As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $150.0 / 250.0
Type:Manufacturers
inquiry109384-19-2 Molecular Formula C10H19NO3 Molecular Weight 201.26 N-BOC-4-Hydroxypiperidine Molecular Formula C10H19NO3 Molecular Weight 201.26 CAS Registry Number 109384-19-2 Name
Cas:109384-19-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:109384-19-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryN-BOC-4-Hydroxypiperidine Basic information Product Name: N-BOC-4-Hydroxypiperidine Synonyms: RARECHEM AH CK 0055;TERT-BUTYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE;TERT-BUTYL 4-HYDROXY-1-PIPE
Cas:109384-19-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHebei Nengqian Chemical Import and Export Co., LTD.. is located in xingtai City, Hebei Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutica
Cas:109384-19-2
Min.Order:1 Gram
FOB Price: $12.0 / 15.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:109384-19-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBeluga chemical professional supply High Quality N-BOC-4-Hydroxypiperidine CAS 109384-19-2 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and r
Cas:109384-19-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:109384-19-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:109384-19-2
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryN-BOC-4-Hydroxypiperidine CAS: 109384-19-2 Specificatio Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should be stored in
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Other
inquiryProduct Name: N-BOC-4-Hydroxypiperidine Synonyms: N - bok - 4 - hydroxy piperidine;N-BOC-4-HydroxypiperidineN-(tert-Butoxycarbonyl)-4-hydroxypiperidine;t-Butyl 4-hydroxypiperidine-1-carboxylate;Boc-(4-hydroxy)piperidine≥ 99% (GC);RARECHEM AH
Cas:109384-19-2
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:109384-19-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:109384-19-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:109384-19-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:109384-19-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:109384-19-2
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:109384-19-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:109384-19-2
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryCompany Profile SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD is a high-tech enterprise dedicated to the fields of fine chemical products.The scope of products covers pharmaceutical intermediates, plant extracts, chemical reagent, animal p
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $38.0 / 69.0
Type:Trading Company
inquirylower price 109384-19-2 N-BOC-4-Hydroxypiperidine manufacturerAppearance:off-white to white powder Storage:dry place Package:according to customers' requirements Application:pharma intermediate Transportation:By air(EMS or EUB or FedEx or TNT ect...)
Cas:109384-19-2
Min.Order:1 Gram
Negotiable
Type:Other
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:109384-19-2
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used in organic synthesis Transportation:as
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:109384-19-2
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:109384-19-2
Min.Order:1 Kilogram
FOB Price: $8.2 / 8.8
Type:Trading Company
inquiry4-HYDROXYPIPERIDINE
di-tert-butyl dicarbonate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In water; tert-butyl alcohol at 20℃; | 100% |
With sodium carbonate In dichloromethane; water for 72h; | 100% |
With sodium carbonate In dichloromethane; water for 72h; Inert atmosphere; | 100% |
N-tert-butyloxycarbonylpiperidin-4-one
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol | 100% |
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With sodium tetrahydroborate In ethanol at 0 - 20℃; for 4h; Stage #2: With water; ammonium chloride In ethanol | 100% |
With sodium hydroxide; sodium borohydrid In methanol | 100% |
4-HYDROXYPIPERIDINE
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With tert-butyldicarbonate; triethylamine In dichloromethane at 0℃; for 21h; | 100% |
4-HYDROXYPIPERIDINE
tert-butyldicarbonate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane for 15h; | 100% |
In tetrahydrofuran at 20℃; | 98.3% |
With triethylamine In tetrahydrofuran at 20℃; | 98.3% |
di-tert-butyl dicarbonate
piperidin-4-ol hydrochloride
sodium hydrogencarbonate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
In 1,4-dioxane | 100% |
In 1,4-dioxane | 100% |
pyridin-4-ol
di-tert-butyl dicarbonate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: pyridin-4-ol With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex In 2,2,2-trifluoroethanol at 50℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: di-tert-butyl dicarbonate With triethylamine In 2,2,2-trifluoroethanol at 20℃; Inert atmosphere; Schlenk technique; Sealed tube; | 99% |
4-HYDROXYPIPERIDINE
carbon monoxide
tert-butyl alcohol
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With 2C7H9N4*Au(1+)*Cu(1+)*2I(1-) In toluene at 90℃; for 8h; Autoclave; | 98% |
di-tert-butyl dicarbonate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; ethyl acetate | 95% |
Multi-step reaction with 2 steps 1: triethylamine / water; 1,4-dioxane / 0 - 20 °C 2: sodium tetrahydroborate; methanol / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0.8 h / 0 - 20 °C 2: sodium tetrahydroborate; methanol / 0.01 h / 0 - 20 °C View Scheme |
di-tert-butyl dicarbonate
A
t-butyl piperidinecarboxylate
B
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; ethyl acetate | A n/a B 94% |
With triethylamine In tetrahydrofuran; ethyl acetate | A n/a B 94% |
With triethylamine In tetrahydrofuran; ethyl acetate | A n/a B 94% |
tert-butyl 4-((4-methoxybenzyl)oxy)piperidine-1-carboxylate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With N,N,N,N-tetraethylammonium tetrafluoroborate In methanol Electrochemical reaction; | 81% |
t-butyl piperidinecarboxylate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With D-glucose; cells of Sphingomonas sp. HXN-200 In phosphate buffer at 30℃; for 2h; pH=8.0; | 69.5% |
4-[(1-{tert-butoxycarbonyl}-4-piperidinyl)oxy]-1-(1-methylethyl)pyridinium iodide
A
tert-butyl 4-{[1-(1-methylethyl)-4-piperidinyl]oxy}-1-piperidinecarboxylate
B
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With platinum (IV) oxide; hydrogen In ethanol at 20℃; under 2587.76 Torr; for 144h; | A 54% B 20% |
di-tert-butyl dicarbonate
piperidin-4-ol hydrochloride
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In water at 25℃; for 1h; |
Methoxyallene
N-tert-butyloxycarbonylpiperidin-4-one
A
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; tert-butyl alcohol In tetrahydrofuran at 20℃; Title compound not separated from byproducts; |
C13H18BrN3O2
N-tert-butyloxycarbonylpiperidin-4-one
A
C23H35BrN4O4
B
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: C18H26BrN3O4 With trifluoroacetic acid In dichloromethane for 0.5h; Stage #2: C13H18BrN3O2; N-tert-butyloxycarbonylpiperidin-4-one With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane at 20℃; for 16h; Stage #3: With water; sodium hydrogencarbonate In dichloromethane; 1,2-dichloro-ethane |
N-tert-butyloxycarbonylpiperidin-4-one
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In tetrahydrofuran; toluene |
3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid
t-butyl 4-hydroxy piperidine-1-carboxylate
titanium(IV) isopropylate
N-tert-butyloxycarbonylpiperidin-4-one
2-phenyl-3-keto-piperazine
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium cyanoborohydride In methanol |
4-[3-(N-BOC-Piperidin-4-yl)propyl]benzoic acid
B
t-butyl 4-hydroxy piperidine-1-carboxylate
di-tert-butyl dicarbonate
4-piperidone monohydrochloride monohydrate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium borohydrid; N-ethyl-N,N-diisopropylamine In N-methyl-acetamide; ethanol; water |
4-HYDROXYPIPERIDINE
3-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid
di-tert-butyl dicarbonate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane |
4-HYDROXYPIPERIDINE
di-tert-butyl dicarbonate
A
4-[(1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydroquinolin-8-yl)-amino]-piperidine-1-carboxylic Acid Amide (Hydrobromide Salt)
B
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran |
(R)-1-cyclohexyl-4-phenyl-3-(piperidin-4-yl)imidazolidin-2-one
N-tert-butyloxycarbonylpiperidin-4-one
A
4-((R)-3-cyclohexyl-2-oxo-5-phenyl-imidazolidin-1-yl)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester
B
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium cyanoborohydride; acetic acid In methanol at 60℃; for 16h; |
4-HYDROXYPIPERIDINE
tert-butyl chloroformate
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine |
di-tert-butyl dicarbonate
4-hydroxypiperazine
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 5h; | 34 g |
tert-butyl 4-(tosyloxy)piperidin-1-carboxylate
C9H15ClMg
B
N-Boc-1,2,3,6-tetrahydropyridine
C
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With dilithium tetrachlorocuprate In tetrahydrofuran at 40℃; |
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
C9H15ClMg
B
N-Boc-1,2,3,6-tetrahydropyridine
C
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With copper dichloride In tetrahydrofuran at 20℃; |
p-toluenesulfonyl chloride
t-butyl 4-hydroxy piperidine-1-carboxylate
tert-butyl 4-(tosyloxy)piperidin-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 20h; | 100% |
at 20℃; for 20h; | 99% |
With triethylamine In dichloromethane at 20℃; | 89% |
methanesulfonyl chloride
t-butyl 4-hydroxy piperidine-1-carboxylate
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 5℃; for 3h; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 2.16667h; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 2.16667h; | 100% |
acetic anhydride
t-butyl 4-hydroxy piperidine-1-carboxylate
2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 5h; | 100% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; | 55.17% |
In pyridine at 25℃; for 6h; | |
With pyridine at 20℃; | 3 g |
With pyridine at 20℃; for 5h; | 3 g |
2-fluorobenzonitrile
t-butyl 4-hydroxy piperidine-1-carboxylate
4-(2-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃; | 100% |
With (E)-[4-(hydroxy)piperidin-1-ylsulphonyl]-2-(3-pyridyl)ethene In DMF (N,N-dimethyl-formamide) for 15h; | |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Stage #2: 2-fluorobenzonitrile at 50℃; for 1h; |
1-chloroisoquinoline
t-butyl 4-hydroxy piperidine-1-carboxylate
1-tert-butoxycarbonyl-4-(1-isoquinolinyloxy)-piperidine
Conditions | Yield |
---|---|
With crown ether; potassium tert-butylate In DMF (N,N-dimethyl-formamide) at 20℃; | 100% |
salicylonitrile
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: salicylonitrile; t-butyl 4-hydroxy piperidine-1-carboxylate With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h; Stage #2: With hydrogenchloride; water In 1,4-dioxane at 20℃; for 18h; | 100% |
4-chlorpyridine hydrochloride
t-butyl 4-hydroxy piperidine-1-carboxylate
2-(piperidin-4-yloxy)pyridine
Conditions | Yield |
---|---|
In tetrahydrofuran; dimethyl sulfoxide | 100% |
In tetrahydrofuran; dimethyl sulfoxide | 100% |
In tetrahydrofuran; dimethyl sulfoxide | 100% |
4-(4-chlorophenoxy)phenol
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 47℃; for 65.1667h; | 100% |
2-(4-hydroxyphenyl)-5-methyl-2H-pyrazole-3-carboxylic acid cyclohexylamide
t-butyl 4-hydroxy piperidine-1-carboxylate
4-[4-(5-cyclohexylcarbamoyl-3-methylpyrazol-1-yl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; | 100% |
2-chloropyrazin
t-butyl 4-hydroxy piperidine-1-carboxylate
t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h; | 100% |
In hexane; dimethyl sulfoxide; ethyl acetate |
4-trifluoromethoxybenzyl bromide
t-butyl 4-hydroxy piperidine-1-carboxylate
4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium t-butanolate In 1,2-dimethoxyethane at 2 - 17℃; for 0.5h; Stage #2: 4-trifluoromethoxybenzyl bromide In 1,2-dimethoxyethane at 12 - 23℃; for 3h; | 100% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice; Stage #2: 4-trifluoromethoxybenzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h; Cooling with ice; | 78% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.5h; Cooling with ice; Stage #2: 4-trifluoromethoxybenzyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h; | 78% |
chloroacetic acid pyrrolidide
t-butyl 4-hydroxy piperidine-1-carboxylate
tert-butyl 4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With trifluoroacetic acid; sodium hydroxide In water; toluene at 25℃; | 100% |
4,6-dichloropyrimidine
t-butyl 4-hydroxy piperidine-1-carboxylate
tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 60℃; for 1h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran; mineral oil at 20℃; for 2h; | 100% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 1h; Inert atmosphere; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃; for 2h; | 72% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 60℃; for 0.5h; Stage #2: 4,6-dichloropyrimidine In tetrahydrofuran at 20℃; | 59% |
3-bromo-5-hydroxy-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester
t-butyl 4-hydroxy piperidine-1-carboxylate
3-bromo-5-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-dipyrido[2,3-b;4',3'-d]pyrrole-9-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
With diethylazodicarboxylate; triphenylphosphine In tetrahydrofuran at 50℃; for 1h; | 100% |
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate
t-butyl 4-hydroxy piperidine-1-carboxylate
methyl 6-(4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-2,6-difluorophenyl)-5-fluoropicolinate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; | 100% |
2-chloro-6-trifluoromethylpyridine
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Stage #2: 2-chloro-6-trifluoromethylpyridine In tetrahydrofuran; mineral oil at 20℃; for 48h; | 100% |
propargyl bromide
t-butyl 4-hydroxy piperidine-1-carboxylate
tert-butyl 4-(prop-2-yn-1-yloxy)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; | 100% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; Inert atmosphere; | 100% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 25℃; for 12h; Inert atmosphere; | 100% |
In tetrahydrofuran; toluene; mineral oil |
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20 - 50℃; for 19h; | 100% |
2,5-dichloro-4-(trifluoromethyl)pyridine
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In 1,2-dimethoxyethane; mineral oil at 20℃; for 1h; Inert atmosphere; Stage #2: 2,5-dichloro-4-(trifluoromethyl)pyridine In 1,2-dimethoxyethane; mineral oil for 2h; Inert atmosphere; Reflux; | 100% |
2-chloro-4-fluorobenzylbromide
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Stage #2: 2-chloro-4-fluorobenzylbromide With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 48h; | 100% |
5-bromo-2,3-dichloropyridine
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: 5-bromo-2,3-dichloropyridine In N,N-dimethyl-formamide; mineral oil at 70℃; for 16h; | 100% |
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In N,N-dimethyl acetamide at 20℃; for 1h; Stage #2: 5-bromo-2,3-dichloropyridine In N,N-dimethyl acetamide at 80℃; Inert atmosphere; | 57% |
methyl 4-hydroxy-2-methoxybenzoate
t-butyl 4-hydroxy piperidine-1-carboxylate
4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxybenzoic acid methyl ester
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 40℃; for 2h; Inert atmosphere; Sonication; | 100% |
2-hydroxyl nicotinic acid ethyl ester
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h; Mitsunobu Displacement; | 100% |
6-methoxypyridine-3-ol
t-butyl 4-hydroxy piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triphenylphosphine In tetrahydrofuran at 20℃; for 9h; Inert atmosphere; | 100% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 1h; Inert atmosphere; | |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40℃; for 1h; Inert atmosphere; |
methanesulfonyl chloride
t-butyl 4-hydroxy piperidine-1-carboxylate
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; ethyl acetate | 100% |
With triethylamine In dichloromethane; ethyl acetate | 100% |
With triethylamine In dichloromethane; ethyl acetate | 100% |
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