CAS号: 609-08-5 EINECS号: 210-175-7 FORMULA: C8H14O4 MW: 174.1944 Appearance:colourless or little yellow liquid Storage:sealed,room temperature Packag
Cas:609-08-5
Min.Order:1 Kilogram
FOB Price: $100.0
Type:Trading Company
inquiryDIETHYL 2-METHYLPROPANEDIOATE DIETHYL METHYLMALONATE METHYLMALONIC ACID DIETHYL ESTER RARECHEM AL BI 0301 2-methyl-malonicaciddiethylester 2-methyl-propanedioicaciddiethylester Diethyl 2-methylmalonate Diethylisosuccinate dlethylmethylmalon
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:609-08-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:609-08-5
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryGood quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:A
Cas:609-08-5
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Diethyl methylmalonate CAS 609-08-5 Methylmalonic acid diethyl ester Ethyl methylmalonate CAS no 609-08-5 Diethyl 2-methylmalonate Propanedioicacid, 2-methyl-, 1,3-diethyl ester 1,3-Adamantanediol dimethacrylate Manufacturer High quality Best
Cas:609-08-5
Min.Order:5 Kiloliter
FOB Price: $3.5 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:609-08-5
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:609-08-5
Min.Order:1 Metric Ton
FOB Price: $500.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:609-08-5
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable & compet
Cas:609-08-5
Min.Order:100 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiry1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and
Cas:609-08-5
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:609-08-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryDiethyl methylmalonate CAS:609-08-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte
Cas:609-08-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:609-08-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:609-08-5
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:609-08-5
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:609-08-5
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:609-08-5
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:609-08-5
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:609-08-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:609-08-5
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:609-08-5
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryHangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it invested two pharmaceutical raw material production plants, one researching company, and several
Cas:609-08-5
Min.Order:1 Metric Ton
FOB Price: $30.0
Type:Manufacturers
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:609-08-5
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:colourless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediat
Cas:609-08-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryConditions | Yield |
---|---|
With P(MeNCH2CH2)3N In hexane; acetonitrile at 25℃; for 0.5h; | 98% |
With sodium In ethanol at 80℃; for 10h; Inert atmosphere; | 97% |
With (3S,4S)-1-benzyl-3,4-pyrrolidin-diol-onium iodide; potassium carbonate In N,N-dimethyl-formamide for 2.5h; Ambient temperature; | 96% |
Conditions | Yield |
---|---|
With sulfuric acid In tetrahydrofuran at 60 - 70℃; | 97.51% |
Conditions | Yield |
---|---|
With sulfuric acid at 20 - 80℃; for 4h; Temperature; | 91.2% |
at 20 - 65℃; for 3h; Temperature; Large scale; |
diethyl malonate
methyl iodide
A
2,2-dimethylmalonic acid diethyl ester
B
Diethyl methylmalonate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 4h; Ambient temperature; | A 5% B 90% |
With sodium hydride 1.) DMSO, cooling, 10 min, 2.) overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
diethyl allylmethylmalonate
A
2-allylnaphthalene
B
Diethyl methylmalonate
Conditions | Yield |
---|---|
Stage #1: diethyl allylmethylmalonate; naphthalen-2-ylzinc(II) bromide With dibromobis(triphenylphosphine)nickel(II); magnesium bromide In tetrahydrofuran; toluene at 20 - 60℃; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran; water; toluene | A 89% B 95 %Spectr. |
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 3h; Heating; | 85% |
With sodium ethanolate In ethanol | |
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: methyl bromide In tetrahydrofuran at 0℃; for 8h; Inert atmosphere; |
Conditions | Yield |
---|---|
In acetoacetic acid methyl ester | 82.6% |
diethyl allylmethylmalonate
Diethyl methylmalonate
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; deallylation; | 81% |
diethyl α-(chloro)-methylmalonate
Diethyl methylmalonate
Conditions | Yield |
---|---|
With zinc In water; acetic acid for 4h; Heating; | 80% |
Diethyl methylmalonate
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; dealkynylation; | 80% |
diethylaminomethyl-methyl-malonic acid diethyl ester
Diethyl methylmalonate
Conditions | Yield |
---|---|
With samarium diiodide In tetrahydrofuran at 20℃; | 77% |
C15H21NO4
Diethyl methylmalonate
Conditions | Yield |
---|---|
With samarium diiodide In tetrahydrofuran Reflux; | 74% |
Diethyl methylmalonate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol under 2100.2 Torr; for 1.5h; | 68% |
Conditions | Yield |
---|---|
With thionyl chloride at 30 - 70℃; for 6h; Temperature; | 65.5% |
A
Diethyl methylmalonate
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -45℃; for 1h; | A 31 % Spectr. B 46% |
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; Rearrangement; depropargylation; | A 31% B 46% |
A
Diethyl methylmalonate
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -45℃; for 1h; | A 34 % Spectr. B 45% |
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; Rearrangement; depropargylation; | A 34% B 45% |
diethyl 2-(but-2-yn-1-yl)-2-methylmalonate
A
Diethyl methylmalonate
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -45℃; for 1h; | A 32 % Spectr. B 42% |
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; Rearrangement; depropargylation; | A 32% B 42% |
4-O,O-t-butyl 1-ethyl 2-(ethoxycarbonyl)monoperoxybutanedioate
A
ethyl 3-(t-butoxy)-2-(ethoxycarbonyl)propionate
B
diethyl (cyclohexylmethyl)propanedioate
C
ethyl diethyl malonate
D
Diethyl methylmalonate
Conditions | Yield |
---|---|
In cyclohexane Ambient temperature; Irradiation; photolysis of further t-butyl percarboxylates in various solvents; | A 40.8% B n/a C 1.3% D 37% E 1.7% |
Conditions | Yield |
---|---|
With carbon monoxide; triethylamine In acetonitrile Ambient temperature; | 38% |
1,2-epoxy-7-methoxy-8-methyl-1,2,3,4-tetrahydro-naphthalene
2-((1S,2S)-2-Hydroxy-7-methoxy-8-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid
B
Diethyl methylmalonate
Conditions | Yield |
---|---|
With sodium In benzene for 30h; Heating; | A 32% B 30% |
diethyl ether
ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate
sodium ethanolate
A
Diethyl methylmalonate
B
1,3-diphenyl-propen-3-one
Conditions | Yield |
---|---|
With ethanol; nickel at 100 - 125℃; Hydrogenation; |
ethanol
diethyl bromomethylmalonate
sodium ethyl acetylacetate enolate
Diethyl methylmalonate
Conditions | Yield |
---|---|
With diethyl ether; nickel Hydrogenation.unter Druck; | |
With ethanol; nickel Hydrogenation.unter Druck; | |
With n-butylmercuric chloride; sodium thiosulfate; HSiPh3 1.) DMSO, 12 h, 2.) DMSO; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With ethanol Irradiation.mit UV-Licht; |
Conditions | Yield |
---|---|
bei der Destillation; |
diethyl 2-(hydroxymethylene)malonate
Diethyl methylmalonate
Conditions | Yield |
---|---|
With ethanol; nickel at 100 - 125℃; Hydrogenation; |
sodium ethanolate
ethyl acetoacetate
diethyl malonate
methyl iodide
A
2-acetylpropanoic acid ethyl ester
B
Diethyl methylmalonate
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol at 0 - 20℃; for 2h; | 100% |
With sodium hydroxide In tetrahydrofuran at 0℃; for 1.5h; | 96% |
Stage #1: Diethyl methylmalonate With potassium hydroxide; water In tetrahydrofuran at 0℃; for 1h; Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0℃; Product distribution / selectivity; | 96% |
1,3-dibromo-propane
Diethyl methylmalonate
heptane-2,2,6,6-tetracarboxylic acid tetraethyl ester
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol at 24℃; Substitution; Heating; | 100% |
(i) NaH, benzene, (ii) /BRN= 635662/; Multistep reaction; |
N-ethoxycarbonylaziridine
Diethyl methylmalonate
3-Methyl-2-oxo-3-pyrrolidincarbonsaeure-ethylester
Conditions | Yield |
---|---|
With triethylamine for 120h; Ambient temperature; | 100% |
ethyl bromoacetate
Diethyl methylmalonate
triethyl propane-1,2,2-tricarboxylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature; | 100% |
2-Bromo-4'-phenylacetophenone
Diethyl methylmalonate
2-(2-Biphenyl-4-yl-2-oxo-ethyl)-2-methyl-malonic acid diethyl ester
Conditions | Yield |
---|---|
With sodium hydride In N,N,N,N,N,N-hexamethylphosphoric triamide for 2h; Ambient temperature; | 100% |
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With sodium ethanolate In ethanol for 0.333333h; Stage #2: allyl bromide In ethanol for 12h; | 100% |
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at 20℃; for 1.5h; | 99% |
Stage #1: Diethyl methylmalonate With sodium hydride In N,N-dimethyl-formamide at 0 - 50℃; Stage #2: allyl bromide In N,N-dimethyl-formamide at 20 - 50℃; | 96% |
ethyl (1-13C)-bromoacetate
Diethyl methylmalonate
Triethyl (1-C=O-13C)-1,1,2-propanetricarboxylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature; | 100% |
With sodium hydride 1.) THF, 2.) THF; Multistep reaction; |
formaldehyd
Diethyl methylmalonate
2-(hydroxymethyl)-2-methylpropanedioic acid diethyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In ethanol; water at 0 - 20℃; for 20h; | 100% |
With sodium hydrogencarbonate In ethanol; water at 0 - 20℃; for 20h; | 100% |
With triethylamine In water; N,N-dimethyl-formamide at 40 - 50℃; for 2h; | 88% |
1-Bromo-2-butyne
Diethyl methylmalonate
diethyl 2-(but-2-yn-1-yl)-2-methylmalonate
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 100% |
Stage #1: Diethyl methylmalonate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: 1-Bromo-2-butyne In tetrahydrofuran at -78℃; for 1h; | 97.6% |
Stage #1: Diethyl methylmalonate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: 1-Bromo-2-butyne In tetrahydrofuran at -78 - 20℃; | 97.6% |
Conditions | Yield |
---|---|
With sodium hydride In toluene for 14h; Heating; | 100% |
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
Diethyl methylmalonate
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); chiral sulfideoxathiane ligand; potassium acetate; N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0℃; for 48h; | 100% |
With N,O-bis-(trimethylsilyl)-acetamide; chiral sulfideoxathiane ligand; potassium acetate; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 48h; | 100% |
Stage #1: rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene With (S)-7,7'-bis[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]-1,1'-spirobiindane; bis(η3-allyl-μ-chloropalladium(II)) In 1,4-dioxane at 20℃; for 0.166667h; Stage #2: Diethyl methylmalonate With diethylzinc In 1,4-dioxane; hexane at 20℃; for 3h; Further stages.; | 96% |
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); N-[(S)-1-(2-(diphenylphosphino)phenyl)ethyl]-1,7,7-trimethylbicyclo[2,2,1]heptan-2-imine; cesium acetate In toluene at 20℃; enantioselective reaction; | 95% |
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); (S)-7-(diphenylphosphino)-2′-isopropyl-2,3-dihydro-5′H-spiro[indene-1,4′-oxazole]; potassium acetate In toluene at 0℃; for 5h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 93% |
(S)-tert-leucinol
Diethyl methylmalonate
N1,N3-bis[(S)-1-hydroxy-3,3-dimethylbutan-2-yl]malonamide
Conditions | Yield |
---|---|
at 110℃; for 72h; | 100% |
In toluene at 120℃; | 82% |
at 120℃; for 72h; Schlenk technique; Inert atmosphere; | |
at 120℃; for 72h; Schlenk technique; Inert atmosphere; |
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran at 25℃; for 0.5h; Stage #2: Allyl acetate With 1,4-di(diphenylphosphino)-butane; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran at 55℃; for 3h; Further stages.; | 100% |
With potassium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere; | 100 %Chromat. |
With 1-ethyl-2,3-dimethylimidazolium tetrafluoroborate; potassium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In dichloromethane at 20℃; for 18 - 24h; Tsuji-Trost Allylation; |
Diethyl methylmalonate
4-benzyloxybenzyl chloride
diethyl 2-(4-(benzyloxy)benzyl)-2-methylmalonate
Conditions | Yield |
---|---|
In tetrahydrofuran; water; ethyl acetate | 100% |
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; Stage #2: 4-benzyloxybenzyl chloride In tetrahydrofuran; mineral oil Reflux; | 91% |
Conditions | Yield |
---|---|
With sodium hydride In mineral oil at 160℃; Inert atmosphere; | 100% |
With sodium hydride at 140℃; for 4h; Inert atmosphere; | 95% |
Diethyl methylmalonate
2-methyl-2-(3-phenyl-2-propenyl)malonic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: cinnamyl halide In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.666667h; Stage #2: 1-bromo-3-phenylprop-2-yne In tetrahydrofuran at -78 - 20℃; | 100% |
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1.33333h; Inert atmosphere; Stage #2: 2-bromo-butyryl bromide In tetrahydrofuran; mineral oil at 0 - 20℃; for 17h; Inert atmosphere; | 100% |
Diethyl methylmalonate
Conditions | Yield |
---|---|
With sodium methylate In methanol at 70℃; for 24h; Inert atmosphere; Cooling with ice; | 100% |
2,4-Difluoronitrobenzene
Diethyl methylmalonate
diethyl 2-(3-fluoro-4-nitrophenyl)-2-methyl-malonate
Conditions | Yield |
---|---|
With sodium hydroxide In N,N-dimethyl-formamide for 5h; | 99.75% |
With sodium hydroxide In N,N-dimethyl-formamide at 25 - 30℃; for 4h; | 91% |
Stage #1: Diethyl methylmalonate With sodium hydride In dimethyl sulfoxide at 15℃; Stage #2: 2,4-Difluoronitrobenzene In dimethyl sulfoxide at 15℃; for 0.5h; | 87% |
Conditions | Yield |
---|---|
With ammonia In methanol for 168h; Ambient temperature; | 99.7% |
With MH3 gas In methanol at 110℃; for 16h; | 98% |
With ammonia; sodium methylate In methanol for 120h; Ambient temperature; | 95% |
1-Bromotetradecane
Diethyl methylmalonate
methyl-tetradecyl-malonic acid diethyl ester
Conditions | Yield |
---|---|
99% | |
(i) Na, (ii) /BRN= 1742640/; Multistep reaction; | |
With sodium ethanolate 1.) ethanol, reflux, 15 min, 2.) ethanol, reflux, overnight; Multistep reaction; |
iodoform
Diethyl methylmalonate
2-diiodomethyl-2-methyl-malonic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate In diethyl ether for 0.5h; Stage #2: With sodium hydride In diethyl ether for 1.5h; Reflux; Stage #3: iodoform for 12h; Reflux; | 99% |
With sodium hydride In diethyl ether Reflux; | 99% |
Stage #1: Diethyl methylmalonate With sodium hydride In diethyl ether; mineral oil at 40℃; for 3h; Inert atmosphere; Stage #2: iodoform In diethyl ether; mineral oil for 24h; Inert atmosphere; Reflux; | 80% |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 1h; Ambient temperature; | 99% |
With potassium hydroxide In water at 0 - 20℃; for 60h; | 71% |
With potassium hydroxide In ethanol; water for 4h; Heating; |
1,8-bis(bromomethyl)naphthalene
Diethyl methylmalonate
2-[8-(2,2-bis-ethoxycarbonyl-propyl)-naphthalen-1-ylmethyl]-2-methyl-malonic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With sodium In ethanol at 20℃; for 0.5h; Stage #2: 1,8-bis(bromomethyl)naphthalene In ethanol for 3h; Heating; | 99% |
phenylacetylene
Diethyl methylmalonate
2-methyl-2-(1-phenylvinyl)malonic acid diethyl ester
Conditions | Yield |
---|---|
indium(III) triflate at 140℃; for 16h; | 99% |
With indium(III) triflate | 99% |
With indium(III) bromide In o-xylene at 130℃; | 92% |
1-Iodooctane
Diethyl methylmalonate
methyloctylpropanedioic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: Diethyl methylmalonate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 1-Iodooctane In N,N-dimethyl-formamide at 0 - 20℃; | 99% |
methanesulfonic acid 3-(anthracen-9-ylmethoxy)propyl ester
Diethyl methylmalonate
diethyl 2-{3-[(anthracen-9-yl)methoxy]propyl}-2-methylmalonate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 60℃; | 99% |
ortho-nitrofluorobenzene
Diethyl methylmalonate
diethyl methyl(2-nitrophenyl)malonate
Conditions | Yield |
---|---|
With triethylsilane; t-Bu-P4 In hexane; N,N-dimethyl-formamide at 80℃; for 1h; | 99% |
Diethyl methylmalonate
acrolein
diethyl 2-methyl-2-(3-oxopropyl)malonate
Conditions | Yield |
---|---|
With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene In dichloromethane at 20℃; Michael addition; Inert atmosphere; | 99% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View