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Joyochem Co., Ltd.

High purity:99.7%, factory, Industrialization production stage Appearance:white to off-white small crystalline powder Storage:make to order Package:25KG/barrel Application:Schizophrenia drug Transportation:by air or sea Port:QINGDAO

Iloperidone

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $580.0 / 750.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Iloperidone Manufacturer/High quality/Best price/In stock

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Iloperidone

Cas:133454-47-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% ILOPERIDONE 133454-47-4 GMP Manufacturer

Cas:133454-47-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Iloperidone

Cas:133454-47-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - ILOPERIDONE

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 133454-47-4 with best quality

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

ILOPERIDONE 133454-47-4

Cas:133454-47-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Iloperidone/ LIDE PHARMA- Factory supply / Best price

Cas:133454-47-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Prodcut name Iloperidone Synonyms 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone MOQ

Iloperidone CAS:133454-47-4

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

ILOPERIDONE

Cas:133454-47-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Supply high quality CAS 133454-47-4 Iloperidone

Cas:133454-47-4

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Iloperidone CAS 133454-47-4

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp

High-purity Iloperidone 133454-47-4

Cas:133454-47-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

ILOPERIDONEpowder cas 133454-47-4

Cas:133454-47-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

ILOPERIDONE CAS:133454-47-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

ILOPERIDONE CAS:133454-47-4

Cas:133454-47-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Iloperidone

Cas:133454-47-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

iloperidone manufacturer with low price

Cas:133454-47-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

High quality and best price Iloperidone powder cas 133454-47-4 with reasonable price

Cas:133454-47-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Iloperidone cas:133454-47-4

Cas:133454-47-4

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Iloperidone

Cas:133454-47-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Iloperidone

Cas:133454-47-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

HP-873 Iloperidone cas 133454-47-4

Cas:133454-47-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

ILOPERIDONE

Cas:133454-47-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Iloperidone

Cas:133454-47-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Enterprice standard Appearance:Off-white or white grey powder Application:Pharmaceutical raw materials Port:Shanghai or Hangzhou port

Iloperidone

Cas:133454-47-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Iloperidone

Cas:133454-47-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

CAS:133454-47-4 IloperidoneAppearance:White powder Storage:Store in cool & dry place Package:according to customers' requirements Application:Medicine Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or acco

CAS:133454-47-4 Iloperidone

Cas:133454-47-4

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermed

Iloperidone

Cas:133454-47-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Stage #1: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With sodium hydroxide In water at 25 - 30℃; for 0.25h; Industrial scale; Green chemistry;
Stage #2: 4-(3-chloropropoxy)-3-methoxyacetophenone In water at 25 - 30℃; for 0.25h; Industrial scale; Green chemistry;
Stage #3: With tetrabutylammomium bromide In n-heptane; water at 65 - 70℃; Reagent/catalyst; Solvent; Temperature; Concentration; Time; Industrial scale; Green chemistry;
95%
With sodium hydrogencarbonate In toluene; acetonitrile at 76℃; for 6h; Temperature;90.5%
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 16h;
4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxy-α-methylbenzenemethanol
133454-55-4

4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxy-α-methylbenzenemethanol

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With oxygen at 120℃; for 10h; Green chemistry;90%
1-[4-(3-bromopropoxy)-3-methoxyphenyl]ethanone
3245-49-6

1-[4-(3-bromopropoxy)-3-methoxyphenyl]ethanone

(2,4-difluorophenyl)(4-piperidinyl)methanone oxime
84163-46-2

(2,4-difluorophenyl)(4-piperidinyl)methanone oxime

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With potassium iodide; lithium hydroxide In ethanol; water at 70℃; for 2h; Temperature; Solvent; Reagent/catalyst;88.76%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxy-benzonitrile

4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxy-benzonitrile

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Stage #1: methyl magnesium iodide; 4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxy-benzonitrile With copper(l) chloride In diethyl ether; toluene for 2h; Reflux;
Stage #2: With sulfuric acid; water In diethyl ether; toluene at 25℃; for 2h; Reflux;
Stage #3: With sodium carbonate In diethyl ether; water; toluene
70%
3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole
329977-73-3

3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole

1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With lithium hydroxide In dichloromethane; water at 180℃; under 33753.4 Torr; Solvent; Flow reactor;64%
With potassium carbonate In butanone at 78 - 80℃;
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

potassium carbonate
584-08-7

potassium carbonate

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

A

3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate
1400590-28-4

3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate

B

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
In N,N-dimethyl-formamideA 20%
B 58%
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

potassium carbonate
584-08-7

potassium carbonate

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
In N-methyl-acetamide
In N-methyl-acetamide5.0 g (58%)
5.0 g (58%)
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 60 - 85 °C
1.2: 0 - 30 °C
2.1: triethylamine / methanol
View Scheme
1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: potassium carbonate / acetonitrile / 60 - 85 °C
2.2: 0 - 30 °C
3.1: triethylamine / methanol
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 20 h / Reflux
2.1: sodium hydroxide / water / 0.25 h / 25 - 30 °C / Industrial scale; Green chemistry
2.2: 0.25 h / 25 - 30 °C / Industrial scale; Green chemistry
2.3: 65 - 70 °C / Industrial scale; Green chemistry
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 25 - 30 °C / Industrial scale; Green chemistry
2.1: sodium hydroxide / water / 0.25 h / 25 - 30 °C / Industrial scale; Green chemistry
2.2: 0.25 h / 25 - 30 °C / Industrial scale; Green chemistry
2.3: 65 - 70 °C / Industrial scale; Green chemistry
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 25 - 30 °C / Industrial scale; Green chemistry
2: N,N-dimethyl-formamide
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 20 h / Reflux
2: N,N-dimethyl-formamide
View Scheme
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 60 - 85 °C
1.2: 0 - 30 °C
2.1: triethylamine / methanol
View Scheme
4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone hydrochloride
1299470-39-5

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone hydrochloride

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With triethylamine In methanol
3-methoxy-4-(3-chloropropoxy) benzaldehyde
151719-92-5

3-methoxy-4-(3-chloropropoxy) benzaldehyde

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / diethyl ether / 1 h / Reflux
1.2: 6 h / 0 °C / Reflux
1.3: Cooling with ice
2.1: potassium dichromate; sulfuric acid / diethyl ether; water / 2 h / 10 - 20 °C
3.1: diisopropylamine / methanol / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium formate; formic acid / 1 h / Reflux
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 9 h / 30 - 90 °C
3.1: copper(l) chloride / toluene; diethyl ether / 2 h / Reflux
3.2: 2 h / 25 °C / Reflux
View Scheme
vanillin
121-33-5

vanillin

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / Reflux
2.1: magnesium / diethyl ether / 1 h / Reflux
2.2: 6 h / 0 °C / Reflux
2.3: Cooling with ice
3.1: potassium dichromate; sulfuric acid / diethyl ether; water / 2 h / 10 - 20 °C
4.1: diisopropylamine / methanol / Reflux
View Scheme
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole
84163-77-9

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With diisopropylamine In methanol Reflux;
Stage #1: 4-(3-chloropropoxy)-3-methoxyacetophenone; 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole In water at 30 - 35℃; for 0.5h;
Stage #2: With sodium hydroxide In methanol; water at 60℃; for 6.75h; Product distribution / selectivity;
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With potassium carbonate; sodium bromide In water; N,N-dimethyl-formamide at 70℃; for 20h;
In N,N-dimethyl-formamide at 90 - 95℃; Concentration;97 g
6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

4'-(3-p-toluenesulfonylpropoxy)-3'-methoxyacetophenone
1309041-89-1

4'-(3-p-toluenesulfonylpropoxy)-3'-methoxyacetophenone

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 65 - 90℃; for 14h;
3-methoxy-4-hydroxybenzonitrile
4421-08-3

3-methoxy-4-hydroxybenzonitrile

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 0.08 h / 25 - 30 °C
1.2: 12.5 h / 25 - 30 °C / Reflux
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 9 h / 30 - 90 °C
3.1: copper(l) chloride / toluene; diethyl ether / 2 h / Reflux
3.2: 2 h / 25 °C / Reflux
View Scheme
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

potassium carbonate
584-08-7

potassium carbonate

A

3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate
1400590-28-4

3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate

B

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 90℃; for 16.1667h;
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

caesium carbonate
534-17-8

caesium carbonate

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole
84163-77-9

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

A

3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate
1400590-28-4

3-(4-acetyl-2-methoxyphenoxy)propyl 4-(6-fluorobenzo[d]isoxazol-3-yl)piperidine-1-carboxylate

B

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 90℃; for 970h; Product distribution / selectivity;
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Stage #1: 1.3-chlorobromopropane; 1-(3-methoxy-4-hydroxyphenyl)ethanone With tetrabutylammomium bromide; potassium carbonate In acetonitrile at 80℃; Industry scale;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With tetrabutylammomium bromide; potassium carbonate In methanol at 60 - 65℃; autoclave;
(Z)-(2,4-difluorophenyl)(piperidin-4-yl)methanone oxime acetate

(Z)-(2,4-difluorophenyl)(piperidin-4-yl)methanone oxime acetate

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydroxide / water; ethanol / 110 °C / 15001.5 Torr / Flow reactor
2: lithium hydroxide / water; dichloromethane / 125 °C / 15001.5 Torr / Flow reactor
3: lithium hydroxide / water; dichloromethane / 180 °C / 33753.4 Torr / Flow reactor
View Scheme
6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole
84163-77-9

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / water; dichloromethane / 125 °C / 15001.5 Torr / Flow reactor
2: lithium hydroxide / water; dichloromethane / 180 °C / 33753.4 Torr / Flow reactor
View Scheme
2-methoxyphenyl acetate
613-70-7

2-methoxyphenyl acetate

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanesulfonic acid / dichloromethane / 15751.6 Torr / Flow reactor
2: lithium hydroxide / water; dichloromethane / 180 °C / 33753.4 Torr / Flow reactor
View Scheme
pyrid-2-ylhydrazine
4930-98-7

pyrid-2-ylhydrazine

iloperidone
133454-47-4

iloperidone

(E)-6-fluoro-3-(1-(3-(2-methoxy-4-(1-(2-(pyridin-2-yl)hydrazono)ethyl)phenoxy)propyl)piperidin-4-yl)benzo[d]isoxazole

(E)-6-fluoro-3-(1-(3-(2-methoxy-4-(1-(2-(pyridin-2-yl)hydrazono)ethyl)phenoxy)propyl)piperidin-4-yl)benzo[d]isoxazole

Conditions
ConditionsYield
In ethanol at 70℃; for 24h;90%
iloperidone
133454-47-4

iloperidone

C24H21(2)H6FN2O4

C24H21(2)H6FN2O4

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; water-d2; potassium carbonate; silver carbonate In toluene at 90℃; for 12h;80%
iloperidone
133454-47-4

iloperidone

4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxy-α-methylbenzenemethanol
133454-55-4

4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxy-α-methylbenzenemethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; methanol for 3h; Ambient temperature;67%
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

iloperidone
133454-47-4

iloperidone

6-fluoro-3-[1-[3-[2-methoxy-4-(1-methylethenyl)phenoxy]propyl]-4-piperidinyl]-1,2-benzisoxazole

6-fluoro-3-[1-[3-[2-methoxy-4-(1-methylethenyl)phenoxy]propyl]-4-piperidinyl]-1,2-benzisoxazole

Conditions
ConditionsYield
With n-butyllithium 1.) THF, hexane, -65 deg C, 1 h, 2.) THF, hexane, RT, 19 h; Multistep reaction;
iloperidone
133454-47-4

iloperidone

(S)-1-(4-{3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propoxy}-3-methoxyphenyl)-ethanol
501373-88-2

(S)-1-(4-{3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propoxy}-3-methoxyphenyl)-ethanol

Conditions
ConditionsYield
With borane complex of (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane at 0℃; for 21.5h;
With (3aR,7R)-1-methyl-3,3-diphenyl-tetrahydropyrrolo[1,2-c][1,3,2]oxazaborol In dichloromethane at 0℃; for 20h; Inert atmosphere;
iloperidone
133454-47-4

iloperidone

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone hydrazone

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone hydrazone

iloperidone
133454-47-4

iloperidone

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3methoxyphenyl]ethanone oxime

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3methoxyphenyl]ethanone oxime

Conditions
ConditionsYield
With ammonium hydroxide In water
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

iloperidone
133454-47-4

iloperidone

A

6-Fluoro]-3-[1-[3-[2-methoxy-4-(1-methylethenyl)phenoxy]propyl]-4-piperidinyl]-1,2-benzisoxazole hydrochloride

6-Fluoro]-3-[1-[3-[2-methoxy-4-(1-methylethenyl)phenoxy]propyl]-4-piperidinyl]-1,2-benzisoxazole hydrochloride

B

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran
iloperidone
133454-47-4

iloperidone

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxime

1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxime

Conditions
ConditionsYield
With ammonium hydroxide In water
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

iloperidone
133454-47-4

iloperidone

A

6-fluoro-3-<1-<3-<2-methoxy-4-(1-methylethenyl)phenoxy>propyl>-4-piperidinyl>-1,2-benzisoxazole hydrochloride

6-fluoro-3-<1-<3-<2-methoxy-4-(1-methylethenyl)phenoxy>propyl>-4-piperidinyl>-1,2-benzisoxazole hydrochloride

B

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran
iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone phosphate
1299470-40-8

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone phosphate

Conditions
ConditionsYield
With phosphoric acid In isopropyl alcohol Reflux;
iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone bisulphate
1299470-41-9

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone bisulphate

Conditions
ConditionsYield
With sulfuric acid In ethanol Reflux;
iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone hydrochloride
1299470-39-5

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water Reflux;
iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone hydrobromide

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In ethanol; water Reflux;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone p-toluenesulphonate
1299470-48-6

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone p-toluenesulphonate

Conditions
ConditionsYield
In ethanol Reflux;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone fumarate
1299470-45-3

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone fumarate

Conditions
ConditionsYield
In ethanol Reflux;
oxalic acid
144-62-7

oxalic acid

iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone oxalate
1299470-44-2

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone oxalate

Conditions
ConditionsYield
In ethanol; water Reflux;
malonic acid
141-82-2

malonic acid

iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone malonate
1299470-42-0

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone malonate

Conditions
ConditionsYield
In ethanol Reflux;
methanesulfonic acid
75-75-2

methanesulfonic acid

iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone methanesulphonate
1299470-47-5

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone methanesulphonate

Conditions
ConditionsYield
In ethanol Reflux;
succinic acid
110-15-6

succinic acid

iloperidone
133454-47-4

iloperidone

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone succinate
1299470-43-1

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone succinate

Conditions
ConditionsYield
In ethanol Reflux;
iloperidone
133454-47-4

iloperidone

benzenesulfonic acid
98-11-3

benzenesulfonic acid

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone benzenesulphonate
1299470-46-4

4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone benzenesulphonate

Conditions
ConditionsYield
In ethanol Reflux;

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