-55-7

6-methylene-androst-4-ene 3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With N,O-Bis(trimethylsilyl)trifluoroacetamide; chloranil; trifluorormethanesulfonic acid In toluene at 108 - 110℃; for 0.75h; Product distribution / selectivity; Heating / reflux;81.8%
With trifluorormethanesulfonic acid; N,O-Bis(trimethylsilyl)trifluoroacetamide; chloranil In toluene Inert atmosphere; Reflux;81%
With tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 0 - 20℃;30.2%
methanol
67-56-1

methanol

6β-hydroxymethylandrosta-1,4-diene-3,17-dione
121021-51-0

6β-hydroxymethylandrosta-1,4-diene-3,17-dione

A

(6S,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

(6S,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

B

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 24h;A 8%
B 60%
6-Methylen-4-androsten-3,17-dion
19457-55-7, 51154-17-7

6-Methylen-4-androsten-3,17-dion

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide; toluene at 85℃; for 48h; Inert atmosphere; Large scale;56.7%
Androsta-1,4-diene-3,17-dione
897-06-3

Androsta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 20 h / Heating
2: 1.10 g / benzene; ethanol; H2O / 5 h / 20 °C
3: 60 percent / conc. HCl / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 6 h / Inert atmosphere; Reflux
2.1: N,N-dimethylammonium chloride / i-Amyl alcohol / 2 h / Inert atmosphere; Reflux
2.2: 15 h / 140 °C
3.1: toluene-4-sulfonic acid / water; acetone / 10 h / 25 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: orthoformic acid triethyl ester; toluene-4-sulfonic acid / tetrahydrofuran / 12 h / 40 - 45 °C / Large scale
2: tetrahydrofuran; ethanol / 10 h / 40 - 45 °C / Large scale
3: hydrogenchloride / tetrahydrofuran; ethanol / 1 h / Large scale
4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; toluene / 48 h / 85 °C / Inert atmosphere; Large scale
View Scheme
1α,3-dipyrrolidinylandrosta-3,5-dien-17-one
67737-88-6

1α,3-dipyrrolidinylandrosta-3,5-dien-17-one

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.10 g / benzene; ethanol; H2O / 5 h / 20 °C
2: 60 percent / conc. HCl / 24 h / 20 °C
View Scheme
1-dehydrotestosterone
846-48-0

1-dehydrotestosterone

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Me2NH*HCl / 1.) isoamyl alcohol, reflux, 2 h, 2.) isoamyl alcohol, reflux, 15 h
2: 85 percent / Jones reagent / acetone / 0.25 h / -20 °C
View Scheme
C21H28O5S
861395-77-9

C21H28O5S

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With potassium hydroxide In methanol; dichloromethane; water at 25℃; Heating / reflux;
pyrographite
7440-44-0

pyrographite

6-methylene-androst-4-ene 3,17-dione
19457-55-7

6-methylene-androst-4-ene 3,17-dione

tert-butyl alcohol
75-65-0

tert-butyl alcohol

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With selenium(IV) oxide In ethyl acetate
6-hydroxymethyl-androsta-1,4-diene-3,17-dione

6-hydroxymethyl-androsta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 80 - 90℃; under 315 Torr; for 4h; Purification / work up;
With toluene-4-sulfonic acid In toluene at 90℃; for 3h; Purification / work up;
With camphor-10-sulfonic acid In toluene at 90℃; for 7h; Purification / work up;
With (1S)-10-camphorsulfonic acid In ethyl acetate at 70 - 80℃; for 32h; Purification / work up;
Stage #1: 6-hydroxymethyl-androsta-1,4-diene-3,17-dione With pyridine; p-toluenesulfonyl chloride at 0℃; for 48h;
Stage #2: With potassium hydroxide In methanol; water at 65℃; for 2h; Purification / work up;
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 1 h / 120 °C / Inert atmosphere
1.2: 0.33 h / 20 °C / Inert atmosphere
1.3: 3 h / 20 °C / Inert atmosphere
2.1: orthoformic acid triethyl ester; toluene-4-sulfonic acid / ethanol; tetrahydrofuran / 3 h / 40 °C
2.2: 4 h / 40 °C
3.1: Arthrobacter simplex ATCC6946 culture / aq. buffer / 33 °C / Microbiological reaction
View Scheme
3-Aethoxy-androstadien-(3,5)-on-(17)
972-46-3

3-Aethoxy-androstadien-(3,5)-on-(17)

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran; ethanol / 10 h / 40 - 45 °C / Large scale
2: hydrogenchloride / tetrahydrofuran; ethanol / 1 h / Large scale
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; toluene / 48 h / 85 °C / Inert atmosphere; Large scale
View Scheme
6-methyleneandrostenediol ketal

6-methyleneandrostenediol ketal

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20 - 25℃; for 10h; Inert atmosphere;
exemestane
107868-30-4

exemestane

FCE27353
184972-12-1

FCE27353

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 48h; Ambient temperature;80%
exemestane
107868-30-4

exemestane

C20H24N6O2

C20H24N6O2

Conditions
ConditionsYield
With copper(l) iodide; tert-Butyl peroxybenzoate; trimethylsilylazide In acetonitrile at 50℃; for 6h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere; Green chemistry;75%
exemestane
107868-30-4

exemestane

A

6α-methylandrost-4-ene-3,17-dione
2241-94-3

6α-methylandrost-4-ene-3,17-dione

B

C20H30O2

C20H30O2

C

6β-methylandrost-4-ene-3,17-dione
5696-36-6

6β-methylandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 5%-palladium/activated carbon In ethanol for 18h; Reflux; stereoselective reaction;A n/a
B 62%
C n/a
formaldehyd
50-00-0

formaldehyd

exemestane
107868-30-4

exemestane

C21H24O2

C21H24O2

Conditions
ConditionsYield
With N,N-dimethylammonium chloride In ethanol at 78℃; for 3h; Temperature; Mannich Aminomethylation;54.1%
4-Fluorobenzenesulfonyl chloride
349-88-2

4-Fluorobenzenesulfonyl chloride

exemestane
107868-30-4

exemestane

(6S,8R,9S,10R,13S,14S)-6-(((4-fluorophenyl)sulfonyl)methyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

(6S,8R,9S,10R,13S,14S)-6-(((4-fluorophenyl)sulfonyl)methyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

Conditions
ConditionsYield
With fac-tris(2-phenylpyridinato-N,C2')iridium(III); tris-(trimethylsilyl)silane In acetonitrile at 20℃; for 16h; Irradiation; diastereoselective reaction;50%
exemestane
107868-30-4

exemestane

A

6-methylandrosta-1,4,6-trien-17β-ol

6-methylandrosta-1,4,6-trien-17β-ol

B

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one
122370-91-6

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one

Conditions
ConditionsYield
With sodium tetrahydroborate; acetic acid; trifluoroacetic acid In dichloromethane; acetonitrile at 20℃; for 11h; Inert atmosphere;A 11.3 mg
B 39%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

exemestane
107868-30-4

exemestane

A

C21H25F3O3

C21H25F3O3

B

C21H25F3O3

C21H25F3O3

Conditions
ConditionsYield
With cobalt(II) tetrafluoroborate hexahydrate; N-isopropyl-N,2-dimethylpropan-2-amine In water; N,N-dimethyl-formamide; acetonitrile at 65℃; for 24h; Sealed tube;A 30%
B 33%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

exemestane
107868-30-4

exemestane

A

C21H25F3O3

C21H25F3O3

B

C21H25F3O3

C21H25F3O3

Conditions
ConditionsYield
With cobalt(II) tetrafluoroborate hexahydrate; N-isopropyl-N,2-dimethylpropan-2-amine In N,N-dimethyl-formamide; acetonitrile at 65℃; for 24h;A 30%
B 33%
nitromethane
75-52-5

nitromethane

exemestane
107868-30-4

exemestane

6α-(2-Nitroethyl)androsta-1,4-dien-3,17-dion
911856-13-8

6α-(2-Nitroethyl)androsta-1,4-dien-3,17-dion

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 22h; Michael addition; Heating;32%
exemestane
107868-30-4

exemestane

A

6α-spirooxiranandrosta-1,4-diene-3,17-dione

6α-spirooxiranandrosta-1,4-diene-3,17-dione

B

6α-spirooxiranandrosta-1,4-diene-3,17-dione

6α-spirooxiranandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
With formic acid; dihydrogen peroxide In dichloromethane at 20℃; for 96h;A 21%
B 76.1 mg
L-Cysteine
52-90-4

L-Cysteine

exemestane
107868-30-4

exemestane

6-methylcysteinylandrosta-1,4-diene-3,17-dione

6-methylcysteinylandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 24h; Inert atmosphere;13%
exemestane
107868-30-4

exemestane

1α,2α-epoxy-6-methylenandrost-4-ene-3,17-dione

1α,2α-epoxy-6-methylenandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With dihydrogen peroxide; sodium hydroxide In methanol; water at 0 - 20℃; for 24.5h;11%
exemestane
107868-30-4

exemestane

diethyl malonate
105-53-3

diethyl malonate

Diethyl-2-(3,17-dioxoandrosta-1,4-dien-6β-ylmethyl)-malonat

Diethyl-2-(3,17-dioxoandrosta-1,4-dien-6β-ylmethyl)-malonat

Conditions
ConditionsYield
With sodium In ethanol for 7h; Michael addition; Heating;6%
exemestane
107868-30-4

exemestane

6α-(2-Oxoethyl)androsta-1,4-dien-3,17-dion
911856-14-9

6α-(2-Oxoethyl)androsta-1,4-dien-3,17-dion

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 32 percent / NaOEt / ethanol / 22 h / Heating
2.1: KOH / methanol / 3 h / 20 °C
2.2: 31 percent / aq. H2SO4 / methanol / 4 h / cooling
View Scheme
exemestane
107868-30-4

exemestane

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-3,5-pyridindicarboxylat

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-3,5-pyridindicarboxylat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 32 percent / NaOEt / ethanol / 22 h / Heating
2.1: KOH / methanol / 3 h / 20 °C
2.2: 31 percent / aq. H2SO4 / methanol / 4 h / cooling
3.1: 58 percent / acetic acid / 22 h / 20 - 60 °C
4.1: 87 percent / CAN / acetone; H2O / 0.5 h
View Scheme
exemestane
107868-30-4

exemestane

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridindicarboxylat
911856-15-0

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridindicarboxylat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 32 percent / NaOEt / ethanol / 22 h / Heating
2.1: KOH / methanol / 3 h / 20 °C
2.2: 31 percent / aq. H2SO4 / methanol / 4 h / cooling
3.1: 58 percent / acetic acid / 22 h / 20 - 60 °C
View Scheme
exemestane
107868-30-4

exemestane

6-Hydroxymethylexemestane

6-Hydroxymethylexemestane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / 50percent m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature
2: 38 percent / 20percent aq. HClO4 / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
exemestane
107868-30-4

exemestane

6α/β-hydroxy-6α/β-hydroxymethylandrosta-1,4-diene-3,17-dione

6α/β-hydroxy-6α/β-hydroxymethylandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / 50percent m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature
2: 42 percent / 20percent aq. HClO4 / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
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