Voriconazole [CAS:137234-62-9] white or off-white crystalline powder HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences o
Product technology and quality stability,perennial production,to meet the supply demand. Product technology and quality stability,perennial production,to meet the supply demand. Quality: 1. Order products, before delivery, according to customer nee
Product Name: Voriconazole Synonyms: Voriconazole2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;Voriconazole solution;(2R,3S)-2-(2,4-Difluorophenyl)-3;2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,
Cas:137234-62-9
Min.Order:100 Gram
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:137234-62-9
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inquiryWe are very compeitive on Voriconazole.Our mfr is GMP certified for this item with DMF document. Product Name: Voriconazole CAS: 137234-62-9 MF: C16H14F3N5O MW: 349.31 EINECS: 629-701-5
Cas:137234-62-9
Min.Order:1 Kilogram
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Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:137234-62-9
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inquiryUnique advantages of Voriconazole Cas 137234-62-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to almost white crystalline powder Storage:Cool dry place Packa
Cas:137234-62-9
Min.Order:1 Gram
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inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:137234-62-9
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inquiry1)Combination With the CYP3A4 substrates, terfenadine, sirolimus, astemizole, cisapride, pimozide or quinidine , can increase blood concentrations of this drug, leading to QT prolongation, and occasionally torsades de pointes ventricular tachycardi
high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:137234-62-9
Min.Order:1 Gram
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Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
TIANFUCHEM--137234-62-9--Voriconazole in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationship
Cas:137234-62-9
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inquiryHebei Nengqian Chemical Import and Export Co., LTD.. is located in xingtai City, Hebei Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutica
Cas:137234-62-9
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:137234-62-9
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time pr
Cas:137234-62-9
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct Name Voriconazole CAS No. 137234-62-9 MF C16H14F3N5O Molecular Weight 349.31 EINECS No 629-701-5
Cas:137234-62-9
Min.Order:1 Kilogram
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Type:Other
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do resea
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Cas:137234-62-9
Min.Order:100 Gram
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Type:Other
inquiry1. USDMF is available. 2. EUDMF is available. 3. CEP is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Hu
Cas:137234-62-9
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Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:137234-62-9
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermed
Cas:137234-62-9
Min.Order:1 Kilogram
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Cas:137234-62-9
Min.Order:10 Gram
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inquirySynonyms: Voriconazole 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;Voriconazole solution;(2R,3S)-2-(2,4-Difluorophenyl)-3;2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)butan-2-ol;2
Cas:137234-62-9
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:137234-62-9
Min.Order:1 Kilogram
FOB Price: $80.0 / 150.0
Type:Trading Company
inquiryBeluga chemical professional supply High quality Voriconazole manufacturer 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and
Cas:137234-62-9
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:137234-62-9
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inquiry(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
voriconazole
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane for 0.5h; | 92% |
With sodium hydrogencarbonate In water; ethyl acetate | 90.47% |
With sodium hydroxide In water at 45 - 55℃; for 2.5h; Product distribution / selectivity; | 87.22% |
voriconazole
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water pH=11 - 12; | 92% |
voriconazole
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane for 0.5h; | 92% |
With sodium hydroxide In dichloromethane; water at 15 - 25℃; pH=10 - 11; |
voriconazole
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane for 0.5h; | 90.8% |
With sodium hydroxide In dichloromethane; water pH=12.3; Product distribution / selectivity; Alkaline aqueous solution; Industry scale; | 72% |
With sodium hydroxide In dichloromethane; water pH=11; Product distribution / selectivity; Alkaline aqueous solution; |
voriconazole
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethanol under 760.051 Torr; | 86.3% |
(2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol
voriconazole
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; potassium formate In ethanol; water at 30℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere; | 84.9% |
With palladium 10% on activated carbon; hydrogen; sodium acetate In water; toluene at -21 - 40℃; under 3750.38 Torr; for 22h; |
(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt
voriconazole
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water at 20℃; for 0.333333h; pH=~ 10; Product distribution / selectivity; | 76% |
With sodium hydroxide In dichloromethane; water pH=11 - 12; Product distribution / selectivity; |
voriconazole
Conditions | Yield |
---|---|
With water In ethanol at 32.5℃; Concentration; Solvent; Temperature; | 76% |
voriconazole
Conditions | Yield |
---|---|
With [(1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid In methanol; acetone for 2h; Reflux; | 43% |
With (R)-10-camphorsulfonic acid In methanol; acetone at 0 - 5℃; Resolution of racemate; | 40.1% |
Multi-step reaction with 2 steps 1: acetone; methanol / 15 h / -20 - 25 °C 2: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme | |
Multi-step reaction with 2 steps 1: methanol; acetone / Reflux 2: sodium hydroxide / water; dichloromethane / pH 11 View Scheme |
5-fluoro-4-vinylpyrimidine
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
voriconazole
Conditions | Yield |
---|---|
With CuF(PPh3)3 methanol solvate; (R)-(−)-1-[(R)-2-(2′-diphenylphosphinophenyl)ferrocenyl]ethylbis(di-3,5-trifluoromethylphenyl)phosphine at 0℃; for 21.5h; Reagent/catalyst; Inert atmosphere; | 40% |
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
voriconazole
Conditions | Yield |
---|---|
Stage #1: 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol With 5%-palladium/activated carbon; hydrogen; sodium acetate In methanol at 25℃; under 760.051 Torr; Stage #2: With [(1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid In methanol; acetone for 2h; Reflux; | 35% |
Multi-step reaction with 3 steps 1.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C 1.2: 25 - 30 °C / 3677.86 Torr 1.3: 0.5 h / 20 - 25 °C 2.1: acetone; methanol / 15 h / -20 - 25 °C 3.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr 1.2: 0.5 h / 20 - 25 °C 1.3: 12.5 h / 25 - 30 °C 2.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12 3.1: acetone; methanol / 15 h / -20 - 25 °C 4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen; sodium acetate; sodium carbonate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr 1.2: 0.5 h / 20 - 25 °C 1.3: 10 - 25 °C 2.1: potassium carbonate / dichloromethane; water / 0.5 h / pH 8 - 10 3.1: acetone; methanol / 15 h / -20 - 25 °C 4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme |
1,2,4-Triazole
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine
A
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol
C
voriconazole
Conditions | Yield |
---|---|
In ethanol at 80℃; for 18h; Inert atmosphere; | A 27% B n/a C n/a |
4-bromo-5-fluoro-pyrimidine
voriconazole
Conditions | Yield |
---|---|
In tetrahydrofuran at -70 - 30℃; for 25h; Temperature; Inert atmosphere; | 26.3% |
2,4-dichloro-5-fluoropyrimidine
voriconazole
Conditions | Yield |
---|---|
In tetrahydrofuran at -70 - 30℃; for 25h; Temperature; Inert atmosphere; | 20.7% |
B
voriconazole
Conditions | Yield |
---|---|
With hydrogen; sodium acetate; palladium on activated charcoal In ethanol at 20℃; |
2-fluoro-3-oxopentanoic acid ethyl ester
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1) MeONa, MeOH 2: POCl3 / Heating 3: LDA / tetrahydrofuran 4: H2, AcONa / Pd/C / ethanol / 20 °C View Scheme |
6-Ethyl-5-fluoropyrimidin-4(3H)-one
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: POCl3 / Heating 2: LDA / tetrahydrofuran 3: H2, AcONa / Pd/C / ethanol / 20 °C View Scheme |
4-chloro-5-fluoro-6-ethylpyrimidine
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LDA / tetrahydrofuran 2: H2, AcONa / Pd/C / ethanol / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere 1.2: 2 h / -80 - -55 °C 1.3: -70 - -10 °C 2.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C 2.2: 25 - 30 °C / 3677.86 Torr 2.3: 0.5 h / 20 - 25 °C 3.1: acetone; methanol / 15 h / -20 - 25 °C 4.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme | |
Multi-step reaction with 5 steps 1.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere 1.2: 2 h / -80 - -55 °C 1.3: -70 - -10 °C 2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr 2.2: 0.5 h / 20 - 25 °C 2.3: 12.5 h / 25 - 30 °C 3.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12 4.1: acetone; methanol / 15 h / -20 - 25 °C 5.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme |
2-(2,4difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol-R(-)-10-camphor sulphonate
voriconazole
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 25 - 35℃; pH=11 - 12; Alkaline conditions; |
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
B
voriconazole
Conditions | Yield |
---|---|
Stage #1: 1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane; 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone With zinc(II) chloride; zinc In tetrahydrofuran at -5 - 5℃; for 1h; Stage #2: With ammonium formate; zinc In methanol at 20℃; for 16h; Stage #3: Product distribution / selectivity; Heating / reflux; |
B
voriconazole
Conditions | Yield |
---|---|
With ammonium formate; zinc In methanol Product distribution / selectivity; |
B
voriconazole
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃; |
2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
voriconazole
Conditions | Yield |
---|---|
Stage #1: 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol With (R)-10-camphorsulfonic acid In methanol; acetone at 25 - 60℃; for 2h; Stage #2: With sodium hydroxide In dichloromethane; water; isopropyl alcohol at 20 - 30℃; pH=12 - 13; Product distribution / selectivity; | |
With (1S)-10-camphorsulfonic acid In methanol; acetone at 20 - 30℃; for 3.5h; Reflux; | |
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 3 h / 45 °C 2: camphor-10-sulfonic acid / methanol; acetone View Scheme |
C6H5FN2O
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / ethanol / 5 h 2.1: triethylamine / dmap / dichloromethane / 20 - 30 °C 3.1: zinc; zinc(II) chloride / tetrahydrofuran / 0 - 30 °C 4.1: (R)-10-camphorsulfonic acid / acetone; methanol / 2 h / 25 - 60 °C 4.2: 20 - 30 °C / pH 12 - 13 View Scheme |
1-(2,6-dichloro-5-fluoropyrimidin-4-yl)ethanone
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogen; sodium acetate / palladium on activated carbon / ethanol / 25 °C 2.1: sodium tetrahydroborate / ethanol / 5 h 3.1: triethylamine / dmap / dichloromethane / 20 - 30 °C 4.1: zinc; zinc(II) chloride / tetrahydrofuran / 0 - 30 °C 5.1: (R)-10-camphorsulfonic acid / acetone; methanol / 2 h / 25 - 60 °C 5.2: 20 - 30 °C / pH 12 - 13 View Scheme |
1-(5-fluoropyrimidin-4-yl)ethanol
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / dmap / dichloromethane / 20 - 30 °C 2.1: zinc; zinc(II) chloride / tetrahydrofuran / 0 - 30 °C 3.1: (R)-10-camphorsulfonic acid / acetone; methanol / 2 h / 25 - 60 °C 3.2: 20 - 30 °C / pH 12 - 13 View Scheme |
2-chloro-1-(2,4-dichlorophenyl)ethanone
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / tetrahydrofuran / 7 h / 20 °C 2: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere 3: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C 4: acetone; methanol / 1 h / Reflux 5: sodium hydrogencarbonate / dichloromethane / 0.5 h View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / tetrahydrofuran / 7 h / 20 °C 2: lead; zinc; iodine / tetrahydrofuran / 2 h / -15 - -10 °C / Inert atmosphere 3: ammonium formate / 10% palladium on charcoal / toluene / 3 h / 80 °C 4: acetone; methanol / 1 h / Reflux 5: sodium hydrogencarbonate / dichloromethane / 0.5 h View Scheme |
6-ethyl-5-fluoro-4-hydroxypyrimidine
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 5 h / 20 °C 2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 12 h / 45 - 50 °C 3: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere 4: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C 5: acetone; methanol / 1 h / Reflux 6: sodium hydrogencarbonate / dichloromethane / 0.5 h View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane / 5 - 10 °C 1.2: 8 h / 10 - 55 °C / Reflux 1.3: 0.5 h / 15 - 20 °C 2.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere 2.2: 2 h / -80 - -55 °C 2.3: -70 - -10 °C 3.1: sodium acetate / ethyl acetate; water / 0.5 h / 25 - 30 °C 3.2: 25 - 30 °C / 3677.86 Torr 3.3: 0.5 h / 20 - 25 °C 4.1: acetone; methanol / 15 h / -20 - 25 °C 5.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane / 5 - 10 °C 1.2: 8 h / 10 - 55 °C / Reflux 1.3: 0.5 h / 15 - 20 °C 2.1: diisopropylamine; n-butyllithium / n-heptane; hexane; tetrahydrofuran / 0.25 h / -80 - -70 °C / Inert atmosphere 2.2: 2 h / -80 - -55 °C 2.3: -70 - -10 °C 3.1: hydrogen; sodium acetate / palladium 10% on activated carbon / ethyl acetate; water / 25 - 30 °C / 3677.86 Torr 3.2: 0.5 h / 20 - 25 °C 3.3: 12.5 h / 25 - 30 °C 4.1: sodium hydroxide / dichloromethane; water / 0.5 h / pH 9 - 12 5.1: acetone; methanol / 15 h / -20 - 25 °C 6.1: sodium hydroxide / dichloromethane; water / 0.25 h / pH 11 - 14 View Scheme |
6-ethyl-5-fluoropyrimidin-4-yl methanesulfonate
voriconazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 12 h / 45 - 50 °C 2: lead; zinc; iodine / tetrahydrofuran / -15 - 20 °C / Inert atmosphere 3: ammonium formate / palladium on carbon / toluene / 3 h / 80 °C 4: acetone; methanol / 1 h / Reflux 5: sodium hydrogencarbonate / dichloromethane / 0.5 h View Scheme | |
Multi-step reaction with 5 steps 1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 12 h / 45 - 50 °C 2: lead; zinc; iodine / tetrahydrofuran / 2 h / -15 - -10 °C / Inert atmosphere 3: ammonium formate / 10% palladium on charcoal / toluene / 3 h / 80 °C 4: acetone; methanol / 1 h / Reflux 5: sodium hydrogencarbonate / dichloromethane / 0.5 h View Scheme |
4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoic acid
voriconazole
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 6h; | 100% |
voriconazole
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 3h; | 100% |
voriconazole
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 1h; | 100% |
(2-chloro-6-fluorophenyl)methanol
voriconazole
Bis(2-chloro-6-fluorobenzyl) (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl phosphate
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; anhydrous phosphorus trichloride; dihydrogen peroxide In dichloromethane; tert-butyl methyl ether; water | 88% |
voriconazole
C16H13F3N6O3
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid at 20℃; for 3h; | 88% |
With sulfuric acid; nitric acid at 0 - 20℃; for 3h; | 77% |
Conditions | Yield |
---|---|
Stage #1: C9H16ClNO5; voriconazole With potassium iodide In acetonitrile for 15h; Reflux; Stage #2: With hydrogenchloride; water In methanol at 50 - 55℃; for 20h; Stage #3: In methanol; tert-butyl methyl ether at 10 - 65℃; for 18h; | 87% |
voriconazole
Conditions | Yield |
---|---|
With nitric acid In methanol; water | 86.62% |
Conditions | Yield |
---|---|
In acetonitrile for 10h; Reflux; | 85% |
Conditions | Yield |
---|---|
In acetonitrile for 12h; Reflux; | 80% |
chloromethyl 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethyl carbonate
voriconazole
Conditions | Yield |
---|---|
In acetonitrile for 14h; Reflux; | 79% |
voriconazole
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water | 78.62% |
Conditions | Yield |
---|---|
With bis-[(trifluoroacetoxy)iodo]benzene; 9-mesityl-10-methylacridinium ion In acetonitrile at 20℃; Irradiation; | A 77% B 11% |
trifluoroacetic acid
voriconazole
Conditions | Yield |
---|---|
With N-Bromosuccinimide for 16h; Inert atmosphere; | 73% |
voriconazole
Conditions | Yield |
---|---|
With N,N,N,N-tetraethylammonium tetrafluoroborate; trifluoroacetic acid; 9-(2-mesityl)-10-methylacridinium perchlorate In water; acetonitrile at 20℃; for 10h; Inert atmosphere; Schlenk technique; Irradiation; regioselective reaction; | 72% |
Conditions | Yield |
---|---|
Stage #1: C9H17ClN2O4; voriconazole With potassium iodide In acetonitrile for 15h; Reflux; Stage #2: With hydrogenchloride; water In methanol at 50 - 55℃; for 20h; Stage #3: In methanol; tert-butyl methyl ether at 10 - 65℃; for 15h; | 70% |
(1S)-10-camphorsulfonic acid
voriconazole
(2R,3S)-2-(2,4-diflurophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1yl)butan-2-ol R-(-)-10-camphor sulphonate salt
Conditions | Yield |
---|---|
In methanol; acetone at 30 - 50℃; for 1.33333h; Heating / reflux; | 65% |
Conditions | Yield |
---|---|
Stage #1: C23H43ClN4O8; voriconazole With potassium iodide In acetonitrile for 15h; Reflux; Stage #2: With hydrogenchloride; water In methanol at 50 - 55℃; for 20h; Stage #3: In methanol; tert-butyl methyl ether at 10 - 65℃; for 18h; | 65% |
Conditions | Yield |
---|---|
Stage #1: chloromethyl (2-methoxyethyl)carbamate; voriconazole With potassium iodide In acetonitrile for 15h; Reflux; Stage #2: In methanol; tert-butyl methyl ether at 10 - 65℃; for 20h; | 63% |
voriconazole
Cyclohexanecarboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; cerium(III) chloride heptahydrate; tetrabutyl-ammonium chloride In 2,2,2-trifluoroethanol; water for 17h; Schlenk technique; Inert atmosphere; Electrochemical reaction; Irradiation; | 60% |
trifluoroacetic acid
voriconazole
Conditions | Yield |
---|---|
Stage #1: potassium trifluoro(isopropenyl)borate(1-); voriconazole With manganese triacetate; acetic acid In water at 50℃; for 18h; Inert atmosphere; Stage #2: trifluoroacetic acid In water; acetonitrile Inert atmosphere; | 58% |
Conditions | Yield |
---|---|
In ethanol; water | 58% |
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