LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryProduct Description Product website: http://www.finerchem.com Product Name 4-Fluorobenzoylacetonitrile CAS No. 4640-67-9
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inquiry4-FLUOROBENZOYLACETONITRILE Basic information Product Name: 4-FLUOROBENZOYLACETONITRILE Synonyms: P-FLUOROBENZOYLACETONITRILE;AKOS B020924;3-(4-FLUORO-PHENYL)-3-OXO-PROPIONITRILE;3-(4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name 4-Fluorobenzoylacetonitrile CAS 4640-67-9 MF C9H6FNO MW 163.15 EINECS 627-421-8 Product Categories HALIDE
we are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga
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inquiryProduct Name: 4-FLUOROBENZOYLACETONITRILE CAS: 4640-67-9 MF: C9H6FNO MW: 163.15 EINECS: 627-421-8 Mol File: 4640-67-9.mol 4-FLUOROBENZOYLACETONITRILE Structure 4-FLUOROBENZOYLACETONITRILE Chemical Properties Melting point 84-8
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inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryProduct name: 4-Fluorobenzoyl Acetonitrile CAS No.:4640-67-9 Molecule Formula:C9H6FNO Molecule Weight:163.14 Purity: 98% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING IT
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryMelting point: 84-88 ° C Boiling point: 311.9 ± 22.0 ° C (predicted) Density :1±0 06 g/cm3(Predicted) Appearance:Yellow powder Storage:Sealed in dry,Room Temperature Package:According to client's requirements Application:pharm
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat
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inquiryStock products, own laboratoryAppearance:Light yellow to yellow crystal powder Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryThe process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
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inquiry1-(4-fluorophenyl)-2-methoxyethan-1-one
acetonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Stage #1: 1-(4-fluorophenyl)-2-methoxyethan-1-one With sodium hydride In toluene at 90℃; for 2h; Stage #2: acetonitrile In toluene for 6.5h; | 93.14% |
4-fluoro-N-methoxy-N-methylbenzamide
acetonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Stage #1: acetonitrile With methyllithium; lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.5h; Inert atmosphere; Stage #2: 4-fluoro-N-methoxy-N-methylbenzamide In tetrahydrofuran; diethyl ether at -78℃; for 1.5h; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In chloroform at 20 - 80℃; for 12.5h; | 92.39% |
sodium cyanide
2-bromo-4'-fluoroacetophenone
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
89% |
α-(tert-butylcarboxy)-β-hydroxy-p-fluorocinnamonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 3.5h; Ambient temperature; | 83% |
methyl 4-flurobenzoate
acetonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With sodium hexamethyldisilazane In tetrahydrofuran; toluene at -5 - 0℃; Reagent/catalyst; Solvent; Temperature; Large scale; | 83% |
With sodium hydride In toluene Reflux; | 78% |
With sodium hydride In tetrahydrofuran for 5h; Reflux; Inert atmosphere; |
4-fluorobenzoyl chloride
cyanoacetic acid
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Stage #1: cyanoacetic acid With [2,2]bipyridinyl; n-butyllithium; magnesium sulfate In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 4-fluorobenzoyl chloride In tetrahydrofuran; methanol; hexane at -78 - 20℃; Inert atmosphere; Stage #3: With hydrogenchloride In tetrahydrofuran; methanol; hexane; water | 80% |
sodium cyanide
2-bromo-4'-fluoroacetophenone
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With tetrabutylammomium bromide In water; toluene at 20℃; chemoselective reaction; | 80% |
In ethanol; water for 16h; Cooling with ice; |
diazoacetonitrile
4-fluorobenzaldehyde
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In dichloromethane at 20℃; | 77% |
4-fluoroboronic acid
malononitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique; | 76% |
With 4,4'-dimethyl-2,2'-bipyridines; water; palladium(II) acetylacetonate; benzenesulfonic acid In toluene at 80℃; for 28h; | 76% |
cyanoacetic acid tert-butyl ester
9-methyl-9H-fluorene-9-carbonyl chloride
1-Bromo-4-fluorobenzene
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Stage #1: cyanoacetic acid tert-butyl ester; 9-methyl-9H-fluorene-9-carbonyl chloride; 1-Bromo-4-fluorobenzene With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; magnesium chloride; tri tert-butylphosphoniumtetrafluoroborate In 1,4-dioxane at 100℃; for 18h; Glovebox; Inert atmosphere; Stage #2: With formic acid In 1,4-dioxane for 1h; Inert atmosphere; | 74% |
3-chloro-3-(4-fluorophenyl)acrylonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With sodium hydroxide In water; dimethyl sulfoxide at 25℃; | 71% |
trimethylsilyl cyanide
((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With iodosylbenzene; boron trifluoride diethyl etherate In acetonitrile at -30℃; for 3h; Inert atmosphere; | 68% |
2-trimethylsilylacetonitrile
4-fluoro-1-iodobenzene
carbon monoxide
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With zinc(II) fluoride; (2-methylallyl)palladium-chloride dimer; copper(ll) bromide In N,N-dimethyl-formamide at 80℃; under 7600.51 Torr; for 12h; | 65% |
methyl 4-flurobenzoate
acetonitrile
A
4-Fluorobenzoic acid
B
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With sodium hydride In tert-butyl methyl ether; water at 90℃; | A 17.5% B 64% |
2-trimethylsilylacetonitrile
4-fluoro-1-iodobenzene
molybdenum hexacarbonyl
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With copper (II)-fluoride; bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 80℃; for 16h; | 61% |
sodium cyanide
2-Chloro-4'-fluoroacetophenone
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
56% |
4-fluorobenzoic acid ethyl ester
acetonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Stage #1: acetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: 4-fluorobenzoic acid ethyl ester In tetrahydrofuran; hexane at -78 - -60℃; for 3h; | 47% |
With sodium hydride In benzene for 14h; Heating; | 31% |
With potassium 2-methylbutan-2-olate In tetrahydrofuran; toluene at 20℃; for 0.333333h; Inert atmosphere; | |
With sodium hydride In tetrahydrofuran for 1h; Reflux; | |
With sodium hydride In toluene for 2h; |
potassium cyanide
2-bromo-4'-fluoroacetophenone
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Stage #1: potassium cyanide; 2-bromo-4'-fluoroacetophenone In ethanol; water at 20℃; for 2h; Stage #2: With hydrogenchloride In ethanol; water pH=5 - 6; | 6% |
In ethanol; water at 20℃; for 2h; Substitution; |
(E/Z)-3-amino-3-(4-fluorophenyl)acrylonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With hydrogenchloride In chloroform | |
With hydrogenchloride In water at 20℃; for 3h; | 91.9 g |
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 20℃; for 3h; Further byproducts given. Title compound not separated from byproducts; |
1-(4'-fluorophenyl)-3-phenylpropane-1,3-dione
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / NCS / CCl4 / 0.5 h / Heating 2: dimethylsulfoxide / 3 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73 percent / AlCl3 / CS2 2: 56 percent View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) ether, 20 min, 2.) ether, RT, 3 h 2: 83 percent / TFA / CH2Cl2 / 3.5 h / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaH, tBuOH / diethyl ether / Heating 2: aq. HCl / CHCl3 View Scheme |
Conditions | Yield |
---|---|
With potassium 2-methylbutan-2-olate In tetrahydrofuran; toluene at 20℃; |
4-fluorobenzylic alcohol
acetonitrile
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With oxygen; potassium hydroxide; copper dichloride In N,N-dimethyl acetamide at 20℃; for 12h; Green chemistry; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium iodide; triethylamine / acetonitrile / 40 °C / Inert atmosphere 2: boron trifluoride diethyl etherate; iodosylbenzene / acetonitrile / 3 h / -30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: copper(ll) bromide / ethyl acetate / Reflux 2: ethanol; water / 16 h / Cooling with ice View Scheme |
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With water; lithium iodide In 1-methyl-pyrrolidin-2-one at 130℃; for 6h; Krapcho Dealkoxycarbonylation; |
cycloactanone
3-(4-fluorophenyl)-3-oxopropionitrile
4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone
Conditions | Yield |
---|---|
With 1-ethyl-3-methylimidazolium tetrafluoroborate at 120℃; for 1h; | 99.8% |
With methanesulfonic acid; phosphorus pentoxide at 50℃; for 15h; | 95% |
With PPA Heating; | 64% |
With phosphoric acid; toluene-4-sulfonic acid In toluene Reflux; Dean-Stark; Large scale; | 54% |
3-(4-fluorophenyl)-3-oxopropionitrile
cyclopentanone
(2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone
Conditions | Yield |
---|---|
With morpholine; sulfur In ethanol at 60℃; for 2h; | 98% |
With sulfur In ethanol at 50℃; for 4h; | 74% |
With morpholine; sulfur In ethanol at 70℃; for 1h; Cyclization; | 45% |
3-(4-fluorophenyl)-3-oxopropionitrile
(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one
2-(4-fluorophenyl)-6-hydroxy-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-4H-pyran-3-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 3-(4-fluorophenyl)-3-oxopropionitrile With (S)-1-(1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-3-phenylpropan-2-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea In chloroform at -10℃; Michael addition; Stage #2: (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one In chloroform at -10℃; Michael addition; optical yield given as %ee; enantioselective reaction; | 98% |
3-(4-fluorophenyl)-3-oxopropionitrile
5-amino-1-phenyl-3-(pyridin-3-yl)-1H-pyrazole
4-methoxy-benzaldehyde
6-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
Conditions | Yield |
---|---|
With acetic acid; triethylamine at 150℃; for 0.25h; Microwave irradiation; | 98% |
3-(4-fluorophenyl)-3-oxopropionitrile
4-dimethylamino-benzaldehyde
(E)-3-(4-(dimethylamino)phenyl)-2-(4-fluorobenzoyl)acrylonitrile
Conditions | Yield |
---|---|
With piperidine In (+/-)-2-pentanol at 120℃; for 0.25h; Knoevenagel condensation; Microwave irradiation; | 98% |
3-(4-fluorophenyl)-3-oxopropionitrile
(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile
Conditions | Yield |
---|---|
With formic acid; C18H24ClIrN3 In water at 80℃; for 3h; Schlenk technique; Inert atmosphere; chemoselective reaction; | 97% |
With formic acid; 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; sodium formate In water at 80℃; for 18h; pH=4.5; Inert atmosphere; chemoselective reaction; | 91% |
With sodium tetrahydroborate In ethanol at 0 - 20℃; | 82% |
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane at 20℃; Reagent/catalyst; Cooling with ice; | 97% |
With sulfuric acid In water at 20℃; | |
With methanesulfonic acid In water at 65 - 70℃; for 3h; |
Conditions | Yield |
---|---|
Stage #1: 3-(4-fluorophenyl)-3-oxopropionitrile With C33H28F5N3O2; potassium carbonate In toluene at 0℃; for 0.0833333h; Stage #2: C15H16O4 In toluene at 0℃; for 48h; enantioselective reaction; | 97% |
Conditions | Yield |
---|---|
With C33H28F5N3O2; potassium carbonate In toluene at 0℃; for 48h; enantioselective reaction; | 97% |
3-(4-fluorophenyl)-3-oxopropionitrile
3-(4-fluorophenyl)-1H-pyrazol-5-amine
Conditions | Yield |
---|---|
With hydrazine hydrate In methanol at 150℃; for 0.0833333h; Microwave irradiation; | 96% |
With hydrazine hydrate In ethanol at 80℃; for 4h; | 33% |
With hydrazine In ethanol for 12h; Reflux; |
3-(4-fluorophenyl)-3-oxopropionitrile
methyl benzylidenepyruvate
methyl 5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate
Conditions | Yield |
---|---|
With C36H50N4O4; 4-(1,1-dimethylethyl)benzoic acid In tert-butyl methyl ether at -30℃; for 72h; Michael Addition; Molecular sieve; Inert atmosphere; | 96% |
3-(4-fluorophenyl)-3-oxopropionitrile
2-amino-benzenethiol
2-(4-fluorophenyl)-benzothiazole
Conditions | Yield |
---|---|
at 200℃; for 0.166667h; Irradiation; microwave; | 95% |
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With formic acid; {Cp*Ir[(R,R)-C6F5SO2DPEN](H2O)}(SO4) In water at 20℃; for 24h; pH=3.5; optical yield given as %ee; enantioselective reaction; | 95% |
With D-glucose; D-glucose dehydrogenase; NADPH; Candida magnoliae carbonyl reductase In phosphate buffer; dimethyl sulfoxide at 20℃; for 24h; pH=7.0; | 90% |
With formic acid In water at 25℃; for 12h; pH=3.5; enantioselective reaction; | n/a |
3-(4-fluorophenyl)-3-oxopropionitrile
p-toluidine
3-(4-fluorophenyl)-3-(p-tolylamino)acrylonitrile
Conditions | Yield |
---|---|
With acetic acid at 80℃; for 6h; optical yield given as %de; | 95% |
3-(4-fluorophenyl)-3-oxopropionitrile
methyl benzylidenepyruvate
(2S,4R)-methyl-5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate
Conditions | Yield |
---|---|
With (S)-1-(1-(4-(benzyloxy)phenyl)-3-(dimethylamino)propan-2-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea In diethyl ether at 20℃; for 12h; Michael addition; optical yield given as %ee; enantioselective reaction; | 95% |
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); C48H50N2O2P2Ru In 1,4-dioxane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction; | 95% |
2-amino-5-chlorobenzenethiol
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
at 200℃; for 0.166667h; Irradiation; microwave; | 94% |
3-(4-fluorophenyl)-3-oxopropionitrile
5-chloroindole 2,3-dione
malononitrile
Conditions | Yield |
---|---|
In ethanol; water at 20℃; Irradiation; Green chemistry; | 94% |
3-(4-fluorophenyl)-3-oxopropionitrile
Cysteamine
2-(4-fluorophenyl)-4,5-dihydrothiazole
Conditions | Yield |
---|---|
at 210℃; under 7757.43 Torr; for 0.166667h; microwave irradiation; | 93% |
2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With Cp*Rh(OAc)2·H2O; water In 1,2-dichloro-ethane at 80℃; for 12h; Schlenk technique; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
In ethanol; water at 20℃; Irradiation; Green chemistry; | 93% |
3-(4-fluorophenyl)-3-oxopropionitrile
Conditions | Yield |
---|---|
With copper acetylacetonate; o-phenylenebis(diphenylphosphine); N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere; | 93% |
ethanol
3-(4-fluorophenyl)-3-oxopropionitrile
3-(4-Fluorphenyl)-3-oxo-propionimidsaeure-ethylester-hydrochlorid
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; chloroform; benzene Ambient temperature; | 92% |
methanol
3-(4-fluorophenyl)-3-oxopropionitrile
methyl (p-fluorobenzoyl)formate
Conditions | Yield |
---|---|
With oxygen In tetrahydrofuran at 20℃; for 24h; Irradiation; | 92% |
Conditions | Yield |
---|---|
In ethanol; water at 20℃; Irradiation; Green chemistry; | 92% |
Conditions | Yield |
---|---|
In ethanol; water at 20℃; Irradiation; Green chemistry; | 92% |
5-fluoro-1H-indole-2,3-dione
3-(4-fluorophenyl)-3-oxopropionitrile
malononitrile
Conditions | Yield |
---|---|
In ethanol; water at 20℃; Irradiation; Green chemistry; | 92% |
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