The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:124655-09-0
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:124655-09-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:124655-09-0
Min.Order:0 Metric Ton
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Type:Manufacturers
inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white powder Storage:room temprature Package:25kg/drum Application:Intermediate of Rosuvastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou
Cas:124655-09-0
Min.Order:1 Kilogram
FOB Price: $75.0 / 85.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:124655-09-0
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:124655-09-0
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:124655-09-0
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryGIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod
Cas:124655-09-0
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryProduct Name: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate Synonyms: tert-butyl (4r-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate;(4r-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-aceti
Cas:124655-09-0
Min.Order:1 Gram
FOB Price: $8900.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:124655-09-0
Min.Order:1 Gram
FOB Price: $1.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:124655-09-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryChemical name (4R-Cis)-6-Hydroxymethyl -2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid,1,1-Dimethyethyl Ester Appearance Colorless or light yellow liquid CAS 124655-09-0 Assay
Cas:124655-09-0
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:124655-09-0
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:124655-09-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:124655-09-0
Min.Order:1 Gram
FOB Price: $80.0 / 100.0
Type:Trading Company
inquiry(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester CAS:124655-09-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade
Cas:124655-09-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:124655-09-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:124655-09-0
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryRosuvastatin calcium Intermediates Product Name: (4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester Synonyms: Rosuvastatin P-2;D-6 (4R-Cis)-6-HydroxyMethyl-2,2-DiMethyl-1,3-Dioxane-4-AceticAcid,1,1-DiMethyl
Cas:124655-09-0
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:124655-09-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:124655-09-0
Min.Order:0
Negotiable
Type:Manufacturers
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:124655-09-0
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:124655-09-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:124655-09-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:Light yellow to brown yellow liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:10g/bag,or as your request Application:For medicine , pesti
Cas:124655-09-0
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryProduct name: (4R-Cis)-6-Hydroxymethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid,1,1-Dimethylethyl Ester CAS No.: 124655-09-0 Molecule Formula:C13H24O5 Molecule Weight:260.33 Purity: 99.0% Package: 25kg/drum Description:White powder Manu
Cas:124655-09-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:124655-09-0
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Product Name: (4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester CAS: 124655-09-0 MF: C13H24O5 MW: 260.33 EINECS: 432-960-5 Mol File: 124655-09-0.mol (4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-d
Cas:124655-09-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirytert-butyl 2-((4R,6S)-6-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxane-4-yl)acetate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate at 31 - 33℃; under 7600 Torr; for 5h; | 100% |
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 750.075 - 1500.15 Torr; Autoclave; | 94% |
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; for 5h; Concentration; | 94% |
With H2; palladium-carbon In ethyl acetate | |
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 25 - 30℃; under 7500.75 Torr; for 5h; Autoclave; |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With potassium carbonate In methanol; water | 98% |
With methanol; potassium carbonate for 0.5h; | 98% |
With methanol; potassium carbonate at 20℃; | 92% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate at 32℃; under 15201 Torr; for 16h; | 90% |
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0℃; for 2h; | 83% |
With sodium tetrahydroborate In methanol at 0℃; |
C18H32O6
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol at 20℃; for 15h; | 81% |
tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 3h; | 80% |
tert-butyl 2-((4R, 6S)-2,2-dimethyl-6-((E)-styryl)-1,3-dioxan-4-yl)acetate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With sodium tetrahydroborate; ozone 1.) methanol; Yield given. Multistep reaction; |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / sodium metaperiodate, water / diethyl ether / 3 h / Ambient temperature 2: 83 percent / sodium borohydride / methanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 85 percent / NaIO4 / diethyl ether; H2O / 2 h / Ambient temperature 2: NaBH4 / methanol / 0 °C View Scheme |
isopropyl (2S,3R,4S,6R)-7-t-butoxycarbonyl-2,3-bis(t-butyldimethylsilyloxy)-4,6-dihydroxyheptanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 99 percent / p-toluenesulfonic acid / 2 h / Ambient temperature 2: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / sodium metaperiodate, water / diethyl ether / 3 h / Ambient temperature 4: 83 percent / sodium borohydride / methanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1: 98 percent / p-TsOH / 2 h / Ambient temperature 2: 99 percent / (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / NaIO4 / diethyl ether; H2O / 2 h / Ambient temperature 4: NaBH4 / methanol / 0 °C View Scheme |
isopropyl (2S,3R,4S,6R)-7-t-butpxycarbonyl-2,3-bis(t-butyldimethylsilyloxy)-4,6-isopropylidenedioxyheptanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / Ambient temperature 2: 85 percent / sodium metaperiodate, water / diethyl ether / 3 h / Ambient temperature 3: 83 percent / sodium borohydride / methanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: 99 percent / (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature 2: 85 percent / NaIO4 / diethyl ether; H2O / 2 h / Ambient temperature 3: NaBH4 / methanol / 0 °C View Scheme |
isopropyl (2S,3S,6R)-7-t-butoxycarbonyl-2,3-bis(t-butyldimethylsilyloxy)-6-hydroxy-4-oxoheptanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) diethyl(methoxy)borane, 2.) sodium borohydride / 1.) THF, methanol, RT, 15 min, 2.) THF, methanol, a) -78 deg C, 4 h, b) from -78 deg C to RT, 8 h 2: 99 percent / p-toluenesulfonic acid / 2 h / Ambient temperature 3: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / Ambient temperature 4: 85 percent / sodium metaperiodate, water / diethyl ether / 3 h / Ambient temperature 5: 83 percent / sodium borohydride / methanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: 76 percent / Et2BOMe, NaBH4 / tetrahydrofuran; methanol / -78 deg C to RT, 12 h 2: 98 percent / p-TsOH / 2 h / Ambient temperature 3: 99 percent / (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature 4: 85 percent / NaIO4 / diethyl ether; H2O / 2 h / Ambient temperature 5: NaBH4 / methanol / 0 °C View Scheme |
isopropyl (2S,3S)-7-t-butoxycarbonyl-2,3-bis(t-butyldimethylsilyloxy)-4,6-dioxoheptanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 60 percent / DIBAL / tetrahydrofuran; hexane / 4 h / -78 °C 2: 1.) diethyl(methoxy)borane, 2.) sodium borohydride / 1.) THF, methanol, RT, 15 min, 2.) THF, methanol, a) -78 deg C, 4 h, b) from -78 deg C to RT, 8 h 3: 99 percent / p-toluenesulfonic acid / 2 h / Ambient temperature 4: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / Ambient temperature 5: 85 percent / sodium metaperiodate, water / diethyl ether / 3 h / Ambient temperature 6: 83 percent / sodium borohydride / methanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 6 steps 1: 60 percent / diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / -78 °C 2: 76 percent / Et2BOMe, NaBH4 / tetrahydrofuran; methanol / -78 deg C to RT, 12 h 3: 98 percent / p-TsOH / 2 h / Ambient temperature 4: 99 percent / (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature 5: 85 percent / NaIO4 / diethyl ether; H2O / 2 h / Ambient temperature 6: NaBH4 / methanol / 0 °C View Scheme |
tert-butyl acetoacetate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 74 percent / NaH, n-BuLi / 20 h / -78 °C 2: 60 percent / diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / -78 °C 3: 76 percent / Et2BOMe, NaBH4 / tetrahydrofuran; methanol / -78 deg C to RT, 12 h 4: 98 percent / p-TsOH / 2 h / Ambient temperature 5: 99 percent / (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature 6: 85 percent / NaIO4 / diethyl ether; H2O / 2 h / Ambient temperature 7: NaBH4 / methanol / 0 °C View Scheme |
(3R,5S)-3,5-Dihydroxy-5-((2S,3S)-3-trimethylsilanyl-oxiranyl)-pentanoic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 81 percent / H(1+) 2: 1.) Bu3SnLi / 2.) Pd(PPh3)4 3: 1.) O3, 2.) NaBH4 / 1.) methanol View Scheme | |
Multi-step reaction with 3 steps 1: 81 percent / H(1+) 2: 90 percent 3: 1.) O3, 2.) NaBH4 / 1.) methanol View Scheme |
(S)-5-Hydroxy-3-oxo-5-((2S,3S)-3-trimethylsilanyl-oxiranyl)-pentanoic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 60 percent / Et2BOMe, NaBH4 2: 81 percent / H(1+) 3: 1.) Bu3SnLi / 2.) Pd(PPh3)4 4: 1.) O3, 2.) NaBH4 / 1.) methanol View Scheme | |
Multi-step reaction with 4 steps 1: 60 percent / Et2BOMe, NaBH4 2: 81 percent / H(1+) 3: 90 percent 4: 1.) O3, 2.) NaBH4 / 1.) methanol View Scheme |
[(4R,6S)-2,2-Dimethyl-6-((2S,3S)-3-trimethylsilanyl-oxiranyl)-[1,3]dioxan-4-yl]-acetic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) Bu3SnLi / 2.) Pd(PPh3)4 2: 1.) O3, 2.) NaBH4 / 1.) methanol View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent 2: 1.) O3, 2.) NaBH4 / 1.) methanol View Scheme |
acetic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / LDA / tetrahydrofuran / 1.75 h / -70 - -15 °C 2: 1). Et3B; 2.) NaBH4, MeOH / 1.) THF, 23 deg C, 15 min; 2.) -70 deg C 3: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C 4: 80 percent / Bu4NF / tetrahydrofuran / 3 h / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 1.2: 2 h / 20 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 2.2: 6 h / 20 °C / Inert atmosphere 3.1: methanol; diethyl methoxy borane; sodium tetrahydroborate / tetrahydrofuran / 2.5 h / -80 - -70 °C / Inert atmosphere 4.1: methanesulfonic acid / 20 °C 5.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 750.08 - 1500.15 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1.1: (S)-5-benzyl 2,2,3-trimethyl-4-thione / ethanol / 0.5 h / 0 °C 1.2: 3 h / 0 - 30 °C 2.1: camphor-10-sulfonic acid / ethyl acetate / 4 h / 20 °C 3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 20 °C View Scheme |
(3R,5S)-tert-butyl 6-(tert-butyldiphenylsilyloxy)-3,5-dihydroxyhexanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C 2: 80 percent / Bu4NF / tetrahydrofuran / 3 h / 0 °C View Scheme |
(5S)-6-(tert-butyl-diphenylsilanyloxy)-5-hydroxy-3-oxohexanoic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1). Et3B; 2.) NaBH4, MeOH / 1.) THF, 23 deg C, 15 min; 2.) -70 deg C 2: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C 3: 80 percent / Bu4NF / tetrahydrofuran / 3 h / 0 °C View Scheme |
1-methyl 6-tert.-butyl (2S,4R)-2,4-O-isopropylidene-2,4-dihydroxyadipate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With hydrogenchloride; sodium borohydrid; ammonium chloride In tetrahydrofuran; methanol | |
With hydrogenchloride; sodium borohydrid; ammonium chloride In methanol |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogenchloride / water / 1 h / 0 °C 2.1: sodium tetrahydroborate / water / 14 h / 0 °C 3.1: acetone / 0.25 h / 25 °C 3.2: 6 h / 48 - 50 °C 4.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 5.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride / water / 1 h / 0 °C 2.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1 h / 25 °C / Inert atmosphere 2.2: 4 h / -78 °C / Inert atmosphere 3.1: acetone / 0.25 h 3.2: 6 h / 48 - 50 °C 4.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 5.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride / water / 1 h / 0 °C 2.1: sodium tetrahydroborate; sodium dodecyl-sulfate / water / 14 h / 0 °C 3.1: acetone / 0.25 h 3.2: 6 h / 48 - 50 °C 4.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 5.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 5 steps 1: hydrogenchloride / water / 1 h / 0 °C 2: sodium tetrahydroborate / water / 14 h / 0 °C 3: (R)-10-camphorsulfonic acid / dichloromethane / 3 h / 40 °C 4: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 5: potassium carbonate; methanol / 0.5 h View Scheme |
(5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetone / 0.25 h / 25 °C 1.2: 6 h / 48 - 50 °C 2.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 3.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1: (R)-10-camphorsulfonic acid / dichloromethane / 3 h / 40 °C 2: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 3: potassium carbonate; methanol / 0.5 h View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 85 °C 2: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water; dichloromethane / 24 h / 20 °C 2: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 3: potassium carbonate; methanol / 0.5 h View Scheme |
Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / water / 14 h / 0 °C 2.1: acetone / 0.25 h / 25 °C 2.2: 6 h / 48 - 50 °C 3.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 4.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 4 steps 1.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1 h / 25 °C / Inert atmosphere 1.2: 4 h / -78 °C / Inert atmosphere 2.1: acetone / 0.25 h 2.2: 6 h / 48 - 50 °C 3.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 4.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate; sodium dodecyl-sulfate / water / 14 h / 0 °C 2.1: acetone / 0.25 h 2.2: 6 h / 48 - 50 °C 3.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 4.1: potassium carbonate; methanol / 0.5 h View Scheme |
1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetone / 0.25 h 1.2: 6 h / 48 - 50 °C 2.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C 3.1: potassium carbonate; methanol / 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1: (1S)-10-camphorsulfonic acid / acetone / 6 h / 48 - 50 °C 2: 1-methyl-pyrrolidin-2-one / 24 h / 95 °C 3: methanol; potassium carbonate / 20 °C View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water; dichloromethane / 48 h / 25 °C 2: potassium carbonate; methanol / 0.5 h View Scheme |
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1-methyl-pyrrolidin-2-one / 24 h / 95 °C 2: methanol; potassium carbonate / 20 °C View Scheme |
tert-butyl (S)-4-(propylene oxide-2-yl)-3-oxobutanoate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 1.2: 6 h / 20 °C / Inert atmosphere 2.1: methanol; diethyl methoxy borane; sodium tetrahydroborate / tetrahydrofuran / 2.5 h / -80 - -70 °C / Inert atmosphere 3.1: methanesulfonic acid / 20 °C 4.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 750.08 - 1500.15 Torr / Autoclave View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-yl)acetic acid
Conditions | Yield |
---|---|
Stage #1: 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate With water; sodium hydroxide In methanol at 40 - 50℃; Stage #2: With hydrogenchloride In water at 15 - 20℃; pH=4 - 4.2; | 100% |
With sodium hydroxide In tetrahydrofuran Reflux; | |
With sodium hydroxide In tetrahydrofuran Reflux; |
1H-imidazole
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
(3R,5S)-6-iodo-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
Conditions | Yield |
---|---|
With iodine; triphenylphosphine In benzene | 99% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In acetone at 50℃; | 99% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Conditions | Yield |
---|---|
Swern oxidation; (further oxidizing agents); | 97% |
Stage #1: 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate With dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 0℃; for 0.5h; Stage #2: With pyridine; sulfur trioxide pyridine complex; dimethyl sulfoxide In dichloromethane at -5 - 20℃; for 1.16667h; | 93% |
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide In dichloromethane; water at 5 - 10℃; for 0.166667h; Temperature; Flow reactor; | 93.5% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
methanesulfonyl chloride
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; for 0.5h; | 90% |
With pyridine In dichloromethane; toluene | |
With triethylamine In dichloromethane | 100 g |
C20H19FN2O3
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
C33H41FN2O7
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -5 - 20℃; Mitsunobu reaction; | 88% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
benzoyl chloride
((4S,6R)-6-(2-tert-butoxy-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl benzoate
Conditions | Yield |
---|---|
Stage #1: 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate With pyridine In dichloromethane at 20℃; for 0.5h; Stage #2: benzoyl chloride In dichloromethane at 20℃; for 1h; | 88% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
acetyl chloride
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate With pyridine In dichloromethane at 20℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 20℃; for 1h; | 86% |
With pyridine In dichloromethane at 20℃; for 0.5h; | 15.9 g |
2-methyl-2-phenylpropionic acid
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; tetrabutylammonium perchlorate; silver perchlorate In dichloromethane at 20℃; for 3h; Electrolysis; Molecular sieve; | 52% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
ethyl (triphenylphosphoranylidene)acetate
C17H28O6
Conditions | Yield |
---|---|
With manganese(IV) oxide In toluene for 17h; Heating / reflux; | 41% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 46 percent / n-BuLi / 2 h / -78 - 25 °C View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
(6-{2-[3-(4-fluorophenyl)-1-isopropyl-5-(4-methoxybenzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 percent / NaHMDS / tetrahydrofuran / 2 h / -78 - 25 °C View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 75 percent / NaHMDS / tetrahydrofuran / 2 h / -78 - 25 °C 2: hydrogen / Pd/C / methanol / 3 h / 25 °C / 2585.81 Torr View Scheme |
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