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Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support ★.Shortest delivery time . There are several standard production bases in Zhejiang, Jiangsu and Shandong P

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $4.0 / 5.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Chloro-6-ethyl-5-fluoropyrimidine Manufacturer/High quality/Best price/In stock

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloro-6-Ethyl-5-Fluoropyimidine supplier in China

Cas:137234-74-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

4-Chloro-6-ethyl-5-fluoropyrimidine CAS No.:137234-74-3 Name: 4-Chloro-6-ethyl-5-fluoropyrimidine Molecular Structure Molecular Formula: C6H6ClFN2

High purity 4-Chloro-6-ethyl-5-fluoropyrimidine CAS No.:137234-74-3

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

137234-74-3 4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 137234-74-3 4-Chloro-6-ethyl-5-fluoropyrimidine (Vor Manufacturer

Cas:137234-74-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

4-Chloro-6-Ethyl-5-Fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1982.html Product Name 4-Chloro-6-ethyl-5-fluoropyrimidine CAS No.

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 137234-74-3 4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-Chloro-6-ethyl-5-fluoropyrimidine CAS 137234-74-3

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 137234-74-3 with competitive price

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Chloro-6-ethyl-5-fluoropyrimidine/ LIDE PHARMA- Factory supply / Best price

Cas:137234-74-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

4-Chloro-6-ethyl-5-fluoropyrimidine;CAS;137234-74-3

Cas:137234-74-3

Min.Order:1 Metric Ton

FOB Price: $20.0 / 30.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

CAS 137234-74-3 Details Chemical Name:4-Chloro-6-ethyl-5-fluoropyrimidine CAS No.: 137234-74-3 Molecular Formula: C6H6ClFN2 Molecular Weight: 160.58 Appearance: Colorless to light yellow liquid Appearance:Colorless to light yellow liquid Storage

4-chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Chloro-6-ethyl-5-fluoropyrimidine 137234-74-3

Cas:137234-74-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:white Storage:Inert atmosp

GMP High Purity 4-Chloro-6-Ethyl-5-Fluoropyrimidine Pharmaceutical Chemicals CAS 137234-74-3

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Antibiotic and Antimicrobial Agents, 4-Chloro-6-ethyl-5-fluoropyrimidine CAS:137234-74-3

Cas:137234-74-3

Min.Order:1 Kilogram

FOB Price: $136.0 / 142.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 4-Chloro-6-ethyl-5-fluoropyrimidine 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exp

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 4-Chloro-6-ethyl-5-fluoropyrimidine Synonyms: 4-Chloro-5-fluoro-6-ethylpyriMidine;PyriMidine, 4-chloro-6-ethyl-5-fluoro-;4-chloro-6-ethyl-5-fluoropyiMidine;4-CHLORO-6-ETHYL-5-FLUOROPYRIMIDINE;6-CHLORO-4-ETHYL-5-FLUORO-1,6-DIHYDROPY

4-Chloro-6-ethyl-5-fluoropyrimidine Manufactory best quality

Cas:137234-74-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Chloro-6-ethyl-5-fluoropyrimidine 137234-74-3

Cas:137234-74-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloro-6-Ethyl-5-Fluoropyrimidine

Cas:137234-74-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-(Chloro)-5-fluoropyrimidine cas no.137234-74-3 0.98

Cas:137234-74-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

4-Chloro-6-ethyl-5-fluoropyrimidine

Cas:137234-74-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-CHLORO-6-ETHYL-5-FLUOROPYRIMIDINE

Cas:137234-74-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

6-ethyl-5-fluoropyrimidin-4(1H)-one
137234-87-8

6-ethyl-5-fluoropyrimidin-4(1H)-one

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Conditions
ConditionsYield
With triethylamine; trichlorophosphate In dichloromethane at 48℃; for 6h; Product distribution / selectivity; Industry scale; Heating / reflux;99%
With triethylamine; trichlorophosphate In dichloromethane for 5h; Product distribution / selectivity; Heating / reflux;90%
With triethylamine; trichlorophosphate In dichloromethane at 40℃; for 5.16667h; Reflux;
6-ethyl-5-fluoro-4-hydroxypyrimidine
137234-87-8

6-ethyl-5-fluoro-4-hydroxypyrimidine

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Conditions
ConditionsYield
Stage #1: 6-ethyl-5-fluoro-4-hydroxypyrimidine With triethylamine; trichlorophosphate In dichloromethane for 5.5h; Heating / reflux;
Stage #2: With hydrogenchloride; water In dichloromethane at 20℃;
95%
With triethylamine; trichlorophosphate In dichloromethane at 40℃; for 8h; Reflux;90%
With trichlorophosphate In N,N-dimethyl-formamide at 90℃; for 5h;90.2%
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
188416-35-5

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

A

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

B

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Conditions
ConditionsYield
With hydrogenchloride In water at 60 - 70℃; Temperature; Reagent/catalyst; Solvent;A 88.4%
B n/a
6-Ethyl-5-fluoropyrimidin-4(3H)-one
137234-87-8

6-Ethyl-5-fluoropyrimidin-4(3H)-one

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Conditions
ConditionsYield
With trichlorophosphate Heating;
2-fluoro-3-oxopentanoic acid ethyl ester
759-67-1

2-fluoro-3-oxopentanoic acid ethyl ester

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) MeONa, MeOH
2: POCl3 / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium methylate / methanol / 20 h / 15 °C
2: trichlorophosphate / 3 h / 60 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
188416-28-6

1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane at 55℃; for 16h; Temperature;98%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 12h; Reflux;95.1%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In dichloromethane for 12h; Reflux;95.1%
p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

4-(4-chloro-phenylsulfanyl)-6-ethyl-5-fluoropyrimidine
1112937-23-1

4-(4-chloro-phenylsulfanyl)-6-ethyl-5-fluoropyrimidine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 20℃; for 2h;96%
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Methyl thiosalicylate
4892-02-8

Methyl thiosalicylate

methyl 2-(6-ethyl-5-fluoropyrimidin-4-yl-sulfanyl)benzoate
1258386-27-4

methyl 2-(6-ethyl-5-fluoropyrimidin-4-yl-sulfanyl)benzoate

Conditions
ConditionsYield
Stage #1: Methyl thiosalicylate With sodium hydride In tetrahydrofuran at 5℃; for 0.666667h;
Stage #2: 4-chloro-6-ethyl-5-fluoropyrimidine In tetrahydrofuran at 20 - 25℃;
96%
thiophenol
108-98-5

thiophenol

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine
1112937-27-5

4-(phenylsulfanyl)-6-ethyl-5-fluoropyrimidine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10℃; for 2h;95%
(3-(3-phenylpropyl)piperidin-3-yl)methanol

(3-(3-phenylpropyl)piperidin-3-yl)methanol

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

(1-(6-ethyl-5-fluoropyrimidin-4-yl)-3-(3-phenylpropyl)piperidin-3-yl)methanol

(1-(6-ethyl-5-fluoropyrimidin-4-yl)-3-(3-phenylpropyl)piperidin-3-yl)methanol

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 17.3h; Sealed tube;81%
(4-(3-phenylpropyl)piperidin-4-yl)methanol hydrochloride

(4-(3-phenylpropyl)piperidin-4-yl)methanol hydrochloride

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

(1-(6-ethyl-5-fluoropyrimidin-4-yl)-4-(3-phenylpropyl)piperidin-4-yl)methanol

(1-(6-ethyl-5-fluoropyrimidin-4-yl)-4-(3-phenylpropyl)piperidin-4-yl)methanol

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube;74%
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

6-ethyl-5-fluoropyrimidine-4-thiol
1119241-48-3

6-ethyl-5-fluoropyrimidine-4-thiol

Conditions
ConditionsYield
With sodium hydrogensulfide In acetonitrile at 48 - 52℃; for 8.75h; Product distribution / selectivity; Industry scale;73%
With sodium hydrogensulfide In methanol at 50℃; for 4.25h; Product distribution / selectivity;
1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

4-ethyl-5-fluoro-6-(1-methyl-1H-tetrazol-5-yl-sulfanyl)pyrimidine

4-ethyl-5-fluoro-6-(1-methyl-1H-tetrazol-5-yl-sulfanyl)pyrimidine

Conditions
ConditionsYield
Stage #1: 1-methyl-5-mercaptotetrazole With sodium hydride In tetrahydrofuran at 5 - 25℃;
Stage #2: 4-chloro-6-ethyl-5-fluoropyrimidine In tetrahydrofuran at 5 - 25℃;
63.4%
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

dl-α-methyl-4-pentafluorophenoxybenzylamine
130339-49-0

dl-α-methyl-4-pentafluorophenoxybenzylamine

6-ethyl-5-fluoro-4-(α-methyl-4-pentafluorophenoxybenzylamino)pyrimidine

6-ethyl-5-fluoro-4-(α-methyl-4-pentafluorophenoxybenzylamino)pyrimidine

Conditions
ConditionsYield
With triethylamine; dmap In N,N-dimethyl-formamide for 8h; Substitution; Heating;
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

dl-α-methyl-4-difluoromethoxybenzylamine
136123-72-3

dl-α-methyl-4-difluoromethoxybenzylamine

6-ethyl-5fluoro-4-(α-methyl-4-difluoromethoxybenzylamino)pyrimidine

6-ethyl-5fluoro-4-(α-methyl-4-difluoromethoxybenzylamino)pyrimidine

Conditions
ConditionsYield
With triethylamine at 20℃; Substitution;
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LDA / tetrahydrofuran
2: H2, AcONa / Pd/C / ethanol / 20 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LDA / tetrahydrofuran
2: H2, AcONa / Pd/C / ethanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C
2.2: 25 - 30 °C / 3677.86 Torr
2.3: 0.5 h / 20 - 25 °C
3.1: acetone; methanol / 15 h / -20 - 25 °C
4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
Multi-step reaction with 5 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 12.5 h / 25 - 30 °C
3.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12
4.1: acetone; methanol / 15 h / -20 - 25 °C
5.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
188416-35-5

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; n-heptane at -70 - -65℃; for 3 - 4h; pH=5 - 8;
1-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]methanamine
1289106-56-4

1-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]methanamine

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

6-ethyl-5-fluoro-N-{[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]methyl}-4-pyrimidinamine hydrochloride

6-ethyl-5-fluoro-N-{[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]methyl}-4-pyrimidinamine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]methanamine; 4-chloro-6-ethyl-5-fluoropyrimidine With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 0℃;
Stage #2: With hydrogenchloride In 1,4-dioxane; methanol
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C
2.2: 25 - 30 °C / 3677.86 Torr
2.3: 0.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 12.5 h / 25 - 30 °C
3.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12
View Scheme
Multi-step reaction with 3 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate; sodium carbonate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 10 - 25 °C
3.1: potassium carbonate / dichloromethane; water / 0.5 h / pH 8 - 10
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
188416-34-4, 137234-71-0

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C
2.2: 25 - 30 °C / 3677.86 Torr
2.3: 0.5 h / 20 - 25 °C
3.1: acetone; methanol / 15 h / -20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 12.5 h / 25 - 30 °C
3.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12
4.1: acetone; methanol / 15 h / -20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate; sodium carbonate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 10 - 25 °C
3.1: potassium carbonate / dichloromethane; water / 0.5 h / pH 8 - 10
4.1: acetone; methanol / 15 h / -20 - 25 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride salt

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride salt

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate; sodium carbonate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 10 - 25 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (+/-)-camphorsulphonate salt

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (+/-)-camphorsulphonate salt

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 12.5 h / 25 - 30 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

(2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

(2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 16 h / Inert atmosphere; Reflux
2.1: lead; zinc; bromine / dichloromethane; tetrahydrofuran / 30 - 50 °C
2.2: 4 h / 20 - 25 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

voriconazole L-camphorsulfate

voriconazole L-camphorsulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 16 h / Inert atmosphere; Reflux
2.1: lead; zinc; bromine / dichloromethane; tetrahydrofuran / 30 - 50 °C
2.2: 4 h / 20 - 25 °C
3.1: sodium hydroxide / water; methanol / 20 - 25 °C / pH 8 - 9
3.2: 55 - 60 °C
3.3: 1 h / 40 - 45 °C
View Scheme
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