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inquiry5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one CAS:120014-30-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, special
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBasic information Product Name:5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one Place of Origin:China CAS No.:120014-30-4 MF:C17H23NO3 MW:289.37 Package : 25kg/Drum, or as your request Delivery Time: prompt Transportation: by air/by sea
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
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inquiry2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone
debenzyldonepezil
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide In methanol; acetic acid at 20℃; under 2311.54 Torr; for 6h; | 99% |
With palladium on activated charcoal; hydrogen; acetic acid In methanol | 74% |
With 5% Pd(II)/C(eggshell); hydrogen; sodium acetate; acetic acid In methanol; dichloromethane at 70 - 75℃; under 4413.43 - 5149.01 Torr; for 10h; | 70% |
donepezil
debenzyldonepezil
Conditions | Yield |
---|---|
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃; for 3h; Heating / reflux; | 97% |
With hydrogen In methanol at 20℃; under 760.051 Torr; for 72h; |
5,6-dimethoxy-2-(4-piperidinylmethyl)-indan-1-one acetate
debenzyldonepezil
Conditions | Yield |
---|---|
In water pH=13; | 95.3% |
debenzyldonepezil
Conditions | Yield |
---|---|
Stage #1: (E)-tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.333333h; Stage #2: With hydrogenchloride In water; ethyl acetate at 20℃; for 3h; | 91% |
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
A
2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone
B
debenzyldonepezil
Conditions | Yield |
---|---|
With hydrogen; acetic acid; palladium on activated charcoal In methanol at 60 - 65℃; for 7h; | A n/a B 90% |
debenzyldonepezil
Conditions | Yield |
---|---|
With perchloric acid; 5% Pd(II)/C(eggshell); hydrogen In methanol; dichloromethane at 60 - 65℃; under 4781.22 Torr; for 10h; | 90% |
tert-butyl 4-((2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)-methyl)piperidine-1-carboxylate
debenzyldonepezil
Conditions | Yield |
---|---|
Stage #1: tert-butyl 4-((2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)-methyl)piperidine-1-carboxylate With hydrogenchloride In ethyl acetate Stage #2: With sodium carbonate In water; ethyl acetate pH=~ 6; | 84% |
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h; | 80% |
debenzyldonepezil
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol; dichloromethane at 75 - 80℃; under 7355.72 Torr; for 8h; | 77% |
A
4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine
B
debenzyldonepezil
Conditions | Yield |
---|---|
With perchloric acid; palladium 10% on activated carbon; hydrogen In methanol at 70 - 75℃; under 4413.43 - 5149.01 Torr; for 7h; | A 22% B 63% |
Conditions | Yield |
---|---|
With trifuran-2-yl-phosphane; C42H32F3N2O2PPd; lithium hydroxide In neat (no solvent) at 100℃; for 48h; Schlenk technique; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction; | 51% |
pyridine-4-carbaldehyde
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme |
5,6-dimethoxy-1-indanone
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / Reflux 2: dihydrogen peroxide / acetic acid / 45 - 50 °C 3: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 8 h / 75 - 80 °C / 7355.72 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h 1.2: 2 h / 20 °C 2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr 2.2: 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 24 h / Reflux 2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene 2: acetic acid; palladium on activated charcoal; hydrogen / methanol View Scheme |
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
B
debenzyldonepezil
Conditions | Yield |
---|---|
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5% Pd on alumina In tetrahydrofuran at 3 - 6℃; under 3000.3 - 7500.75 Torr; for 3 - 5h; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water Product distribution / selectivity; | |
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5% Pd on alumina In tetrahydrofuran at 14 - 20℃; under 3750.38 - 7500.75 Torr; for 0.833333h; Stage #2: With hydrogenchloride In tetrahydrofuran; water | |
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5% Pd on alumina In toluene at 9 - 12℃; under 1500.15 - 6000.6 Torr; for 2.33333 - 5h; Stage #2: With hydrogenchloride In ethanol; water; toluene Product distribution / selectivity; | |
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran; toluene at 30 - 60℃; under 1551.49 - 1810.07 Torr; for 2h; Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene at 25 - 30℃; Product distribution / selectivity; |
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
A
donepezil
B
debenzyldonepezil
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 0 - 2℃; under 760.051 Torr; for 1.5h; | |
With hydrogen; palladium 10% on activated carbon In toluene at 0 - 1℃; under 6000.6 - 7500.75 Torr; for 5h; |
debenzyldonepezil
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In water at 60 - 95℃; under 7500.75 Torr; for 8h; |
5,6-dimethoxy-2-(pyridine-4-ylmethylene)indan-1-one hydrochloride
debenzyldonepezil
Conditions | Yield |
---|---|
With hydrogen; acetic acid; palladium 10% on activated carbon In methanol at 68 - 72℃; under 3800.26 Torr; for 7h; |
pyridine-4-carbaldehyde
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / Reflux 2: dihydrogen peroxide / acetic acid / 45 - 50 °C 3: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 8 h / 75 - 80 °C / 7355.72 Torr View Scheme | |
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 24 h / Reflux 2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene 2: acetic acid; palladium on activated charcoal; hydrogen / methanol View Scheme |
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dihydrogen peroxide / acetic acid / 45 - 50 °C 2: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 8 h / 75 - 80 °C / 7355.72 Torr View Scheme | |
With hydrogen In neat (no solvent) at 50℃; under 760.051 Torr; for 144h; |
4-piperidinemethanol
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran; ethyl acetate / 6 h / 20 °C 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Inert atmosphere; Reflux 3.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere 3.2: 5 h / 50 °C / Inert atmosphere 4.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C 5.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme |
tert butyl 4-formylpiperidine-1-carboxylate
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere 1.2: 5 h / 50 °C / Inert atmosphere 2.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C 3.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h 1.2: 2 h / 20 °C 2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr 2.2: 3 h / 20 °C View Scheme |
4-carbethoxypiperidine
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 2.1: tetrahydrofuran; ethyl acetate / 6 h / 20 °C 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Inert atmosphere; Reflux 4.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere 4.2: 5 h / 50 °C / Inert atmosphere 5.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C 6.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme |
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Inert atmosphere; Reflux 2.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere 2.2: 5 h / 50 °C / Inert atmosphere 3.1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C 4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h 2.2: 2 h / 20 °C 3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr 3.2: 3 h / 20 °C View Scheme |
tert-butyl 4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)piperidine-1-carboxylate
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diphenylsilane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) / chloroform / 24 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C View Scheme |
3,4-methoxycinnamic acid
debenzyldonepezil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: phosphorus pentoxide; toluene-4-sulfonic acid / 0.08 h / 120 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h 2.2: 2 h / 20 °C 3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 0.33 h / 20 °C / 760.05 Torr 3.2: 3 h / 20 °C View Scheme |
3-Cyanobenzaldehyde
debenzyldonepezil
Conditions | Yield |
---|---|
Stage #1: 3-Cyanobenzaldehyde; debenzyldonepezil In 1,2-dichloro-ethane Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 3h; | 100% |
With sodium tris(acetoxy)borohydride; acetic acid In ethyl acetate; 1,2-dichloro-ethane |
debenzyldonepezil
Conditions | Yield |
---|---|
With hydrogenchloride In water; toluene at 10℃; Temperature; Reflux; | 95.35% |
2-chloro-N-(4-nitro-phenyl)-acetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 93% |
Conditions | Yield |
---|---|
With sodium carbonate In ethanol at 50 - 60℃; for 6h; | 92.3% |
With triethylamine In dichloromethane for 4h; Heating / reflux; | |
Stage #1: benzyl bromide; debenzyldonepezil With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20℃; Stage #2: With hydrogenchloride In methanol |
2-nitrophenylmethyl bromide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 92% |
1-bromomethyl-4-nitro-benzene
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 92% |
2-chloro-N-(6-methoxy-1,3-benzothiazol-2-yl)acetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 92% |
N-chloroacetyl-aniline
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 92% |
2-chloro-N-(4-fluorophenyl)acetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 91% |
2-chloro-N-(4-chlorophenyl)acetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 90% |
debenzyldonepezil
N-benzothiazol-2-yl-2-chloroacetamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 89% |
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 89% |
debenzyldonepezil
N-(4-methoxyphenyl)-2-chloroacetamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 89% |
2-(bromomethyl)-6-fluoropyridine
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 88% |
5-(chloromethyl)quinolin-8-ol
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 88% |
2-chloro-N-(6-fluorobenzo[d]thiazol-2-yl)acetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 88% |
isopropyl formate
debenzyldonepezil
Conditions | Yield |
---|---|
Stage #1: debenzyldonepezil With potassium carbonate In methanol; water at 20℃; for 2h; Stage #2: isopropyl formate at 50℃; for 2h; | 88% |
debenzyldonepezil
2-chloro-N-(6-methylbenzothiazol-2-yl)acetamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 87% |
2-chloro-N1-(3,4-dimethoxyphenyl)-acetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 87% |
acrylonitrile
debenzyldonepezil
Conditions | Yield |
---|---|
With sodium In methanol at 55℃; for 12h; Inert atmosphere; | 87% |
4-Fluorobenzyl bromide
debenzyldonepezil
2-((1-(4-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 86% |
N-(p-tolyl)-2-chloroacetamide
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 40℃; for 12h; | 86% |
(S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid
debenzyldonepezil
C30H41N3O6S
Conditions | Yield |
---|---|
Stage #1: (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 0℃; for 0.166667h; Stage #2: debenzyldonepezil In N,N-dimethyl acetamide at 20℃; for 18h; | 85% |
2-bromomethyl-3,5-dimethylpyridine
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 85% |
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