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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Fluorobenzoylacetonitrile Manufacturer/High quality/Best price/In stock

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 4-Fluorobenzoylacetonitrile CAS No. 4640-67-9

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

4-FLUOROBENZOYLACETONITRILE Basic information Product Name: 4-FLUOROBENZOYLACETONITRILE Synonyms: P-FLUOROBENZOYLACETONITRILE;AKOS B020924;3-(4-FLUORO-PHENYL)-3-OXO-PROPIONITRILE;3-(4&#3

4-Fluorobenzoylacetonitrile ,98%

Cas:4640-67-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 4640-67-9 with competitive price

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 4-Fluorobenzoylacetonitrile CAS 4640-67-9 MF C9H6FNO MW 163.15 EINECS 627-421-8 Product Categories HALIDE

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

we are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga

4-FLUOROBENZOYLACETONITRILECAS NO.: 4640-67-9

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $0.2 / 1.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 4-FLUOROBENZOYLACETONITRILE CAS: 4640-67-9 MF: C9H6FNO MW: 163.15 EINECS: 627-421-8 Mol File: 4640-67-9.mol 4-FLUOROBENZOYLACETONITRILE Structure 4-FLUOROBENZOYLACETONITRILE Chemical Properties Melting point 84-8

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzenepropanenitrile,4-fluoro-beta-oxo-

Cas:4640-67-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-Fluorbenzoylacetonitrile

Cas:4640-67-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenepropanenitrile,4-fluoro-beta-oxo-

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity 4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Fluorobenzoyl Acetonitrile CAS No.:4640-67-9 Molecule Formula:C9H6FNO Molecule Weight:163.14 Purity: 98% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING IT

High Quality 4-Fluorobenzoyl Acetonitrile in stock

Cas:4640-67-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Melting point: 84-88 ° C Boiling point: 311.9 ± 22.0 ° C (predicted) Density :1±0 06 g/cm3(Predicted) Appearance:Yellow powder Storage:Sealed in dry,Room Temperature Package:According to client's requirements Application:pharm

4-FLUOROBENZOYLACETONITRILE China manufacture

Cas:4640-67-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Benzenepropanenitrile,4-fluoro-beta-oxo-

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Other

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/4-Fluorobenzoylacetonitrile/SAGECHEM/Manufacturer in China

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

3-(4-fluorophenyl)-3-oxopropanenitrile

Cas:4640-67-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 15.0

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Light yellow to yellow crystal powder Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Fluorobenzoylacetonitrile cas no. 4640-67-9 98%

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

4-FLUOROBENZOYLACETONITRILE

Cas:4640-67-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Other

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

4-FLUOROBENZOYLACETONITRILE CAS 4640-67-9

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-Fluorobenzoylacetonitrile

Cas:4640-67-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 4-Fluorobenzoylacetonitrile 500g

Cas:4640-67-9

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-(4-fluorophenyl)-2-methoxyethan-1-one
247179-37-9

1-(4-fluorophenyl)-2-methoxyethan-1-one

acetonitrile
75-05-8

acetonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Stage #1: 1-(4-fluorophenyl)-2-methoxyethan-1-one With sodium hydride In toluene at 90℃; for 2h;
Stage #2: acetonitrile In toluene for 6.5h;
93.14%
4-fluoro-N-methoxy-N-methylbenzamide
116332-54-8

4-fluoro-N-methoxy-N-methylbenzamide

acetonitrile
75-05-8

acetonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Stage #1: acetonitrile With methyllithium; lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 4-fluoro-N-methoxy-N-methylbenzamide In tetrahydrofuran; diethyl ether at -78℃; for 1.5h; Inert atmosphere;
93%
fluorobenzene
462-06-6

fluorobenzene

malononitrile
109-77-3

malononitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In chloroform at 20 - 80℃; for 12.5h;92.39%
sodium cyanide
143-33-9

sodium cyanide

2-bromo-4'-fluoroacetophenone
403-29-2

2-bromo-4'-fluoroacetophenone

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
89%
α-(tert-butylcarboxy)-β-hydroxy-p-fluorocinnamonitrile
133550-56-8

α-(tert-butylcarboxy)-β-hydroxy-p-fluorocinnamonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 3.5h; Ambient temperature;83%
methyl 4-flurobenzoate
403-33-8

methyl 4-flurobenzoate

acetonitrile
75-05-8

acetonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran; toluene at -5 - 0℃; Reagent/catalyst; Solvent; Temperature; Large scale;83%
With sodium hydride In toluene Reflux;78%
With sodium hydride In tetrahydrofuran for 5h; Reflux; Inert atmosphere;
4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

cyanoacetic acid
372-09-8

cyanoacetic acid

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Stage #1: cyanoacetic acid With [2,2]bipyridinyl; n-butyllithium; magnesium sulfate In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 4-fluorobenzoyl chloride In tetrahydrofuran; methanol; hexane at -78 - 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; methanol; hexane; water
80%
sodium cyanide
773837-37-9

sodium cyanide

2-bromo-4'-fluoroacetophenone
403-29-2

2-bromo-4'-fluoroacetophenone

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With tetrabutylammomium bromide In water; toluene at 20℃; chemoselective reaction;80%
In ethanol; water for 16h; Cooling with ice;
diazoacetonitrile
13138-21-1

diazoacetonitrile

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃;77%
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

malononitrile
109-77-3

malononitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique;76%
With 4,4'-dimethyl-2,2'-bipyridines; water; palladium(II) acetylacetonate; benzenesulfonic acid In toluene at 80℃; for 28h;76%
cyanoacetic acid tert-butyl ester
1116-98-9

cyanoacetic acid tert-butyl ester

9-methyl-9H-fluorene-9-carbonyl chloride
82102-37-2

9-methyl-9H-fluorene-9-carbonyl chloride

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Stage #1: cyanoacetic acid tert-butyl ester; 9-methyl-9H-fluorene-9-carbonyl chloride; 1-Bromo-4-fluorobenzene With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; magnesium chloride; tri tert-butylphosphoniumtetrafluoroborate In 1,4-dioxane at 100℃; for 18h; Glovebox; Inert atmosphere;
Stage #2: With formic acid In 1,4-dioxane for 1h; Inert atmosphere;
74%
3-chloro-3-(4-fluorophenyl)acrylonitrile
205984-77-6

3-chloro-3-(4-fluorophenyl)acrylonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With sodium hydroxide In water; dimethyl sulfoxide at 25℃;71%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane
58518-77-7

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With iodosylbenzene; boron trifluoride diethyl etherate In acetonitrile at -30℃; for 3h; Inert atmosphere;68%
2-trimethylsilylacetonitrile
18293-53-3

2-trimethylsilylacetonitrile

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With zinc(II) fluoride; (2-methylallyl)palladium-chloride dimer; copper(ll) bromide In N,N-dimethyl-formamide at 80℃; under 7600.51 Torr; for 12h;65%
methyl 4-flurobenzoate
403-33-8

methyl 4-flurobenzoate

acetonitrile
75-05-8

acetonitrile

A

4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

B

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With sodium hydride In tert-butyl methyl ether; water at 90℃;A 17.5%
B 64%
2-trimethylsilylacetonitrile
18293-53-3

2-trimethylsilylacetonitrile

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With copper (II)-fluoride; bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 80℃; for 16h;61%
sodium cyanide
143-33-9

sodium cyanide

2-Chloro-4'-fluoroacetophenone
456-04-2

2-Chloro-4'-fluoroacetophenone

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
56%
4-fluorobenzoic acid ethyl ester
451-46-7

4-fluorobenzoic acid ethyl ester

acetonitrile
75-05-8

acetonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Stage #1: acetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: 4-fluorobenzoic acid ethyl ester In tetrahydrofuran; hexane at -78 - -60℃; for 3h;
47%
With sodium hydride In benzene for 14h; Heating;31%
With potassium 2-methylbutan-2-olate In tetrahydrofuran; toluene at 20℃; for 0.333333h; Inert atmosphere;
With sodium hydride In tetrahydrofuran for 1h; Reflux;
With sodium hydride In toluene for 2h;
potassium cyanide
151-50-8

potassium cyanide

2-bromo-4'-fluoroacetophenone
403-29-2

2-bromo-4'-fluoroacetophenone

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Stage #1: potassium cyanide; 2-bromo-4'-fluoroacetophenone In ethanol; water at 20℃; for 2h;
Stage #2: With hydrogenchloride In ethanol; water pH=5 - 6;
6%
In ethanol; water at 20℃; for 2h; Substitution;
(E/Z)-3-amino-3-(4-fluorophenyl)acrylonitrile
55330-46-6

(E/Z)-3-amino-3-(4-fluorophenyl)acrylonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With hydrogenchloride In chloroform
With hydrogenchloride In water at 20℃; for 3h;91.9 g
sodium cyanide
143-33-9

sodium cyanide

2-chloro-1-(4-fluoro-phenyl)-3-phenyl-propane-1,3-dione

2-chloro-1-(4-fluoro-phenyl)-3-phenyl-propane-1,3-dione

A

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

B

2-benzoyl-3-hydroxy-3-phenylacrylonitrile

2-benzoyl-3-hydroxy-3-phenylacrylonitrile

C

(Z)-2-Benzoyl-3-(4-fluoro-phenyl)-3-hydroxy-acrylonitrile

(Z)-2-Benzoyl-3-(4-fluoro-phenyl)-3-hydroxy-acrylonitrile

D

(Z)-2-(4-Fluoro-benzoyl)-3-(4-fluoro-phenyl)-3-hydroxy-acrylonitrile

(Z)-2-(4-Fluoro-benzoyl)-3-(4-fluoro-phenyl)-3-hydroxy-acrylonitrile

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 3h; Further byproducts given. Title compound not separated from byproducts;
1-(4'-fluorophenyl)-3-phenylpropane-1,3-dione
38448-95-2

1-(4'-fluorophenyl)-3-phenylpropane-1,3-dione

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / NCS / CCl4 / 0.5 h / Heating
2: dimethylsulfoxide / 3 h / 20 °C
View Scheme
fluorobenzene
462-06-6

fluorobenzene

benzothienyllithium

benzothienyllithium

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / AlCl3 / CS2
2: 56 percent
View Scheme
4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) ether, 20 min, 2.) ether, RT, 3 h
2: 83 percent / TFA / CH2Cl2 / 3.5 h / Ambient temperature
View Scheme
4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH, tBuOH / diethyl ether / Heating
2: aq. HCl / CHCl3
View Scheme
acetonitrile
75-05-8

acetonitrile

p-fluoro-benzoic acid ester

p-fluoro-benzoic acid ester

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With potassium 2-methylbutan-2-olate In tetrahydrofuran; toluene at 20℃;
4-fluorobenzylic alcohol
459-56-3

4-fluorobenzylic alcohol

acetonitrile
75-05-8

acetonitrile

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With oxygen; potassium hydroxide; copper dichloride In N,N-dimethyl acetamide at 20℃; for 12h; Green chemistry;
1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide; triethylamine / acetonitrile / 40 °C / Inert atmosphere
2: boron trifluoride diethyl etherate; iodosylbenzene / acetonitrile / 3 h / -30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: copper(ll) bromide / ethyl acetate / Reflux
2: ethanol; water / 16 h / Cooling with ice
View Scheme
C11H8FNO3

C11H8FNO3

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Conditions
ConditionsYield
With water; lithium iodide In 1-methyl-pyrrolidin-2-one at 130℃; for 6h; Krapcho Dealkoxycarbonylation;
cycloactanone
502-49-8

cycloactanone

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone
132812-72-7

4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone

Conditions
ConditionsYield
With 1-ethyl-3-methylimidazolium tetrafluoroborate at 120℃; for 1h;99.8%
With methanesulfonic acid; phosphorus pentoxide at 50℃; for 15h;95%
With PPA Heating;64%
With phosphoric acid; toluene-4-sulfonic acid In toluene Reflux; Dean-Stark; Large scale;54%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

cyclopentanone
120-92-3

cyclopentanone

(2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone
304018-03-9

(2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

Conditions
ConditionsYield
With morpholine; sulfur In ethanol at 60℃; for 2h;98%
With sulfur In ethanol at 50℃; for 4h;74%
With morpholine; sulfur In ethanol at 70℃; for 1h; Cyclization;45%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one
3108-32-5, 86571-25-7

(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one

2-(4-fluorophenyl)-6-hydroxy-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-4H-pyran-3-carbonitrile
1204589-64-9

2-(4-fluorophenyl)-6-hydroxy-4-phenyl-6-(trifluoromethyl)-5,6-dihydro-4H-pyran-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-(4-fluorophenyl)-3-oxopropionitrile With (S)-1-(1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-3-phenylpropan-2-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea In chloroform at -10℃; Michael addition;
Stage #2: (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one In chloroform at -10℃; Michael addition; optical yield given as %ee; enantioselective reaction;
98%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

5-amino-1-phenyl-3-(pyridin-3-yl)-1H-pyrazole
1152711-48-2

5-amino-1-phenyl-3-(pyridin-3-yl)-1H-pyrazole

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

6-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
1357585-60-4

6-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Conditions
ConditionsYield
With acetic acid; triethylamine at 150℃; for 0.25h; Microwave irradiation;98%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

(E)-3-(4-(dimethylamino)phenyl)-2-(4-fluorobenzoyl)acrylonitrile
1370042-90-2

(E)-3-(4-(dimethylamino)phenyl)-2-(4-fluorobenzoyl)acrylonitrile

Conditions
ConditionsYield
With piperidine In (+/-)-2-pentanol at 120℃; for 0.25h; Knoevenagel condensation; Microwave irradiation;98%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile
136568-65-5

(RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile

Conditions
ConditionsYield
With formic acid; C18H24ClIrN3 In water at 80℃; for 3h; Schlenk technique; Inert atmosphere; chemoselective reaction;97%
With formic acid; 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; sodium formate In water at 80℃; for 18h; pH=4.5; Inert atmosphere; chemoselective reaction;91%
With sodium tetrahydroborate In ethanol at 0 - 20℃;82%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

3-(4-fluorophenyl)-3-oxopropanamide

3-(4-fluorophenyl)-3-oxopropanamide

Conditions
ConditionsYield
With dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane at 20℃; Reagent/catalyst; Cooling with ice;97%
With sulfuric acid In water at 20℃;
With methanesulfonic acid In water at 65 - 70℃; for 3h;
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

C15H16O4

C15H16O4

C22H18FNO3

C22H18FNO3

Conditions
ConditionsYield
Stage #1: 3-(4-fluorophenyl)-3-oxopropionitrile With C33H28F5N3O2; potassium carbonate In toluene at 0℃; for 0.0833333h;
Stage #2: C15H16O4 In toluene at 0℃; for 48h; enantioselective reaction;
97%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

C15H16O4

C15H16O4

C22H18FNO3

C22H18FNO3

Conditions
ConditionsYield
With C33H28F5N3O2; potassium carbonate In toluene at 0℃; for 48h; enantioselective reaction;97%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

3-(4-fluorophenyl)-1H-pyrazol-5-amine
72411-52-0, 1242422-48-5

3-(4-fluorophenyl)-1H-pyrazol-5-amine

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 150℃; for 0.0833333h; Microwave irradiation;96%
With hydrazine hydrate In ethanol at 80℃; for 4h;33%
With hydrazine In ethanol for 12h; Reflux;
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

methyl benzylidenepyruvate
107969-78-8

methyl benzylidenepyruvate

methyl 5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate
1435943-40-0

methyl 5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate

Conditions
ConditionsYield
With C36H50N4O4; 4-(1,1-dimethylethyl)benzoic acid In tert-butyl methyl ether at -30℃; for 72h; Michael Addition; Molecular sieve; Inert atmosphere;96%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

2-(4-fluorophenyl)-benzothiazole
1629-26-1

2-(4-fluorophenyl)-benzothiazole

Conditions
ConditionsYield
at 200℃; for 0.166667h; Irradiation; microwave;95%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

(R)-3-(4'-fluorophenyl)-3-hydroxypropanenitrile

(R)-3-(4'-fluorophenyl)-3-hydroxypropanenitrile

Conditions
ConditionsYield
With formic acid; {Cp*Ir[(R,R)-C6F5SO2DPEN](H2O)}(SO4) In water at 20℃; for 24h; pH=3.5; optical yield given as %ee; enantioselective reaction;95%
With D-glucose; D-glucose dehydrogenase; NADPH; Candida magnoliae carbonyl reductase In phosphate buffer; dimethyl sulfoxide at 20℃; for 24h; pH=7.0;90%
With formic acid In water at 25℃; for 12h; pH=3.5; enantioselective reaction;n/a
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

p-toluidine
106-49-0

p-toluidine

3-(4-fluorophenyl)-3-(p-tolylamino)acrylonitrile
1159001-65-6

3-(4-fluorophenyl)-3-(p-tolylamino)acrylonitrile

Conditions
ConditionsYield
With acetic acid at 80℃; for 6h; optical yield given as %de;95%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

methyl benzylidenepyruvate
107969-78-8

methyl benzylidenepyruvate

(2S,4R)-methyl-5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate
1217974-60-1

(2S,4R)-methyl-5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate

Conditions
ConditionsYield
With (S)-1-(1-(4-(benzyloxy)phenyl)-3-(dimethylamino)propan-2-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea In diethyl ether at 20℃; for 12h; Michael addition; optical yield given as %ee; enantioselective reaction;95%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

cis-(±)-4-[(methoxycarbonyl)oxy]cyclohex-2-en-1-yl methyl carbonate

cis-(±)-4-[(methoxycarbonyl)oxy]cyclohex-2-en-1-yl methyl carbonate

(3aS,7aS)-2-(4-fluorophenyl)-3a,4,5,7a-tetrahydrobenzofuran-3-carbonitrile

(3aS,7aS)-2-(4-fluorophenyl)-3a,4,5,7a-tetrahydrobenzofuran-3-carbonitrile

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); C48H50N2O2P2Ru In 1,4-dioxane at 20℃; for 24h; Schlenk technique; Inert atmosphere; stereoselective reaction;95%
2-amino-5-chlorobenzenethiol
23474-98-8

2-amino-5-chlorobenzenethiol

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

6-chloro-2-(4-fluorophenyl)benzo[d]thiazole

6-chloro-2-(4-fluorophenyl)benzo[d]thiazole

Conditions
ConditionsYield
at 200℃; for 0.166667h; Irradiation; microwave;94%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

5-chloroindole 2,3-dione
17630-76-1

5-chloroindole 2,3-dione

malononitrile
109-77-3

malononitrile

2'-amino-5-chloro-6'-(4-fluorophenyl)-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

2'-amino-5-chloro-6'-(4-fluorophenyl)-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

Conditions
ConditionsYield
In ethanol; water at 20℃; Irradiation; Green chemistry;94%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

Cysteamine
60-23-1

Cysteamine

2-(4-fluorophenyl)-4,5-dihydrothiazole
96159-82-9

2-(4-fluorophenyl)-4,5-dihydrothiazole

Conditions
ConditionsYield
at 210℃; under 7757.43 Torr; for 0.166667h; microwave irradiation;93%
2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one
20718-17-6

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

(±)-5-fluoro-2-hydroxy-2,8-diphenyl-2,3-dihydrobenzo[de]chromene-9-carbonitrile

(±)-5-fluoro-2-hydroxy-2,8-diphenyl-2,3-dihydrobenzo[de]chromene-9-carbonitrile

Conditions
ConditionsYield
With Cp*Rh(OAc)2·H2O; water In 1,2-dichloro-ethane at 80℃; for 12h; Schlenk technique; Inert atmosphere;93%
5-nitroisatin
611-09-6

5-nitroisatin

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

malononitrile
109-77-3

malononitrile

2'-amino-6'-(4-fluorophenyl)-5-nitro-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

2'-amino-6'-(4-fluorophenyl)-5-nitro-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

Conditions
ConditionsYield
In ethanol; water at 20℃; Irradiation; Green chemistry;93%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

1-p-toluenesulfonyl-4-ethynyl-1,4-dihydro-2H-benzo[d][1,3]-azahexan-2-one

1-p-toluenesulfonyl-4-ethynyl-1,4-dihydro-2H-benzo[d][1,3]-azahexan-2-one

N-(2-(4-cyano-5-(4-fluorophenyl)-2-methylfuran-3-yl)phenyl)-4-methylbenzenesulfonamide

N-(2-(4-cyano-5-(4-fluorophenyl)-2-methylfuran-3-yl)phenyl)-4-methylbenzenesulfonamide

Conditions
ConditionsYield
With copper acetylacetonate; o-phenylenebis(diphenylphosphine); N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;93%
ethanol
64-17-5

ethanol

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

3-(4-Fluorphenyl)-3-oxo-propionimidsaeure-ethylester-hydrochlorid
81471-35-4

3-(4-Fluorphenyl)-3-oxo-propionimidsaeure-ethylester-hydrochlorid

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; chloroform; benzene Ambient temperature;92%
methanol
67-56-1

methanol

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

methyl (p-fluorobenzoyl)formate
156276-23-2

methyl (p-fluorobenzoyl)formate

Conditions
ConditionsYield
With oxygen In tetrahydrofuran at 20℃; for 24h; Irradiation;92%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

benzaldehyde
100-52-7

benzaldehyde

malononitrile
109-77-3

malononitrile

2-amino-6-(4-fluorophenyl)-4-phenyl-4H-pyran-3,5-dicarbonitrile

2-amino-6-(4-fluorophenyl)-4-phenyl-4H-pyran-3,5-dicarbonitrile

Conditions
ConditionsYield
In ethanol; water at 20℃; Irradiation; Green chemistry;92%
3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

indole-2,3-dione
91-56-5

indole-2,3-dione

malononitrile
109-77-3

malononitrile

2'-amino-6'-(4-fluorophenyl)-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

2'-amino-6'-(4-fluorophenyl)-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

Conditions
ConditionsYield
In ethanol; water at 20℃; Irradiation; Green chemistry;92%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3-(4-fluorophenyl)-3-oxopropionitrile
4640-67-9

3-(4-fluorophenyl)-3-oxopropionitrile

malononitrile
109-77-3

malononitrile

2'-amino-5-fluoro-6'-(4-fluorophenyl)-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

2'-amino-5-fluoro-6'-(4-fluorophenyl)-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarbonitrile

Conditions
ConditionsYield
In ethanol; water at 20℃; Irradiation; Green chemistry;92%
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