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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product Description Product Name Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate CAS No. 131707-24-9 Appearance Yellowish to off-white powder Assay ≥99%

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 131707-24-9 Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct sale CAS 131707-24-9 with high-quality service

Cas:131707-24-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

CAS 131707-24-9 Synonyms Si-5;Ethyl 6-bromo-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate;6-broMo-5-hydroxy-1-Methyl-2-phenyl S-Methyl indole-3-carboxylic acid ethyl ester;Ethyl 6-br

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate CAS: 131707-24-9

Cas:131707-24-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Indole-3-carboxylicacid, 6-bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester 131707-24-9

Cas:131707-24-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate: 131707-24-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical i

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate: 131707-24-9

Cas:131707-24-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indole-3-carboxylicacid, 6-bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-(Phenylsulfanylmethyl)Indole-3-Carboxylate

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP like plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 6-BROMO-5-HYDROXY-1-METHYL-2-(PHENYLSULFANYLMETHYL)INDOLE-3-CARBOXYLATE CAS 131707-24-9

Cas:131707-24-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Indole-3-carboxylicacid, 6-bromo-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-, ethyl ester

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-(Phenylsulfanylmethyl)Indole-3-Carboxylate

Cas:131707-24-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-(Phenylsulfanylmethyl)Indole-3-Carboxylate CAS No.:131707-24-9 Molecule Formula:C19H18BrNO3S Molecule Weight:420.32 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufac

Best Quality Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-(Phenylsulfanylmethyl)Indole-3-Carboxylate with good supplier

Cas:131707-24-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Ethyl6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-(Phenylsulfanylmethyl)Indole-3-Carboxylate

Cas:131707-24-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Ethyl 6-Bromo-5-Hydroxy-1-Methyl-2-(Phenylsulfanylmethyl)Indole-3-Carboxylate

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Ethyl 6-bromo-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate

Cas:131707-24-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

thiophenol
108-98-5

thiophenol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In methanol for 3h; Ambient temperature;96.4%
Stage #1: thiophenol With sodium hydroxide In methanol for 2h;
Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol for 3h;
90.8%
Stage #1: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester; thiophenol With sodium hydroxide In methanol at 15 - 20℃; for 1h;
Stage #2: With acetic acid In methanol; acetone for 1h; Reflux;
88.6%
C14H13Br2NO4

C14H13Br2NO4

thiophenol
108-98-5

thiophenol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 25h;80.2%
arbidol
131707-25-0

arbidol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With 1H-imidazole In xylene Heating;55%
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
40945-79-7

1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / Br2 / CCl4 / 2 h / Heating
2: 96.4 percent / KOH / methanol / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
2.1: sodium hydroxide / methanol / 2 h
2.2: 3 h
View Scheme
Multi-step reaction with 2 steps
1.1: bromine / tetrachloromethane / 16 h / Reflux; Inert atmosphere
2.1: potassium hydroxide / methanol / 0.25 h / 20 °C / Inert atmosphere
2.2: 3 h / Cooling with ice; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux
2.1: potassium hydroxide / methanol / 0.25 h / 20 °C / Inert atmosphere
2.2: 3 h / Inert atmosphere; Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere
2.1: potassium hydroxide; methanol / 0.25 h / 20 °C
2.2: 4 h / 20 °C
View Scheme
C14H17NO4

C14H17NO4

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
3.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
4.1: sodium hydroxide / methanol / 2 h
4.2: 3 h
View Scheme
ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate
20862-91-3

ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
2.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
3.1: sodium hydroxide / methanol / 2 h
3.2: 3 h
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Cooling with ice; Inert atmosphere
2.1: bromine / tetrachloromethane / 16 h / Reflux; Inert atmosphere
3.1: potassium hydroxide / methanol / 0.25 h / 20 °C / Inert atmosphere
3.2: 3 h / Cooling with ice; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice
2.1: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux
3.1: potassium hydroxide / methanol / 0.25 h / 20 °C / Inert atmosphere
3.2: 3 h / Inert atmosphere; Cooling with ice
View Scheme
4-nitro-phenol
100-02-7

4-nitro-phenol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pyridine / acetone / 4 h / 20 °C / Reflux
2.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux
3.1: indium(III) bromide / dichloromethane / 3 h / Reflux
4.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
6.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
7.1: sodium hydroxide / methanol / 2 h
7.2: 3 h
View Scheme
4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux
2.1: indium(III) bromide / dichloromethane / 3 h / Reflux
3.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
5.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
6.1: sodium hydroxide / methanol / 2 h
6.2: 3 h
View Scheme
p-aminophenyl acetate
13871-68-6

p-aminophenyl acetate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: indium(III) bromide / dichloromethane / 3 h / Reflux
2.1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
4.1: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
5.1: sodium hydroxide / methanol / 2 h
5.2: 3 h
View Scheme
ethyl 5-hydroxy-2-methylindole-3-carboxylate
7598-91-6

ethyl 5-hydroxy-2-methylindole-3-carboxylate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / 1 h / Inert atmosphere; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Cooling with ice; Inert atmosphere
3.1: bromine / tetrachloromethane / 16 h / Reflux; Inert atmosphere
4.1: potassium hydroxide / methanol / 0.25 h / 20 °C / Inert atmosphere
4.2: 3 h / Cooling with ice; Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine / 1 h / Inert atmosphere; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice
3.1: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux
4.1: potassium hydroxide / methanol / 0.25 h / 20 °C / Inert atmosphere
4.2: 3 h / Inert atmosphere; Cooling with ice
View Scheme
ethyl 6-bromo-2-(bromomethyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate

ethyl 6-bromo-2-(bromomethyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate

thiophenol
108-98-5

thiophenol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: thiophenol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere;
Stage #2: ethyl 6-bromo-2-(bromomethyl)-5-hydroxy-1-methyl-1H-indole-3-carboxylate In methanol; dichloromethane for 3h; Cooling with ice; Inert atmosphere;
362 mg
C14H15NO4

C14H15NO4

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dibenzoyl peroxide; bromine / tetrachloromethane / 6 h / Reflux
2: potassium hydroxide / methanol / 25 h / 20 °C
View Scheme
ethyl acetoacetate
141-97-9

ethyl acetoacetate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: water / 8 h / 20 °C
2: 1,2-dichloro-ethane / 12 h / 50 °C / Reflux
3: triethylamine / acetone / 6 h / 20 °C
4: dibenzoyl peroxide; bromine / tetrachloromethane / 6 h / Reflux
5: potassium hydroxide / methanol / 25 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 3 h / 20 - 30 °C / Cooling with ice
2.1: zinc(II) chloride / dichloromethane / 4 h / 10 - 20 °C
3.1: sodium acetate / dichloromethane / 3 h / Reflux
4.1: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
5.1: sodium hydroxide / methanol / 1 h / 15 - 20 °C
5.2: 1 h / Reflux
View Scheme
ethyl 3-methylaminocrotonate
870-85-9

ethyl 3-methylaminocrotonate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1,2-dichloro-ethane / 12 h / 50 °C / Reflux
2: triethylamine / acetone / 6 h / 20 °C
3: dibenzoyl peroxide; bromine / tetrachloromethane / 6 h / Reflux
4: potassium hydroxide / methanol / 25 h / 20 °C
View Scheme
mecarbinate
15574-49-9

mecarbinate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / acetone / 6 h / 20 °C
2: dibenzoyl peroxide; bromine / tetrachloromethane / 6 h / Reflux
3: potassium hydroxide / methanol / 25 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium acetate / dichloromethane / 3 h / Reflux
2.1: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
3.1: sodium hydroxide / methanol / 1 h / 15 - 20 °C
3.2: 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: 4 h / Reflux
2.1: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere
3.1: potassium hydroxide; methanol / 0.25 h / 20 °C
3.2: 4 h / 20 °C
View Scheme
ethyl N-methyl β-aminocrotonate
65578-36-1

ethyl N-methyl β-aminocrotonate

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: zinc(II) chloride / dichloromethane / 4 h / 10 - 20 °C
2.1: sodium acetate / dichloromethane / 3 h / Reflux
3.1: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
4.1: sodium hydroxide / methanol / 1 h / 15 - 20 °C
4.2: 1 h / Reflux
View Scheme
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

2-bromoethanol
540-51-2

2-bromoethanol

C21H22BrNO4S

C21H22BrNO4S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 8h;88.7%
formaldehyd
50-00-0

formaldehyd

dimethyl amine
124-40-3

dimethyl amine

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Arbidol hydrochloride
131707-23-8

Arbidol hydrochloride

Conditions
ConditionsYield
Stage #1: formaldehyd; dimethyl amine; 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester With aminosulfonic acid In water at 30 - 40℃; for 3h; Cooling with ice;
Stage #2: With hydrogenchloride In water; acetone at 60℃; pH=1;
85.6%
formaldehyd
50-00-0

formaldehyd

dimethyl amine
124-40-3

dimethyl amine

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

arbidol
131707-25-0

arbidol

Conditions
ConditionsYield
With acetic acid In water at 65 - 75℃; for 0.5h;85.1%
Stage #1: formaldehyd; dimethyl amine With acetic acid In water at 0℃; for 0.25h;
Stage #2: 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester In water at 80℃; for 4h;
60%
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

1-methyl-2-phenylthiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole sulfoxide

1-methyl-2-phenylthiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole sulfoxide

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid for 48h; Ambient temperature;76.6%
bis-(dimethylamino)methane
51-80-9

bis-(dimethylamino)methane

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

arbidol
131707-25-0

arbidol

Conditions
ConditionsYield
In 1,4-dioxane for 3h; Heating;70%
In 1,4-dioxane for 3.5h; Reflux; Inert atmosphere;51%
Stage #1: bis-(dimethylamino)methane; 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester In 1,4-dioxane for 3.5h; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride In water; ethyl acetate
51%
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

2-Benzenesulfinylmethyl-6-bromo-4-dimethylaminomethyl-5-hydroxy-1-methyl-1H-indole-3-carboxylic acid ethyl ester

2-Benzenesulfinylmethyl-6-bromo-4-dimethylaminomethyl-5-hydroxy-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76.6 percent / 30percent H2O2, glacial AcOH / 48 h / Ambient temperature
2: dioxane / 4 h / Heating
View Scheme
formaldehyd
50-00-0

formaldehyd

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

arbidol
131707-25-0

arbidol

Conditions
ConditionsYield
With potassium hydroxide; acetic acid; dimethyl amine
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

C29H36BrN3O5S

C29H36BrN3O5S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,4-dioxane / 3.5 h / Reflux; Inert atmosphere
2: 1,4-dioxane / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1,4-dioxane / 3.5 h / Inert atmosphere; Reflux
2: 1,4-dioxane / Inert atmosphere; Reflux
View Scheme
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

C26H32BrN3O4S

C26H32BrN3O4S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,4-dioxane / 3.5 h / Reflux; Inert atmosphere
2: 1,4-dioxane / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1,4-dioxane / 3.5 h / Inert atmosphere; Reflux
2: 1,4-dioxane / Inert atmosphere; Reflux
View Scheme
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

ethyl 6-methyl-7-(phenylthiomethyl)-2,3-dihydro-1,4-dioxino[2,3-f]indole-8-carboxylate

ethyl 6-methyl-7-(phenylthiomethyl)-2,3-dihydro-1,4-dioxino[2,3-f]indole-8-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C
2: caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; palladium diacetate / toluene / 4 h / Reflux
View Scheme
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

ethyl 6-methyl-7-(phenylsulfinylmethyl)-2,3-dihydro-1,4-dioxin[2,3-f]indole-8-carboxylate

ethyl 6-methyl-7-(phenylsulfinylmethyl)-2,3-dihydro-1,4-dioxin[2,3-f]indole-8-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C
2: caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; palladium diacetate / toluene / 4 h / Reflux
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -20 °C
View Scheme

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