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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Adefovir dipivoxil Manufacturer/High quality/Best price/In stock

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to almost white crystalline powder White crystalline powder Identification

High purity Various Specifications Adefovir Dipivoxyl CAS:142340-99-6

Cas:142340-99-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Adefovir dipivoxil Cas 142340-99-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white powder Storage:Cool dry place Package:1kg/foill b

Reliable factory supply Adefovir dipivoxil Cas 142340-99-6 with high quality and best price

Cas:142340-99-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Rich experie

Best price Adefovir dipivoxil

Cas:142340-99-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Adefovir dipivoxil 142340-99-6 GMP Manufacturer

Cas:142340-99-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Adefovir dipivoxil CAS NO.142340-99-6

Cas:142340-99-6

Min.Order:5 Gram

FOB Price: $960.0 / 1000.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Adefovir dipivoxil Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVI

Adefovir dipivoxil 142340-99-6

Cas:142340-99-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Adefovir Dipivoxil :142340-99-6

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 142340-99-6 with best quality

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Adefovir dipivoxil/ LIDE PHARMA- Factory supply / Best price

Cas:142340-99-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $65.0 / 75.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Name: Adefovir dipivoxil Molecular Formula: C20H32N5O8P Formula Weight: 501.47 CAS No.: 142340-99-6 EINECS:200-001-8 White to white crystalline powder. Adefovir Dipivoxyl is a prescription medicine used to treat infections

Adefovir Dipivoxyl CAS:142340-99-6

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

99%min Adefovir dipivoxil Manufacturer

Cas:142340-99-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Hot Sale API 99% Adefovir Dipivoxil Powder CAS 142340-99-6 with Factory Price

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

Hot sale 98.0% Adefovir dipivoxil

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

About us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $1200.0 / 1300.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Adefovir Dipivoxil CAS 142340-99-6 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo

Adefovir Dipivoxil CAS 142340-99-6

Cas:142340-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Adefovir dipivoxil CAS NO.142340-99-6

Cas:142340-99-6

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

China factory competitive price Adefovir dipivoxil

Cas:142340-99-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:as customer request Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Port:QINGDAO

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Adefovir dipivoxil Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVIR PIVOXIL;Adefovir Dipivoxyl;Bis(Pivalo

Adefovir dipivoxil Manufactuered in China best quality

Cas:142340-99-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Adefovir dipivoxil Synonyms 9-[2-[Bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine Molecular Structure

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Adefovir dipivoxil 142340-99-6

Cas:142340-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Adefovir Dipivoxil CAS 142340-99-6 with Fast Shipment

Cas:142340-99-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Adefovir dipivoxil

Cas:142340-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

Adefovirdipivoxil

Cas:142340-99-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

Chloromethyl pivalate
18997-19-8

Chloromethyl pivalate

Adefovir
106941-25-7

Adefovir

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 50 - 55℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Large scale;78.1%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 25℃; for 24h;75%
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 65 - 75℃; for 2h; Temperature; Reagent/catalyst; Solvent;57.5%
[[2-chloroethoxy]methyl]phosphonic acid bis(pivaloyloxymethyl) ester

[[2-chloroethoxy]methyl]phosphonic acid bis(pivaloyloxymethyl) ester

7H-purin-6-ylamine
73-24-5

7H-purin-6-ylamine

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90 - 95℃; for 9h; Large scale;46.18%
chloropentyl pivalate

chloropentyl pivalate

Adefovir
106941-25-7

Adefovir

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 30 - 60℃; for 16h; Reagent/catalyst;32.6%
2,2-Dimethyl-propionic acid (2,2-dimethyl-propionyloxymethoxy)-[2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-ethoxymethyl]-phosphinoyloxymethyl ester

2,2-Dimethyl-propionic acid (2,2-dimethyl-propionyloxymethoxy)-[2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-ethoxymethyl]-phosphinoyloxymethyl ester

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
With acetic acid In methanol for 12h; Ambient temperature; Yield given;
iodomethyl pivaloate
53064-79-2

iodomethyl pivaloate

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 36 h / Ambient temperature
2: aq. AcOH / methanol / 12 h / Ambient temperature
View Scheme
N6-(4-monomethoxytrityl)-9-(2-phosphonomethoxyethyl)adenine
153235-86-0

N6-(4-monomethoxytrityl)-9-(2-phosphonomethoxyethyl)adenine

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 36 h / Ambient temperature
2: aq. AcOH / methanol / 12 h / Ambient temperature
View Scheme
N4-dimethylaminomethyledino-9-(2-phosphonomethoxyethyl)adenine di(pivaloyloxymethyl) ester
922494-99-3

N4-dimethylaminomethyledino-9-(2-phosphonomethoxyethyl)adenine di(pivaloyloxymethyl) ester

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Stage #1: N4-dimethylaminomethylideno-9-(2-phosphonomethoxyethyl)adinine di(pivaloyloxymethyl) ester With acetic acid In water at 25 - 55℃; for 3h;
Stage #2: With triethylamine In water; ethyl acetate pH=7.5;
Stage #1: N4-dimethylaminomethylideno-9-(2-phosphonomethoxyethyl)adinine di(pivaloyloxymethyl) ester With water; acetic acid at 25 - 55℃; for 3h;
Stage #2: With triethylamine In water; ethyl acetate pH=7.5;
Chloromethyl pivalate
18997-19-8

Chloromethyl pivalate

Adefovir
106941-25-7

Adefovir

A

9-[2-({bis[(pivaloyloxy)methoxy]phosphinyl}methoxy)ethyl]-6-[(hydroxymethyl)amino]purine
323201-04-3

9-[2-({bis[(pivaloyloxy)methoxy]phosphinyl}methoxy)ethyl]-6-[(hydroxymethyl)amino]purine

B

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
In dimethyl sulfoxide; triethylamine at 43℃; for 4h;
Stage #1: Chloromethyl pivalate; Adefovir With triethylamine In dimethyl sulfoxide at 40℃; for 5h;
Stage #2: With water In dichloromethane; dimethyl sulfoxide at 10 - 20℃; for 0.0833333h; Product distribution / selectivity;
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 - 85 °C
1.2: 20 h
2.1: water; hydrogen bromide / 4 h / 90 - 95 °C
2.2: 25 - 30 °C / pH 2.8
3.1: triethylamine; tetrabutylammomium bromide / ethyl acetate; N,N-dimethyl-formamide / 1 h / 25 - 35 °C
3.2: 25 - 35 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 60 °C
2.1: ammonia / methanol / 14 h
3.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: 20 h / 35 °C / Inert atmosphere
4.1: sodium bromide; 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane / 12 h / 60 °C / Inert atmosphere
4.2: 6 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / acetonitrile / 14 h / 125 °C / Inert atmosphere
2: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C
3: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C
4: triethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 30 - 60 °C
View Scheme
[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
116384-53-3

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; hydrogen bromide / 4 h / 90 - 95 °C
1.2: 25 - 30 °C / pH 2.8
2.1: triethylamine; tetrabutylammomium bromide / ethyl acetate; N,N-dimethyl-formamide / 1 h / 25 - 35 °C
2.2: 25 - 35 °C
View Scheme
Chloromethyl pivalate
18997-19-8

Chloromethyl pivalate

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
116384-53-3

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Stage #1: [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester With 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane; sodium bromide at 60℃; for 12h; Inert atmosphere;
Stage #2: Chloromethyl pivalate With triethylamine at 60℃; for 6h;
9-(2-hydroxyethyl)adenine
707-99-3

9-(2-hydroxyethyl)adenine

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
1.2: 20 h / 35 °C / Inert atmosphere
2.1: sodium bromide; 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane / 12 h / 60 °C / Inert atmosphere
2.2: 6 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 5 °C / Large scale
1.2: 5 h / 5 °C / Large scale
2.1: trimethylsilyl bromide / acetonitrile / 3 h / 20 °C / Large scale
2.2: 2 h / Reflux; Large scale
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 2 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C
2: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C
3: triethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 30 - 60 °C
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 78 - 82 °C
1.2: 78 - 82 °C
2.1: trimethylsilyl bromide / 80 - 85 °C
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 50 °C
View Scheme
benzoic acid 2-(6-amino-purin-9-yl)-ethyl ester

benzoic acid 2-(6-amino-purin-9-yl)-ethyl ester

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonia / methanol / 14 h
2.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 20 h / 35 °C / Inert atmosphere
3.1: sodium bromide; 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane / 12 h / 60 °C / Inert atmosphere
3.2: 6 h / 60 °C
View Scheme
6-Chloro-9-(β-hydroxyethylamino)purine
1670-62-8

6-Chloro-9-(β-hydroxyethylamino)purine

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
1.2: 48 h / 50 °C
2.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice
3.1: N,N'-dicyclohexyl-4-morpholine carboxamidine; triethylamine / N,N-dimethyl-formamide / 12 h / 48 - 52 °C
View Scheme
6-chloro-9-(ethoxycarbonylmethyl)-9H-purine
56791-59-4

6-chloro-9-(ethoxycarbonylmethyl)-9H-purine

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanol; sodium tetrahydroborate / 0 °C
2.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
2.2: 48 h / 50 °C
3.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice
4.1: N,N'-dicyclohexyl-4-morpholine carboxamidine; triethylamine / N,N-dimethyl-formamide / 12 h / 48 - 52 °C
View Scheme
6-chloropurine
87-42-3

6-chloropurine

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 0.17 h / 20 °C
2.1: methanol; sodium tetrahydroborate / 0 °C
3.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
3.2: 48 h / 50 °C
4.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice
5.1: N,N'-dicyclohexyl-4-morpholine carboxamidine; triethylamine / N,N-dimethyl-formamide / 12 h / 48 - 52 °C
View Scheme
maleic acid
110-16-7

maleic acid

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

adefovir dipivoxil maleate

adefovir dipivoxil maleate

Conditions
ConditionsYield
In ethyl acetate at 40℃; for 3h; Temperature;98%
adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

C20H30(2)H2N5O8P

C20H30(2)H2N5O8P

Conditions
ConditionsYield
With deuterium In tetrahydrofuran; cyclohexane at 55℃; under 1500.15 Torr; for 36h; Reagent/catalyst; Glovebox;96%
saccharin
81-07-2

saccharin

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

adefovir dipivoxil:saccharin salt
1403836-42-9

adefovir dipivoxil:saccharin salt

Conditions
ConditionsYield
In acetone at 0 - 50℃; Product distribution / selectivity;90%
In ethanol at 25℃; for 0.166667h;
nicotinamide
98-92-0

nicotinamide

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

adefovir dipivoxil:nicotinamide cocrystal
1403836-41-8

adefovir dipivoxil:nicotinamide cocrystal

Conditions
ConditionsYield
In ethyl acetate at 20 - 70℃; for 25.25h; Product distribution / selectivity;80%
adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

salicylamide
65-45-2

salicylamide

adefovir dipivoxil:salicylamide cocrystal

adefovir dipivoxil:salicylamide cocrystal

Conditions
ConditionsYield
In tert-butyl methyl ether; acetone at 20℃; Product distribution / selectivity; Reflux;78%
pivaloyl chloride
3282-30-2

pivaloyl chloride

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

bis[(2-(6-pivaloylamino-9H-purin-9-yl)ethoxy)methyl]phosphonic acid bis(pivaloyloxymethyl) ester

bis[(2-(6-pivaloylamino-9H-purin-9-yl)ethoxy)methyl]phosphonic acid bis(pivaloyloxymethyl) ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 8h; Cooling with ice;76.13%
adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

9-{2-[O,O'-bis(pivaloyloxymethyl)thiophosphonomethoxy]ethyl}adenine
1443213-13-5

9-{2-[O,O'-bis(pivaloyloxymethyl)thiophosphonomethoxy]ethyl}adenine

Conditions
ConditionsYield
With 2,4-bis(methylthio)-1,3-dithia-2,4-diphosphetane-2,4-disulfide In benzene at 0 - 80℃; for 2.5h;29%
adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

adefovir dipivoxil monohydrate
1110441-05-8

adefovir dipivoxil monohydrate

Conditions
ConditionsYield
With water In dichloromethane at 20 - 25℃; for 24h;
With water for 24h;
formic acid
64-18-6

formic acid

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

adefovir dipivoxil formic acid

adefovir dipivoxil formic acid

Conditions
ConditionsYield
In ethyl acetate at 20 - 40℃;
adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 1h; pH=7.5; Enzymatic reaction;

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