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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Manufacturer/High quality/Best price/In stock

Cas:115473-15-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5,6,7,7A-Tetrahydrothieno[3,2-C]Pyridine-2(4H)-Onehydrochloride supplier in China

Cas:115473-15-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product Name 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride CAS No. 115473-15-9 Appearance White powder Assay ≥99% Capacity 100mt/

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Gram

FOB Price: $43.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Prasugrel Cas 115473-15-9Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Package:10g/foil bag,1kg/foil bag ;25kg/drum or per your request

High quality organic intermediate Prasugrel Cas 115473-15-9 with best price

Cas:115473-15-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2-(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Win-Win chemical Co.Ltd

Stock products, own laboratory Appearance:Light Tan Solid Storage:Inert atmosphere,Store in freezer, under -20°C Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai

Cas no.115473-15-9 98% 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name: Prasugrel Synonyms: 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride prasugrel intermediate I;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridin-2(4H)-one Hydrochloride;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridinone Hydrochloride;

115473-15-9 Prasugrel

Cas:115473-15-9

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 115473-15-9 with competitive price

Cas:115473-15-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Prasugrel CAS115473-15-9

Cas:115473-15-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Light Tan Solid Storage:Inert atmosphere,Store in freezer, under -20°C Package:25kg/Barrel Application:pharmaceutical intermediates Transportation:Express/Sea/Air Port:Shanghai

Factory supply 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-onehydrochloride

Cas:115473-15-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride 115473-15-9

Cas:115473-15-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: Prasugrel CAS: 115473-15-9 MF: C7H10ClNOS MW: 191.68 EINECS: 601-365-4 Mol File: 115473-15-9.mol Prasugrel Structure Prasugrel Chemical Properties Melting point 2100C (dec) storage temp. -20°C Freezer, Un

Prasugrel

Cas:115473-15-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride CAS:115473-15-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediat

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride CAS:115473-15-9

Cas:115473-15-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

5,6,7,7a-tetrahydrothiopheno [3,2-c] pyridine-2(4H) -ketone hydrochloride

Cas:115473-15-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Prasugrel intermediate 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:115473-15-9

Cas:115473-15-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Prasugrel intermediate Product Name: Prasugrel intermediate Synonyms: 5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridin-2(4H)-one Hydrochloride;5,6,7,7a-Tetrahydro-thieno[3,2-c]pyridinone Hydrochloride;5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name: Prasugrel intermediate CAS: 115473-15-9 Stock: Fresh Purity: not less than 99% Standard: In-house Package:25kg drum Application:Prasugrel intermediate

Prasugrel intermediate

Cas:115473-15-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5,6,7,7A-Tetrahydrothieno(3,2-C)Pyridine-2(4H)-One Hydrochloride

Cas:115473-15-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:detailed see specifications Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common product

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

Cas:115473-15-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine
109904-26-9

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 25 - 50℃; for 1h;99%
With hydrogenchloride In ethanol at 45℃; Solvent; Inert atmosphere;76%
With hydrogenchloride; water In acetone at 56℃; for 3h;
5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine
109904-25-8

5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions
ConditionsYield
Stage #1: N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine With N,N,N,N,-tetramethylethylenediamine; n-hexyllithium In toluene at 0℃; Large scale;
Stage #2: With boric acid tributyl ester In toluene at 0℃; for 1h; Large scale; Further stages;
86.1%
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
1.2: 1 h / 0 - 15 °C / Inert atmosphere
1.3: 2 h / 0 - 30 °C
2.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C
1.2: -5 - 10 °C
2.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
1.2: 1 h / 0 - 15 °C
1.3: 1.75 h / 0 - 30 °C / Reflux
2.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux
View Scheme
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
2.2: 1 h / 0 - 15 °C / Inert atmosphere
2.3: 2 h / 0 - 30 °C
3.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 12 - 28 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C
2.2: -5 - 10 °C
3.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
2.2: 1 h / 0 - 15 °C
2.3: 1.75 h / 0 - 30 °C / Reflux
3.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / 1,4-dioxane / 0.5 h / 80 °C
1.2: 1 h
2.1: copper dichloride / methanol / 4 h
3.1: methanol / 24 h / Inert atmosphere; Reflux
4.1: hydrogenchloride / methanol / 12 h / 20 °C
View Scheme
[2-(2-thyenyl)ethyl]amine
30433-91-1

[2-(2-thyenyl)ethyl]amine

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dichloromethane / 40 - 45 °C
1.2: 20 - 70 °C
2.1: triethylamine / dichloromethane / 12 - 28 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C
3.2: -5 - 10 °C
4.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C
View Scheme
6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester
230301-73-2

6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper dichloride / methanol / 4 h
2: methanol / 24 h / Inert atmosphere; Reflux
3: hydrogenchloride / methanol / 12 h / 20 °C
View Scheme
2-methoxy-5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-methoxy-5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 12h;6.5 g
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions
ConditionsYield
With ammonium bicarbonate In dichloromethane at 5 - 20℃;98%
With copper(l) iodide; sodium carbonate; XPhos In 1,4-dioxane at 60℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere;90.2%
With potassium phosphate; iodine In 1,4-dioxane at 80℃; for 4h; Temperature; Time; Reagent/catalyst;87.6%

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

2-Oxoclopidogrel
1147350-75-1

2-Oxoclopidogrel

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;70%
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;70%
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With water; potassium carbonate In dichloromethane for 0.166667h;
Stage #2: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester In dichloromethane for 6h; Reflux;
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;18.1 g
With potassium carbonate In acetonitrile at 25 - 35℃; for 12h;25.4 g
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

(R)-2-(2-chlorophenyl)-2-(4-nitro sulfonyloxy)acetic acid methyl ester-d3

(R)-2-(2-chlorophenyl)-2-(4-nitro sulfonyloxy)acetic acid methyl ester-d3

(2S)-2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridine-5(2H,4H,6H)-yl)acetic acid methyl ester-d3

(2S)-2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridine-5(2H,4H,6H)-yl)acetic acid methyl ester-d3

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;70%
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;70%
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

methyl 2-bromo-2-(2-chlorophenyl)acetate
85259-19-4

methyl 2-bromo-2-(2-chlorophenyl)acetate

(SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

(SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃;62%
With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 2h;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

2-bromo-2-cyclopropyl-1-phenylethan-1-one
84040-29-9

2-bromo-2-cyclopropyl-1-phenylethan-1-one

5-(α-cyclopropylcarbonylbenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)pyridine

5-(α-cyclopropylcarbonylbenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)pyridine

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 10 - 15℃;60%
(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

A

(S)-(2-chlorophenyl)(2-hydroxy-6,7-dihydro-4H-thiophene[3,2-c]pyridin-5-yl)acetic acid methyl ester
1360591-38-3

(S)-(2-chlorophenyl)(2-hydroxy-6,7-dihydro-4H-thiophene[3,2-c]pyridin-5-yl)acetic acid methyl ester

B

C16H16ClNO3S

C16H16ClNO3S

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile for 15h; Inert atmosphere;A 54%
B n/a
α-cyclopropylcarbonyl-2-fluorobenzyl chloride
178688-43-2

α-cyclopropylcarbonyl-2-fluorobenzyl chloride

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 60℃; for 12h; Inert atmosphere;52%
With sodium carbonate In acetonitrile at 60℃; for 12h; Molecular sieve; Inert atmosphere;50%
methyl 2-chloro-2-(2-chlorophenyl)acetate
90055-47-3

methyl 2-chloro-2-(2-chlorophenyl)acetate

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

(SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

(SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions
ConditionsYield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 0.05h; Inert atmosphere;
Stage #2: methyl 2-chloro-2-(2-chlorophenyl)acetate In N,N-dimethyl-formamide at 55℃; for 0.166667h; Inert atmosphere;
44%
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

acetic anhydride
108-24-7

acetic anhydride

5-acetyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

5-acetyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Inert atmosphere;20.03%
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

2,4-dihydroxy-5- isopropylbenzoic acid
1184181-48-3

2,4-dihydroxy-5- isopropylbenzoic acid

5-(2,4-dihydroxy-5-isopropylbenzoyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

5-(2,4-dihydroxy-5-isopropylbenzoyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; for 4h;10%
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h;
Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 6h;
Stage #3: acetic anhydride With triethylamine In acetonitrile at 0 - 30℃; for 6.5h;
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50 - 55℃; for 2h;
Stage #2: acetic anhydride In N,N-dimethyl-formamide at 10 - 45℃;
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
150322-39-7

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Conditions
ConditionsYield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h;
Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 7h;
Stage #3: With hydrogenchloride In ethyl acetate; acetone at 25 - 30℃; for 1h;
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetone; acetonitrile at 25 - 30℃; for 7.5h;
Stage #2: With hydrogenchloride In ethyl acetate; acetone at 25 - 30℃; for 1h;
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

CS-747 hydrochloride

CS-747 hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 6 h / 25 - 30 °C
1.3: 6.5 h / 0 - 30 °C
2.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere
View Scheme
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 7 h / 25 - 30 °C
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 7 h / 25 - 30 °C
2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
3.2: 6 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 6 h / 25 - 30 °C
1.3: 0 - 30 °C
2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
2.2: 6 h / 0 - 5 °C
View Scheme
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

CS-747 hydrochloride

CS-747 hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 7 h / 25 - 30 °C
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 7 h / 25 - 30 °C
2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
3.2: 6 h / 0 - 5 °C
4.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 6 h / 25 - 30 °C
1.3: 0 - 30 °C
2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
2.2: 6 h / 0 - 5 °C
3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 0 - 5 °C
View Scheme
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
150322-39-7

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
1.2: 7 h / 25 - 30 °C
2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
3.1: ammonia / dichloromethane; water / 0 - 30 °C
3.2: 1 h / 25 - 30 °C
View Scheme
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide
1243654-57-0

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide

Conditions
ConditionsYield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h;
Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 6h;
Stage #3: With hydrogen bromide In water; acetone at 0 - 30℃;
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile for 0.5h;
Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 10 - 15℃; for 2.5h;
Stage #3: With hydrogen bromide In water; acetone at 0 - 30℃; for 3h;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2-(tert-butyldimethylsilyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-(tert-butyldimethylsilyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 20 °C / Inert atmosphere
3: hydrogenchloride; water / ethyl acetate / 20 °C
View Scheme
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 20 °C / Inert atmosphere
View Scheme
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

C13H23NOSSi*ClH

C13H23NOSSi*ClH

Conditions
ConditionsYield
With triethylamine In dichloromethane at 28 - 30℃; for 1.75h;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

C15H12FNO7S

C15H12FNO7S

5-(α-methoxycarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c ]pyridine

5-(α-methoxycarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c ]pyridine

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

C15H12ClNO7S

C15H12ClNO7S

(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
1360923-54-1

(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

(R)-methyl 2-(2-chlorophenyl)-2-(4-nitrophenylsulfonyloxy)-acetate

(R)-methyl 2-(2-chlorophenyl)-2-(4-nitrophenylsulfonyloxy)-acetate

(SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

(SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
115473-15-9

5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

methyl 2-phenyl-2-(((p-nitrophenyl)sulfonyl)oxy)acetate
142026-00-4, 87119-37-7

methyl 2-phenyl-2-(((p-nitrophenyl)sulfonyl)oxy)acetate

Methyl alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno [3,2-c] 5-pyridyl) phenyl-acetate
109904-28-1

Methyl alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno [3,2-c] 5-pyridyl) phenyl-acetate

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 20℃;

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