As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:115473-15-9
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct Description Product Name 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride CAS No. 115473-15-9 Appearance White powder Assay ≥99% Capacity 100mt/
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inquiryUnique advantages for Prasugrel Cas 115473-15-9Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Package:10g/foil bag,1kg/foil bag ;25kg/drum or per your request
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inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryStock products, own laboratory Appearance:Light Tan Solid Storage:Inert atmosphere,Store in freezer, under -20°C Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai
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inquiryProduct Name: Prasugrel Synonyms: 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride prasugrel intermediate I;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridin-2(4H)-one Hydrochloride;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridinone Hydrochloride;
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers
Cas:115473-15-9
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inquiryAppearance:Light Tan Solid Storage:Inert atmosphere,Store in freezer, under -20°C Package:25kg/Barrel Application:pharmaceutical intermediates Transportation:Express/Sea/Air Port:Shanghai
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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inquiryProduct Name: Prasugrel CAS: 115473-15-9 MF: C7H10ClNOS MW: 191.68 EINECS: 601-365-4 Mol File: 115473-15-9.mol Prasugrel Structure Prasugrel Chemical Properties Melting point 2100C (dec) storage temp. -20°C Freezer, Un
5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride CAS:115473-15-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediat
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Prasugrel intermediate Product Name: Prasugrel intermediate Synonyms: 5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridin-2(4H)-one Hydrochloride;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridinone Hydrochloride;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one
Cas:115473-15-9
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:115473-15-9
Min.Order:10 Gram
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inquiryProduct name: Prasugrel intermediate CAS: 115473-15-9 Stock: Fresh Purity: not less than 99% Standard: In-house Package:25kg drum Application:Prasugrel intermediate
Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryAppearance:detailed see specifications Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common product
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 25 - 50℃; for 1h; | 99% |
With hydrogenchloride In ethanol at 45℃; Solvent; Inert atmosphere; | 76% |
With hydrogenchloride; water In acetone at 56℃; for 3h; |
5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine With N,N,N,N,-tetramethylethylenediamine; n-hexyllithium In toluene at 0℃; Large scale; Stage #2: With boric acid tributyl ester In toluene at 0℃; for 1h; Large scale; Further stages; | 86.1% |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 1.2: -5 - 10 °C 2.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C 1.3: 1.75 h / 0 - 30 °C / Reflux 2.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux View Scheme |
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C / Inert atmosphere 2.3: 2 h / 0 - 30 °C 3.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 12 - 28 °C 2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 2.2: -5 - 10 °C 3.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C 2.3: 1.75 h / 0 - 30 °C / Reflux 3.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / 1,4-dioxane / 0.5 h / 80 °C 1.2: 1 h 2.1: copper dichloride / methanol / 4 h 3.1: methanol / 24 h / Inert atmosphere; Reflux 4.1: hydrogenchloride / methanol / 12 h / 20 °C View Scheme |
[2-(2-thyenyl)ethyl]amine
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme |
6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: copper dichloride / methanol / 4 h 2: methanol / 24 h / Inert atmosphere; Reflux 3: hydrogenchloride / methanol / 12 h / 20 °C View Scheme |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; for 12h; | 6.5 g |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
Conditions | Yield |
---|---|
With ammonium bicarbonate In dichloromethane at 5 - 20℃; | 98% |
With copper(l) iodide; sodium carbonate; XPhos In 1,4-dioxane at 60℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere; | 90.2% |
With potassium phosphate; iodine In 1,4-dioxane at 80℃; for 4h; Temperature; Time; Reagent/catalyst; | 87.6% |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
2-Oxoclopidogrel
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; | 70% |
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; | 70% |
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With water; potassium carbonate In dichloromethane for 0.166667h; Stage #2: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester In dichloromethane for 6h; Reflux; | |
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; | 18.1 g |
With potassium carbonate In acetonitrile at 25 - 35℃; for 12h; | 25.4 g |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; | 70% |
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; | 70% |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
methyl 2-bromo-2-(2-chlorophenyl)acetate
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; | 62% |
With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 2h; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
2-bromo-2-cyclopropyl-1-phenylethan-1-one
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 10 - 15℃; | 60% |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
A
(S)-(2-chlorophenyl)(2-hydroxy-6,7-dihydro-4H-thiophene[3,2-c]pyridin-5-yl)acetic acid methyl ester
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile for 15h; Inert atmosphere; | A 54% B n/a |
α-cyclopropylcarbonyl-2-fluorobenzyl chloride
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile at 60℃; for 12h; Inert atmosphere; | 52% |
With sodium carbonate In acetonitrile at 60℃; for 12h; Molecular sieve; Inert atmosphere; | 50% |
methyl 2-chloro-2-(2-chlorophenyl)acetate
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 0.05h; Inert atmosphere; Stage #2: methyl 2-chloro-2-(2-chlorophenyl)acetate In N,N-dimethyl-formamide at 55℃; for 0.166667h; Inert atmosphere; | 44% |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
acetic anhydride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Inert atmosphere; | 20.03% |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
2,4-dihydroxy-5- isopropylbenzoic acid
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; for 4h; | 10% |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 6h; Stage #3: acetic anhydride With triethylamine In acetonitrile at 0 - 30℃; for 6.5h; | |
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50 - 55℃; for 2h; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 10 - 45℃; |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 7h; Stage #3: With hydrogenchloride In ethyl acetate; acetone at 25 - 30℃; for 1h; | |
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetone; acetonitrile at 25 - 30℃; for 7.5h; Stage #2: With hydrogenchloride In ethyl acetate; acetone at 25 - 30℃; for 1h; |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 6 h / 25 - 30 °C 1.3: 6.5 h / 0 - 30 °C 2.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 3.2: 6 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 6 h / 25 - 30 °C 1.3: 0 - 30 °C 2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 2.2: 6 h / 0 - 5 °C View Scheme |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C 3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 3.2: 6 h / 0 - 5 °C 4.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 6 h / 25 - 30 °C 1.3: 0 - 30 °C 2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 2.2: 6 h / 0 - 5 °C 3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 0 - 5 °C View Scheme |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: ammonia / dichloromethane; water / 0 - 30 °C 3.2: 1 h / 25 - 30 °C View Scheme |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide
Conditions | Yield |
---|---|
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 6h; Stage #3: With hydrogen bromide In water; acetone at 0 - 30℃; | |
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 10 - 15℃; for 2.5h; Stage #3: With hydrogen bromide In water; acetone at 0 - 30℃; for 3h; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
tert-butyldimethylsilyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere 3: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere View Scheme |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
tert-butyldimethylsilyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 28 - 30℃; for 1.75h; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere; |
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
methyl 2-phenyl-2-(((p-nitrophenyl)sulfonyl)oxy)acetate
Methyl alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno [3,2-c] 5-pyridyl) phenyl-acetate
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In acetonitrile at 20℃; |
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