DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica
We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : Donepezil CAS No:120014-06-4 As
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $100.0
Type:Trading Company
inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:120014-06-4
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryDonepezil CAS 120014-06-4 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing t
The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry, m
Cas:120014-06-4
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:120014-06-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $2.0 / 6.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:120014-06-4
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryProduct name Donepezil Appearance: White or off-white crystalline powder CAS NO. 120014-06-4 Molecular Formula C24H29NO3 Molecular Weight 379.49200 Melting point
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:120014-06-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:120014-06-4
Min.Order:1 Gram
FOB Price: $188.0
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,
Donepezil CAS:120014-06-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:120014-06-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:120014-06-4
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryProduct name:Donepezil (base) Other name:2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one CAS No.:120014-06-4 Stock: Fresh Standard:In-house Purity: Not less than 99% Individual impurity: Not more than 0.5% Applica
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq
Cas:120014-06-4
Min.Order:1 Kilogram
FOB Price: $0.1 / 0.2
Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:120014-06-4
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquirydonepezil
Conditions | Yield |
---|---|
In methanol | 99% |
donepezil
Conditions | Yield |
---|---|
With sodium hydroxide In water; ethyl acetate for 0.5h; pH=11.7; Reagent/catalyst; Solvent; pH-value; | 97.5% |
With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.5h; Purification / work up; | |
Stage #1: donepezil hydrochloride With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.75h; Stage #2: In water; isopropyl alcohol at 10 - 70℃; for 10h; Product distribution / selectivity; |
benzyl bromide
donepezil
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Product distribution / selectivity; | 96% |
Conditions | Yield |
---|---|
With sodium carbonate In ethanol at 50 - 60℃; for 6h; | 92.3% |
With triethylamine In dichloromethane for 4h; Heating / reflux; | |
Stage #1: benzyl bromide; debenzyldonepezil With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20℃; Stage #2: With hydrogenchloride In methanol |
2-(3,4-dimethoxybenzyl)-3-(N-benzyl-4-piperidine)propionic acid
donepezil
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; trifluoroacetic anhydride In dichloromethane at 24 - 28℃; Inert atmosphere; chemoselective reaction; | 90% |
donepezil
Conditions | Yield |
---|---|
With sodium dithionite; tetrabutylammomium bromide; sodium hydrogencarbonate In water; ethyl acetate | 88% |
With sodium dithionite; tetrabutylammomium bromide; water; sodium hydrogencarbonate In ethyl acetate at 65℃; for 0.5h; Solvent; Temperature; Time; | 88% |
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 12h; | 78% |
With hydrogen; palladium carbon In methanol at 20℃; under 760.051 Torr; for 2h; | 31 g |
With hydrogen In tetrahydrofuran; water; isopropyl alcohol at 25℃; under 760.051 Torr; for 20h; Catalytic behavior; Flow reactor; chemoselective reaction; | 95 %Spectr. |
Conditions | Yield |
---|---|
With aluminum oxide; Pt/Al2O3 In tetrahydrofuran; ethanol; water; isopropyl alcohol at 45 - 55℃; for 7h; Temperature; Solvent; Reagent/catalyst; Aldol Condensation; | 88% |
Multi-step reaction with 2 steps 1: sodium methylate / tetrahydrofuran 2: palladium 10% on activated carbon; hydrogenchloride / ethanol; water View Scheme |
1-benzyl-4-[(5,6-dimethoxy-1-indanol)-2-yl]methylpiperidine
donepezil
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; tetrabutylammomium bromide In decane; benzene at 40℃; for 24h; Sealed tube; chemoselective reaction; | 85% |
Conditions | Yield |
---|---|
With bis(μ-chloro)-bis[1,3-di(2-pyridyl)-4,6-dimethylbenzene-N,C(2'),N-iridium chloride]; caesium carbonate In tert-Amyl alcohol for 12h; Reflux; | 85% |
With [Ir(dpyx-N,C,N)Cl(i-Cl)]2; caesium carbonate In tert-Amyl alcohol at 130℃; for 2h; Reagent/catalyst; | 85% |
With potassium phosphate tribasic trihydrate; C39H32Cl2N5PRu In tert-Amyl alcohol at 120℃; for 4h; Inert atmosphere; Schlenk technique; | 83% |
donepezil
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water for 1h; Heating / reflux; | 80% |
With potassium hydroxide In ethanol; water for 1h; Heating / reflux; | 80% |
donepezil
Conditions | Yield |
---|---|
With acetic acid; L-proline at 120℃; for 24h; Green chemistry; | 77% |
donepezil
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water | 76.34% |
benzaldehyde
donepezil
Conditions | Yield |
---|---|
Stage #1: 2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt With hydrogen; sodium acetate; palladium 10% on activated carbon In methanol under 760.051 Torr; for 10h; Stage #2: benzaldehyde In methanol for 8h; Product distribution / selectivity; | 62% |
5-[(1-benzyl-4-piperidyl)methyl]-5-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
donepezil
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In nitromethane at 100℃; for 0.5h; Friedel-Crafts acylation; | 61% |
Conditions | Yield |
---|---|
With trifuran-2-yl-phosphane; C42H32F3N2O2PPd; lithium hydroxide In neat (no solvent) at 100℃; for 48h; Schlenk technique; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction; | 56% |
donepezil
Conditions | Yield |
---|---|
With platinum(IV) oxide; hydrogen In methanol at 23℃; under 760.051 Torr; for 24h; Inert atmosphere; | 50% |
2-((1-benzoylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
donepezil
Conditions | Yield |
---|---|
With trifluoromethylsulfonic anhydride; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 20℃; for 2h; | 49% |
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
donepezil
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 16h; | 37% |
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; under 760.051 Torr; for 6h; | |
With hydrogen; nickel In tetrahydrofuran at 8 - 38℃; under 750.075 - 9000.9 Torr; for 0.666667 - 6h; Product distribution / selectivity; |
donepezil
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In tetrahydrofuran under 760 Torr; for 6h; Ambient temperature; | |
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride In methanol; acetic acid at 25 - 45℃; Stage #2: With hydrogen; 5%-palladium/activated carbon In methanol; acetic acid under 1103.36 - 1471.14 Torr; | |
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 6h; | |
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride With hydrogen; acetic acid; 5% Pd(II)/C(eggshell) In methanol at 28 - 33℃; under 1103.36 - 1471.14 Torr; Stage #2: With sodium carbonate In dichloromethane; water for 7 - 8h; Stage #3: With hydrogenchloride In isopropyl alcohol at 25 - 30℃; pH=2; |
Conditions | Yield |
---|---|
With sodium carbonate In methanol; isopropyl alcohol at 60 - 65℃; for 11h; |
5,6-dimethoxy-1-indanone
donepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / methanol; H2O / Heating 1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C 2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C 3: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 1.5 h / 38 °C 2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite / water; ethyl acetate View Scheme | |
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 1.5 h / 38 °C 2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite; water / ethyl acetate / 0.5 h / 65 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / 24 h / Reflux 2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr 3: sodium carbonate / isopropyl alcohol / 12 h / 50 °C View Scheme |
1-benzyl-4-formylpiperidine
donepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / methanol; H2O / Heating 1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C 2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: piperidinium acetate / ethanol / 0.5 h 1.2: 47 percent / NaBH3CN / ethanol / 0 - 20 °C 2.1: 44 percent / K2CO3 / dimethylformamide 3.1: 61 percent / TfOH / nitromethane / 0.5 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 1.5 h / 38 °C 2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite / water; ethyl acetate View Scheme |
pyridine-4-carbaldehyde
donepezil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C 3: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C View Scheme |
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
donepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C 2: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetonitrile / 24 h / Reflux 2: platinum(IV) oxide; hydrogen / methanol / 24 h / 23 °C / 760.05 Torr / Inert atmosphere View Scheme |
5-(1-benzyl-piperidin-4-ylmethyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione
donepezil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 44 percent / K2CO3 / dimethylformamide 2: 61 percent / TfOH / nitromethane / 0.5 h / 100 °C View Scheme |
benzyl bromide
donepezil
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20 - 25℃; for 1h; | |
Stage #1: benzyl bromide; 5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride With monopotassium carbonate; tetrabutylammomium bromide In methylene chlorid; water at 20 - 25℃; for 1h; Stage #2: With hydrogenchloride In dichloromethane; water at 20 - 25℃; for 0.25h; Stage #3: With ammonia In water; ethyl acetate pH=9.5; |
donepezil
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene at 20 - 40℃; for 2h; |
Conditions | Yield |
---|---|
With potassium carbonate; tetra-(n-butyl)ammonium iodide In acetone at 60℃; | |
With potassium carbonate; polyethylene glycol In water; ethyl acetate at 45℃; | |
With potassium carbonate In water; ethyl acetate at 50 - 55℃; for 14h; Inert atmosphere; | |
With sodium hydrogencarbonate In ethanol at 65℃; for 0.5h; Temperature; |
benzaldehyde
donepezil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen; platinum on activated charcoal / toluene / 80 °C / Flow reactor 2: diisobutylaluminium hydride / toluene; hexane / 2.5 h / -78 °C / Flow reactor 3: water / isopropyl alcohol; tetrahydrofuran / 3 h / 55 °C / Flow reactor 4: hydrogen / isopropyl alcohol; water; tetrahydrofuran / 20 h / 25 °C / 760.05 Torr / Flow reactor View Scheme |
donepezil
Conditions | Yield |
---|---|
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 3h; Inert atmosphere; | 98% |
donepezil
debenzyldonepezil
Conditions | Yield |
---|---|
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃; for 3h; Heating / reflux; | 97% |
With hydrogen In methanol at 20℃; under 760.051 Torr; for 72h; |
donepezil
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol | 96.2% |
With hydrogenchloride In ethanol | 96.5% |
With hydrogenchloride In ethanol | 96.4% |
donepezil
donepezil-d1
Conditions | Yield |
---|---|
With tris(pentafluorophenyl)borate; water-d2 In tetrahydrofuran at 100℃; for 12h; Solvent; Inert atmosphere; regioselective reaction; | 96% |
With sodium methylate at 20℃; Reagent/catalyst; | 50% |
(2E)-but-2-enedioic acid
donepezil
Conditions | Yield |
---|---|
In ethanol at 20 - 60℃; for 2h; | 95.4% |
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; | |
In methanol at 25 - 30℃; for 5h; | 5.1 g |
In ethanol; water at 20 - 60℃; Sealed tube; |
chloroformic acid ethyl ester
donepezil
4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-1-ethoxycarbonylpiperidine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In benzene | 94% |
donepezil
Donepezil sulphate
Conditions | Yield |
---|---|
With sulfuric acid In isopropyl alcohol at 0℃; for 2h; | 92.4% |
With sulfuric acid In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; |
maleic acid
donepezil
Conditions | Yield |
---|---|
In isopropyl alcohol at 20 - 60℃; for 1h; | 91.2% |
In water; toluene at 25 - 30℃; | 90% |
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; | |
In methanol; water at 20 - 100℃; Sealed tube; |
donepezil
Conditions | Yield |
---|---|
With hydrogen bromide In isopropyl alcohol | 89.9% |
With hydrogen bromide In ethanol; water at 10 - 35℃; for 12.33h; | 58.9% |
With hydrogen bromide In methanol; water Purification / work up; | |
With hydrogen bromide In methanol; water at 0 - 5℃; for 2 - 3h; |
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; Heating / reflux; | 89.2% |
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; | |
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; | |
In isopropyl alcohol for 168h; |
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; Heating / reflux; | 87.5% |
In ethanol; ethyl acetate Product distribution / selectivity; | |
In ethanol; ethyl acetate Product distribution / selectivity; | |
In isopropyl alcohol for 168h; | |
In ethanol; water at 20 - 80℃; Sealed tube; |
toluene-4-sulfonic acid
donepezil
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; Heating / reflux; | 84.2% |
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; | |
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity; | |
In ethyl acetate; acetone at 25 - 30℃; for 12h; | 6.5 g |
In isopropyl alcohol for 168h; |
Conditions | Yield |
---|---|
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc(II) chloride; lithium diisopropyl amide at -10℃; for 12h; | 83% |
Conditions | Yield |
---|---|
Stage #1: n-heptanoic anhydride; donepezil With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 10℃; Inert atmosphere; Stage #2: In tetrahydrofuran at -78 - 30℃; | 81.7% |
donepezil
Conditions | Yield |
---|---|
With P2O5; MeSO3H In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane | 80% |
Ethyl bromodifluoroacetate
donepezil
Conditions | Yield |
---|---|
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc(II) chloride; lithium diisopropyl amide at -10℃; for 12h; | 80% |
palmitic anhydride
donepezil
Conditions | Yield |
---|---|
Stage #1: palmitic anhydride; donepezil With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 10℃; Inert atmosphere; Stage #2: In tetrahydrofuran at -78 - 30℃; | 79.5% |
donepezil
Conditions | Yield |
---|---|
With hydrogen bromide; dimethyl sulfoxide In water; ethyl acetate at 60℃; | 78% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View