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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Buy Reliable Quality Hot Sale 211915-84-3 Cheap Price

Cas:211915-84-3

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester

Cas:211915-84-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Dabigatran intermediate Cas 211915-84-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Package:10g,100g,1kg/foil bag ;25kg/drum or per

High quality Dabigatran intermediate Cas 211915-84-3 with best price and good service

Cas:211915-84-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester CAS No.:211915-84-3 Name: 3-[[[2-[[(4-Cyanophenyl)amino]met

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl N-{(2-{[(4-cyanophenyl)-amino]-methyl}-1-methyl-1H-benzimidazol-5-yl}-carbonyl}-N-pyridin-2-yl-β-alaninate

Cas:211915-84-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/228.html Product Name 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol -5-yl]carb

Henan Tianfu Chemical Co., Ltd.

Product Name: 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester Synonyms: 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]

LIDE PHARMACEUTICALS LIMITED

(1) Company profile: Company profile: Lide pharmaceuticals limited Main products: APIs; Intermediate and other fine chemical products; Piperazine series; Custom Synthesis. Main Markets: North America; South America; Eastern Europe; Southeast

3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester

Cas:211915-84-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.25 ± 0.1 g/cm3 (Predicted) Melting point: 149-151 ° C Boiling point: 756.4 ± 60.0 ° C (Predicted) Flash point: 411.245 ° C Steam pressure: 0mmHg at 25 ° C Solubility: DMSO (Slightly, Sonicated), Methanol (Very

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 211915-84-3 with best quality

Cas:211915-84-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name Dabigatran Intermediate 3 CAS 211915-84-3 Other name 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic aci

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 211915-84-3 Dabigatran iMpurity I with best price

Cas:211915-84-3

Min.Order:10 Gram

Negotiable

Type:Other

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Hangzhou Maytime Bio-Tech Co.,Ltd.

good quality , competitive price Appearance:0.5%max. Storage:keep from moisture,store in tight container Package:25kgs/fiber drum Application:Dabigatran Port:shanghai or hangzhou

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Qingdao Beluga Import and Export Co., LTD

3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester CAS:211915-84-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester Synonyms: 211915-84-3;Ethyl 3-(2-((4-cyanophenylaMino)Methyl)-1-Methyl-N-(pyridin-2-yl)-;3-[[[2-[[(4-Cyanophen

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

ethyl N-[(2-{[(4-cyanophenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alaninate

Cas:211915-84-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester

Cas:211915-84-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

Synthetic route

1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide p-toluenesulfonate

1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide p-toluenesulfonate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With ammonium hydroxide In dichloromethane; water pH=8 - 10;95.5%
(4-cyanophenyl)glycine
42288-26-6

(4-cyanophenyl)glycine

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
212322-56-0

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (4-cyanophenyl)glycine; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate With 1,1'-carbonyldiimidazole In Isopropyl acetate at 20℃; for 4h;
Stage #2: With acetic acid In Isopropyl acetate for 2h; Reflux;
95%
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In toluene at 50℃;
Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In toluene at 20 - 25℃; Temperature;
93.97%
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 3℃; for 1h;
Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In N,N-dimethyl-formamide at 20℃; for 6h; Temperature; Further stages;
91.1%
3-({3-[2-(4-cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-pyridin-2-yl-amino)-ethyl propanoate
948551-71-1

3-({3-[2-(4-cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-pyridin-2-yl-amino)-ethyl propanoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With acetic acid at 110℃; for 2h; Large scale;92%
With acetic acid In acetic acid butyl ester at 85 - 90℃;90.8%
Stage #1: 3-({3-[2-(4-cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-pyridin-2-yl-amino)-ethyl propanoate With acetic acid In dichloromethane at 80 - 85℃; for 10h; Large scale;
Stage #2: With ammonia In dichloromethane pH=9; Reagent/catalyst; Solvent; Large scale;
83.3%
With acetic acid for 1h; Heating;
In toluene Reflux;120 g
isopropyl 2‑(4‑cyanophenylamino)acetate

isopropyl 2‑(4‑cyanophenylamino)acetate

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
212322-56-0

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 35℃;82%
ethyl 2-((4-cyanophenyl)amino)acetate

ethyl 2-((4-cyanophenyl)amino)acetate

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
212322-56-0

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
In propionic acid at 130℃; for 12h; Solvent; Temperature;81%
2-(4-cyanophenylamino)acetamide

2-(4-cyanophenylamino)acetamide

C19H23N3O4

C19H23N3O4

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With acetic acid; 1,1'-carbonyldiimidazole In ethyl acetate at 50℃; for 6h; Concentration;47.7%
4-methylamino-3-nitro-benzoic acid chloride
82357-48-0

4-methylamino-3-nitro-benzoic acid chloride

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Et3N / tetrahydrofuran / 20 °C
2.1: 65 percent / H2 / 10percent Pd/C / methanol / 20 °C
3.1: CDI / tetrahydrofuran / 50 °C
3.2: tetrahydrofuran / 24 h / Heating
4.1: glacial acetic acid / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran; dichloromethane / 2 h / 40 °C
2.1: palladium on activated charcoal; hydrogen / water; ethanol / 50 °C / Autoclave
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.67 h / Inert atmosphere; Reflux
3.2: 7 h / Inert atmosphere; Reflux
3.3: 3 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 0 - 10 °C
1.2: 0 - 30 °C
2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr
3.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C
3.2: 0.08 h / 0 - 5 °C
4.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 12 h / 20 °C
2.1: palladium 10% on activated carbon / 20 h / 22801.5 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C
3.2: 20 °C
View Scheme
4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: SOCl2 / dimethylformamide / 0.5 h / Heating
2.1: Et3N / tetrahydrofuran / 20 °C
3.1: 65 percent / H2 / 10percent Pd/C / methanol / 20 °C
4.1: CDI / tetrahydrofuran / 50 °C
4.2: tetrahydrofuran / 24 h / Heating
5.1: glacial acetic acid / 1 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride / tetrahydrofuran / 0.67 - 0.75 h / Reflux; Inert atmosphere
2.1: triethylamine / tetrahydrofuran; dichloromethane / 2 h / 40 °C
3.1: palladium on activated charcoal; hydrogen / water; ethanol / 50 °C / Autoclave
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.67 h / Inert atmosphere; Reflux
4.2: 7 h / Inert atmosphere; Reflux
4.3: 3 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 1.25 h / 25 - 80 °C
1.2: 1 h
2.1: palladium on activated charcoal / ethyl acetate / 0.33 h / 25 - 55 °C / High pressure
3.1: 1,1'-carbonyldiimidazole / toluene / 2 h / 55 - 60 °C
3.2: 6 h / 60 - 100 °C
View Scheme
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
212322-56-0

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: CDI / tetrahydrofuran / 50 °C
1.2: tetrahydrofuran / 24 h / Heating
2.1: glacial acetic acid / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C
1.2: 0.08 h / 0 - 5 °C
2.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C
1.2: 20 °C
2.1: acetic acid / acetic acid butyl ester / 85 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 6 h / 0 - 5 °C / Large scale
1.2: 24 h / 20 °C / Large scale
2.1: acetic acid / dichloromethane / 10 h / 80 - 85 °C / Large scale
2.2: pH 9 / Large scale
View Scheme
ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
429659-01-8

ethyl 3-{[{1-(methylamino)-2-nitrophen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 65 percent / H2 / 10percent Pd/C / methanol / 20 °C
2.1: CDI / tetrahydrofuran / 50 °C
2.2: tetrahydrofuran / 24 h / Heating
3.1: glacial acetic acid / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal / ethyl acetate / 0.33 h / 25 - 55 °C / High pressure
2.1: 1,1'-carbonyldiimidazole / toluene / 2 h / 55 - 60 °C
2.2: 6 h / 60 - 100 °C
View Scheme
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal / ethyl acetate / 25 - 55 °C
2.1: 1,1'-carbonyldiimidazole / toluene / 25 - 60 °C
2.2: 6 h / 60 - 100 °C
View Scheme
4-Aminobenzonitrile
873-74-5

4-Aminobenzonitrile

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium iodide; sodium hydrogencarbonate; tetrabutylammomium bromide / water / 24 h / 90 - 95 °C
1.2: 0.33 h / 20 - 30 °C / pH 7.5
1.3: 3 h / 20 - 30 °C / pH 2.5
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 50 - 55 °C
2.2: 50 h / 50 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1.1: water / 16 h / 100 °C
2.1: 1,1'-carbonyldiimidazole / toluene / 2 h / 55 - 60 °C
2.2: 6 h / 60 - 100 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium iodide; tetrabutylammomium bromide; sodium hydrogencarbonate / water / 24 h / 90 - 95 °C
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 50 - 55 °C
2.2: 52 h / 50 - 65 °C
2.3: 5 h / 95 - 100 °C
View Scheme
ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride hemisulfate

ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]propanoate hydrochloride hemisulfate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal; hydrogen / water; ethanol / 50 °C / Autoclave
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.67 h / Inert atmosphere; Reflux
2.2: 7 h / Inert atmosphere; Reflux
2.3: 3 h / Reflux
View Scheme
2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate
103041-38-9

2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 0 - 10 °C
1.2: 0 - 30 °C
2.1: hydrogen / ethyl acetate / 60 - 65 °C / 7500.75 Torr
3.1: pivaloyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 5 °C
3.2: 0.08 h / 0 - 5 °C
4.1: ammonium hydroxide / water; dichloromethane / pH 8 - 10
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 12 h / 20 °C
2.1: palladium 10% on activated carbon / 20 h / 22801.5 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 0 °C
3.2: 20 °C
View Scheme
1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt
1188417-09-5

1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With ammonium hydroxide In dichloromethane; water at 25 - 35℃; for 0.166667h; pH=9.5;55 g
(4-cyanophenyl)glycine
42288-26-6

(4-cyanophenyl)glycine

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dichloromethane / Reflux
2.1: dichloromethane / 4 h / Reflux
3.1: toluene / Dean-Stark; Reflux
3.2: 0.5 h / Reflux
4.1: ammonium hydroxide / dichloromethane; water / 0.17 h / 25 - 35 °C / pH 9.5
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane / 20 - 25 °C / Inert atmosphere
2: toluene / 3 h / 50 °C
3: toluene / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C
1.2: 20 °C
2.1: acetic acid / acetic acid butyl ester / 85 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 6 h / 0 - 5 °C / Large scale
1.2: 24 h / 20 °C / Large scale
2.1: acetic acid / dichloromethane / 10 h / 80 - 85 °C / Large scale
2.2: pH 9 / Large scale
View Scheme
4-(2-imidazol-1-yl-2-oxoethylamino)benzonitrile

4-(2-imidazol-1-yl-2-oxoethylamino)benzonitrile

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane / 4 h / Reflux
2.1: toluene / Dean-Stark; Reflux
2.2: 0.5 h / Reflux
3.1: ammonium hydroxide / dichloromethane; water / 0.17 h / 25 - 35 °C / pH 9.5
View Scheme
3-amino-4-[N-[2-(4-cyanophenylamino)acetyl]-N-methylamino]benzoic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

3-amino-4-[N-[2-(4-cyanophenylamino)acetyl]-N-methylamino]benzoic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / Dean-Stark; Reflux
1.2: 0.5 h / Reflux
2.1: ammonium hydroxide / dichloromethane; water / 0.17 h / 25 - 35 °C / pH 9.5
View Scheme
methyl 3-methoxy-4-aminobenzoate
41608-64-4

methyl 3-methoxy-4-aminobenzoate

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran / 3.5 h / 0 - 25 °C
2: ethyl acetate / 12 h / 25 °C
3: 1,1'-carbonyldiimidazole; acetic acid / ethyl acetate / 6 h / 50 °C
View Scheme
C27H26N6O6

C27H26N6O6

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With 5% Pd(OH)2/C; hydrogen; acetic acid In ethyl acetate under 750.075 Torr;14.9 mg
C27H29N7O4

C27H29N7O4

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

Conditions
ConditionsYield
With acetic acid for 1.5h; Reflux;
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester

3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol at 35 - 42℃;
Stage #2: With ammonium carbonate; ammonia In ethanol at 0 - 32℃;
96.61%
With lithium hexamethyldisilazane In tetrahydrofuran at -5 - 20℃; for 2h; Solvent;95%
With hydrogenchloride In ethanol at 20℃;92%
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid
212322-77-5

3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 20℃; for 2h;96.1%
ethanol
64-17-5

ethanol

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

3-({2-[(4-ethoxycarbonimidoylphenylamino)methyl]1-methyl-1H-benzimidazol-5-carbonyl}pyridin-2-yl-amino)ethyl propanoate hydrochloride
1354727-65-3

3-({2-[(4-ethoxycarbonimidoylphenylamino)methyl]1-methyl-1H-benzimidazol-5-carbonyl}pyridin-2-yl-amino)ethyl propanoate hydrochloride

Conditions
ConditionsYield
With trichlorophosphate at 0 - 25℃;93%
With hydrogenchloride at 10 - 35℃; for 24h;
With hydrogenchloride In chloroform; toluene at 10℃; for 24h; Solvent; Temperature;
benzenesulfonic acid
98-11-3

benzenesulfonic acid

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

ethyl 3-[[[2-[[(4-amidinophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propanoate benzensulfonate

ethyl 3-[[[2-[[(4-amidinophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propanoate benzensulfonate

Conditions
ConditionsYield
Stage #1: benzenesulfonic acid; 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol; water at -5 - 20℃; for 24h;
Stage #2: With ammonia In ethanol; water at 0 - 20℃; for 24h; Temperature; Concentration;
92.6%
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride salt

1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride salt

Conditions
ConditionsYield
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol at 10 - 25℃;
Stage #2: With ammonium hydroxide at 0 - 20℃;
81.9%
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol at 25℃; for 25h;
Stage #2: With ammonium hydroxide In ethanol for 6h; pH=8.5 - 9.5;
77%
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride; propionyl chloride; Ethyl propionate In ethanol; water at 10 - 40℃; for 10h; Pinner Amidine Synthesis; Large scale;
Stage #2: With ammonium hydroxide In ethanol; water at 50℃; for 10h; pH=9; Solvent; Reagent/catalyst; Concentration; Large scale;
75.4%
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

C27H29N7O4
658078-29-6

C27H29N7O4

Conditions
ConditionsYield
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol
Stage #2: With hydroxylamine hydrochloride; triethylamine In ethanol
80%
diethyl ether
60-29-7

diethyl ether

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid
212322-77-5

3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water78%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

1-methyl-2-[N-(4-amidino-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-2-(ethoxycarbonylethyl)-amide p-toluenesulfonic acid salt
872728-85-3

1-methyl-2-[N-(4-amidino-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-2-(ethoxycarbonylethyl)-amide p-toluenesulfonic acid salt

Conditions
ConditionsYield
Stage #1: toluene-4-sulfonic acid; 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol at 25 - 30℃; for 20h; Autoclave; Large scale;
Stage #2: With ammonia In ethanol at 20 - 30℃; for 2h; Autoclave; Large scale;
Stage #3: With sodium hydroxide In ethanol; water at 20℃; for 1h; Autoclave; Large scale;
73.48%
With hydrogenchloride In ethanol at 0 - 17℃; for 18h; Temperature;26.2 g
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

1-methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide
658078-29-6

1-methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide

Conditions
ConditionsYield
With hydroxylamine hydrochloride; triethylamine In dimethyl sulfoxide at 20 - 30℃; for 24h; Solvent; Reagent/catalyst; Temperature;70%
With hydroxylamine hydrochloride; sodium ethanolate In ethanol at 0 - 58℃; for 24h;
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

1-methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid (N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide

1-methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid (N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide

Conditions
ConditionsYield
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With hydrogenchloride In ethanol at 0 - 20℃; for 5h;
Stage #2: With hydroxylamine hydrochloride; triethylamine In ethanol at 0 - 20℃; for 2h;
61.5%
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

N-[[2-[[[4-(N'-hydroxycarbamimidoyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridyl)-β-alanine ethyl ester hydrochloride

N-[[2-[[[4-(N'-hydroxycarbamimidoyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridyl)-β-alanine ethyl ester hydrochloride

Conditions
ConditionsYield
With hydroxylamine hydrochloride; triethylamine In methanol at 50 - 55℃; for 3h; Solvent; Temperature; Reagent/catalyst;50%
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

dabigatran

dabigatran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: HCl / ethanol / 0 °C
1.2: 71 percent / (NH4)2CO3 / ethanol / 20 °C
2.1: 91 percent / aq. NaOH / ethanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / ethanol / 12 h / 20 °C
1.2: 5 h / 20 °C
2.1: sodium hydroxide; water / ethanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 18 h / 10 - 15 °C
2.1: acetone / 2 h / 20 °C
3.1: potassium carbonate / water / 20 - 25 °C / pH Ca. 10
3.2: 8 h
4.1: sodium hydroxide / water; ethanol / 6 h
View Scheme
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

dabigatran etexilate
211915-06-9

dabigatran etexilate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: HCl / ethanol / 0 °C
1.2: 71 percent / (NH4)2CO3 / ethanol / 20 °C
2.1: aq. K2CO3 / tetrahydrofuran / 0.25 h / 20 °C
2.2: 51 percent / tetrahydrofuran / 1 h / 20 °C
View Scheme
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

BrH*C27H26N6O3
1046806-03-4

BrH*C27H26N6O3

Conditions
ConditionsYield
With hydrogen bromide In water; isopropyl alcohol at 7 - 38℃; for 1.33333h; pH=0.6 - 1.3; Industry scale;
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

dabigatran etexilate
211915-06-9

dabigatran etexilate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: calcium(II) chloride dihydrate / ethanol / 0.33 h
1.2: 13 h / 0 - 30 °C
1.3: 10.5 h / 0 - 35 °C
2.1: ethanol / 6.75 h / 25 - 60 °C
3.1: potassium carbonate / acetonitrile; water / 0.25 h / 12 - 18 °C
3.2: 4.5 h / 12 - 18 °C
View Scheme
Multi-step reaction with 3 steps
1.1: calcium(II) chloride dihydrate / ethanol / 0.33 h
1.2: 13 h / 0 - 30 °C
1.3: 10.5 h / 0 - 35 °C
2.1: ethanol / 6.75 h / 25 - 60 °C
3.1: potassium carbonate / acetonitrile; water / 0.25 h / 12 - 18 °C
3.2: 14.42 h / 12 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / ethanol; dichloromethane / 6 h / 15 - 30 °C
1.2: 15 - 30 °C
2.1: triethylamine / water; acetonitrile / 15 °C
View Scheme
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide hydrochloride

1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / isopropyl alcohol / 1 h / 0 - 35 °C
2: hydrogenchloride / 24 h / 30 °C
3: ammonium carbonate / ethanol / 20 °C / Inert atmosphere
View Scheme
Stage #1: 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester With calcium(II) chloride dihydrate In ethanol for 0.333333h;
Stage #2: With hydrogenchloride at 0 - 30℃; for 13h;
Stage #3: With ammonium formate; ammonium carbonate at 0 - 35℃; for 10h;
45 g
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

ethyl N-[(2-[(p-[ethoxyimidoyl]phenyl)amino]methyl)-1-methyl-1H-benzimidazole-5-carbonyl]-N-(2-pyridyl)-3-aminopropionate hydrochloride

ethyl N-[(2-[(p-[ethoxyimidoyl]phenyl)amino]methyl)-1-methyl-1H-benzimidazole-5-carbonyl]-N-(2-pyridyl)-3-aminopropionate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / isopropyl alcohol / 1 h / 0 - 35 °C
2: hydrogenchloride / 24 h / 30 °C
View Scheme
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

dabigatran etexilate
211915-06-9

dabigatran etexilate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / isopropyl alcohol / 1 h / 0 - 35 °C
2: hydrogenchloride / 24 h / 30 °C
3: ammonium carbonate / ethanol / 20 °C / Inert atmosphere
4: triethylamine / acetone / 1.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / ethanol / 18 h / 0 - 17 °C
2: potassium carbonate / acetone; water / 1.5 h / 12 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / ethanol / 24 h / 20 °C
1.2: 10 - 20 °C
2.1: potassium carbonate / water; acetone / 10 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 24 h / 20 - 30 °C
2.1: hydrogen; acetic acid / water / 24 h / 55 - 65 °C
2.2: 1 h
3.1: potassium carbonate / water; acetone / 10 - 20 °C
View Scheme
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
211915-84-3

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

ethyl N-[(2-[(p-cyanophenyl)amino]methyl)-1-methyl-1H-benzimidazole-5-carbonyl]-N-(2-pyridyl)-3-aminopropionate hydrochloride

ethyl N-[(2-[(p-cyanophenyl)amino]methyl)-1-methyl-1H-benzimidazole-5-carbonyl]-N-(2-pyridyl)-3-aminopropionate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 0 - 35℃; for 1h;

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