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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3alpha-Hydroxy-7-oxo-5beta-cholanic acid

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID (OCA-A) Cas 4651-67-6 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White Powder Package:1kg/foil ba

Chemical supplier 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID (OCA-A) Cas 4651-67-6 in Wuhan

Cas:4651-67-6

Min.Order:1 Gram

FOB Price: $55.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

3alpha-Hydroxy-7-oxo-5beta-cholic acid CAS No.:4651-67-6 Name: 3alpha-Hydroxy-7-oxo-5beta-cholic acid Synonyms: 7-Oxolithocholic acid; 7-keto-Lithocholic acid; NSC 226118; Nutriacholic acid Molecular Structure:

High purity 3alpha-Hydroxy-7-oxo-5beta-cholic acid CAS No.:4651-67-6

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-α-hydroxy-7-oxo-5-β-cholan-24-oic acid

Cas:4651-67-6

Min.Order:1

Negotiable

Type:Other

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Jinan Finer Chemical Co., Ltd

Product description: Product name 3alpha-Hydroxy-7-oxo-5beta-cholic acid CAS number 4651-67-6 Assay ≥99% Appearance White powder Capacity 20mt/year Application Pharmaceutical

3alpha-Hydroxy-7-oxo-5beta-cholic acid

Cas:4651-67-6

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID 4651-67-6 GMP Manufacturer

Cas:4651-67-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3alpha-Hydroxy-7-oxo-5beta-cholic acid

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3α-Hydroxy-7-ketocholanic acid

Cas:4651-67-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

3-Hydroxy-7-oxocholan-24-oic acid

Cas:4651-67-6

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--4651-67-6--3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established

TIANFUCHEM--4651-67-6--3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID factory price

Cas:4651-67-6

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3alpha-Hydroxy-7-oxo-5beta-cholanic Acid

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 4651-67-6 with best quality

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Obeticholic acid Intermediates//7-Ketolithocholic acid 4651-67-6

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $860.0 / 900.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acid 4651-67-6

Cas:4651-67-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $186.0 / 210.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3alpha-Hydroxy-7-oxo-5beta-cholanic Acid CAS:4651-67-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

3alpha-Hydroxy-7-oxo-5beta-cholanic Acid CAS:4651-67-6

Cas:4651-67-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acid

Cas:4651-67-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acid/ LIDE PHARMA- Factory supply / Best price

Cas:4651-67-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Obeticholic acid Intermediates//7-Ketolithocholic acid

Cas:4651-67-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID

Cas:4651-67-6

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Factory Manufacturer sales 7-KETOLITHOCHOLIC ACID CAS 4651-67-6

Cas:4651-67-6

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acid

Cas:4651-67-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic acid

Cas:4651-67-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic acid

Cas:4651-67-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID Synonyms: ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID;alpha-Hydroxy-7-oxo-5beta-cholic acid;7-KETOLITHOCHOLIC ACID;3ALPHA-HYDROXY-7-KETO-5BETA-CHOLANIC ACID;3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC A

Ocaliva intermediate 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID Manufactuered in China best quality

Cas:4651-67-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic acid

Cas:4651-67-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7-KETOLITHOCHOLIC ACID

Cas:4651-67-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acid

Cas:4651-67-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3α-hydroxy-7-keto-5β-chol-11-en-24-oic acid

3α-hydroxy-7-keto-5β-chol-11-en-24-oic acid

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 70℃; under 30003 Torr; for 12h;99%
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h;95%
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h;95%
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride In dichloromethane at -30℃; for 1.5h; Temperature; Swern Oxidation;98.6%
With sodium bromate; sulfuric acid; sodium bromide In dichloromethane at 20 - 30℃; for 6h;96.1%
With N-Bromosuccinimide In water; acetone at 20℃; for 2h; Darkness;94%
sodium chenodeoxycholate
2646-38-0

sodium chenodeoxycholate

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; Acinetobacter calcoaceticus lwoffii 7α-hydroxysteroid dehydrogenase; sodium pyruvate; NAD; 2-hydroxyethanethiol; lactate dehydrogenase In aq. phosphate buffer at 22℃; pH=8.5; Enzymatic reaction;97%
With Xanthomonas maltophilia BS6 broth In water at 30℃; for 48h;99 % Chromat.
chenodeoxycholic acid

chenodeoxycholic acid

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Stage #1: chenodeoxycholic acid With tartaric acid In methanol for 0.5h;
Stage #2: With sodium hypochlorite In methanol at 15 - 22℃; for 1h;
96.1%
7-ketolithocholic methyl ester
10538-59-7

7-ketolithocholic methyl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; methanol for 3h; Reflux;95%
With water; lithium hydroxide In tetrahydrofuran at 20℃; for 4h;74%
With water; sodium hydroxide In methanol for 2h; Solvent; Reflux;32 g
methyl 3α-acetoxy-7-oxo-5β-cholan-24-oate
10452-65-0

methyl 3α-acetoxy-7-oxo-5β-cholan-24-oate

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With methanol; sodium hydroxide In tetrahydrofuran for 3h; Reflux;95%
With water; sodium hydroxide In ethanol for 2h; Reflux;32 g
C42H52O7

C42H52O7

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With hydrogen In isopropyl alcohol at 50℃; under 22502.3 Torr; for 24h;95%
With hydrogen In isopropyl alcohol at 50℃; under 22502.3 Torr; for 24h;95%
chenodeoxycholic acid

chenodeoxycholic acid

A

3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

B

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Stage #1: chenodeoxycholic acid With tartaric acid In methanol for 0.5h;
Stage #2: With calcium hypochlorite In methanol at 15 - 22℃; for 1h;
A 5.13%
B 93.3%
C31H42O4

C31H42O4

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h;90%
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h;90%
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

A

3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

B

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With sodium bromate; ammonium cerium (IV) nitrate In water; acetonitrile at 60℃; for 0.5h; Green chemistry;A 9%
B 83%
Dodecanoic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-7-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
186649-60-5

Dodecanoic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-7-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 90℃; for 3h;79%
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

A

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

B

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With air; Xanthomonas maltophilia CBS 827.97 In sodium hydroxide at 30℃; for 4h; pH=8; epimerisation;A 27%
B 23%
With Xanthomonas maltophilia In water at 30℃; for 24h; pH=8; anaerobic;A 27%
B 23%
3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With ethanol; platinum Hydrogenation;
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

acetic acid
64-19-7

acetic acid

chromium (VI)-oxide

chromium (VI)-oxide

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

acetic acid
64-19-7

acetic acid

chromium (VI)-oxide

chromium (VI)-oxide

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

acetone
67-64-1

acetone

K2cro4

K2cro4

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

acetic acid
64-19-7

acetic acid

acetone
67-64-1

acetone

K2cro4

K2cro4

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

preparation of 3α-hydroxy-7-oxo-5β-<24-14C>cholan-24-oic acid

preparation of 3α-hydroxy-7-oxo-5β-<24-14C>cholan-24-oic acid

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

ethanol
64-17-5

ethanol

3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

platinum

platinum

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Hydrogenation;
chenodeoxycholic acid methyl ester
3057-04-3

chenodeoxycholic acid methyl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100
2: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
3: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C
View Scheme
methyl cholate
1448-36-8

methyl cholate

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 100 percent / 20 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100
2: 91 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 1 h / 0 °C
3: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
4: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether
5: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100
6: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
7: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dmap / toluene / 20 °C / Large scale
1.2: 19 h / 20 °C / Large scale
2.1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / Large scale
3.1: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 4 h / 120 - 210 °C / Large scale
4.1: sulfuric acid; sodium bromide; sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1: pyridine
2: chromium(VI) oxide
3: Alkaline conditions
5: nicotinamide adenine dinucleotide phosphate; 7α-hydroxysteroid dehydrogenase / Enzymatic reaction
View Scheme
Dodecanoic acid (3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
186649-59-2

Dodecanoic acid (3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
2: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C
View Scheme
Dodecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
151112-03-7

Dodecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 91 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 1 h / 0 °C
2: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
3: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether
4: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100
5: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
6: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C
View Scheme
Dodecanoic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7-acetoxy-12-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
186649-57-0

Dodecanoic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7-acetoxy-12-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
2: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether
3: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100
4: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
5: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C
View Scheme
Dodecanoic acid (3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-acetoxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
186649-58-1

Dodecanoic acid (3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-acetoxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether
2: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100
3: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
4: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C
View Scheme
methyl 5β-3α-ethoxycarbonyloxy-7-carbonylcholanate
96475-64-8

methyl 5β-3α-ethoxycarbonyloxy-7-carbonylcholanate

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With potassium hydroxide; water for 1h; Reflux;
Lithocholic acid
434-13-9

Lithocholic acid

A

Deoxycholic acid
83-44-3

Deoxycholic acid

B

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

C

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

D

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

E

ursocholic acid
2955-27-3

ursocholic acid

Conditions
ConditionsYield
With Saccharothrix longispora VKM Ac-1265 In methanol; aq. phosphate buffer pH=7; Microbiological reaction;
methyl 3α,7α-diacetoxy-12α-hydroxy cholanate
3749-87-9

methyl 3α,7α-diacetoxy-12α-hydroxy cholanate

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / Large scale
2: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 4 h / 120 - 210 °C / Large scale
3: sulfuric acid; sodium bromide; sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1: chromium(VI) oxide
2: Alkaline conditions
4: nicotinamide adenine dinucleotide phosphate; 7α-hydroxysteroid dehydrogenase / Enzymatic reaction
View Scheme
methanol
67-56-1

methanol

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

7-ketolithocholic methyl ester
10538-59-7

7-ketolithocholic methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 20℃; for 2h;100%
With sulfuric acid for 1h; Reflux;99%
With hydrogenchloride In water for 4h; Reflux;98%
ethanol
64-17-5

ethanol

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

3α-hydroxy-7-oxo-5β-cholan-24-oic acid ethyl ester
126432-25-5

3α-hydroxy-7-oxo-5β-cholan-24-oic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid for 10h; Reflux;98.4%
With toluene-4-sulfonic acid for 1h; Reflux;93.1%
With sulfuric acid at 80℃; for 5h;86%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

benzyl bromide
100-39-0

benzyl bromide

3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester
1352328-64-3

3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With potassium carbonate In tetrahydrofuran for 1h; Reflux;
Stage #2: benzyl bromide In tetrahydrofuran for 12h;
98.1%
With triethylamine In toluene at 111℃; for 5h;88%
With potassium carbonate In tetrahydrofuran for 12h; Reflux;82.8%
Stage #1: 7-Ketolithocholic acid With caesium carbonate In acetonitrile at 150℃; Inert atmosphere;
Stage #2: benzyl bromide In acetonitrile for 24h; Inert atmosphere; Reflux;
1.5 g
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With glucose dehydrogenase; D-Glucose; NADPH; 7β-hydroxysteroid dehydrogenase In aq. phosphate buffer at 30℃; for 1h; pH=8; Concentration; pH-value; Enzymatic reaction;98%
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In aq. phosphate buffer at 37℃; pH=7;93%
With potassium borohydride; potassium tert-butylate In isopropyl alcohol at 40℃; for 24h;92%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

3α-hydroxy-7-oxo-5β-cholanoic acid trimethylsilylethyl ester

3α-hydroxy-7-oxo-5β-cholanoic acid trimethylsilylethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 16h;97.1%
9-Fluorenylmethanol
24324-17-2

9-Fluorenylmethanol

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

C38H48O4

C38H48O4

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 16h;97.1%
chloro-methylsulfanyl-methane
2373-51-5

chloro-methylsulfanyl-methane

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

3α-hydroxy-7-oxo-5β-cholanoic acid methylthiomethyl ester

3α-hydroxy-7-oxo-5β-cholanoic acid methylthiomethyl ester

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With potassium hydroxide In ethanol at 20℃; for 2h;
Stage #2: chloro-methylsulfanyl-methane With 18-crown-6 ether; sodium iodide In toluene for 12h; Reflux;
97.1%
2-chlorotetrahydrofuran
13369-70-5

2-chlorotetrahydrofuran

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

3α-hydroxy-7-oxo-5β-cholanoic acid 2-tetrahydrofuranyl ester

3α-hydroxy-7-oxo-5β-cholanoic acid 2-tetrahydrofuranyl ester

Conditions
ConditionsYield
With triethylamine at 50℃; for 8h;96.2%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With potassium tert-butylate; palladium(II) hydroxide; potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h;
Stage #2: With hydrogen In isopropyl alcohol at 40 - 80℃; Reagent/catalyst; Temperature;
A n/a
B 95%
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 20℃; for 0.5h; var. reducing agents;A 94%
B 2%
With potassium In tert-butyl alcohol for 0.5h; Heating; var. reducing agents;A 6%
B 94%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

benzyl chloride
100-44-7

benzyl chloride

3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester
1352328-64-3

3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃;95%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

C32H48N2O3

C32H48N2O3

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With oxalyl dichloride In dichloromethane at 0 - 10℃; for 3h;
Stage #2: N,N-dimethyl-aniline With triethylamine In dichloromethane at 20℃; Reagent/catalyst;
94%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0℃; for 2h;93%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

Conditions
ConditionsYield
In acetone Jones oxidation;92%
With chromium(VI) oxide; acetic acid
1-methyl-piperazine
109-01-3

1-methyl-piperazine

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

C29H48N2O3

C29H48N2O3

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With oxalyl dichloride In dichloromethane at 0 - 10℃; for 3h;
Stage #2: 1-methyl-piperazine With triethylamine In dichloromethane at 20℃; Reagent/catalyst;
92%
piperidine
110-89-4

piperidine

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

7-keto-lithocholic acid 3-N,N’-pentamethylenocarbamoyl piperidine

7-keto-lithocholic acid 3-N,N’-pentamethylenocarbamoyl piperidine

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid; 1,1'-carbonyldiimidazole In dichloromethane for 1h; Inert atmosphere;
Stage #2: piperidine In dichloromethane; water for 1h; Inert atmosphere;
92%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

C48H76N2O6

C48H76N2O6

Conditions
ConditionsYield
With hydrazine hydrate In acetic acid at 20℃; for 24h;91%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

benzyl chloride
100-44-7

benzyl chloride

3-α-benzyl ether-7-keto-5β-cholanic acid benzyl ester

3-α-benzyl ether-7-keto-5β-cholanic acid benzyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 7h;91%
Stage #1: 7-Ketolithocholic acid With triethylamine In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: benzyl chloride In tetrahydrofuran at 20℃; for 2h; Time;
71.9%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Lithocholic acid
434-13-9

Lithocholic acid

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With hydrazine hydrate In diethylene glycol at 120℃; for 2h;
Stage #2: With potassium hydroxide at 70 - 200℃; for 6h;
91%
Benzyloxymethyl chloride
3587-60-8

Benzyloxymethyl chloride

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

3α-hydroxy-7-oxo-5β-cholanoic acid benzyloxymethyl ester

3α-hydroxy-7-oxo-5β-cholanoic acid benzyloxymethyl ester

Conditions
ConditionsYield
With sodium hydroxide In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 48h;90.7%
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