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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 120014-30-4 Letimovir intermediate Manufacturer

Cas:120014-30-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one Manufacturer/High quality/Best price/In stock

Cas:120014-30-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one

Cas:120014-30-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 120014-30-4 with best quality

Cas:120014-30-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one 120014-30-4

Cas:120014-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one CAS:120014-30-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, special

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one CAS:120014-30-4

Cas:120014-30-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:120014-30-4

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5,6-Dimethoxy-2(Pyridine-4-Yl)Methylene-Indan-1-One

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Zhengzhou Yuanli Biological Technology Co., Ltd.

Basic information Product Name:5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one Place of Origin:China CAS No.:120014-30-4 MF:C17H23NO3 MW:289.37 Package : 25kg/Drum, or as your request Delivery Time: prompt Transportation: by air/by sea

99% 120014-30-4 manufacturer;High quality/Best price

Cas:120014-30-4

Min.Order:500 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5,6-Dimethoxy-2(Pyridine-4-Yl)Methylene-Indan-1-One

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

high quality 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Other

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Pale Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:50kg/plastic drum; or as per your request Application:An impurity of Donepezil T

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Yellow to light yellow solid Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one cas no. 120014-30-4 98%

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

5,6-DiMethoxy-2-(piperidin-4-ylMethyl)-2,3-dihydro-1H-inden-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

High Purity 4-[(5,6-Dimethoxy-1-Indanone) -2-Methyl] Piperidine 120014-30-4

Cas:120014-30-4

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-[(5,6-Dimethoxy-1-Indanone) -2-Methyl] Piperidine

Cas:120014-30-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

4-[(5,6-Dimethoxy-1-Indanone) -2-Methyl] Piperidine

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Other

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Cas:120014-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone
4803-57-0

2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In methanol; acetic acid at 20℃; under 2311.54 Torr; for 6h;99%
With palladium on activated charcoal; hydrogen; acetic acid In methanol74%
With 5% Pd(II)/C(eggshell); hydrogen; sodium acetate; acetic acid In methanol; dichloromethane at 70 - 75℃; under 4413.43 - 5149.01 Torr; for 10h;70%
donepezil
120014-06-4

donepezil

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃; for 3h; Heating / reflux;97%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 72h;
5,6-dimethoxy-2-(4-piperidinylmethyl)-indan-1-one acetate
861675-47-0

5,6-dimethoxy-2-(4-piperidinylmethyl)-indan-1-one acetate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
In water pH=13;95.3%
(E)-tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate

(E)-tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Stage #1: (E)-tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.333333h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 20℃; for 3h;
91%
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
877606-65-0

(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one

A

2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone
4803-57-0

2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone

B

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal In methanol at 60 - 65℃; for 7h;A n/a
B 90%
5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one

5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With perchloric acid; 5% Pd(II)/C(eggshell); hydrogen In methanol; dichloromethane at 60 - 65℃; under 4781.22 Torr; for 10h;90%
tert-butyl 4-((2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)-methyl)piperidine-1-carboxylate
948550-60-5

tert-butyl 4-((2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)-methyl)piperidine-1-carboxylate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Stage #1: tert-butyl 4-((2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)-methyl)piperidine-1-carboxylate With hydrogenchloride In ethyl acetate
Stage #2: With sodium carbonate In water; ethyl acetate pH=~ 6;
84%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h;80%
(2E)-5,6-dimethoxy-2-(pyridin-4-yl-methylene)indan-1-one-N-oxide

(2E)-5,6-dimethoxy-2-(pyridin-4-yl-methylene)indan-1-one-N-oxide

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol; dichloromethane at 75 - 80℃; under 7355.72 Torr; for 8h;77%
5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one

5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one

A

4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine
844694-83-3

4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine

B

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With perchloric acid; palladium 10% on activated carbon; hydrogen In methanol at 70 - 75℃; under 4413.43 - 5149.01 Torr; for 7h;A 22%
B 63%
4-piperidinemethanol
6457-49-4

4-piperidinemethanol

5,6-dimethoxy-1-indanone
2107-69-9

5,6-dimethoxy-1-indanone

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With trifuran-2-yl-phosphane; C42H32F3N2O2PPd; lithium hydroxide In neat (no solvent) at 100℃; for 48h; Schlenk technique; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction;51%
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

N6-protected N2-Fmoc-lysine on Wang resin

N6-protected N2-Fmoc-lysine on Wang resin

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating
2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C
View Scheme
5,6-dimethoxy-1-indanone
2107-69-9

5,6-dimethoxy-1-indanone

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating
2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / Reflux
2: dihydrogen peroxide / acetic acid / 45 - 50 °C
3: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 8 h / 75 - 80 °C / 7355.72 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
1.2: 2 h / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr
2.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 24 h / Reflux
2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene
2: acetic acid; palladium on activated charcoal; hydrogen / methanol
View Scheme
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
120014-07-5

1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine

A

donepezil hydrochloride

donepezil hydrochloride

B

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5% Pd on alumina In tetrahydrofuran at 3 - 6℃; under 3000.3 - 7500.75 Torr; for 3 - 5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water Product distribution / selectivity;
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5% Pd on alumina In tetrahydrofuran at 14 - 20℃; under 3750.38 - 7500.75 Torr; for 0.833333h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5% Pd on alumina In toluene at 9 - 12℃; under 1500.15 - 6000.6 Torr; for 2.33333 - 5h;
Stage #2: With hydrogenchloride In ethanol; water; toluene Product distribution / selectivity;
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran; toluene at 30 - 60℃; under 1551.49 - 1810.07 Torr; for 2h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene at 25 - 30℃; Product distribution / selectivity;
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
120014-07-5

1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine

A

donepezil
120014-06-4

donepezil

B

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 0 - 2℃; under 760.051 Torr; for 1.5h;
With hydrogen; palladium 10% on activated carbon In toluene at 0 - 1℃; under 6000.6 - 7500.75 Torr; for 5h;
5,6-dimethoxy-2-[1-(4-pyridinyl)methylidene]-1-indanone tosylate

5,6-dimethoxy-2-[1-(4-pyridinyl)methylidene]-1-indanone tosylate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In water at 60 - 95℃; under 7500.75 Torr; for 8h;
5,6-dimethoxy-2-(pyridine-4-ylmethylene)indan-1-one hydrochloride
942424-77-3

5,6-dimethoxy-2-(pyridine-4-ylmethylene)indan-1-one hydrochloride

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium 10% on activated carbon In methanol at 68 - 72℃; under 3800.26 Torr; for 7h;
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / Reflux
2: dihydrogen peroxide / acetic acid / 45 - 50 °C
3: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 8 h / 75 - 80 °C / 7355.72 Torr
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 24 h / Reflux
2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene
2: acetic acid; palladium on activated charcoal; hydrogen / methanol
View Scheme
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
877606-65-0

(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dihydrogen peroxide / acetic acid / 45 - 50 °C
2: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 8 h / 75 - 80 °C / 7355.72 Torr
View Scheme
With hydrogen In neat (no solvent) at 50℃; under 760.051 Torr; for 144h;
4-piperidinemethanol
6457-49-4

4-piperidinemethanol

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; ethyl acetate / 6 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Inert atmosphere; Reflux
3.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere
3.2: 5 h / 50 °C / Inert atmosphere
4.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
View Scheme
tert butyl 4-formylpiperidine-1-carboxylate
137076-22-3

tert butyl 4-formylpiperidine-1-carboxylate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere
1.2: 5 h / 50 °C / Inert atmosphere
2.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
1.2: 2 h / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr
2.2: 3 h / 20 °C
View Scheme
4-carbethoxypiperidine
1126-09-6

4-carbethoxypiperidine

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.1: tetrahydrofuran; ethyl acetate / 6 h / 20 °C
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Inert atmosphere; Reflux
4.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere
4.2: 5 h / 50 °C / Inert atmosphere
5.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
View Scheme
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
123855-51-6

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Inert atmosphere; Reflux
2.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere
2.2: 5 h / 50 °C / Inert atmosphere
3.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
2.2: 2 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr
3.2: 3 h / 20 °C
View Scheme
tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate
1020717-67-2

tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
View Scheme
3,4-methoxycinnamic acid
2107-70-2

3,4-methoxycinnamic acid

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: phosphorus pentoxide; toluene-4-sulfonic acid / 0.08 h / 120 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
2.2: 2 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr
3.2: 3 h / 20 °C
View Scheme
3-Cyanobenzaldehyde
24964-64-5

3-Cyanobenzaldehyde

debenzyldonepezil
120014-30-4

debenzyldonepezil

1-(3-cyanobenzyl)-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine

1-(3-cyanobenzyl)-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine

Conditions
ConditionsYield
Stage #1: 3-Cyanobenzaldehyde; debenzyldonepezil In 1,2-dichloro-ethane
Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 3h;
100%
With sodium tris(acetoxy)borohydride; acetic acid In ethyl acetate; 1,2-dichloro-ethane
debenzyldonepezil
120014-30-4

debenzyldonepezil

5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride

5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 10℃; Temperature; Reflux;95.35%
2-chloro-N-(4-nitro-phenyl)-acetamide
17329-87-2

2-chloro-N-(4-nitro-phenyl)-acetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-nitrophenyl)acetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-nitrophenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;93%
benzyl bromide
100-39-0

benzyl bromide

debenzyldonepezil
120014-30-4

debenzyldonepezil

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With sodium carbonate In ethanol at 50 - 60℃; for 6h;92.3%
With triethylamine In dichloromethane for 4h; Heating / reflux;
Stage #1: benzyl bromide; debenzyldonepezil With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20℃;
Stage #2: With hydrogenchloride In methanol
2-nitrophenylmethyl bromide
3958-60-9

2-nitrophenylmethyl bromide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-((1-(2-(2-nitrobenzyl))piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

2-((1-(2-(2-nitrobenzyl))piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 8h; Reflux;92%
1-bromomethyl-4-nitro-benzene
100-11-8

1-bromomethyl-4-nitro-benzene

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-((1-(2-(4-nitrobenzyl))piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

2-((1-(2-(4-nitrobenzyl))piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 8h; Reflux;92%
2-chloro-N-(6-methoxy-1,3-benzothiazol-2-yl)acetamide
3427-30-3

2-chloro-N-(6-methoxy-1,3-benzothiazol-2-yl)acetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

N-(6-methoxybenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

N-(6-methoxybenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;92%
N-chloroacetyl-aniline
587-65-5

N-chloroacetyl-aniline

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-phenylacetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-phenylacetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;92%
2-chloro-N-(4-fluorophenyl)acetamide
351-04-2

2-chloro-N-(4-fluorophenyl)acetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-fluorophenyl)acetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-fluorophenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;91%
2-chloro-N-(4-chlorophenyl)acetamide
3289-75-6

2-chloro-N-(4-chlorophenyl)acetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-chlorophenyl)acetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-chlorophenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;90%
debenzyldonepezil
120014-30-4

debenzyldonepezil

N-benzothiazol-2-yl-2-chloroacetamide
3028-02-2

N-benzothiazol-2-yl-2-chloroacetamide

N-(benzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

N-(benzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;89%
debenzyldonepezil
120014-30-4

debenzyldonepezil

2-chloro-N-(6-nitro-1,3-benzothiazol-2-yl)acetamide

2-chloro-N-(6-nitro-1,3-benzothiazol-2-yl)acetamide

N-(6-nitrobenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

N-(6-nitrobenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;89%
debenzyldonepezil
120014-30-4

debenzyldonepezil

N-(4-methoxyphenyl)-2-chloroacetamide
22303-36-2

N-(4-methoxyphenyl)-2-chloroacetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-methoxyphenyl)acetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-methoxyphenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;89%
2-(bromomethyl)-6-fluoropyridine
100202-78-6

2-(bromomethyl)-6-fluoropyridine

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-((1-((6-fluoropyridin-2-yl)methyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

2-((1-((6-fluoropyridin-2-yl)methyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 8h; Reflux;88%
5-(chloromethyl)quinolin-8-ol
10136-57-9

5-(chloromethyl)quinolin-8-ol

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-((1-((8-hydroxyquinolin-5-yl)methyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

2-((1-((8-hydroxyquinolin-5-yl)methyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 8h; Reflux;88%
2-chloro-N-(6-fluorobenzo[d]thiazol-2-yl)acetamide
263239-23-2

2-chloro-N-(6-fluorobenzo[d]thiazol-2-yl)acetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

N-(6-fluorobenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

N-(6-fluorobenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;88%
isopropyl formate
625-55-8

isopropyl formate

debenzyldonepezil
120014-30-4

debenzyldonepezil

4-(2,3-dihydro-5,6-dimethoxy-1-indanone-2-ylmethyl)piperidine-1-carbaldehyde

4-(2,3-dihydro-5,6-dimethoxy-1-indanone-2-ylmethyl)piperidine-1-carbaldehyde

Conditions
ConditionsYield
Stage #1: debenzyldonepezil With potassium carbonate In methanol; water at 20℃; for 2h;
Stage #2: isopropyl formate at 50℃; for 2h;
88%
debenzyldonepezil
120014-30-4

debenzyldonepezil

2-chloro-N-(6-methylbenzothiazol-2-yl)acetamide
3174-15-0

2-chloro-N-(6-methylbenzothiazol-2-yl)acetamide

N-(6-methylbenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

N-(6-methylbenzo[d]thiazol-2-yl)-2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;87%
2-chloro-N1-(3,4-dimethoxyphenyl)-acetamide
62593-78-6

2-chloro-N1-(3,4-dimethoxyphenyl)-acetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(3,4-dimethoxyphenyl)acetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(3,4-dimethoxyphenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;87%
acrylonitrile
107-13-1

acrylonitrile

debenzyldonepezil
120014-30-4

debenzyldonepezil

3-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)propanenitrile

3-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)propanenitrile

Conditions
ConditionsYield
With sodium In methanol at 55℃; for 12h; Inert atmosphere;87%
4-Fluorobenzyl bromide
459-46-1

4-Fluorobenzyl bromide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-((1-(4-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
351532-09-7

2-((1-(4-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 8h; Reflux;86%
N-(p-tolyl)-2-chloroacetamide
16634-82-5

N-(p-tolyl)-2-chloroacetamide

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-tolyl)acetamide

2-(4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)-N-(p-tolyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 40℃; for 12h;86%
(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid
126300-99-0, 149356-90-1

(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid

debenzyldonepezil
120014-30-4

debenzyldonepezil

C30H41N3O6S
1609138-31-9

C30H41N3O6S

Conditions
ConditionsYield
Stage #1: (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 0℃; for 0.166667h;
Stage #2: debenzyldonepezil In N,N-dimethyl acetamide at 20℃; for 18h;
85%
2-bromomethyl-3,5-dimethylpyridine
170289-36-8

2-bromomethyl-3,5-dimethylpyridine

debenzyldonepezil
120014-30-4

debenzyldonepezil

2-((1-((3,5-dimethylpyridin-2-yl)methyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

2-((1-((3,5-dimethylpyridin-2-yl)methyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 8h; Reflux;85%

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