As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Assay 98%min -----------------------------------------------------------------------------------------------
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryFaropenem sodium English name: Faropenem sodium Chemical name: Monosodium (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(R)-tetrahydrofuran- 2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hemipentahy
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryProduct Name Faropenem Sodium Chemical Name (5R-(3(R*),5-alpha,6-alpha(R*)))-6-(1-Hydroxyethyl)-7-oxo-3- (tetrahydro-2-furanyl)-4-thia-1-azabicyclo(3.2.0) hept-2-ene-2-c
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryAppearance:White to Light yellow to light brown powder Storage:-20°C Package:25kg/drum Application:Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. Transportation:Express/Sea/Air Port:any port in china
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiryFaropenem sodium CAS:122547-49-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
(5R,6S)-6-((R)-1-hydroxyethyl)-2-((R)-tetrahydro-2-furyl)penem-3-carboxylic acid allyl ester
Furopenem
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; sodium 2-ethylhexanoic acid In water; ethyl acetate at 20℃; for 5h; Inert atmosphere; Large scale reaction; | 86.5% |
Stage #1: (5R,6S)-6-((R)-1-hydroxyethyl)-2-((R)-tetrahydro-2-furyl)penem-3-carboxylic acid allyl ester With sodium isooctanoate; sodium caprylate; triphenylphosphine In dichloromethane; ethyl acetate at 20℃; Stage #2: With tetrakis(triphenylphosphine) palladium(0) In dichloromethane; ethyl acetate at 25 - 30℃; for 0.666667h; Inert atmosphere; | 73.3% |
With tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; sodium 2-ethylhexanoic acid In ethyl acetate for 1h; Ambient temperature; |
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aq. NaHCO3 / acetone / 4 h / 60 °C 2: Et3N / CH2Cl2 / 0.17 h / -20 °C 3: triethyl phosphite / xylene / 11 h / Heating 4: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 5: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide / acetone / 2 h / 0 - 20 °C / pH 8 - 10 2: triethylamine / dichloromethane / 2 h / 0 - 5 °C 3: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux 4: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 3040.2 Torr 5: sodium 2-ethylhexanoic acid / tetrahydrofuran; water / 2 h / 20 °C View Scheme |
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aq. NaHCO3 / acetone / 4 h / 60 °C 2: Et3N / CH2Cl2 / 0.17 h / -20 °C 3: triethyl phosphite / xylene / 11 h / Heating 4: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 5: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide / acetone / 2 h / 0 - 20 °C / pH 8 - 10 2: triethylamine / dichloromethane / 2 h / 0 - 5 °C 3: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux 4: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 3040.2 Torr 5: sodium 2-ethylhexanoic acid / tetrahydrofuran; water / 2 h / 20 °C View Scheme |
(R)-Tetrahydro-furan-2-carbothioic acid S-{(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl} ester
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Et3N / CH2Cl2 / 0.17 h / -20 °C 2: triethyl phosphite / xylene / 11 h / Heating 3: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 4: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 5 °C 2: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux 3: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 3040.2 Torr 4: sodium 2-ethylhexanoic acid / tetrahydrofuran; water / 2 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 3 h / -20 - -15 °C 2: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 4.5 h / 150 °C 3: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 30 °C 4: palladium 10% on activated carbon; sodium hydrogencarbonate; hydrogen / ethyl acetate; water / 16 h / 25 - 35 °C View Scheme |
allyl (5R,6S)-6((R)-1-t-butyldimethylsilyloxyethyl)-7-oxo-3-((R)-2-tetrahydrofuryl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 2: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme |
(3S,4R)-1-(allyloxy)oxoacetyl-3-((R)-1-hydroxyethyl)-4-((R)-2-tetrahydrofuranyl)carbonylthio-azetidin-2-one
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethyl phosphite / xylene / 11 h / Heating 2: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 °C 3: Ph3P, tetrakis(triphenylphosphine)palladium, sodium 2-ethylhexanoate / ethyl acetate / 1 h / Ambient temperature View Scheme |
faropenem
Furopenem
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In tetrahydrofuran; water at 20℃; for 2h; | 125 g |
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux 2: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 3040.2 Torr 3: sodium 2-ethylhexanoic acid / tetrahydrofuran; water / 2 h / 20 °C View Scheme |
Furopenem
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate In water; ethyl acetate at 25 - 35℃; for 16h; |
Furopenem
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 4.5 h / 150 °C 2: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 30 °C 3: palladium 10% on activated carbon; sodium hydrogencarbonate; hydrogen / ethyl acetate; water / 16 h / 25 - 35 °C View Scheme |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; potassium iodide; benzyltri(n-butyl)ammonium chloride In tetrahydrofuran at 30 - 55℃; for 5h; | 99.11% |
With sodium hydrogencarbonate; potassium iodide; tetrabutyl-ammonium chloride In acetone at 50℃; for 4h; Conversion of starting material; | 94.2% |
With benzyltri(n-butyl)ammonium chloride; sodium hydrogencarbonate; potassium iodide In tetrahydrofuran at 30 - 55℃; for 6h; Product distribution / selectivity; | 70% |
With sodium hydrogencarbonate; benzyltri(n-butyl)ammonium chloride In tetrahydrofuran at 50℃; for 4h; Conversion of starting material; | 36.7% |
Furopenem
Sodium; (5S,6S)-6-((R)-1-hydroxy-ethyl)-7-oxo-3-(R)-tetrahydro-furan-2-yl-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate
Conditions | Yield |
---|---|
In water Irradiation; |
chlorosulfuric acid chloromethyl ester
Furopenem
tetrabutylammonium sulfate
chloromethyl (5R,6S)-6-[(R)-1-hydroxyethyl]-2-[(R)-2-tetrahydrofuryl]penem-3-carboxylate
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In dichloromethane; water |
Furopenem
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide |
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