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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-CHLORO-4-(4-FLUOROPHENYL)-5,6,7,8,9,10-HEXAHYDROCYCLOOCTA[B]PYRIDINE

Cas:132813-14-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Kilogram

FOB Price: $0.8 / 1.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

StandardCAS 132813-14-0 with high quality products

Cas:132813-14-0

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have stoc

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine CAS:132813-14-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical inte

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine CAS:132813-14-0

Cas:132813-14-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Cycloocta[b]pyridine,2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-

Cas:132813-14-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cycloocta[b]pyridine,2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-4-(4-Fluorophenyl)-5,6,7,8,9,10-Hexahydrocycloocta[B]Pyridine

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cycloocta[b]pyridine,2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

2-Chloro-4-(4-Fluorophenyl)-5,6,7,8,9,10-Hexahydrocycloocta[B]Pyridine

Cas:132813-14-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Cycloocta[b]pyridine,2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-

Cas:132813-14-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Application:132813-14-0 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Synthetic route

4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone
132812-72-7

4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
With trichlorophosphate95%
With phosphorus pentachloride In N,N-dimethyl-formamide at 5 - 15℃; for 3h;93.6%
With hydrogenchloride In water; acetic anhydride at 10 - 20℃; for 6h; Cooling with ice; Green chemistry;93.24%
cycloactanone
502-49-8

cycloactanone

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / PPA / Heating
2: 95 percent / POCl3
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid; phosphoric acid / toluene / Reflux; Dean-Stark; Large scale
2: P,P-dichlorophenylphosphine oxide / toluene; dichloromethane / 80 - 148 °C / Large scale
View Scheme
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / PPA / Heating
2: 95 percent / POCl3
View Scheme
Multi-step reaction with 3 steps
1: methanesulfonic acid / water / 3 h / 65 - 70 °C
2: methanesulfonic acid / water / 2 h / 110 - 115 °C
3: Dichlorophenylphosphine / 4 h / 155 - 160 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid; phosphoric acid / toluene / Reflux; Dean-Stark; Large scale
2: P,P-dichlorophenylphosphine oxide / toluene; dichloromethane / 80 - 148 °C / Large scale
View Scheme
3-(4-fluorophenyl)-3-oxopropanamide

3-(4-fluorophenyl)-3-oxopropanamide

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanesulfonic acid / water / 2 h / 110 - 115 °C
2: Dichlorophenylphosphine / 4 h / 155 - 160 °C
View Scheme
methyl 4-flurobenzoate
403-33-8

methyl 4-flurobenzoate

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hexamethyldisilazane / toluene; tetrahydrofuran / -5 - 0 °C / Large scale
2: toluene-4-sulfonic acid; phosphoric acid / toluene / Reflux; Dean-Stark; Large scale
3: P,P-dichlorophenylphosphine oxide / toluene; dichloromethane / 80 - 148 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / tert-butyl methyl ether; water / 90 °C
2: toluene-4-sulfonic acid; phosphoric acid / toluene / Reflux; Dean-Stark; Large scale
3: P,P-dichlorophenylphosphine oxide / toluene; dichloromethane / 80 - 148 °C / Large scale
View Scheme
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

blonanserin

blonanserin

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃; for 5h;98.6%
Stage #1: 4-ethylpiperazine; 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine With sodium t-butanolate In toluene at 10℃; under 75.0075 Torr; for 0.0333333h; Inert atmosphere;
Stage #2: With palladium diacetate; triphenylphosphine In toluene at 70℃; under 75.0075 Torr; for 7h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
89.12%
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 75 - 85℃; for 3h; Large scale;88%
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine 1-oxide
143213-96-1

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine 1-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In chloroform97%
1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(piperazine-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(piperazine-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
Stage #1: 1-t-Butoxycarbonylpiperazine; 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine With potassium iodide In N,N-dimethyl-formamide for 12h; Reflux;
Stage #2: With hydrogenchloride In N,N-dimethyl-formamide at 30℃; for 2h; Temperature; Solvent; Reagent/catalyst;
80%
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-cycloocta[b]pyridine

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-cycloocta[b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol
848301-81-5

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
4: 99 percent / SeO2 / dioxane
5: 49 percent / HCl / methanol
6: 85 percent / H2 / PtO2 / ethanol
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-cycloocta[b]pyridin-8-ol

2-chloro-4-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-cycloocta[b]pyridin-8-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
4: 99 percent / SeO2 / dioxane
5: 49 percent / HCl / methanol
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2,10-dichloro-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
143213-95-0

2,10-dichloro-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

formic acid 2-chloro-4-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-cycloocta[b]pyridin-8-yl ester

formic acid 2-chloro-4-(4-fluoro-phenyl)-5,6,7,8-tetrahydro-cycloocta[b]pyridin-8-yl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
4: 99 percent / SeO2 / dioxane
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(4-ethyl-piperazin-1-yl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol
848301-82-6

2-(4-ethyl-piperazin-1-yl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
4: 99 percent / SeO2 / dioxane
5: 49 percent / HCl / methanol
6: 85 percent / H2 / PtO2 / ethanol
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(4-ethyl-piperazin-1-yl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol

2-(4-ethyl-piperazin-1-yl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
4: 99 percent / SeO2 / dioxane
5: 49 percent / HCl / methanol
6: 85 percent / H2 / PtO2 / ethanol
7: resolution using CHIRACEL OJ column
View Scheme
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(4-ethyl-piperazin-1-yl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol

2-(4-ethyl-piperazin-1-yl)-4-(4-fluoro-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridin-8-ol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 97 percent / m-CPBA / CHCl3
2: 97 percent / POCl3; Et3N / CHCl3
3: 84 percent / DBU / dimethylsulfoxide
4: 99 percent / SeO2 / dioxane
5: 49 percent / HCl / methanol
6: 85 percent / H2 / PtO2 / ethanol
7: resolution using CHIRACEL OJ column
View Scheme
piperazine
110-85-0

piperazine

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(piperazine-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(piperazine-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

Conditions
ConditionsYield
With potassium iodide at 165 - 170℃; for 8h;8.5 g
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

blonanserin sulfate

blonanserin sulfate

Conditions
ConditionsYield
Stage #1: 4-ethylpiperazine; 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine With sodium t-butanolate In toluene at 10℃; under 75.0075 Torr; for 0.0333333h; Inert atmosphere;
Stage #2: With palladium diacetate; triphenylphosphine In toluene at 70℃; under 75.0075 Torr; for 7h; Inert atmosphere;
Stage #3: With sulfuric acid In ethanol; toluene at 0 - 10℃; for 0.5h; Inert atmosphere;
6.76 g

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