As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:142340-99-6
Min.Order:1 Kilogram
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inquiryItems Standard Result Appearance White to almost white crystalline powder White crystalline powder Identification
Cas:142340-99-6
Min.Order:1 Gram
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Type:Manufacturers
inquiryUnique advantages of Adefovir dipivoxil Cas 142340-99-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white powder Storage:Cool dry place Package:1kg/foill b
Cas:142340-99-6
Min.Order:1 Kilogram
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inquiryFull experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Rich experie
Cas:142340-99-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:142340-99-6
Min.Order:1 Gram
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Type:Manufacturers
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cas:142340-99-6
Min.Order:5 Gram
FOB Price: $960.0 / 1000.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:142340-99-6
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Type:Manufacturers
inquiryProduct Name: Adefovir dipivoxil Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVI
Cas:142340-99-6
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:142340-99-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:142340-99-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:142340-99-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryChemical Name: Adefovir dipivoxil Molecular Formula: C20H32N5O8P Formula Weight: 501.47 CAS No.: 142340-99-6 EINECS:200-001-8 White to white crystalline powder. Adefovir Dipivoxyl is a prescription medicine used to treat infections
Cas:142340-99-6
Min.Order:1 Kilogram
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Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:142340-99-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:142340-99-6
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
Cas:142340-99-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAbout us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.
Cas:142340-99-6
Min.Order:1 Kilogram
FOB Price: $1200.0 / 1300.0
Type:Trading Company
inquiryBeluga chemical professional supply Adefovir Dipivoxil CAS 142340-99-6 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo
Cas:142340-99-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:142340-99-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:142340-99-6
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:142340-99-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:as customer request Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Port:QINGDAO
Cas:142340-99-6
Min.Order:10 Gram
FOB Price: $1.0 / 10.0
Type:Lab/Research institutions
inquiryProduct Name: Adefovir dipivoxil Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVIR PIVOXIL;Adefovir Dipivoxyl;Bis(Pivalo
Cas:142340-99-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryName Adefovir dipivoxil Synonyms 9-[2-[Bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine Molecular Structure
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:142340-99-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:142340-99-6
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:142340-99-6
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:142340-99-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryNewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 50 - 55℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Large scale; | 78.1% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 25℃; for 24h; | 75% |
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 65 - 75℃; for 2h; Temperature; Reagent/catalyst; Solvent; | 57.5% |
7H-purin-6-ylamine
adefovir dipivoxyl
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 90 - 95℃; for 9h; Large scale; | 46.18% |
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 30 - 60℃; for 16h; Reagent/catalyst; | 32.6% |
adefovir dipivoxyl
Conditions | Yield |
---|---|
With acetic acid In methanol for 12h; Ambient temperature; Yield given; |
iodomethyl pivaloate
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 36 h / Ambient temperature 2: aq. AcOH / methanol / 12 h / Ambient temperature View Scheme |
N6-(4-monomethoxytrityl)-9-(2-phosphonomethoxyethyl)adenine
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 36 h / Ambient temperature 2: aq. AcOH / methanol / 12 h / Ambient temperature View Scheme |
N4-dimethylaminomethyledino-9-(2-phosphonomethoxyethyl)adenine di(pivaloyloxymethyl) ester
adefovir dipivoxyl
Conditions | Yield |
---|---|
Stage #1: N4-dimethylaminomethylideno-9-(2-phosphonomethoxyethyl)adinine di(pivaloyloxymethyl) ester With acetic acid In water at 25 - 55℃; for 3h; Stage #2: With triethylamine In water; ethyl acetate pH=7.5; | |
Stage #1: N4-dimethylaminomethylideno-9-(2-phosphonomethoxyethyl)adinine di(pivaloyloxymethyl) ester With water; acetic acid at 25 - 55℃; for 3h; Stage #2: With triethylamine In water; ethyl acetate pH=7.5; |
Chloromethyl pivalate
Adefovir
A
9-[2-({bis[(pivaloyloxy)methoxy]phosphinyl}methoxy)ethyl]-6-[(hydroxymethyl)amino]purine
B
adefovir dipivoxyl
Conditions | Yield |
---|---|
In dimethyl sulfoxide; triethylamine at 43℃; for 4h; | |
Stage #1: Chloromethyl pivalate; Adefovir With triethylamine In dimethyl sulfoxide at 40℃; for 5h; Stage #2: With water In dichloromethane; dimethyl sulfoxide at 10 - 20℃; for 0.0833333h; Product distribution / selectivity; |
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 - 85 °C 1.2: 20 h 2.1: water; hydrogen bromide / 4 h / 90 - 95 °C 2.2: 25 - 30 °C / pH 2.8 3.1: triethylamine; tetrabutylammomium bromide / ethyl acetate; N,N-dimethyl-formamide / 1 h / 25 - 35 °C 3.2: 25 - 35 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 60 °C 2.1: ammonia / methanol / 14 h 3.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 3.2: 20 h / 35 °C / Inert atmosphere 4.1: sodium bromide; 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane / 12 h / 60 °C / Inert atmosphere 4.2: 6 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / acetonitrile / 14 h / 125 °C / Inert atmosphere 2: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C 3: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C 4: triethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 30 - 60 °C View Scheme |
[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: water; hydrogen bromide / 4 h / 90 - 95 °C 1.2: 25 - 30 °C / pH 2.8 2.1: triethylamine; tetrabutylammomium bromide / ethyl acetate; N,N-dimethyl-formamide / 1 h / 25 - 35 °C 2.2: 25 - 35 °C View Scheme |
Chloromethyl pivalate
[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
adefovir dipivoxyl
Conditions | Yield |
---|---|
Stage #1: [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester With 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane; sodium bromide at 60℃; for 12h; Inert atmosphere; Stage #2: Chloromethyl pivalate With triethylamine at 60℃; for 6h; |
9-(2-hydroxyethyl)adenine
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 1.2: 20 h / 35 °C / Inert atmosphere 2.1: sodium bromide; 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane / 12 h / 60 °C / Inert atmosphere 2.2: 6 h / 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 5 °C / Large scale 1.2: 5 h / 5 °C / Large scale 2.1: trimethylsilyl bromide / acetonitrile / 3 h / 20 °C / Large scale 2.2: 2 h / Reflux; Large scale 3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 2 h / 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C 2: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C 3: triethylamine / 1-methyl-pyrrolidin-2-one / 16 h / 30 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 78 - 82 °C 1.2: 78 - 82 °C 2.1: trimethylsilyl bromide / 80 - 85 °C 3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 50 °C View Scheme |
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonia / methanol / 14 h 2.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 2.2: 20 h / 35 °C / Inert atmosphere 3.1: sodium bromide; 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane / 12 h / 60 °C / Inert atmosphere 3.2: 6 h / 60 °C View Scheme |
6-Chloro-9-(β-hydroxyethylamino)purine
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 1.2: 48 h / 50 °C 2.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice 3.1: N,N'-dicyclohexyl-4-morpholine carboxamidine; triethylamine / N,N-dimethyl-formamide / 12 h / 48 - 52 °C View Scheme |
6-chloro-9-(ethoxycarbonylmethyl)-9H-purine
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanol; sodium tetrahydroborate / 0 °C 2.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 2.2: 48 h / 50 °C 3.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice 4.1: N,N'-dicyclohexyl-4-morpholine carboxamidine; triethylamine / N,N-dimethyl-formamide / 12 h / 48 - 52 °C View Scheme |
6-chloropurine
adefovir dipivoxyl
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 0.17 h / 20 °C 2.1: methanol; sodium tetrahydroborate / 0 °C 3.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 3.2: 48 h / 50 °C 4.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice 5.1: N,N'-dicyclohexyl-4-morpholine carboxamidine; triethylamine / N,N-dimethyl-formamide / 12 h / 48 - 52 °C View Scheme |
Conditions | Yield |
---|---|
In ethyl acetate at 40℃; for 3h; Temperature; | 98% |
adefovir dipivoxyl
Conditions | Yield |
---|---|
With deuterium In tetrahydrofuran; cyclohexane at 55℃; under 1500.15 Torr; for 36h; Reagent/catalyst; Glovebox; | 96% |
Conditions | Yield |
---|---|
In acetone at 0 - 50℃; Product distribution / selectivity; | 90% |
In ethanol at 25℃; for 0.166667h; |
nicotinamide
adefovir dipivoxyl
adefovir dipivoxil:nicotinamide cocrystal
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 70℃; for 25.25h; Product distribution / selectivity; | 80% |
Conditions | Yield |
---|---|
In tert-butyl methyl ether; acetone at 20℃; Product distribution / selectivity; Reflux; | 78% |
pivaloyl chloride
adefovir dipivoxyl
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 8h; Cooling with ice; | 76.13% |
adefovir dipivoxyl
9-{2-[O,O'-bis(pivaloyloxymethyl)thiophosphonomethoxy]ethyl}adenine
Conditions | Yield |
---|---|
With 2,4-bis(methylthio)-1,3-dithia-2,4-diphosphetane-2,4-disulfide In benzene at 0 - 80℃; for 2.5h; | 29% |
adefovir dipivoxyl
adefovir dipivoxil monohydrate
Conditions | Yield |
---|---|
With water In dichloromethane at 20 - 25℃; for 24h; | |
With water for 24h; |
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 40℃; |
adefovir dipivoxyl
Adefovir
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 1h; pH=7.5; Enzymatic reaction; |
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