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Hangzhou Think Chemical Co. Ltd

Voriconazole [CAS:137234-62-9] white or off-white crystalline powder HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences o

good quality Voriconazole stock

Cas:137234-62-9

Min.Order:1 Kilogram

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Type:Other

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Chongqing Lummy Long Yu Pharmaceutical Co. ,Ltd

Product technology and quality stability,perennial production,to meet the supply demand. Product technology and quality stability,perennial production,to meet the supply demand. Quality: 1. Order products, before delivery, according to customer nee

Voriconazole

Cas:137234-62-9

Min.Order:1 Kilogram

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Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Voriconazole Synonyms: Voriconazole2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;Voriconazole solution;(2R,3S)-2-(2,4-Difluorophenyl)-3;2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,

Voriconazole 99% Manufactuered in China best quality

Cas:137234-62-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Voriconazole Manufacturer/High quality/Best price/In stock

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

We are very compeitive on Voriconazole.Our mfr is GMP certified for this item with DMF document. Product Name: Voriconazole CAS: 137234-62-9 MF: C16H14F3N5O MW: 349.31 EINECS: 629-701-5

factory supply GMP,DMF 137234-62-9 Voriconazole

Cas:137234-62-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Voriconazole CAS No.137234-62-9

Cas:137234-62-9

Min.Order:1 Gram

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Voriconazole Cas 137234-62-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to almost white crystalline powder Storage:Cool dry place Packa

High quality Voriconazole Cas 137234-62-9 with factory best price and good service

Cas:137234-62-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Anti-fungal API raw material 99% Voriconazole powder price cas 137234-62-9

Cas:137234-62-9

Min.Order:100 Gram

FOB Price: $4.9 / 6.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

1)Combination With the CYP3A4 substrates, terfenadine, sirolimus, astemizole, cisapride, pimozide or quinidine , can increase blood concentrations of this drug, leading to QT prolongation, and occasionally torsades de pointes ventricular tachycardi

Voriconazole

Cas:137234-62-9

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Voriconazole

Cas:137234-62-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Voriconazole

Cas:137234-62-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Voriconazole 137234-62-9 ISO Producer

Cas:137234-62-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Voriconazole

Cas:137234-62-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Voriconazole

Cas:137234-62-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--137234-62-9--Voriconazole in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationship

TIANFUCHEM--137234-62-9--Voriconazole in stock

Cas:137234-62-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Hebei Nengqian Chemical Import and Export Co., LTD.. is located in xingtai City, Hebei Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutica

Voriconazole Manufacturer/High quality/Best price/In stock CAS NO.137234-62-9

Cas:137234-62-9

Min.Order:1 Gram

FOB Price: $12.0 / 15.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 137234-62-9 with best quality

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time pr

High Quality Voriconazole 137234-62-9 With Best Price

Cas:137234-62-9

Min.Order:1 Kilogram

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Voriconazole/ LIDE PHARMA- Factory supply / Best price

Cas:137234-62-9

Min.Order:0

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Henan Sinotech Import&Export Corporation

Product Name Voriconazole CAS No. 137234-62-9 MF C16H14F3N5O Molecular Weight 349.31 EINECS No 629-701-5

Voriconazole CAS:137234-62-9

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do resea

voriconazole

Cas:137234-62-9

Min.Order:1000 Gram

FOB Price: $1100.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Antifungal Drug Voriconazole CAS: 137234-62-9 White Powder

Cas:137234-62-9

Min.Order:100 Gram

Negotiable

Type:Other

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Hangzhou Huarong Pharm Co., Ltd.

1. USDMF is available. 2. EUDMF is available. 3. CEP is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Hu

Voriconazole

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Hot Selling Antifungal Voriconazol Powder CAS 137234-62-9 Voriconazole

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed

Voriconazole 99%

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Synonyms: Voriconazole 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;Voriconazole solution;(2R,3S)-2-(2,4-Difluorophenyl)-3;2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)butan-2-ol;2

Voriconazole 137234-62-9 Large in supply

Cas:137234-62-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Voriconazole

Cas:137234-62-9

Min.Order:1 Kilogram

FOB Price: $80.0 / 150.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Voriconazole manufacturer 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and

High quality Voriconazole manufacturer

Cas:137234-62-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Factory stock, favorable price CAS 137234-62-9 Voriconazole

Cas:137234-62-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Synthetic route

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
188416-34-4, 137234-71-0

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane for 0.5h;92%
With sodium hydrogencarbonate In water; ethyl acetate90.47%
With sodium hydroxide In water at 45 - 55℃; for 2.5h; Product distribution / selectivity;87.22%
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol R-(-)-10-camphorsulfonate

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol R-(-)-10-camphorsulfonate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water pH=11 - 12;92%
voriconazole L-camphorsulfate

voriconazole L-camphorsulfate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane for 0.5h;92%
With sodium hydroxide In dichloromethane; water at 15 - 25℃; pH=10 - 11;
voriconazole L-camphor sulfonate

voriconazole L-camphor sulfonate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane for 0.5h;90.8%
With sodium hydroxide In dichloromethane; water pH=12.3; Product distribution / selectivity; Alkaline aqueous solution; Industry scale;72%
With sodium hydroxide In dichloromethane; water pH=11; Product distribution / selectivity; Alkaline aqueous solution;
C26H28F3N5O5S

C26H28F3N5O5S

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol under 760.051 Torr;86.3%
(2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol
188416-38-8

(2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With palladium 10% on activated carbon; potassium formate In ethanol; water at 30℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;84.9%
With palladium 10% on activated carbon; hydrogen; sodium acetate In water; toluene at -21 - 40℃; under 3750.38 Torr; for 22h;
(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt
848469-32-9

(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium carbonate In dichloromethane; water at 20℃; for 0.333333h; pH=~ 10; Product distribution / selectivity;76%
With sodium hydroxide In dichloromethane; water pH=11 - 12; Product distribution / selectivity;
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ((1R,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1yl)methanesulfonate

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ((1R,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1yl)methanesulfonate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With water In ethanol at 32.5℃; Concentration; Solvent; Temperature;76%
2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol

2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With [(1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid In methanol; acetone for 2h; Reflux;43%
With (R)-10-camphorsulfonic acid In methanol; acetone at 0 - 5℃; Resolution of racemate;40.1%
Multi-step reaction with 2 steps
1: acetone; methanol / 15 h / -20 - 25 °C
2: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
Multi-step reaction with 2 steps
1: methanol; acetone / Reflux
2: sodium hydroxide / water; dichloromethane / pH 11
View Scheme
5-fluoro-4-vinylpyrimidine
1602485-93-7

5-fluoro-4-vinylpyrimidine

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With CuF(PPh3)3 methanol solvate; (R)-(−)-1-[(R)-2-(2′-diphenylphosphinophenyl)ferrocenyl]ethylbis(di-3,5-trifluoromethylphenyl)phosphine at 0℃; for 21.5h; Reagent/catalyst; Inert atmosphere;40%
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
188416-35-5

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Stage #1: 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol With 5%-palladium/activated carbon; hydrogen; sodium acetate In methanol at 25℃; under 760.051 Torr;
Stage #2: With [(1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid In methanol; acetone for 2h; Reflux;
35%
Multi-step reaction with 3 steps
1.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C
1.2: 25 - 30 °C / 3677.86 Torr
1.3: 0.5 h / 20 - 25 °C
2.1: acetone; methanol / 15 h / -20 - 25 °C
3.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
1.2: 0.5 h / 20 - 25 °C
1.3: 12.5 h / 25 - 30 °C
2.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12
3.1: acetone; methanol / 15 h / -20 - 25 °C
4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogen; sodium acetate; sodium carbonate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
1.2: 0.5 h / 20 - 25 °C
1.3: 10 - 25 °C
2.1: potassium carbonate / dichloromethane; water / 0.5 h / pH 8 - 10
3.1: acetone; methanol / 15 h / -20 - 25 °C
4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine
1474024-68-4

4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

A

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol
1028563-65-6

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol

B

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

C

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
In ethanol at 80℃; for 18h; Inert atmosphere;A 27%
B n/a
C n/a
4-bromo-5-fluoro-pyrimidine
1003706-87-3

4-bromo-5-fluoro-pyrimidine

(3S)-2-(2,4-difluorophenyl)-3-methyl-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

(3S)-2-(2,4-difluorophenyl)-3-methyl-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
In tetrahydrofuran at -70 - 30℃; for 25h; Temperature; Inert atmosphere;26.3%
(3S)-2-(2,4-difluorophenyl)-3-methyl-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

(3S)-2-(2,4-difluorophenyl)-3-methyl-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

2,4-dichloro-5-fluoropyrimidine
347418-42-2

2,4-dichloro-5-fluoropyrimidine

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
In tetrahydrofuran at -70 - 30℃; for 25h; Temperature; Inert atmosphere;20.7%
(2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

A

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

B

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With hydrogen; sodium acetate; palladium on activated charcoal In ethanol at 20℃;
2-fluoro-3-oxopentanoic acid ethyl ester
759-67-1

2-fluoro-3-oxopentanoic acid ethyl ester

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1) MeONa, MeOH
2: POCl3 / Heating
3: LDA / tetrahydrofuran
4: H2, AcONa / Pd/C / ethanol / 20 °C
View Scheme
6-Ethyl-5-fluoropyrimidin-4(3H)-one
137234-87-8

6-Ethyl-5-fluoropyrimidin-4(3H)-one

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: POCl3 / Heating
2: LDA / tetrahydrofuran
3: H2, AcONa / Pd/C / ethanol / 20 °C
View Scheme
4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LDA / tetrahydrofuran
2: H2, AcONa / Pd/C / ethanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C
2.2: 25 - 30 °C / 3677.86 Torr
2.3: 0.5 h / 20 - 25 °C
3.1: acetone; methanol / 15 h / -20 - 25 °C
4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
Multi-step reaction with 5 steps
1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
1.2: 2 h / -80 - -55 °C
1.3: -70 - -10 °C
2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
2.2: 0.5 h / 20 - 25 °C
2.3: 12.5 h / 25 - 30 °C
3.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12
4.1: acetone; methanol / 15 h / -20 - 25 °C
5.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
2-(2,4difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol-R(-)-10-camphor sulphonate
321589-01-9

2-(2,4difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol-R(-)-10-camphor sulphonate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water at 25 - 35℃; pH=11 - 12; Alkaline conditions;
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
188416-28-6

1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

A

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

B

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Stage #1: 1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane; 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone With zinc(II) chloride; zinc In tetrahydrofuran at -5 - 5℃; for 1h;
Stage #2: With ammonium formate; zinc In methanol at 20℃; for 16h;
Stage #3: Product distribution / selectivity; Heating / reflux;
3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride

3-(6-chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride

A

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

B

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With ammonium formate; zinc In methanol Product distribution / selectivity;
C10H16O4S*C16H14F3N5O

C10H16O4S*C16H14F3N5O

A

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

B

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃;
2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
182230-43-9

2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Stage #1: 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol With (R)-10-camphorsulfonic acid In methanol; acetone at 25 - 60℃; for 2h;
Stage #2: With sodium hydroxide In dichloromethane; water; isopropyl alcohol at 20 - 30℃; pH=12 - 13; Product distribution / selectivity;
With (1S)-10-camphorsulfonic acid In methanol; acetone at 20 - 30℃; for 3.5h; Reflux;
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 3 h / 45 °C
2: camphor-10-sulfonic acid / methanol; acetone
View Scheme
C6H5FN2O
1289559-75-6

C6H5FN2O

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / ethanol / 5 h
2.1: triethylamine / dmap / dichloromethane / 20 - 30 °C
3.1: zinc; zinc(II) chloride / tetrahydrofuran / 0 - 30 °C
4.1: (R)-10-camphorsulfonic acid / acetone; methanol / 2 h / 25 - 60 °C
4.2: 20 - 30 °C / pH 12 - 13
View Scheme
1-(2,6-dichloro-5-fluoropyrimidin-4-yl)ethanone
1289559-65-4

1-(2,6-dichloro-5-fluoropyrimidin-4-yl)ethanone

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogen; sodium acetate / palladium on activated carbon / ethanol / 25 °C
2.1: sodium tetrahydroborate / ethanol / 5 h
3.1: triethylamine / dmap / dichloromethane / 20 - 30 °C
4.1: zinc; zinc(II) chloride / tetrahydrofuran / 0 - 30 °C
5.1: (R)-10-camphorsulfonic acid / acetone; methanol / 2 h / 25 - 60 °C
5.2: 20 - 30 °C / pH 12 - 13
View Scheme
1-(5-fluoropyrimidin-4-yl)ethanol
1289559-66-5

1-(5-fluoropyrimidin-4-yl)ethanol

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dmap / dichloromethane / 20 - 30 °C
2.1: zinc; zinc(II) chloride / tetrahydrofuran / 0 - 30 °C
3.1: (R)-10-camphorsulfonic acid / acetone; methanol / 2 h / 25 - 60 °C
3.2: 20 - 30 °C / pH 12 - 13
View Scheme
2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / tetrahydrofuran / 7 h / 20 °C
2: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere
3: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C
4: acetone; methanol / 1 h / Reflux
5: sodium hydrogencarbonate / dichloromethane / 0.5 h
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / tetrahydrofuran / 7 h / 20 °C
2: lead; zinc; iodine / tetrahydrofuran / 2 h / -15 - -10 °C / Inert atmosphere
3: ammonium formate / 10% palladium on charcoal / toluene / 3 h / 80 °C
4: acetone; methanol / 1 h / Reflux
5: sodium hydrogencarbonate / dichloromethane / 0.5 h
View Scheme
6-ethyl-5-fluoro-4-hydroxypyrimidine
137234-87-8

6-ethyl-5-fluoro-4-hydroxypyrimidine

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 5 h / 20 °C
2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 12 h / 45 - 50 °C
3: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere
4: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C
5: acetone; methanol / 1 h / Reflux
6: sodium hydrogencarbonate / dichloromethane / 0.5 h
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 5 - 10 °C
1.2: 8 h / 10 - 55 °C / Reflux
1.3: 0.5 h / 15 - 20 °C
2.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
2.2: 2 h / -80 - -55 °C
2.3: -70 - -10 °C
3.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C
3.2: 25 - 30 °C / 3677.86 Torr
3.3: 0.5 h / 20 - 25 °C
4.1: acetone; methanol / 15 h / -20 - 25 °C
5.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 5 - 10 °C
1.2: 8 h / 10 - 55 °C / Reflux
1.3: 0.5 h / 15 - 20 °C
2.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere
2.2: 2 h / -80 - -55 °C
2.3: -70 - -10 °C
3.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr
3.2: 0.5 h / 20 - 25 °C
3.3: 12.5 h / 25 - 30 °C
4.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12
5.1: acetone; methanol / 15 h / -20 - 25 °C
6.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14
View Scheme
6-ethyl-5-fluoropyrimidin-4-yl methanesulfonate
1237496-99-9

6-ethyl-5-fluoropyrimidin-4-yl methanesulfonate

voriconazole
137234-62-9

voriconazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 12 h / 45 - 50 °C
2: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere
3: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C
4: acetone; methanol / 1 h / Reflux
5: sodium hydrogencarbonate / dichloromethane / 0.5 h
View Scheme
Multi-step reaction with 5 steps
1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 12 h / 45 - 50 °C
2: lead; zinc; iodine / tetrahydrofuran / 2 h / -15 - -10 °C / Inert atmosphere
3: ammonium formate / 10% palladium on charcoal / toluene / 3 h / 80 °C
4: acetone; methanol / 1 h / Reflux
5: sodium hydrogencarbonate / dichloromethane / 0.5 h
View Scheme
4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoic acid
150994-82-4

4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoic acid

voriconazole
137234-62-9

voriconazole

4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoate 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-5-fluoropyrimidin-1-ium

4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoate 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-5-fluoropyrimidin-1-ium

Conditions
ConditionsYield
In acetonitrile at 50℃; for 6h;100%
(2E)-4-((1,3-bis(dodecanoyloxy)propan-2-yl)oxy)-4-oxobut-2-enoic acid

(2E)-4-((1,3-bis(dodecanoyloxy)propan-2-yl)oxy)-4-oxobut-2-enoic acid

voriconazole
137234-62-9

voriconazole

(2E)-4-((1,3-bis(dodecanoyloxy)propan-2-yl)oxy)-4-oxobut-2-enoate 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-5-fluoropyrimidin-1-ium

(2E)-4-((1,3-bis(dodecanoyloxy)propan-2-yl)oxy)-4-oxobut-2-enoate 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-5-fluoropyrimidin-1-ium

Conditions
ConditionsYield
In acetonitrile at 50℃; for 3h;100%
voriconazole
137234-62-9

voriconazole

voriconazole hydrochloride

voriconazole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 1h;100%
(2-chloro-6-fluorophenyl)methanol
56456-50-9

(2-chloro-6-fluorophenyl)methanol

voriconazole
137234-62-9

voriconazole

Bis(2-chloro-6-fluorobenzyl) (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl phosphate
194798-93-1

Bis(2-chloro-6-fluorobenzyl) (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl phosphate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; anhydrous phosphorus trichloride; dihydrogen peroxide In dichloromethane; tert-butyl methyl ether; water88%
voriconazole
137234-62-9

voriconazole

C16H13F3N6O3
1620283-07-9

C16H13F3N6O3

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 20℃; for 3h;88%
With sulfuric acid; nitric acid at 0 - 20℃; for 3h;77%
C9H16ClNO5

C9H16ClNO5

voriconazole
137234-62-9

voriconazole

C20H22F3N6O4(1+)*I(1-)

C20H22F3N6O4(1+)*I(1-)

Conditions
ConditionsYield
Stage #1: C9H16ClNO5; voriconazole With potassium iodide In acetonitrile for 15h; Reflux;
Stage #2: With hydrogenchloride; water In methanol at 50 - 55℃; for 20h;
Stage #3: In methanol; tert-butyl methyl ether at 10 - 65℃; for 18h;
87%
voriconazole
137234-62-9

voriconazole

C16H14F3N5O*HNO3

C16H14F3N5O*HNO3

Conditions
ConditionsYield
With nitric acid In methanol; water86.62%
chloromethyl 2-methoxyethyl carbonate
432037-32-6

chloromethyl 2-methoxyethyl carbonate

voriconazole
137234-62-9

voriconazole

C21H23F3N5O5(1+)*Cl(1-)

C21H23F3N5O5(1+)*Cl(1-)

Conditions
ConditionsYield
In acetonitrile for 10h; Reflux;85%
chloromethyl 2-methoxyethyl carbonate
432037-32-6

chloromethyl 2-methoxyethyl carbonate

voriconazole
137234-62-9

voriconazole

C21H23F3N5O5(1+)*Cl(1-)

C21H23F3N5O5(1+)*Cl(1-)

Conditions
ConditionsYield
In acetonitrile for 12h; Reflux;80%
chloromethyl 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyl carbonate
431894-46-1

chloromethyl 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyl carbonate

voriconazole
137234-62-9

voriconazole

C38H56F3N5O15(2+)*2Cl(1-)

C38H56F3N5O15(2+)*2Cl(1-)

Conditions
ConditionsYield
In acetonitrile for 14h; Reflux;79%
voriconazole
137234-62-9

voriconazole

voriconazole hydrochloride

voriconazole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water78.62%
isobutyric Acid
79-31-2

isobutyric Acid

voriconazole
137234-62-9

voriconazole

A

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-6-isopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-6-isopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

B

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-2,6-diisopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-2,6-diisopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Conditions
ConditionsYield
With bis-[(trifluoroacetoxy)iodo]benzene; 9-mesityl-10-methylacridinium ion In acetonitrile at 20℃; Irradiation;A 77%
B 11%
trifluoroacetic acid
76-05-1

trifluoroacetic acid

voriconazole
137234-62-9

voriconazole

(2R,3S)-2-(5-bromo-2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol trifluoroacetic acid

(2R,3S)-2-(5-bromo-2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol trifluoroacetic acid

Conditions
ConditionsYield
With N-Bromosuccinimide for 16h; Inert atmosphere;73%
potassium trifluoro(isopropenyl)borate(1-)

potassium trifluoro(isopropenyl)borate(1-)

voriconazole
137234-62-9

voriconazole

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-6-isopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-6-isopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Conditions
ConditionsYield
With N,N,N,N-tetraethylammonium tetrafluoroborate; trifluoroacetic acid; 9-(2-mesityl)-10-methylacridinium perchlorate In water; acetonitrile at 20℃; for 10h; Inert atmosphere; Schlenk technique; Irradiation; regioselective reaction;72%
C9H17ClN2O4

C9H17ClN2O4

voriconazole
137234-62-9

voriconazole

C20H23F3N7O3(1+)*I(1-)

C20H23F3N7O3(1+)*I(1-)

Conditions
ConditionsYield
Stage #1: C9H17ClN2O4; voriconazole With potassium iodide In acetonitrile for 15h; Reflux;
Stage #2: With hydrogenchloride; water In methanol at 50 - 55℃; for 20h;
Stage #3: In methanol; tert-butyl methyl ether at 10 - 65℃; for 15h;
70%
(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

voriconazole
137234-62-9

voriconazole

(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt
848469-32-9

(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt

Conditions
ConditionsYield
In methanol; acetone at 30 - 50℃; for 1.33333h; Heating / reflux;65%
C23H43ClN4O8

C23H43ClN4O8

voriconazole
137234-62-9

voriconazole

C24H33F3N9O3(1+)*I(1-)

C24H33F3N9O3(1+)*I(1-)

Conditions
ConditionsYield
Stage #1: C23H43ClN4O8; voriconazole With potassium iodide In acetonitrile for 15h; Reflux;
Stage #2: With hydrogenchloride; water In methanol at 50 - 55℃; for 20h;
Stage #3: In methanol; tert-butyl methyl ether at 10 - 65℃; for 18h;
65%
chloromethyl (2-methoxyethyl)carbamate
1402915-09-6

chloromethyl (2-methoxyethyl)carbamate

voriconazole
137234-62-9

voriconazole

C21H24F3N6O4(1+)*I(1-)

C21H24F3N6O4(1+)*I(1-)

Conditions
ConditionsYield
Stage #1: chloromethyl (2-methoxyethyl)carbamate; voriconazole With potassium iodide In acetonitrile for 15h; Reflux;
Stage #2: In methanol; tert-butyl methyl ether at 10 - 65℃; for 20h;
63%
voriconazole
137234-62-9

voriconazole

Cyclohexanecarboxylic acid
98-89-5

Cyclohexanecarboxylic acid

(2R,3S)-3-(6-cyclohexyl-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2R,3S)-3-(6-cyclohexyl-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Conditions
ConditionsYield
With hydrogenchloride; cerium(III) chloride heptahydrate; tetrabutyl-ammonium chloride In 2,2,2-trifluoroethanol; water for 17h; Schlenk technique; Inert atmosphere; Electrochemical reaction; Irradiation;60%
potassium trifluoro(isopropenyl)borate(1-)

potassium trifluoro(isopropenyl)borate(1-)

trifluoroacetic acid
76-05-1

trifluoroacetic acid

voriconazole
137234-62-9

voriconazole

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-6-isopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol trifluoroacetic acid

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-6-isopropylpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol trifluoroacetic acid

Conditions
ConditionsYield
Stage #1: potassium trifluoro(isopropenyl)borate(1-); voriconazole With manganese triacetate; acetic acid In water at 50℃; for 18h; Inert atmosphere;
Stage #2: trifluoroacetic acid In water; acetonitrile Inert atmosphere;
58%
silver perchlorate

silver perchlorate

voriconazole
137234-62-9

voriconazole

Ag(1+)*ClO4(1-)*2C16H14F3N5O

Ag(1+)*ClO4(1-)*2C16H14F3N5O

Conditions
ConditionsYield
In ethanol; water58%
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