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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl Ethylmalonate supplier in China

Cas:133-13-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Diethyl 2-Ethylmalonate

Cas:133-13-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethylmalonic acid diethyl ester

Cas:133-13-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--133-13-1--Diethyl ethylmalonate factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business r

TIANFUCHEM--133-13-1--Diethyl ethylmalonate factory price

Cas:133-13-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

133-13-1 Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 133-13-1 with fast shipping

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Diethyl ethylmalonate CAS133-13-1

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name:Diethyl ethylmalonate CAS No:133-13-1 Appearance: colorless liquid Content:98% Appearance:colorless liquid Storage:Preserve in well-closed, light-resistant and airtight containers

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Propanedioicacid, 2-ethyl-, 1,3-diethyl ester 133-13-1

Cas:133-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Diethyl ethylmalonate 99%

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $12.0 / 20.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanedioicacid, 2-ethyl-, 1,3-diethyl ester

Cas:133-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl Ethylmalonate

Cas:133-13-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance: colorless transparent liquid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common produc

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Diethyl ethylmalonate CAS 133-13-1

Cas:133-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:CLEAR COLOURLESS LIQUID Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Drug

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

Diethyl ethylmalonateCAS NO.: 133-13-1

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Diethyl ethylmalonate Basic information Product Name: Diethyl ethylmalonate Synonyms: Diethyl 2-ethylmalonate;Ethylethylmalonate;Ethylmalonicacid,diethylest;DIETHYL ETHYLMALONATE FOR SYNTHESIS;Ethyl Malonic acidethyl ester two;Diethyl EthylMal

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

133-13-1 CAS NO.133-13-1

Cas:133-13-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

Diethyl ethylmalonateAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Diethyl ethylmalonate

Cas:133-13-1

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

ethyl iodide
75-03-6

ethyl iodide

diethyl malonate
105-53-3

diethyl malonate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With P(MeNCH2CH2)3N In hexane; acetonitrile at 25℃; for 0.5h;92%
With silver(l) oxide
With ethanol; magnesium ethylate
ethyl bromide
74-96-4

ethyl bromide

diethyl malonate
105-53-3

diethyl malonate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride In N,N-dimethyl-formamide at 60℃; for 4h;90%
With potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride In N,N-dimethyl-formamide at 60℃; for 4h; Product distribution; other solvent, other temperature, other reaction time;90%
With sodium acetylide In benzene at 20 - 25℃; for 0.5h; further reagent (sodium phenylacetylide);89%
diethyl cyclopropane-1,1-dicarboxylate
1559-02-0

diethyl cyclopropane-1,1-dicarboxylate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With samarium diiodide; tris(dibenzoylmethano)iron(III); tert-butyl alcohol In tetrahydrofuran for 0.5h; Ambient temperature;89%
With hydrogen; palladium on activated charcoal In methanol Product distribution;
With (5,10,15,20-tetrakis-4-tolylporphyrinato)(methyl)rhodium(III); isopropyl alcohol In benzene-d6 at 200℃; for 48h; Darkness; Sealed tube; regioselective reaction;14 %Spectr.
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

BuMnCl
88626-90-8

BuMnCl

A

diethyl (1-methyl-pentyl)malonate
82297-04-9

diethyl (1-methyl-pentyl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;A 87%
B 6%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

butyl-iodo-manganese
62485-87-4

butyl-iodo-manganese

A

diethyl (1-methyl-pentyl)malonate
82297-04-9

diethyl (1-methyl-pentyl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In diethyl ether at -30℃; for 2h;A 83%
B 11%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

C12H27Mn(1-)*Cl(1-)*Mg(2+)

C12H27Mn(1-)*Cl(1-)*Mg(2+)

A

diethyl (1-methyl-pentyl)malonate
82297-04-9

diethyl (1-methyl-pentyl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;A 82%
B 12%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

C12H27Mn

C12H27Mn

A

diethyl (1-methyl-pentyl)malonate
82297-04-9

diethyl (1-methyl-pentyl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;A 82%
B 8%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

lithium tri-n-butylmanganate

lithium tri-n-butylmanganate

A

diethyl (1-methyl-pentyl)malonate
82297-04-9

diethyl (1-methyl-pentyl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;A 80%
B 7%
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

methylaluminum dichloride
917-65-7

methylaluminum dichloride

A

diethyl isopropylmalonate
759-36-4

diethyl isopropylmalonate

B

diethyl (1-methyl-pentyl)malonate
82297-04-9

diethyl (1-methyl-pentyl)malonate

C

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
Stage #1: n-butyllithium; methylaluminum dichloride In hexane; toluene at -40℃; for 1h; Substitution;
Stage #2: With boron trifluoride diethyl etherate In hexane; toluene for 1h; Addition;
Stage #3: diethyl ethylidenemalonate In hexane; toluene at -40℃; for 18h; Reduction; Michael addition;
A 7 % Chromat.
B 74%
C 6 % Chromat.
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

C3H7ClMn
105486-13-3

C3H7ClMn

A

diethyl 2-(3-methylbutan-2-yl)malonate
759-29-5

diethyl 2-(3-methylbutan-2-yl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;A 70%
B 11%
bronidox
30007-47-7

bronidox

C9H15LiO4

C9H15LiO4

A

5-(1,3-dioxa-5-cyclohexylidene)-1,3-dioxane
86251-75-4

5-(1,3-dioxa-5-cyclohexylidene)-1,3-dioxane

B

5-nitro-5-(5-nitro-1,3-dioxa-5-cyclohexyl)-1,3-dioxacyclohexane
86251-74-3

5-nitro-5-(5-nitro-1,3-dioxa-5-cyclohexyl)-1,3-dioxacyclohexane

C

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

D

diethyl ethyl(5-nitro-1,3-dioxan-5-yl)malonate

diethyl ethyl(5-nitro-1,3-dioxan-5-yl)malonate

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 12h; Yield given;A n/a
B 11%
C n/a
D 67%
In dimethyl sulfoxide at 20℃; for 12h;A n/a
B 11%
C n/a
D 67%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

tert.-butyl lithium
594-19-4

tert.-butyl lithium

methylaluminum dichloride
917-65-7

methylaluminum dichloride

A

diethyl isopropylmalonate
759-36-4

diethyl isopropylmalonate

B

diethyl 2-(3,3-dimethylbutan-2-yl)malonate
125001-54-9

diethyl 2-(3,3-dimethylbutan-2-yl)malonate

C

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
Stage #1: tert.-butyl lithium; methylaluminum dichloride In hexane; toluene; pentane at -40℃; for 1h; Substitution;
Stage #2: With boron trifluoride diethyl etherate In hexane; toluene; pentane for 1h; Addition;
Stage #3: diethyl ethylidenemalonate In hexane; toluene; pentane at -40℃; Reduction; Michael addition;
A 2 % Chromat.
B 66%
C 6 % Chromat.
hex-3-yne
928-49-4

hex-3-yne

diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

A

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

B

diethyl (E-2-ethyl-1-methyl-pent-2-enyl)malonate

diethyl (E-2-ethyl-1-methyl-pent-2-enyl)malonate

Conditions
ConditionsYield
Stage #1: hex-3-yne With diisobutylaluminium hydride In n-heptane; toluene at 50℃; for 3h; Addition;
Stage #2: diethyl ethylidenemalonate In n-heptane; toluene at -40℃; for 18h; Michael addition;
A 21 % Chromat.
B 43%
4-O,O-t-butyl 1-ethyl 2-(ethoxycarbonyl)monoperoxybutanedioate
89317-62-4

4-O,O-t-butyl 1-ethyl 2-(ethoxycarbonyl)monoperoxybutanedioate

A

ethyl 3-(t-butoxy)-2-(ethoxycarbonyl)propionate
91368-88-6

ethyl 3-(t-butoxy)-2-(ethoxycarbonyl)propionate

B

diethyl (cyclohexylmethyl)propanedioate
29805-59-2

diethyl (cyclohexylmethyl)propanedioate

C

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

D

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

E

2-(tert-butoxy)butanedioic acid diethyl ester

2-(tert-butoxy)butanedioic acid diethyl ester

Conditions
ConditionsYield
In cyclohexane Ambient temperature; Irradiation; photolysis of further t-butyl percarboxylates in various solvents;A 40.8%
B n/a
C 1.3%
D 37%
E 1.7%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

t-butylmanganese chloride
125001-53-8

t-butylmanganese chloride

A

diethyl 2-(3,3-dimethylbutan-2-yl)malonate
125001-54-9

diethyl 2-(3,3-dimethylbutan-2-yl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;A 10%
B 40%
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

A

diethyl 2-(3,3-dimethylbutan-2-yl)malonate
125001-54-9

diethyl 2-(3,3-dimethylbutan-2-yl)malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With t-butylmanganese chloride In tetrahydrofuran at -30℃; for 2h; var. organomanganeses.;A 10%
B 40%
2-Ethyl-2-(2-phenylsulfanyl-acetyl)-malonic acid diethyl ester
93845-20-6

2-Ethyl-2-(2-phenylsulfanyl-acetyl)-malonic acid diethyl ester

A

diethyl (acetyl)ethylmalonate
3378-01-6

diethyl (acetyl)ethylmalonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With nickel In acetoneA 20%
B 24%
2-acetylpropanoic acid ethyl ester
609-14-3

2-acetylpropanoic acid ethyl ester

ethyl 2-bromopropanedioic acid diethyl ester
29237-78-3

ethyl 2-bromopropanedioic acid diethyl ester

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

ethyl bromide
74-96-4

ethyl bromide

sodium diethylmalonate
996-82-7

sodium diethylmalonate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl sulfate
64-67-5

diethyl sulfate

sodium diethylmalonate
996-82-7

sodium diethylmalonate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-Ethyl-3-oxo-succinic acid diethyl ester
26103-77-5

2-Ethyl-3-oxo-succinic acid diethyl ester

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
at 160℃;
ethanol
64-17-5

ethanol

2-ethyl-3-oxo-acrylic acid ethyl ester
24489-48-3

2-ethyl-3-oxo-acrylic acid ethyl ester

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

ethanol
64-17-5

ethanol

propane-1,1,1-tricarboxylic acid triethyl ester
16515-91-6

propane-1,1,1-tricarboxylic acid triethyl ester

sodium ethanolate
141-52-6

sodium ethanolate

A

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

B

Diethyl carbonate
105-58-8

Diethyl carbonate

ethanol
64-17-5

ethanol

ethyl-malonyl bromide
98024-97-6

ethyl-malonyl bromide

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

ethanol
64-17-5

ethanol

1,3-diethyl-2,4-dioxo-cyclobutane-1,3-dicarboxylic acid diethyl ester
36832-92-5

1,3-diethyl-2,4-dioxo-cyclobutane-1,3-dicarboxylic acid diethyl ester

sodium ethanolate
141-52-6

sodium ethanolate

A

monoethyl DL-ethyl-malonate
69923-74-6, 2985-34-4

monoethyl DL-ethyl-malonate

B

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-ethyl-3-oxo-acrylic acid ethyl ester
24489-48-3

2-ethyl-3-oxo-acrylic acid ethyl ester

sodium methylate
124-41-4

sodium methylate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With diethyl ether; nickel under 73550.8 - 95616 Torr;
With ethanol; nickel under 73550.8 - 95616 Torr;
With palladium Hydrogenation;
ethyl propionyl-2-diazoacetate
2009-98-5

ethyl propionyl-2-diazoacetate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
at 250℃;
ethyl bromide
74-96-4

ethyl bromide

sodium ethanolate
141-52-6

sodium ethanolate

ethyl acetoacetate
141-97-9

ethyl acetoacetate

diethyl malonate
105-53-3

diethyl malonate

A

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

B

ethyl 2-ethyl-3-oxobutanoate
607-97-6

ethyl 2-ethyl-3-oxobutanoate

sodium diethylmalonate
996-82-7, 34727-00-9, 73177-21-6

sodium diethylmalonate

ethyl iodide
75-03-6

ethyl iodide

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

Conditions
ConditionsYield
With diethyl ether
With ethanol
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

monoethyl DL-ethyl-malonate
69923-74-6, 2985-34-4

monoethyl DL-ethyl-malonate

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With potassium hydroxide; water In ethanol
Stage #2: With hydrogenchloride In water pH=2;
100%
With hydrogenchloride; potassium hydroxide 1.) EtOH, room temp.; overnight;95%
With potassium hydroxide In ethanol for 24h; Ambient temperature;73%
linolenyl tosylate
66605-62-7

linolenyl tosylate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

ethyl (all-Z)-2-ethyl-2-ethoxycarbonyl-11,14,17-eicosatrienoate
1022975-94-5

ethyl (all-Z)-2-ethyl-2-ethoxycarbonyl-11,14,17-eicosatrienoate

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;
Stage #2: linolenyl tosylate With sodium iodide In tetrahydrofuran; N,N-dimethyl-formamide at 70℃; for 2h;
100%
1-(methyl)-thiourea
598-52-7

1-(methyl)-thiourea

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

5-ethyl-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

5-ethyl-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Conditions
ConditionsYield
With sodium methylate In methanol for 16h; Reflux;99%
benzyl 2-fluoro-5-nitrobenzyl(methyl)carbamate
1508298-05-2

benzyl 2-fluoro-5-nitrobenzyl(methyl)carbamate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-(2-((((benzyloxy)carbonyl)(methyl)amino)methyl)-4-nitrophenyl)-2-ethylmalonate
1508295-78-0

diethyl 2-(2-((((benzyloxy)carbonyl)(methyl)amino)methyl)-4-nitrophenyl)-2-ethylmalonate

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With sodium hydride In dimethyl sulfoxide at 20℃; for 0.333333h;
Stage #2: benzyl 2-fluoro-5-nitrobenzyl(methyl)carbamate In dimethyl sulfoxide at 65℃;
98%
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

4-Allyloxymethylbenzyl chloride
350671-26-0

4-Allyloxymethylbenzyl chloride

Diethyl 2-(4-allyloxymethylbenzyl)-2-ethylmalonate
350671-27-1

Diethyl 2-(4-allyloxymethylbenzyl)-2-ethylmalonate

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With potassium tert-butylate In toluene for 0.5h; Heating;
Stage #2: 4-Allyloxymethylbenzyl chloride In toluene for 6.5h; Heating;
97.7%
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

epichlorohydrin
106-89-8

epichlorohydrin

2-carbethoxy-2-ethyl-4-(chloromethyl)butyrolactone
94958-06-2

2-carbethoxy-2-ethyl-4-(chloromethyl)butyrolactone

Conditions
ConditionsYield
With potassium tert-butylate for 12h; Heating;97%
With ethanol; sodium ethanolate Behandeln des Reaktionsgemisches mit wss. Salzsaeure;
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-nitro-N-(phenyl-λ3-iodaneylidene)benzenesulfonamide
149552-41-0

2-nitro-N-(phenyl-λ3-iodaneylidene)benzenesulfonamide

C15H18N2O8S

C15H18N2O8S

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 18h;97%
2-Methylpyrimido<1,6-a>benzimidazole-1,3-(2H,5H)-dione
94447-78-6

2-Methylpyrimido<1,6-a>benzimidazole-1,3-(2H,5H)-dione

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

4-Hydroxy-2-methyl-5-ethyl-1H,6H-2,6a,10b-triazafluoranthene-1,3,6(2H)-trione
136296-03-2

4-Hydroxy-2-methyl-5-ethyl-1H,6H-2,6a,10b-triazafluoranthene-1,3,6(2H)-trione

Conditions
ConditionsYield
With trichlorophenol at 280℃; for 0.5h;96%
tetrabutylammonium chloride monohydrate

tetrabutylammonium chloride monohydrate

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-chloro-2-ethylmalonate
29263-83-0

diethyl 2-chloro-2-ethylmalonate

Conditions
ConditionsYield
With potassium carbonate In tetrachloromethane96%
acrylonitrile
107-13-1

acrylonitrile

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-(2-cyanoethyl)-2-ethylmalonate
10444-12-9

diethyl 2-(2-cyanoethyl)-2-ethylmalonate

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 0 - 25℃; for 1h;95%
With potassium carbonate In tetrahydrofuran; 1,2-dimethoxyethane at 65℃; for 8h;92%
With 1,4-dioxane; N-benzyl-trimethylammonium hydroxide at 30 - 40℃;
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-ethyl-1,3-propandiol
2612-29-5

2-ethyl-1,3-propandiol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 72h; Reflux;95%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 72h; Inert atmosphere; Reflux;95%
With lithium aluminium tetrahydride for 14h; Reflux; Inert atmosphere;95%
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

ethylmalonic acid
601-75-2

ethylmalonic acid

Conditions
ConditionsYield
With sodium hydroxide In water for 2h; Heating;95%
With potassium hydroxide In water for 2h; Heating;94%
With potassium hydroxide; water ueber mehrere Stufen;
4-(bromomethyl)-4'-methyl-2,2'-bipyridine dihydrobromide
118724-31-5

4-(bromomethyl)-4'-methyl-2,2'-bipyridine dihydrobromide

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-ethyl-2-(4'-methyl-[2,2']bipyridinyl-4-ylmethyl)-malonic acid diethyl ester

2-ethyl-2-(4'-methyl-[2,2']bipyridinyl-4-ylmethyl)-malonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With sodium hydride In N,N-dimethyl-formamide for 0.5h; Metallation;
Stage #2: 4-(bromomethyl)-4'-methyl-2,2'-bipyridine dihydrobromide In N,N-dimethyl-formamide for 5h; Alkylation;
95%
2-propynyl chloride
624-65-7

2-propynyl chloride

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-ethyl-2-(1-propyn-3-yl)malonate
84928-67-6

diethyl 2-ethyl-2-(1-propyn-3-yl)malonate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 6h;95%
[N-(p-tolylsulfonyl)imino]phenyliodinane
55962-05-5

[N-(p-tolylsulfonyl)imino]phenyliodinane

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-(1-(4-methylphenylsulfonamido)ethyl)malonate
1373511-56-8

diethyl 2-(1-(4-methylphenylsulfonamido)ethyl)malonate

Conditions
ConditionsYield
With 1,10-Phenanthroline; 2,6-di-tert-butyl-4-methyl-phenol; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 20℃; for 18h; Molecular sieve; Inert atmosphere;95%
[N-(p-tolylsulfonyl)imino]phenyliodinane
55962-05-5

[N-(p-tolylsulfonyl)imino]phenyliodinane

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

A

diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

B

diethyl 2-(1-(4-methylphenylsulfonamido)ethyl)malonate
1373511-56-8

diethyl 2-(1-(4-methylphenylsulfonamido)ethyl)malonate

Conditions
ConditionsYield
With 1,10-Phenanthroline; copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 20℃; for 4h; Molecular sieve; Inert atmosphere;A 2%
B 95%
6-(difluoro(phenylsulfonyl)methyl)phenanthridine

6-(difluoro(phenylsulfonyl)methyl)phenanthridine

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-(difluoro(phenanthridin-6-yl)methyl)-2-ethylmalonate

diethyl 2-(difluoro(phenanthridin-6-yl)methyl)-2-ethylmalonate

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: 6-(difluoro(phenylsulfonyl)methyl)phenanthridine In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; Inert atmosphere;
95%
4-hydroxy-1,6-dimethylpyridin-2(1H)-one
6052-75-1

4-hydroxy-1,6-dimethylpyridin-2(1H)-one

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

C12H13NO4
955377-05-6

C12H13NO4

Conditions
ConditionsYield
In diphenylether Heating;94%
para-bromobenzenethiol
106-53-6

para-bromobenzenethiol

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-((4-bromophenyl)thio)-2-ethylmalonate

diethyl 2-((4-bromophenyl)thio)-2-ethylmalonate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;94%
With caesium carbonate In N,N-dimethyl-formamide at 20℃;89%
2,6-Diaminopyridine
141-86-6

2,6-Diaminopyridine

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

7-amino-3-ethyl-1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine
120537-85-1

7-amino-3-ethyl-1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine

Conditions
ConditionsYield
In diphenylether for 0.5h; Heating;93%
benzalacetophenone
94-41-7

benzalacetophenone

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

ethyl-2-carbethoxy-3,6-diphenyl-2-ethyl-5-oxopentanoate
75919-29-8

ethyl-2-carbethoxy-3,6-diphenyl-2-ethyl-5-oxopentanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane under 7500600 Torr; for 70h; Ambient temperature;93%
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride for 2h; Ambient temperature;75%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30℃; under 10000 Torr; for 48h;35%
2-bromonicotinonitrile
20577-26-8

2-bromonicotinonitrile

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-(ethyl malonic acid diethyl ester), 3-cyano pyridine
86369-45-1

2-(ethyl malonic acid diethyl ester), 3-cyano pyridine

Conditions
ConditionsYield
With potassium tert-butylate; ammonium chloride In ammonia for 0.166667h; Irradiation;92%
1-bromomethyl-2-[(phenylsulfonyl)methyl]benzene
88116-02-3

1-bromomethyl-2-[(phenylsulfonyl)methyl]benzene

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

4-Benzenesulfonyl-2-ethyl-3-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester
88116-04-5

4-Benzenesulfonyl-2-ethyl-3-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran Ambient temperature;92%
ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

benzyl alcohol
100-51-6

benzyl alcohol

dibenzyl ethylmalonate
74254-53-8

dibenzyl ethylmalonate

Conditions
ConditionsYield
With sodium methylate In toluene for 5h; Heating;92%
2-guanidinobenzimidazole
5418-95-1

2-guanidinobenzimidazole

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

2-(1H-Benzoimidazol-2-ylamino)-5-ethyl-6-hydroxy-3H-pyrimidin-4-one

2-(1H-Benzoimidazol-2-ylamino)-5-ethyl-6-hydroxy-3H-pyrimidin-4-one

Conditions
ConditionsYield
In diphenylether at 200 - 220℃;92%
1-bromo-6-benzyloxyhexane
54247-27-7

1-bromo-6-benzyloxyhexane

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

diethyl 2-(6-(benzyloxy)hexyl)-2-ethylmalonate
1416792-20-5

diethyl 2-(6-(benzyloxy)hexyl)-2-ethylmalonate

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1.5h; Inert atmosphere;
Stage #2: 1-bromo-6-benzyloxyhexane In N,N-dimethyl-formamide; mineral oil at 20℃; for 3.5h; Inert atmosphere;
91%
Stage #1: ethyl diethyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1.5h; Inert atmosphere;
Stage #2: 1-bromo-6-benzyloxyhexane In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 3.5h; Inert atmosphere;
91%
5-oxabicyclo<2.2.0>hex-2-en-6-one
22980-23-0

5-oxabicyclo<2.2.0>hex-2-en-6-one

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

cis-4-(1-ethoxy-2-(ethoxycarbonyl)-1-oxobutan-2-yl)cyclobut-2-enecarboxylic acid

cis-4-(1-ethoxy-2-(ethoxycarbonyl)-1-oxobutan-2-yl)cyclobut-2-enecarboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl diethyl malonate With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: 5-oxabicyclo<2.2.0>hex-2-en-6-one With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; diethyl ether at 0℃; Inert atmosphere;
Stage #3: With hydrogenchloride In water pH=Ca. 2; Inert atmosphere; diastereoselective reaction;
90%

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