Lonwin Industry group limited as a professional manufactor & exporter of chemical materials ,we totally haver more than 230 stuffs, we have been on this line for more than 9 years. Our chemical materials are exported to lot of countries and
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inquiryItems Standard Result Appearance White or almost white crystalline powder Complies Assay &ge
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Almost white to slightly yellow powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryAs a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid CAS NO: 112811-72-0 Grade:Medical scientific research and export Molecular formula:C14H11F2NO4 Molecular weight:295.2382 Product Quality 12 years of chemi
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inquiryAbout Product Technical Details
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inquiry1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Basic information Product Name: 1-Cyclopr
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiry1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid CAS:112811-72-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of che
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White or almost white crystalline powder / See
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inquiryProduct Name: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Synonyms: 3-QUINOLINECARBOXYLIC ACID, 1-CYCLOPROPYL-6,7-DIFLUORO-1,4-DIHYDRO-8-METHOXY-4-OXO-;1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3
Cas:112811-72-0
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 65℃; for 15h; Solvent; Temperature; | 96.83% |
With sulfuric acid; acetic acid In water for 2h; Reflux; | 95.92% |
With hydrogenchloride for 3h; Heating; | 90% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid
dimethyl sulfate
A
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid methyl ester
B
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With potassium chloride In acetone Product distribution / selectivity; Heating / reflux; |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid methyl ester
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With water; potassium carbonate for 0.5h; Product distribution / selectivity; Heating / reflux; |
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With sodium fluoride In N,N-dimethyl-formamide | |
Multi-step reaction with 2 steps 1: sodiumfluoride / N,N-dimethyl-formamide / 5 h 2: sulfuric acid; water / acetic acid / 1 h View Scheme |
2,4,5-trifluoro-3-methoxy-benzamide
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: sulfuric acid / 3.5 h / 100 °C 2: thionyl chloride / 3 h 3: magnesium ethylate / toluene 4: toluene-4-sulfonic acid / water / 9 h 5: acetic anhydride / 11 h 6: ethanol / 2 h / 20 °C 7: sodiumfluoride / N,N-dimethyl-formamide / 5 h 8: sulfuric acid; water / acetic acid / 1 h View Scheme |
3-methoxy-2,4,5-trifluorobenzonitrile
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: sulfuric acid; water / 1 h / 110 °C 2: sulfuric acid / 3.5 h / 100 °C 3: thionyl chloride / 3 h 4: magnesium ethylate / toluene 5: toluene-4-sulfonic acid / water / 9 h 6: acetic anhydride / 11 h 7: ethanol / 2 h / 20 °C 8: sodiumfluoride / N,N-dimethyl-formamide / 5 h 9: sulfuric acid; water / acetic acid / 1 h View Scheme |
diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / water / 9 h 2: acetic anhydride / 11 h 3: ethanol / 2 h / 20 °C 4: sodiumfluoride / N,N-dimethyl-formamide / 5 h 5: sulfuric acid; water / acetic acid / 1 h View Scheme |
1-bromo-2,4,5-trifluoro-3-methoxybenzene
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C 2: sulfuric acid; water / 1 h / 110 °C 3: sulfuric acid / 3.5 h / 100 °C 4: thionyl chloride / 3 h 5: magnesium ethylate / toluene 6: toluene-4-sulfonic acid / water / 9 h 7: acetic anhydride / 11 h 8: ethanol / 2 h / 20 °C 9: sodiumfluoride / N,N-dimethyl-formamide / 5 h 10: sulfuric acid; water / acetic acid / 1 h View Scheme |
3-methoxy-2,4,5-trifluorobenzoic acid
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: thionyl chloride / 3 h 2: magnesium ethylate / toluene 3: toluene-4-sulfonic acid / water / 9 h 4: acetic anhydride / 11 h 5: ethanol / 2 h / 20 °C 6: sodiumfluoride / N,N-dimethyl-formamide / 5 h 7: sulfuric acid; water / acetic acid / 1 h View Scheme |
2,4,5-trifluoro-3-methoxybenzoyl chloride
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: magnesium ethylate / toluene 2: toluene-4-sulfonic acid / water / 9 h 3: acetic anhydride / 11 h 4: ethanol / 2 h / 20 °C 5: sodiumfluoride / N,N-dimethyl-formamide / 5 h 6: sulfuric acid; water / acetic acid / 1 h View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetic anhydride / 11 h 2: ethanol / 2 h / 20 °C 3: sodiumfluoride / N,N-dimethyl-formamide / 5 h 4: sulfuric acid; water / acetic acid / 1 h View Scheme |
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 2 h / 20 °C 2: sodiumfluoride / N,N-dimethyl-formamide / 5 h 3: sulfuric acid; water / acetic acid / 1 h View Scheme |
1,1'-carbonyldiimidazole
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-6,7-difluoro-3-(imidazole-1-carbonyl)-8-methoxy-1H-quinolin-4-one
Conditions | Yield |
---|---|
In tetrahydrofuran Heating / reflux; | 100% |
In chloroform Heating / reflux; | 100% |
In tetrahydrofuran Heating / reflux; | 100% |
In tetrahydrofuran Heating / reflux; | 100% |
boric acid
acetic anhydride
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
Conditions | Yield |
---|---|
Stage #1: boric acid; acetic anhydride With potassium hydroxide; zinc(II) chloride at 100℃; for 12h; Stage #2: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid at 50℃; for 1h; Concentration; Temperature; Reagent/catalyst; | 97.4% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at 20 - 66℃; for 6.08333h; | 97% |
With boron trifluoride diethyl etherate; potassium carbonate In tetrahydrofuran at 20 - 66℃; Inert atmosphere; | 97% |
With BF3OEt In various solvent(s) Cyclization; Heating; | 83% |
With boron trifluoride diethyl etherate In tetrahydrofuran for 36h; Heating / reflux; | |
Multi-step reaction with 2 steps 1: acetonitrile / 1 h / 70 - 80 °C / Inert atmosphere; Large scale 2: 1 h / 0 - 15 °C / Large scale View Scheme |
boron trifluoride diethyl etherate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: boron trifluoride diethyl etherate In tetrahydrofuran at 60℃; for 6h; Temperature; Reagent/catalyst; | 97% |
2-Amino-2-methyl-1-propanol
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
In toluene at 105 - 115℃; Temperature; Solvent; Inert atmosphere; Industrial scale; | 96.6% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin
Conditions | Yield |
---|---|
With [BCl2(4-picoline)][AlCl4]; triethylamine In methanol at 85℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; | 96% |
In dimethyl sulfoxide at 65 - 70℃; for 6 - 8h; | 89.7% |
With triethylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 78℃; for 11h; Reflux; | 66% |
[R,R]-2,8-diazabicyclo[4.3.0]nonane
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.416667h; Reflux; | 96% |
at 150℃; Microwave irradiation; | 83% |
triacetoxyborane
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
In water at 0 - 90℃; for 4h; | 95.3% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-methylaminopiperidine dihydrochloride; 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 26h; Stage #2: With methanol for 6h; Reflux; Stage #3: With sodium hydroxide In methanol; water at 20℃; for 16h; pH=8; | 92% |
With triethylamine In acetonitrile |
(+/-)-2-methylpiperazine bis(hydrochloride)
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
gatifloxacin
Conditions | Yield |
---|---|
Stage #1: (+/-)-2-methylpiperazine bis(hydrochloride); 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 25h; Stage #2: With methanol for 5h; Reflux; Stage #3: With sodium hydroxide In methanol; water at 20℃; for 16h; pH=7; | 91% |
L-Tartaric acid
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
L(+)-moxifloxacin tartrate
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In N,N-dimethyl-formamide at 65 - 70℃; for 6 - 8h; Stage #2: L-Tartaric acid In N,N-dimethyl-formamide at 25 - 80℃; for 13 - 16h; Product distribution / selectivity; | 90.32% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; calcium chloride In water; dimethyl sulfoxide at -5 - 25℃; for 3.5h; pH=4; | 90% |
With hydrogen bromide; acetic acid at 100℃; for 24h; | |
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With hydrogen bromide In acetic acid at 100℃; for 1h; Stage #2: With water In acetic acid at 0℃; | |
With hydrogen bromide; acetic acid at 100℃; for 24h; |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With titanium(IV) isopropylate; triethylamine In isopropyl alcohol at 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In methanol at 20℃; for 1h; pH=1; Solvent; Reagent/catalyst; | 90% |
Multi-step reaction with 2 steps 1: Alkaline conditions 2: hydrogenchloride View Scheme | |
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 85℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 15℃; for 1h; pH=1.4 - 1.8; Inert atmosphere; | 3.3 g |
cycloperhydroisoindole
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 24h; Reflux; | 89% |
pyrrolidine
Trimethyl borate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
In ethanol; acetonitrile | 88.2% |
diethyl amine hydrochloride
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-N,N-diethyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 10 - 35℃; Inert atmosphere; | 87.3% |
diphenyldisulfane
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With palladium diacetate; triphenylphosphine; silver carbonate In dimethyl sulfoxide at 130℃; for 12h; Schlenk technique; | 87% |
Trimethyl borate
(RS)-3-(acetyl-methyl-amino)-pyrrolidine
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
In ethanol; acetonitrile | 83.9% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h; | 82.3% |
(RS)-2-methylpiperazine
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
gatifloxacin
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 76 - 80℃; for 1h; Heating / reflux; Stage #2: With boron trifluoride diethyl etherate In acetonitrile at 0 - 25℃; for 2h; Stage #3: (RS)-2-methylpiperazine With triethylamine In acetonitrile at 15 - 25℃; for 3h; pH=~ 9; | 81.8% |
In dimethyl sulfoxide at 55℃; for 24h; | 66% |
In dimethyl sulfoxide at 60 - 65℃; for 29 - 45h; | 53.7% |
In dimethyl sulfoxide at 20 - 73℃; for 13.9167 - 14.3333h; | 52% |
In dimethyl sulfoxide at 70 - 95℃; for 2h; |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h; | 81.8% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h; | 81.5% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
C21H19FN4O6
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation; | 79% |
4,4-ethylenedioxy-piperidine
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-cylopropyl-7-(1,4-dioxa-8-aza-spiro[4,5]dec-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation; | 73% |
decahydroisoquinoline
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 24h; Reflux; | 73% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
1-cyclopropyl-6-fluoro-8-hydroxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With isobutylamine; copper dichloride In methanol; ethylene glycol at 50℃; for 4h; Inert atmosphere; Stage #2: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In methanol; ethylene glycol for 5h; Reflux; Stage #3: With sodium hydroxide In methanol; water; ethylene glycol for 1h; Reflux; | 72.1% |
Thiomorpholin
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
1-Cyclopropyl-6-fluoro-8-methoxy-7-thiomorpholino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation; | 70% |
N,N-diethylpiperidine-3-carboxamide
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
C24H30FN3O5
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation; | 70% |
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