Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:4651-67-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryUnique advantages for 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID (OCA-A) Cas 4651-67-6 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White Powder Package:1kg/foil ba
Cas:4651-67-6
Min.Order:1 Gram
FOB Price: $55.0
Type:Trading Company
inquiry3alpha-Hydroxy-7-oxo-5beta-cholic acid CAS No.:4651-67-6 Name: 3alpha-Hydroxy-7-oxo-5beta-cholic acid Synonyms: 7-Oxolithocholic acid; 7-keto-Lithocholic acid; NSC 226118; Nutriacholic acid Molecular Structure:
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:4651-67-6
Min.Order:1
Negotiable
Type:Other
inquiryProduct description: Product name 3alpha-Hydroxy-7-oxo-5beta-cholic acid CAS number 4651-67-6 Assay ≥99% Appearance White powder Capacity 20mt/year Application Pharmaceutical
Cas:4651-67-6
Min.Order:10 Gram
FOB Price: $12.0
Type:Lab/Research institutions
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:4651-67-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $5.0 / 10.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:4651-67-6
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cas:4651-67-6
Min.Order:1000 Gram
FOB Price: $500.0
Type:Trading Company
inquiryTIANFUCHEM--4651-67-6--3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established
Cas:4651-67-6
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $50.0 / 100.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:4651-67-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $860.0 / 900.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:4651-67-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $186.0 / 210.0
Type:Trading Company
inquiry3alpha-Hydroxy-7-oxo-5beta-cholanic Acid CAS:4651-67-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q
Cas:4651-67-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:4651-67-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:4651-67-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:4651-67-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:4651-67-6
Min.Order:1 Kilogram
FOB Price: $30.0 / 50.0
Type:Lab/Research institutions
inquiryPRODUCT DETAILS
Cas:4651-67-6
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:4651-67-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:4651-67-6
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai
Cas:4651-67-6
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID Synonyms: ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID;alpha-Hydroxy-7-oxo-5beta-cholic acid;7-KETOLITHOCHOLIC ACID;3ALPHA-HYDROXY-7-KETO-5BETA-CHOLANIC ACID;3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC A
Cas:4651-67-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:4651-67-6
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:4651-67-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:4651-67-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry7-Ketolithocholic acid
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 70℃; under 30003 Torr; for 12h; | 99% |
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h; | 95% |
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h; | 95% |
Conditions | Yield |
---|---|
With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride In dichloromethane at -30℃; for 1.5h; Temperature; Swern Oxidation; | 98.6% |
With sodium bromate; sulfuric acid; sodium bromide In dichloromethane at 20 - 30℃; for 6h; | 96.1% |
With N-Bromosuccinimide In water; acetone at 20℃; for 2h; Darkness; | 94% |
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; Acinetobacter calcoaceticus lwoffii 7α-hydroxysteroid dehydrogenase; sodium pyruvate; NAD; 2-hydroxyethanethiol; lactate dehydrogenase In aq. phosphate buffer at 22℃; pH=8.5; Enzymatic reaction; | 97% |
With Xanthomonas maltophilia BS6 broth In water at 30℃; for 48h; | 99 % Chromat. |
7-Ketolithocholic acid
Conditions | Yield |
---|---|
Stage #1: chenodeoxycholic acid With tartaric acid In methanol for 0.5h; Stage #2: With sodium hypochlorite In methanol at 15 - 22℃; for 1h; | 96.1% |
7-ketolithocholic methyl ester
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; methanol for 3h; Reflux; | 95% |
With water; lithium hydroxide In tetrahydrofuran at 20℃; for 4h; | 74% |
With water; sodium hydroxide In methanol for 2h; Solvent; Reflux; | 32 g |
methyl 3α-acetoxy-7-oxo-5β-cholan-24-oate
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With methanol; sodium hydroxide In tetrahydrofuran for 3h; Reflux; | 95% |
With water; sodium hydroxide In ethanol for 2h; Reflux; | 32 g |
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With hydrogen In isopropyl alcohol at 50℃; under 22502.3 Torr; for 24h; | 95% |
With hydrogen In isopropyl alcohol at 50℃; under 22502.3 Torr; for 24h; | 95% |
Conditions | Yield |
---|---|
Stage #1: chenodeoxycholic acid With tartaric acid In methanol for 0.5h; Stage #2: With calcium hypochlorite In methanol at 15 - 22℃; for 1h; | A 5.13% B 93.3% |
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h; | 90% |
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 70℃; under 30003 Torr; for 8h; | 90% |
chenodeoxycholic acid
A
3,7-diketocholanic acid
B
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With sodium bromate; ammonium cerium (IV) nitrate In water; acetonitrile at 60℃; for 0.5h; Green chemistry; | A 9% B 83% |
Dodecanoic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-7-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 90℃; for 3h; | 79% |
Conditions | Yield |
---|---|
With air; Xanthomonas maltophilia CBS 827.97 In sodium hydroxide at 30℃; for 4h; pH=8; epimerisation; | A 27% B 23% |
With Xanthomonas maltophilia In water at 30℃; for 24h; pH=8; anaerobic; | A 27% B 23% |
Conditions | Yield |
---|---|
With ethanol; platinum Hydrogenation; |
Conditions | Yield |
---|---|
With chromium(VI) oxide; acetic acid |
N-Bromosuccinimide
chenodeoxycholic acid
acetone
7-Ketolithocholic acid
7-Ketolithocholic acid
ethanol
3,7-diketocholanic acid
A
chenodeoxycholic acid
B
7-Ketolithocholic acid
Conditions | Yield |
---|---|
Hydrogenation; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 2: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 3: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 100 percent / 20 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 2: 91 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 1 h / 0 °C 3: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 4: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 5: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 6: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 7: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: dmap / toluene / 20 °C / Large scale 1.2: 19 h / 20 °C / Large scale 2.1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / Large scale 3.1: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 4 h / 120 - 210 °C / Large scale 4.1: sulfuric acid; sodium bromide; sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / Large scale View Scheme | |
Multi-step reaction with 5 steps 1: pyridine 2: chromium(VI) oxide 3: Alkaline conditions 5: nicotinamide adenine dinucleotide phosphate; 7α-hydroxysteroid dehydrogenase / Enzymatic reaction View Scheme |
Dodecanoic acid (3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
7-Ketolithocholic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 2: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme |
Dodecanoic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
7-Ketolithocholic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 91 percent / pyridine, 4-(N,N-dimethylamino)pyridine / 1 h / 0 °C 2: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 3: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 4: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 5: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 6: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme |
Dodecanoic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7-acetoxy-12-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
7-Ketolithocholic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 100 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 2: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 3: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 4: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 5: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme |
Dodecanoic acid (3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-acetoxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
7-Ketolithocholic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1) aq. NaOH, hydrazine hydrate / 1) diethylene glycol, 100 deg C, 2 h, 2) CH2Cl2, ether 2: 100 percent / 48 h / 60 °C / 8 Torr / Candida antarctica lipase immobilized on Florisil with Triton X-100 3: 95 percent / Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature 4: 79 percent / NaOH / ethanol; H2O / 3 h / 90 °C View Scheme |
methyl 5β-3α-ethoxycarbonyloxy-7-carbonylcholanate
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With potassium hydroxide; water for 1h; Reflux; |
Lithocholic acid
A
Deoxycholic acid
B
chenodeoxycholic acid
C
ursodeoxycholic acid
D
7-Ketolithocholic acid
E
ursocholic acid
Conditions | Yield |
---|---|
With Saccharothrix longispora VKM Ac-1265 In methanol; aq. phosphate buffer pH=7; Microbiological reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; sodium hypochlorite / ethyl acetate / 30 - 40 °C / Large scale 2: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 4 h / 120 - 210 °C / Large scale 3: sulfuric acid; sodium bromide; sodium bromate; water / butan-1-ol; dichloromethane / 0 - 55 °C / Large scale View Scheme | |
Multi-step reaction with 4 steps 1: chromium(VI) oxide 2: Alkaline conditions 4: nicotinamide adenine dinucleotide phosphate; 7α-hydroxysteroid dehydrogenase / Enzymatic reaction View Scheme |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid at 20℃; for 2h; | 100% |
With sulfuric acid for 1h; Reflux; | 99% |
With hydrogenchloride In water for 4h; Reflux; | 98% |
ethanol
7-Ketolithocholic acid
3α-hydroxy-7-oxo-5β-cholan-24-oic acid ethyl ester
Conditions | Yield |
---|---|
With sulfuric acid for 10h; Reflux; | 98.4% |
With toluene-4-sulfonic acid for 1h; Reflux; | 93.1% |
With sulfuric acid at 80℃; for 5h; | 86% |
7-Ketolithocholic acid
benzyl bromide
3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid With potassium carbonate In tetrahydrofuran for 1h; Reflux; Stage #2: benzyl bromide In tetrahydrofuran for 12h; | 98.1% |
With triethylamine In toluene at 111℃; for 5h; | 88% |
With potassium carbonate In tetrahydrofuran for 12h; Reflux; | 82.8% |
Stage #1: 7-Ketolithocholic acid With caesium carbonate In acetonitrile at 150℃; Inert atmosphere; Stage #2: benzyl bromide In acetonitrile for 24h; Inert atmosphere; Reflux; | 1.5 g |
Conditions | Yield |
---|---|
With glucose dehydrogenase; D-Glucose; NADPH; 7β-hydroxysteroid dehydrogenase In aq. phosphate buffer at 30℃; for 1h; pH=8; Concentration; pH-value; Enzymatic reaction; | 98% |
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In aq. phosphate buffer at 37℃; pH=7; | 93% |
With potassium borohydride; potassium tert-butylate In isopropyl alcohol at 40℃; for 24h; | 92% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 16h; | 97.1% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 16h; | 97.1% |
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid With potassium hydroxide In ethanol at 20℃; for 2h; Stage #2: chloro-methylsulfanyl-methane With 18-crown-6 ether; sodium iodide In toluene for 12h; Reflux; | 97.1% |
2-chlorotetrahydrofuran
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With triethylamine at 50℃; for 8h; | 96.2% |
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid With potassium tert-butylate; palladium(II) hydroxide; potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h; Stage #2: With hydrogen In isopropyl alcohol at 40 - 80℃; Reagent/catalyst; Temperature; | A n/a B 95% |
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 20℃; for 0.5h; var. reducing agents; | A 94% B 2% |
With potassium In tert-butyl alcohol for 0.5h; Heating; var. reducing agents; | A 6% B 94% |
7-Ketolithocholic acid
benzyl chloride
3α-hydroxy-7-keto-5β-24-cholanic acid benzyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; | 95% |
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid With oxalyl dichloride In dichloromethane at 0 - 10℃; for 3h; Stage #2: N,N-dimethyl-aniline With triethylamine In dichloromethane at 20℃; Reagent/catalyst; | 94% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0℃; for 2h; | 93% |
Conditions | Yield |
---|---|
In acetone Jones oxidation; | 92% |
With chromium(VI) oxide; acetic acid |
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid With oxalyl dichloride In dichloromethane at 0 - 10℃; for 3h; Stage #2: 1-methyl-piperazine With triethylamine In dichloromethane at 20℃; Reagent/catalyst; | 92% |
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid; 1,1'-carbonyldiimidazole In dichloromethane for 1h; Inert atmosphere; Stage #2: piperidine In dichloromethane; water for 1h; Inert atmosphere; | 92% |
7-Ketolithocholic acid
Conditions | Yield |
---|---|
With hydrazine hydrate In acetic acid at 20℃; for 24h; | 91% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 7h; | 91% |
Stage #1: 7-Ketolithocholic acid With triethylamine In tetrahydrofuran at 20℃; for 0.5h; Stage #2: benzyl chloride In tetrahydrofuran at 20℃; for 2h; Time; | 71.9% |
Conditions | Yield |
---|---|
Stage #1: 7-Ketolithocholic acid With hydrazine hydrate In diethylene glycol at 120℃; for 2h; Stage #2: With potassium hydroxide at 70 - 200℃; for 6h; | 91% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 48h; | 90.7% |
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