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ZiBO KuoDing Trade company Ltd

CAS号: 609-08-5 EINECS号: 210-175-7 FORMULA: C8H14O4 MW: 174.1944 Appearance:colourless or little yellow liquid Storage:sealed,room temperature Packag

Diethyl methylmalonate

Cas:609-08-5

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Shandong Xinhua Pharmaceutical Co.,Ltd

DIETHYL 2-METHYLPROPANEDIOATE DIETHYL METHYLMALONATE METHYLMALONIC ACID DIETHYL ESTER RARECHEM AL BI 0301 2-methyl-malonicaciddiethylester 2-methyl-propanedioicaciddiethylester Diethyl 2-methylmalonate Diethylisosuccinate dlethylmethylmalon

Diethyl Methylmalonate

Cas:609-08-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Diethyl methylmalonate Manufacturer/High quality/Best price/In stock

Cas:609-08-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl Methylmalonate supplier in China

Cas:609-08-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:A

609-08-5Diethyl methylmalonate

Cas:609-08-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl methylmalonate

Cas:609-08-5

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Diethyl Methylmalonate

Cas:609-08-5

Min.Order:1 Metric Ton

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Chemwill Asia Co., Ltd.

Diethyl methylmalonate CAS 609-08-5 Methylmalonic acid diethyl ester Ethyl methylmalonate CAS no 609-08-5 Diethyl 2-methylmalonate Propanedioicacid, 2-methyl-, 1,3-diethyl ester 1,3-Adamantanediol dimethacrylate Manufacturer High quality Best

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

top quality Diethyl methylmalonate

Cas:609-08-5

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Diethyl methylmalonate 609-08-5

Cas:609-08-5

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best PurityCAS 609-08-5 with fast shipping

Cas:609-08-5

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable & compet

Diethyl methylmalonate CAS NO.:609-08-5

Cas:609-08-5

Min.Order:100 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of Diethyl methylmalonate at Factory Price

Cas:609-08-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Propanedioicacid, 2-methyl-, 1,3-diethyl ester 609-08-5

Cas:609-08-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Diethyl methylmalonate CAS:609-08-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

Diethyl methylmalonate CAS:609-08-5

Cas:609-08-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Diethyl Methylmalonate

Cas:609-08-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

High quality best price Diethyl methylmalonate 609-08-5 with reasonable price and fast delivery

Cas:609-08-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Ethyl methylmalonate cas:609-08-5

Cas:609-08-5

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Diethyl methylmalonate

Cas:609-08-5

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Methylmalonic Acid Diethyl Ester

Cas:609-08-5

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

609-08-5 Diethyl methylmalonate

Cas:609-08-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Diethyl methylmalonate

Cas:609-08-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Diethyl methylmalonate

Cas:609-08-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Diethyl methylmalonate

Cas:609-08-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Diethyl methylmalonate

Cas:609-08-5

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Diethyl methylmalonate

Cas:609-08-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Diethyl Methylmalonate

Cas:609-08-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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hangzhou verychem science and technology co.ltd

Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it invested two pharmaceutical raw material production plants, one researching company, and several

DIETHYL METHYL MALONATE

Cas:609-08-5

Min.Order:1 Metric Ton

FOB Price: $30.0

Type:Manufacturers

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

609-08-5 Diethyl methylmalonate

Cas:609-08-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:colourless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediat

Propanedioicacid, 2-methyl-, 1,3-diethyl ester

Cas:609-08-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

diethyl malonate
105-53-3

diethyl malonate

methyl iodide
74-88-4

methyl iodide

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With P(MeNCH2CH2)3N In hexane; acetonitrile at 25℃; for 0.5h;98%
With sodium In ethanol at 80℃; for 10h; Inert atmosphere;97%
With (3S,4S)-1-benzyl-3,4-pyrrolidin-diol-onium iodide; potassium carbonate In N,N-dimethyl-formamide for 2.5h; Ambient temperature;96%
ethanol
64-17-5

ethanol

2-methylmalononitrile
3696-36-4

2-methylmalononitrile

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran at 60 - 70℃;97.51%
2-cyanopropanoic acid
632-07-5

2-cyanopropanoic acid

ethanol
64-17-5

ethanol

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With sulfuric acid at 20 - 80℃; for 4h; Temperature;91.2%
at 20 - 65℃; for 3h; Temperature; Large scale;
diethyl malonate
105-53-3

diethyl malonate

methyl iodide
74-88-4

methyl iodide

A

2,2-dimethylmalonic acid diethyl ester
1619-62-1

2,2-dimethylmalonic acid diethyl ester

B

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 4h; Ambient temperature;A 5%
B 90%
With sodium hydride 1.) DMSO, cooling, 10 min, 2.) overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
diethyl allylmethylmalonate
53651-72-2

diethyl allylmethylmalonate

naphthalen-2-ylzinc(II) bromide

naphthalen-2-ylzinc(II) bromide

A

2-allylnaphthalene
2489-87-4

2-allylnaphthalene

B

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
Stage #1: diethyl allylmethylmalonate; naphthalen-2-ylzinc(II) bromide With dibromobis(triphenylphosphine)nickel(II); magnesium bromide In tetrahydrofuran; toluene at 20 - 60℃; Inert atmosphere;
Stage #2: With ammonium chloride In tetrahydrofuran; water; toluene
A 89%
B 95 %Spectr.
methyl bromide
74-83-9

methyl bromide

diethyl malonate
105-53-3

diethyl malonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 3h; Heating;85%
With sodium ethanolate In ethanol
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: methyl bromide In tetrahydrofuran at 0℃; for 8h; Inert atmosphere;
diethyl malonate
105-53-3

diethyl malonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
In acetoacetic acid methyl ester82.6%
diethyl allylmethylmalonate
53651-72-2

diethyl allylmethylmalonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; deallylation;81%
diethyl α-(chloro)-methylmalonate
29263-82-9

diethyl α-(chloro)-methylmalonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With zinc In water; acetic acid for 4h; Heating;80%
2-methyl-2-trimethylsilanylethynyl-malonic acid diethyl ester

2-methyl-2-trimethylsilanylethynyl-malonic acid diethyl ester

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; dealkynylation;80%
diethylaminomethyl-methyl-malonic acid diethyl ester
80073-77-4

diethylaminomethyl-methyl-malonic acid diethyl ester

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With samarium diiodide In tetrahydrofuran at 20℃;77%
C15H21NO4
1187336-84-0

C15H21NO4

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With samarium diiodide In tetrahydrofuran Reflux;74%
2-(3-Methoxy-phenoxymethylene)-malonic acid diethyl ester

2-(3-Methoxy-phenoxymethylene)-malonic acid diethyl ester

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2100.2 Torr; for 1.5h;68%
ethanol
64-17-5

ethanol

methyl-propanedioic acid
516-05-2

methyl-propanedioic acid

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With thionyl chloride at 30 - 70℃; for 6h; Temperature;65.5%
diethyl 2-methyl-2-(3-phenylprop-2-yn-1-yl)malonate

diethyl 2-methyl-2-(3-phenylprop-2-yn-1-yl)malonate

A

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

B

ethyl 4-(ethoxycarbonyl)-2-methyl-5-phenyl-4-(E)-pentenoate

ethyl 4-(ethoxycarbonyl)-2-methyl-5-phenyl-4-(E)-pentenoate

Conditions
ConditionsYield
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -45℃; for 1h;A 31 % Spectr.
B 46%
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; Rearrangement; depropargylation;A 31%
B 46%
diethyl methyl(2-nonynyl)malonate

diethyl methyl(2-nonynyl)malonate

A

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

B

ethyl 4-(ethoxycarbonyl)-2-methyl-5-(E)-undecenoate

ethyl 4-(ethoxycarbonyl)-2-methyl-5-(E)-undecenoate

Conditions
ConditionsYield
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -45℃; for 1h;A 34 % Spectr.
B 45%
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; Rearrangement; depropargylation;A 34%
B 45%
diethyl 2-(but-2-yn-1-yl)-2-methylmalonate
182809-41-2

diethyl 2-(but-2-yn-1-yl)-2-methylmalonate

A

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

B

ethyl 4-(ethoxycarbonyl)-2-methyl-4-(E)-hexenoate

ethyl 4-(ethoxycarbonyl)-2-methyl-4-(E)-hexenoate

Conditions
ConditionsYield
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -45℃; for 1h;A 32 % Spectr.
B 42%
With titanium(IV) isopropylate; isopropylmagnesium chloride In diethyl ether at -50 - -40℃; for 1h; Rearrangement; depropargylation;A 32%
B 42%
4-O,O-t-butyl 1-ethyl 2-(ethoxycarbonyl)monoperoxybutanedioate
89317-62-4

4-O,O-t-butyl 1-ethyl 2-(ethoxycarbonyl)monoperoxybutanedioate

A

ethyl 3-(t-butoxy)-2-(ethoxycarbonyl)propionate
91368-88-6

ethyl 3-(t-butoxy)-2-(ethoxycarbonyl)propionate

B

diethyl (cyclohexylmethyl)propanedioate
29805-59-2

diethyl (cyclohexylmethyl)propanedioate

C

ethyl diethyl malonate
133-13-1

ethyl diethyl malonate

D

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

E

2-(tert-butoxy)butanedioic acid diethyl ester

2-(tert-butoxy)butanedioic acid diethyl ester

Conditions
ConditionsYield
In cyclohexane Ambient temperature; Irradiation; photolysis of further t-butyl percarboxylates in various solvents;A 40.8%
B n/a
C 1.3%
D 37%
E 1.7%
dipropionatopalladium(II)

dipropionatopalladium(II)

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With carbon monoxide; triethylamine In acetonitrile Ambient temperature;38%
1,2-epoxy-7-methoxy-8-methyl-1,2,3,4-tetrahydro-naphthalene
27982-94-1

1,2-epoxy-7-methoxy-8-methyl-1,2,3,4-tetrahydro-naphthalene

2-((1S,2S)-2-Hydroxy-7-methoxy-8-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid
27767-56-2

2-((1S,2S)-2-Hydroxy-7-methoxy-8-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid

B

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With sodium In benzene for 30h; Heating;A 32%
B 30%
methyl bromide
74-83-9

methyl bromide

sodium diethylmalonate
996-82-7

sodium diethylmalonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl ether
60-29-7

diethyl ether

ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate
77670-31-6

ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate

sodium ethanolate
141-52-6

sodium ethanolate

A

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

B

1,3-diphenyl-propen-3-one
614-47-1

1,3-diphenyl-propen-3-one

diethyl aminomethylenemalonate
6296-99-7

diethyl aminomethylenemalonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With ethanol; nickel at 100 - 125℃; Hydrogenation;
ethanol
64-17-5

ethanol

diethyl bromomethylmalonate
29263-94-3

diethyl bromomethylmalonate

sodium ethyl acetylacetate enolate
1007476-32-5

sodium ethyl acetylacetate enolate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

ethanol
64-17-5

ethanol

methyl-malonyl bromide
98020-11-2

methyl-malonyl bromide

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl methylenemalonate
3377-20-6

diethyl methylenemalonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With diethyl ether; nickel Hydrogenation.unter Druck;
With ethanol; nickel Hydrogenation.unter Druck;
With n-butylmercuric chloride; sodium thiosulfate; HSiPh3 1.) DMSO, 12 h, 2.) DMSO; Yield given. Multistep reaction;
ethyl 2-diazo-3-oxobutanoate
2009-97-4

ethyl 2-diazo-3-oxobutanoate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With ethanol Irradiation.mit UV-Licht;
diethyl oxalpropionate
759-65-9

diethyl oxalpropionate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
bei der Destillation;
diethyl 2-(hydroxymethylene)malonate
20734-18-3

diethyl 2-(hydroxymethylene)malonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Conditions
ConditionsYield
With ethanol; nickel at 100 - 125℃; Hydrogenation;
sodium ethanolate
141-52-6

sodium ethanolate

ethyl acetoacetate
141-97-9

ethyl acetoacetate

diethyl malonate
105-53-3

diethyl malonate

methyl iodide
74-88-4

methyl iodide

A

2-acetylpropanoic acid ethyl ester
609-14-3

2-acetylpropanoic acid ethyl ester

B

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

monoethyl methylmalonate
2985-33-3

monoethyl methylmalonate

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 0 - 20℃; for 2h;100%
With sodium hydroxide In tetrahydrofuran at 0℃; for 1.5h;96%
Stage #1: Diethyl methylmalonate With potassium hydroxide; water In tetrahydrofuran at 0℃; for 1h;
Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0℃; Product distribution / selectivity;
96%
1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

heptane-2,2,6,6-tetracarboxylic acid tetraethyl ester
33524-34-4

heptane-2,2,6,6-tetracarboxylic acid tetraethyl ester

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 24℃; Substitution; Heating;100%
(i) NaH, benzene, (ii) /BRN= 635662/; Multistep reaction;
N-ethoxycarbonylaziridine
671-51-2

N-ethoxycarbonylaziridine

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

3-Methyl-2-oxo-3-pyrrolidincarbonsaeure-ethylester
79232-62-5

3-Methyl-2-oxo-3-pyrrolidincarbonsaeure-ethylester

Conditions
ConditionsYield
With triethylamine for 120h; Ambient temperature;100%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

triethyl propane-1,2,2-tricarboxylate
39994-45-1

triethyl propane-1,2,2-tricarboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature;100%
2-Bromo-4'-phenylacetophenone
135-73-9

2-Bromo-4'-phenylacetophenone

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-(2-Biphenyl-4-yl-2-oxo-ethyl)-2-methyl-malonic acid diethyl ester
88598-79-2

2-(2-Biphenyl-4-yl-2-oxo-ethyl)-2-methyl-malonic acid diethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N,N,N,N,N-hexamethylphosphoric triamide for 2h; Ambient temperature;100%
allyl bromide
106-95-6

allyl bromide

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl allylmethylmalonate
53651-72-2

diethyl allylmethylmalonate

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium ethanolate In ethanol for 0.333333h;
Stage #2: allyl bromide In ethanol for 12h;
100%
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at 20℃; for 1.5h;99%
Stage #1: Diethyl methylmalonate With sodium hydride In N,N-dimethyl-formamide at 0 - 50℃;
Stage #2: allyl bromide In N,N-dimethyl-formamide at 20 - 50℃;
96%
ethyl (1-13C)-bromoacetate
61203-71-2

ethyl (1-13C)-bromoacetate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

Triethyl (1-C=O-13C)-1,1,2-propanetricarboxylate
157246-97-4

Triethyl (1-C=O-13C)-1,1,2-propanetricarboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature;100%
With sodium hydride 1.) THF, 2.) THF; Multistep reaction;
formaldehyd
50-00-0

formaldehyd

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-(hydroxymethyl)-2-methylpropanedioic acid diethyl ester
72999-08-7

2-(hydroxymethyl)-2-methylpropanedioic acid diethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water at 0 - 20℃; for 20h;100%
With sodium hydrogencarbonate In ethanol; water at 0 - 20℃; for 20h;100%
With triethylamine In water; N,N-dimethyl-formamide at 40 - 50℃; for 2h;88%
1-Bromo-2-butyne
3355-28-0

1-Bromo-2-butyne

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl 2-(but-2-yn-1-yl)-2-methylmalonate
182809-41-2

diethyl 2-(but-2-yn-1-yl)-2-methylmalonate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;100%
Stage #1: Diethyl methylmalonate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 1-Bromo-2-butyne In tetrahydrofuran at -78℃; for 1h;
97.6%
Stage #1: Diethyl methylmalonate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: 1-Bromo-2-butyne In tetrahydrofuran at -78 - 20℃;
97.6%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-methyl-malonic acid bis-(2-trimethylsilanyl-ethyl) ester

2-methyl-malonic acid bis-(2-trimethylsilanyl-ethyl) ester

Conditions
ConditionsYield
With sodium hydride In toluene for 14h; Heating;100%
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
87751-69-7

rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl 2-((E)-(S)-1,3-diphenyl-allyl)-α-methylmalonate

diethyl 2-((E)-(S)-1,3-diphenyl-allyl)-α-methylmalonate

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); chiral sulfideoxathiane ligand; potassium acetate; N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0℃; for 48h;100%
With N,O-bis-(trimethylsilyl)-acetamide; chiral sulfideoxathiane ligand; potassium acetate; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 48h;100%
Stage #1: rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene With (S)-7,7'-bis[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]-1,1'-spirobiindane; bis(η3-allyl-μ-chloropalladium(II)) In 1,4-dioxane at 20℃; for 0.166667h;
Stage #2: Diethyl methylmalonate With diethylzinc In 1,4-dioxane; hexane at 20℃; for 3h; Further stages.;
96%
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); N-[(S)-1-(2-(diphenylphosphino)phenyl)ethyl]-1,7,7-trimethylbicyclo[2,2,1]heptan-2-imine; cesium acetate In toluene at 20℃; enantioselective reaction;95%
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); (S)-7-(diphenylphosphino)-2′-isopropyl-2,3-dihydro-5′H-spiro[indene-1,4′-oxazole]; potassium acetate In toluene at 0℃; for 5h; Inert atmosphere; Schlenk technique; enantioselective reaction;93%
(S)-tert-leucinol
112245-13-3

(S)-tert-leucinol

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

N1,N3-bis[(S)-1-hydroxy-3,3-dimethylbutan-2-yl]malonamide
909713-82-2

N1,N3-bis[(S)-1-hydroxy-3,3-dimethylbutan-2-yl]malonamide

Conditions
ConditionsYield
at 110℃; for 72h;100%
In toluene at 120℃;82%
at 120℃; for 72h; Schlenk technique; Inert atmosphere;
at 120℃; for 72h; Schlenk technique; Inert atmosphere;
Allyl acetate
591-87-7

Allyl acetate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl allylmethylmalonate
53651-72-2

diethyl allylmethylmalonate

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran at 25℃; for 0.5h;
Stage #2: Allyl acetate With 1,4-di(diphenylphosphino)-butane; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran at 55℃; for 3h; Further stages.;
100%
With potassium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;100 %Chromat.
With 1-ethyl-2,3-dimethylimidazolium tetrafluoroborate; potassium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In dichloromethane at 20℃; for 18 - 24h; Tsuji-Trost Allylation;
Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

4-benzyloxybenzyl chloride
836-42-0

4-benzyloxybenzyl chloride

diethyl 2-(4-(benzyloxy)benzyl)-2-methylmalonate
144871-72-7

diethyl 2-(4-(benzyloxy)benzyl)-2-methylmalonate

Conditions
ConditionsYield
In tetrahydrofuran; water; ethyl acetate100%
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #2: 4-benzyloxybenzyl chloride In tetrahydrofuran; mineral oil Reflux;
91%
2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

N,N'-bis(1-hydroxy-2-methylpropan-2-yl)-2-methylmalonamide

N,N'-bis(1-hydroxy-2-methylpropan-2-yl)-2-methylmalonamide

Conditions
ConditionsYield
With sodium hydride In mineral oil at 160℃; Inert atmosphere;100%
With sodium hydride at 140℃; for 4h; Inert atmosphere;95%
Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

cinnamyl halide

cinnamyl halide

2-methyl-2-(3-phenyl-2-propenyl)malonic acid diethyl ester
156382-65-9

2-methyl-2-(3-phenyl-2-propenyl)malonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: cinnamyl halide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
100%
Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

1-bromo-3-phenylprop-2-yne
1794-48-5

1-bromo-3-phenylprop-2-yne

diethyl 2-methyl-2-(3-phenylprop-2-yn-1-yl)malonate

diethyl 2-methyl-2-(3-phenylprop-2-yn-1-yl)malonate

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.666667h;
Stage #2: 1-bromo-3-phenylprop-2-yne In tetrahydrofuran at -78 - 20℃;
100%
2-bromo-butyryl bromide
26074-52-2

2-bromo-butyryl bromide

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

C12H19BrO5

C12H19BrO5

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1.33333h; Inert atmosphere;
Stage #2: 2-bromo-butyryl bromide In tetrahydrofuran; mineral oil at 0 - 20℃; for 17h; Inert atmosphere;
100%
3,5-dibromophenylamidine hydrochloride

3,5-dibromophenylamidine hydrochloride

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-(3,5-dibromophenyl)-4,6-dihydroxy-5-methylpyrimidine

2-(3,5-dibromophenyl)-4,6-dihydroxy-5-methylpyrimidine

Conditions
ConditionsYield
With sodium methylate In methanol at 70℃; for 24h; Inert atmosphere; Cooling with ice;100%
2,4-Difluoronitrobenzene
446-35-5

2,4-Difluoronitrobenzene

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl 2-(3-fluoro-4-nitrophenyl)-2-methyl-malonate
78543-06-3

diethyl 2-(3-fluoro-4-nitrophenyl)-2-methyl-malonate

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide for 5h;99.75%
With sodium hydroxide In N,N-dimethyl-formamide at 25 - 30℃; for 4h;91%
Stage #1: Diethyl methylmalonate With sodium hydride In dimethyl sulfoxide at 15℃;
Stage #2: 2,4-Difluoronitrobenzene In dimethyl sulfoxide at 15℃; for 0.5h;
87%
Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-methyl-malonamide
1113-63-9

2-methyl-malonamide

Conditions
ConditionsYield
With ammonia In methanol for 168h; Ambient temperature;99.7%
With MH3 gas In methanol at 110℃; for 16h;98%
With ammonia; sodium methylate In methanol for 120h; Ambient temperature;95%
1-Bromotetradecane
112-71-0

1-Bromotetradecane

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

methyl-tetradecyl-malonic acid diethyl ester
114289-75-7

methyl-tetradecyl-malonic acid diethyl ester

Conditions
ConditionsYield
99%
(i) Na, (ii) /BRN= 1742640/; Multistep reaction;
With sodium ethanolate 1.) ethanol, reflux, 15 min, 2.) ethanol, reflux, overnight; Multistep reaction;
iodoform
75-47-8

iodoform

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-diiodomethyl-2-methyl-malonic acid diethyl ester
311807-55-3

2-diiodomethyl-2-methyl-malonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate In diethyl ether for 0.5h;
Stage #2: With sodium hydride In diethyl ether for 1.5h; Reflux;
Stage #3: iodoform for 12h; Reflux;
99%
With sodium hydride In diethyl ether Reflux;99%
Stage #1: Diethyl methylmalonate With sodium hydride In diethyl ether; mineral oil at 40℃; for 3h; Inert atmosphere;
Stage #2: iodoform In diethyl ether; mineral oil for 24h; Inert atmosphere; Reflux;
80%
Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

methyl-propanedioic acid
516-05-2

methyl-propanedioic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 1h; Ambient temperature;99%
With potassium hydroxide In water at 0 - 20℃; for 60h;71%
With potassium hydroxide In ethanol; water for 4h; Heating;
1,8-bis(bromomethyl)naphthalene
2025-95-8

1,8-bis(bromomethyl)naphthalene

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-[8-(2,2-bis-ethoxycarbonyl-propyl)-naphthalen-1-ylmethyl]-2-methyl-malonic acid diethyl ester
849706-62-3

2-[8-(2,2-bis-ethoxycarbonyl-propyl)-naphthalen-1-ylmethyl]-2-methyl-malonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium In ethanol at 20℃; for 0.5h;
Stage #2: 1,8-bis(bromomethyl)naphthalene In ethanol for 3h; Heating;
99%
phenylacetylene
536-74-3

phenylacetylene

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-methyl-2-(1-phenylvinyl)malonic acid diethyl ester
35293-95-9

2-methyl-2-(1-phenylvinyl)malonic acid diethyl ester

Conditions
ConditionsYield
indium(III) triflate at 140℃; for 16h;99%
With indium(III) triflate99%
With indium(III) bromide In o-xylene at 130℃;92%
1-Iodooctane
629-27-6

1-Iodooctane

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

methyloctylpropanedioic acid diethyl ester
98061-08-6

methyloctylpropanedioic acid diethyl ester

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: 1-Iodooctane In N,N-dimethyl-formamide at 0 - 20℃;
99%
methanesulfonic acid 3-(anthracen-9-ylmethoxy)propyl ester
877995-16-9

methanesulfonic acid 3-(anthracen-9-ylmethoxy)propyl ester

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl 2-{3-[(anthracen-9-yl)methoxy]propyl}-2-methylmalonate
929210-63-9

diethyl 2-{3-[(anthracen-9-yl)methoxy]propyl}-2-methylmalonate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 60℃;99%
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

diethyl methyl(2-nitrophenyl)malonate
71127-36-1

diethyl methyl(2-nitrophenyl)malonate

Conditions
ConditionsYield
With triethylsilane; t-Bu-P4 In hexane; N,N-dimethyl-formamide at 80℃; for 1h;99%
Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

acrolein
107-02-8

acrolein

diethyl 2-methyl-2-(3-oxopropyl)malonate
3576-11-2

diethyl 2-methyl-2-(3-oxopropyl)malonate

Conditions
ConditionsYield
With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene In dichloromethane at 20℃; Michael addition; Inert atmosphere;99%
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