The area of Chengdu Baishixing is 35,000 square metre , the staff members are 88, our output value is over 120 millions per year. Baishiying cooporates with Life Science Academy of Wuhan University to develop amino acids series pr
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inquiryUnique advantages for N-Carbobenzyloxy-L-valine Cas 1149-26-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White Powder Storage:2-8°C Package:1kg/foil bag, 25kg/d
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inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
Items Standard Result Appearance White powder Complies Assay 98.0%min 99.29%
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquirySichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality manage
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inquiryProduct Name: N-Carbobenzyloxy-L-valine Synonyms: n-[(phenylmethoxy)carbonyl]-l-valin;BENZYLOXYCARBONYL-L-VALINE;CBZ-VAL-OH;CBZ-L-VALINE;CBZ-L-VAL-OH;CARBOBENZYLOXY-L-VALINE;L-VALINE, N-[(PHEN
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name Cbz -Val-OH CAS No. 1149-26-4 Synonyms N-Benzyloxycarbonyl-L-valine Purity 98.0% min Molecular Formula C13H17NO4 Molecular Weight 251.28 Appearance: white powd
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Cas:1149-26-4
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inquiryAppearance:white to light yellow crystal powder Storage:Keep in dark place,Sealed in dry,Room Temperature Package:25kg/Barrel Application:pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in China
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A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryConditions | Yield |
---|---|
With sodium hydrogencarbonate In water Inert atmosphere; | 100% |
With sodium hydroxide In water at 0 - 20℃; | 100% |
With potassium carbonate In water at 0 - 2℃; pH=1.5 - Ca. 2; Reagent/catalyst; pH-value; Temperature; Solvent; | 99% |
C13H15N2O2(1+)*CF3O3S(1-)
(L)-valine methyl ester triflate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Stage #1: C13H15N2O2(1+)*CF3O3S(1-); (L)-valine methyl ester triflate With 1,1’-carbonylbis-(3-ethylimidazolium) triflate In nitromethane at 20℃; for 60h; Inert atmosphere; Stage #2: With water; sodium hydroxide In nitromethane at 20℃; for 2h; Inert atmosphere; | 80% |
Conditions | Yield |
---|---|
With 2-hydroxypyridin; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 20℃; for 72h; | 79% |
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With cerium(III) chloride; sodium iodide In acetonitrile for 2h; Heating; | 92% |
With sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 5h; | 91% |
With sodium iodide; zirconium(IV) chloride In acetonitrile for 2h; Heating; | 91% |
4-isopropyl-2,5-dioxo-oxazolidine-3-carboxylic acid benzyl ester
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Stage #1: 4-isopropyl-2,5-dioxo-oxazolidine-3-carboxylic acid benzyl ester With methanol; 4 A molecular sieve In diethyl ether at 0℃; for 22h; Stage #2: With water Further stages.; | 40% |
benzyl (S)-1-(tert-butoxycarbonyl)-2-methylpropylcarbamate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 1.08333h; |
benzyl chloroformate
A
N-[(benzyloxy)carbonyl]-D-valine
B
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Stage #1: DL-Val/PyS With alpha cyclodextrin In ethanol; dimethyl sulfoxide at 30℃; for 24h; Stage #2: benzyl chloroformate |
(S)-2-Benzyloxycarbonylamino-3-methyl-butyric acid 2,2-dibromo-1-tert-butylcarbamoyl-propyl ester
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium metaborate; cobalt(II) phthalocyanine In ethanol at 20℃; for 1h; | 64% |
(S)-2-Benzyloxycarbonylamino-3-methyl-butyric acid allyl ester
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With morpholine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 30℃; for 12h; | 79% |
L-valine hydrochloride
benzyl chloroformate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium carbonate In tetrahydrofuran; water at 0 - 20℃; for 16h; Solvent; Temperature; |
methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With 2C33H37N*H2O7S2; water at 80℃; for 9h; optical yield given as %ee; | 86% |
With sodium hydroxide In methanol |
potassium ethyl xanthogenate
(S)-2-Benzyloxycarbonylamino-3-methyl-butyric acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester
A
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium dithionite In tetrahydrofuran; water | A 67% B 72% |
N-(Benzyloxycarbonyloxy)succinimide
L-valine
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium hydroxide; sodium hydrogencarbonate In 1,4-dioxane; water at 0℃; | |
With sodium hydrogencarbonate In acetone at 20℃; |
L-valine
N-(benzyloxycarbonyl)benzothiazolin-2-thione
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane for 12h; Ambient temperature; | 90% |
L-valine
1-Benzyloxycarbonylbenzimidazoline-2-thione
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane for 12h; Ambient temperature; | 91% |
Conditions | Yield |
---|---|
With triethylamine In water Ambient temperature; | 82% |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / Et3N / acetonitrile / 2 h / 5 °C 2: 82 percent / Et3N / H2O / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 89 percent / quinoline; CH2Cl2 / 12 h / Ambient temperature 2: 74 percent / triethylamine; CHCl3; H2O / 18 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 38 percent / NaHCO3 / CH2Cl2; H2O / Ambient temperature 2: Jones' reagent / acetone / 3 h / 0 °C View Scheme |
L-valine
O-benzyl S-(pyridin-2-yl)carbonothioate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane for 12h; Ambient temperature; | 82% |
L-valine
benzyl 2-thioxobenzo[d]oxazol-3(2H)-carboxylate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane for 12h; Ambient temperature; | 81% |
4-isopropyl-2,5-oxazolidinedione
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NMM / tetrahydrofuran / -25 - 20 °C 2.1: 20 mol percent DHQD-PHN; 4 Angstroem molecular sieves; methanol / diethyl ether / 22 h / 0 °C 2.2: 40 percent / H2O View Scheme |
Conditions | Yield |
---|---|
With thiolsubtilisin In water; N,N-dimethyl-formamide Ambient temperature; pH 8.0 phosphate buffer containing PhB(OH)2 traces; |
(2S)-amino-4-methylpentanamide hydrochloride
Z-L-Val carbamoylmethyl ester
A
(S)-N-(benzyloxycarbonyl)valine
B
Z-L-Val-L-Leu-NH2
Conditions | Yield |
---|---|
With α-chymotripsin on Celite; Tris buffer; TEA In acetonitrile at 30℃; for 48h; | A 6.8% B 13.6% |
sodium phenyl-methanolate
A
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / tetrahydrofuran / 6 h / 30 °C 2: aq. NaOH / methanol View Scheme | |
Multi-step reaction with 2 steps 1: 72 percent / tetrahydrofuran / 6 h / 30 °C 2: 79 percent / DBU, morpholine / Pd(dba)2, PPh3 / acetonitrile / 12 h / 30 °C View Scheme |
(S)-N-[Bis(methylthio)methylene]valine allyl ester
A
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 72 percent / tetrahydrofuran / 6 h / 30 °C 2: 79 percent / DBU, morpholine / Pd(dba)2, PPh3 / acetonitrile / 12 h / 30 °C View Scheme |
picolyl N-Cbz-L-valinate
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With magnesium In methanol at 20℃; for 4h; |
N-benzyloxycarbonyl-L-valinol
A
N-[(benzyloxy)carbonyl]-D-valine
B
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With jones' reagent In acetone at 0℃; for 3h; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With cetyltrimethylammonim bromide; Dec-L-His In acetonitrile at 25℃; Rate constant; 0.02M phosphate buffer, pH=7.3; other catalysts; | |
With papain (preactivated with 2E-3M ethylenediaminotetraacetic acid (tetrasodium salt) and 5E-3M L-cysteine); water In acetonitrile at 21℃; Kinetics; pH=3.4-4.0 (formate and acetate buffers); pre-steady-state and steady-state parameters describing papain action; | |
With water at 21℃; Rate constant; Mechanism; pH dependence of the rate constant and catalytic effect of amino acid; |
Conditions | Yield |
---|---|
In chloroform; water; triethylamine for 18h; Ambient temperature; | 74% |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1) NaH / 1) THF, reflux, 2h, 2) room temperature, 1h 2: tetrahydrofuran / 3 h / Ambient temperature 3: 92 percent / standard pH stat conditions View Scheme |
Conditions | Yield |
---|---|
standard pH stat conditions; | 92% |
diazomethane
(S)-N-(benzyloxycarbonyl)valine
methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate
Conditions | Yield |
---|---|
In diethyl ether | 100% |
With diethyl ether |
(S)-N-(benzyloxycarbonyl)valine
Z-(L)-Val-Cl
Conditions | Yield |
---|---|
With oxalyl dichloride In chloroform; N,N-dimethyl-formamide at 20℃; for 5h; Cooling with ice; Reflux; | 100% |
With diethyl ether; phosphorus pentachloride | |
With thionyl chloride In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile at -5 - 0℃; for 0.25h; |
L-Valine methyl ester
(S)-N-(benzyloxycarbonyl)valine
methyl (S)-2-((S)-2-benzyloxycarbonyl-amino-3-methylbutyrylamino)-3-methylbutyrate
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; | 100% |
With N-ethyl-N,N-diisopropylamine; <4-nitro-6-(trifluoromethyl)benzotriazol-1-yloxy>tris(pyrrolidino)phosphonium hexafluorophosphate at 20℃; for 1h; | 98% |
With 3,3'-Dicyano-4,4',6,6'-tetramethyl-2,2'-dipyridinyl-disulfid; triphenylphosphine In dichloromethane at -20 - -15℃; for 12h; | 84% |
(S)-N-(benzyloxycarbonyl)valine
methyl N-methyl-L-valinate hydrochloride
N--L-N-methylvaline methyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In dichloromethane 1) 1 min in the cold, 2) 1 h at r.t.; other coupling reagents; | 100% |
With N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate In dichloromethane for 3h; Ambient temperature; | 96% |
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In dichloromethane 1.) 0 deg C, 1 min, 2.) r.t., 3 h; | 90% |
With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Ambient temperature; | 71% |
With N-ethyl-N,N-diisopropylamine; <6-(trifluoromethyl)benzotriazol-1-yloxy>tris(dimethylamino)phosphonium hexafluorophosphate In dichloromethane at 35℃; for 1h; | 49% |
(S)-N-(benzyloxycarbonyl)valine
(2S,3S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-butane-1,4-diol
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 24h; Ambient temperature; | 100% |
Conditions | Yield |
---|---|
Stage #1: (S)-N-(benzyloxycarbonyl)valine With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -15℃; for 0.25h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at -15℃; for 1h; | 100% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 25℃; | |
Multi-step reaction with 2 steps 1: DCC / ethyl acetate / 20 h / 20 °C 2: NaBH4; AcOH / methanol; dioxane View Scheme |
(S)-N-(benzyloxycarbonyl)valine
benzylamine
(S)-benzyl (1-(benzylamino)-3-methyl-1-oxobutan-2-yl)carbamate
Conditions | Yield |
---|---|
With N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic azide; triethylamine In dichloromethane | 100% |
Stage #1: (S)-N-(benzyloxycarbonyl)valine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.75h; Stage #2: benzylamine at 0 - 20℃; for 17h; | 89% |
With triethylamine; isobutyl chloroformate In tetrahydrofuran for 16h; Ambient temperature; |
(S)-N-(benzyloxycarbonyl)valine
(R)-2-N-(tert-butoxycarbonyl)amino-2-methyl-3-hydroxypropanoic acid methyl ester
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; | 100% |
(S)-N-(benzyloxycarbonyl)valine
(1R,2S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryloxy)-1-tert-butoxycarbonylamino-cyclohexanecarboxylic acid methyl ester
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; | 100% |
(S)-N-(benzyloxycarbonyl)valine
2-(3,4-dimethoxyphenyl)-ethylamine
benzyl (1S)-1-({[2-(3,4-dimethoxyphenyl)ethyl]amino}carbonyl)-2-methylpropylcarbamate
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃; | 100% |
With 1,1'-carbonyldiimidazole In tetrahydrofuran; dichloromethane |
(S)-N-(benzyloxycarbonyl)valine
N4-(4-ethyl-6-methoxy-5-propoxy-quinolin-8-yl)-pentane-1,4-diamine
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h; | 100% |
(S)-N-(benzyloxycarbonyl)valine
N4-(4-ethyl-5-hexyloxy-6-methoxy-quinolin-8-yl)-pentane-1,4-diamine
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h; | 100% |
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With potassium carbonate; copper(I) bromide In dichloromethane at 20℃; | 100% |
(S)-N-(benzyloxycarbonyl)valine
(S)-2-benzyloxycarbonyl-amino-3-methylbutyric acid-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester
Conditions | Yield |
---|---|
Stage #1: (2R,3R,11bR)-dihydrotetrabenazine With dmap In dichloromethane Stage #2: (S)-N-(benzyloxycarbonyl)valine In dichloromethane for 0.0833333h; Stage #3: With dicyclohexyl-carbodiimide In dichloromethane | 100% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane | 95.7 g |
(S)-N-(benzyloxycarbonyl)valine
L-2-hydroxy-3-methylbutanoic acid allyl ester
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; | 100% |
(S)-N-(benzyloxycarbonyl)valine
glycine ethyl ester hydrochloride
ethyl N-(benzyloxycarbonyl)-L-valylglycinate
Conditions | Yield |
---|---|
With 3,3'-(phenylphosphinylidene)bis<2(3H)-benzothiazolone; triethylamine In dichloromethane for 2h; Ambient temperature; | 99% |
With TEA; diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate In dichloromethane for 2h; Ambient temperature; | 99% |
With TEA; 1,2-benzisoxazol-3-yl diphenyl phosphate In dichloromethane for 2h; Ambient temperature; | 95% |
(S)-Leu-OMe
(S)-N-(benzyloxycarbonyl)valine
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoate
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane | 99% |
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide |
(S)-N-(benzyloxycarbonyl)valine
L-α-hydroxyisovaleric acid t-butyl ester
benzyloxycarbonyl-L-valyl-L-α-hydroxyisovaleric acid t-butyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 24h; Ambient temperature; | 99% |
(i) PhSO2Cl, Py, (ii) /BRN= 4658890/; Multistep reaction; |
(S)-N-(benzyloxycarbonyl)valine
L-alanine benzyl ester hydrochloride
Z-(S)-Val-(S)-Ala-OBzl
Conditions | Yield |
---|---|
With TEA; diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate In dichloromethane for 2h; Ambient temperature; | 99% |
(S)-N-(benzyloxycarbonyl)valine
Isopropenyl Succinimido Carbonate
2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate
Conditions | Yield |
---|---|
With dmap In acetonitrile for 4h; Ambient temperature; | 99% |
(S)-N-(benzyloxycarbonyl)valine
Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester isopropenyl ester
N-(benzyloxycarbonyl)-L-valine N-hydroxy-5-norbornene-2,3-dicarboximide ester
Conditions | Yield |
---|---|
With dmap In acetonitrile for 4h; Ambient temperature; | 99% |
(S)-N-(benzyloxycarbonyl)valine
N,O-dimethylhydroxylamine*hydrochloride
Nα-(benzyloxycarbonyl)-N-methoxy-N-methyl-L-valinamide
Conditions | Yield |
---|---|
Stage #1: (S)-N-(benzyloxycarbonyl)valine With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene In ethyl acetate; acetonitrile at 0℃; for 0.166667h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In ethyl acetate; acetonitrile at 0℃; for 0.5h; | 99% |
Stage #1: (S)-N-(benzyloxycarbonyl)valine With triethylamine; HATU In dichloromethane at 20℃; for 0.25h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; | 85.4% |
Stage #1: (S)-N-(benzyloxycarbonyl)valine With triethylamine; HATU In dichloromethane at 20℃; for 0.25h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; | 85.4% |
(S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
Stage #1: (S)-N-tert-butoxycarbonyl-2-[bis(2-methylphenyl)phosphinomethyl]pyrrolidine With hydrogenchloride In 1,4-dioxane at 0 - 20℃; Inert atmosphere; Stage #2: (S)-N-(benzyloxycarbonyl)valine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at -20 - 20℃; for 19.5h; | 99% |
(S)-N-(benzyloxycarbonyl)valine
1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 99% |
(S)-N-(benzyloxycarbonyl)valine
methyl (L)-leucinate hydrochloride
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoate
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h; | 99% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 12h; | 69% |
(S)-N-(benzyloxycarbonyl)valine
(S)-N-benzyloxycarbonylvalinamide
Conditions | Yield |
---|---|
Stage #1: (S)-N-(benzyloxycarbonyl)valine With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: With ammonium chloride In N,N-dimethyl-formamide at 23℃; for 16h; | 98% |
Stage #1: (S)-N-(benzyloxycarbonyl)valine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With ammonium chloride In tetrahydrofuran; water at 0℃; for 0.5h; | 93% |
With hexamethylphosphorous triamide dichloride; ammonia In dichloromethane 1) 30 min, -20 deg C, 2) 4 h, r.t.; | 87.5% |
(S)-N-(benzyloxycarbonyl)valine
Penciclovir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 32h; Ambient temperature; | 98% |
(S)-N-(benzyloxycarbonyl)valine
3,5-Dimethylphenol
N-benzyloxycarbonyl-L-valine 3,5-dimethylphenyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexaflu; orophosphate In dichloromethane at 20℃; | 98% |
(S)-N-(benzyloxycarbonyl)valine
Conditions | Yield |
---|---|
With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -15 - 20℃; | 98% |
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