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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Adefovir Synonyms: 9-[2- (phosphonomethoxy) ethyl] adenine, alternate name adefovir[PMEA];[2-(6-Amino-9H-purine-9-yl)ethoxymethyl]phosphonic acid;Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- (9CI);9-[2-(6-Amino-9H-pur

Adefovir 99% Manufactuered in China best quality

Cas:106941-25-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Adefovir supplier in China

Cas:106941-25-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Adefovir CAS:106941-25-7

Cas:106941-25-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Adefovir Cas 106941-25-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:cool dry place Package:25kg/drum Application:medicine

Manufacturer high quality Adefovir Cas 106941-25-7 with good price

Cas:106941-25-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Adefovir

Cas:106941-25-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Adefovir 106941-25-7 GMP Manufacturer

Cas:106941-25-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Adefovir

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Adefovir

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Adefovir

Cas:106941-25-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Adefovir CAS NO: 106941-25-7 Grade:Medical scientific research and export Molecular formula:C8H12N5O4P Molecular weight:273.18600 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da

Adefovir/cas:106941-25-7/Raw material spot

Cas:106941-25-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

106941-25-7

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Adefovir

Cas:106941-25-7

Min.Order:1 Gram

FOB Price: $1.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 106941-25-7 with best quality

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High purity Adefovir with best price and good quality CAS NO.106941-25-7

Cas:106941-25-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Adefovir CAS106941-25-7

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name Adefovir CAS No. 106941-25-7 Molecular Formula C8H12N5O4P EINECS 600-789-7 Molecular Weight 273.19 Form P

Adefovir

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Adefovir 106941-25-7

Cas:106941-25-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Adefovir 99%

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Adefovir CAS:106941-25-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Adefovir CAS:106941-25-7

Cas:106941-25-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Adefovir

Cas:106941-25-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

cure for hepatitis b adefovir

Cas:106941-25-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Adefovir CAS 106941-25-7

Cas:106941-25-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Adefovir

Cas:106941-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High purity Adefovir with best price and good quality CAS NO.106941-25-7

Cas:106941-25-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

9-[2-(Phosphono Methoxy)Ethyl]Adenine (PMEA)

Cas:106941-25-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Adefovir

Cas:106941-25-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

GS0393 Adefovir 106941-25-7

Cas:106941-25-7

Min.Order:200 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Adefovir

Cas:106941-25-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Adefovir CAS 106941-25-7

Cas:106941-25-7

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Adefovir

Cas:106941-25-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
116384-53-3

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With trimethylsilyl bromide95%
Stage #1: [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester With trimethylsilyl bromide In acetonitrile at 20℃; for 3h; Large scale;
Stage #2: With sodium hydroxide In water for 2h; Reflux; Large scale;
86.3%
With hydrogen bromide In water at 90℃; for 5h; Temperature; Time;86%
[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid diisopropyl ester
142340-94-1

[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid diisopropyl ester

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With hydrogenchloride In water at 140℃; for 0.166667h; Microwave irradiation; Sealed tube;95%
Multi-step reaction with 2 steps
1: acetonitrile
2: aq. NH3
View Scheme
Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine
107021-27-2

Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With trimethylsilyl iodide; triethylamine carbonate 1) DMF, R.T., 16 h 2) 80 deg C; Yield given. Multistep reaction;
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

9-(2-hydroxyethyl)adenine
707-99-3

9-(2-hydroxyethyl)adenine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With trimethylsilyl bromide; sodium t-butanolate 1.) DMF; Yield given. Multistep reaction;
C14H28N5O4PSi2

C14H28N5O4PSi2

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With ammonium hydroxide Yield given;
With water33.0 g
[2-(5-Amino-6-chloro-pyrimidin-4-ylamino)-ethoxymethyl]-phosphonic acid diethyl ester
212894-84-3

[2-(5-Amino-6-chloro-pyrimidin-4-ylamino)-ethoxymethyl]-phosphonic acid diethyl ester

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 3 h / 120 °C
2: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C
3: 95 percent / TMSBr
View Scheme
O,O-diethyl((2-(6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonate
185900-69-0

O,O-diethyl((2-(6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonate

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C
2: 95 percent / TMSBr
View Scheme
9-(2-Hydroxyethyl)-N6-benzoyladenine
55343-28-7

9-(2-Hydroxyethyl)-N6-benzoyladenine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) NaH 2) 0.5 mol l-1 NaOH / 1)DMF, R.T., 48 h, 2) 50 deg C, 6 h
2: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C
View Scheme
9-(2-hydroxyethyl)adenine
707-99-3

9-(2-hydroxyethyl)adenine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / chlorotrimethylsilane / pyridine
2: 1) NaH 2) 0.5 mol l-1 NaOH / 1)DMF, R.T., 48 h, 2) 50 deg C, 6 h
3: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C
View Scheme
Multi-step reaction with 2 steps
1: 1) NaH, 2) 0.5 mol l-1 NaOH / 1) DMF, R.T., 48 h, 2) 50 deg C, 6 h
2: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 5 °C / Large scale
1.2: 5 h / 5 °C / Large scale
2.1: trimethylsilyl bromide / acetonitrile / 3 h / 20 °C / Large scale
2.2: 2 h / Reflux; Large scale
View Scheme
Multi-step reaction with 2 steps
1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C
2: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 78 - 82 °C
1.2: 78 - 82 °C
2.1: trimethylsilyl bromide / 80 - 85 °C
View Scheme
9-(2-Diethoxyphosphonomethoxyethyl)adenine

9-(2-Diethoxyphosphonomethoxyethyl)adenine

trimethylsilyl bromide
2857-97-8

trimethylsilyl bromide

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
In dichloromethane; water; acetone
disodium {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonothioate

disodium {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonothioate

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
for 24h; Conversion of starting material; Complete medium (extra-cellular medium mimick);
With CEM-SS culture medium at 37℃; pH=7.4; aq. buffer;
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphinic acid
159531-21-2

{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphinic acid

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridine; N,O-bis-(trimethylsilyl)-acetamide / 1 h / 20 °C / Inert atmosphere
1.2: 0.5 h / Inert atmosphere
1.3: Dowex 50WX2 (Na+ form)
2.1: CEM-SS culture medium / 37 °C / pH 7.4 / aq. buffer
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 - 85 °C
1.2: 20 h
2.1: water; hydrogen bromide / 4 h / 90 - 95 °C
2.2: 25 - 30 °C / pH 2.8
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / acetonitrile / 14 h / 125 °C / Inert atmosphere
2: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C
3: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C
View Scheme
C32H41FN7O6P

C32H41FN7O6P

A

Adefovir
106941-25-7

Adefovir

B

PMEA-F

PMEA-F

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction;
adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 1h; pH=7.5; Enzymatic reaction;
C32H42N7O6P

C32H42N7O6P

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction;
C18H30N7O6P
168537-58-4

C18H30N7O6P

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction;
6-Chloro-9-(β-hydroxyethylamino)purine
1670-62-8

6-Chloro-9-(β-hydroxyethylamino)purine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
1.2: 48 h / 50 °C
2.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
6-chloro-9-(ethoxycarbonylmethyl)-9H-purine
56791-59-4

6-chloro-9-(ethoxycarbonylmethyl)-9H-purine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanol; sodium tetrahydroborate / 0 °C
2.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
2.2: 48 h / 50 °C
3.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
6-chloropurine
87-42-3

6-chloropurine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 0.17 h / 20 °C
2.1: methanol; sodium tetrahydroborate / 0 °C
3.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
3.2: 48 h / 50 °C
4.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
(di-tert-butoxyphosphoryl)methyl methanesulfonate

(di-tert-butoxyphosphoryl)methyl methanesulfonate

9-(2-hydroxyethyl)adenine
707-99-3

9-(2-hydroxyethyl)adenine

Adefovir
106941-25-7

Adefovir

Conditions
ConditionsYield
Stage #1: 9-(2-hydroxyethyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 22h; Schlenk technique; Inert atmosphere;
Stage #3: With hydrogenchloride In water at 60℃; Schlenk technique; Inert atmosphere;
morpholine
110-91-8

morpholine

N,N'-di-cyclohexylformamidine
2303-89-1

N,N'-di-cyclohexylformamidine

Adefovir
106941-25-7

Adefovir

9-(2-Morpholinophosphonylmethoxyethyl)adenine N,N'-dicyclohexylcarboxamidinium salt

9-(2-Morpholinophosphonylmethoxyethyl)adenine N,N'-dicyclohexylcarboxamidinium salt

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In water; tert-butyl alcohol for 11h; Heating;96%
Adefovir
106941-25-7

Adefovir

9-(2-Phosphonylmethoxyethyl)hypoxanthine
113884-65-4

9-(2-Phosphonylmethoxyethyl)hypoxanthine

Conditions
ConditionsYield
With isopentyl nitrite In acetic acid for 72h; Ambient temperature;93%
3,5-Dihydroxybenzoic acid
99-10-5

3,5-Dihydroxybenzoic acid

Adefovir
106941-25-7

Adefovir

C8H12N5O4P*C7H6O4*H2O

C8H12N5O4P*C7H6O4*H2O

Conditions
ConditionsYield
With water at 90℃; for 3h;90%
N-formyldiethylamine
617-84-5

N-formyldiethylamine

Adefovir
106941-25-7

Adefovir

C13H19Cl2N6O2P
1056998-35-6

C13H19Cl2N6O2P

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane for 4.5h; Heating / reflux;89%
With oxalyl dichloride In dichloromethane for 4.5h; Heating / reflux;
Adefovir
106941-25-7

Adefovir

(Z)-4-(2-chloroethylidenyl)-2,3-dimethoxy-Δα,β-butenolide
347363-99-9

(Z)-4-(2-chloroethylidenyl)-2,3-dimethoxy-Δα,β-butenolide

[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-[2-(3,4-dimethoxy-5-oxo-5H-furan-2-ylidene)-ethyl] ester

[2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-[2-(3,4-dimethoxy-5-oxo-5H-furan-2-ylidene)-ethyl] ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 1h;88%
1,1,1-trichloroethanol
115-20-8

1,1,1-trichloroethanol

Adefovir
106941-25-7

Adefovir

9-<2-(phosphonomethoxy)ethyl>adenine, mono-2,2,2-trichloroethyl ester

9-<2-(phosphonomethoxy)ethyl>adenine, mono-2,2,2-trichloroethyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;86%
methanol
67-56-1

methanol

Adefovir
106941-25-7

Adefovir

Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine
107021-27-2

Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;85%
Adefovir
106941-25-7

Adefovir

ethylenediamine
107-15-3

ethylenediamine

C10H18N7O3P

C10H18N7O3P

Conditions
ConditionsYield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃;85%
Adefovir
106941-25-7

Adefovir

vitamin E
895518-38-4

vitamin E

C66H108N5O6P

C66H108N5O6P

Conditions
ConditionsYield
With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h;79.36%
2-chloroethanal
107-20-0

2-chloroethanal

Adefovir
106941-25-7

Adefovir

9-(2-phosphonylmethoxyethyl)-1,N6-ethenoadenine
120139-27-7

9-(2-phosphonylmethoxyethyl)-1,N6-ethenoadenine

Conditions
ConditionsYield
In water at 40℃; for 24h; pH 4.5;78.1%
Chloromethyl pivalate
18997-19-8

Chloromethyl pivalate

Adefovir
106941-25-7

Adefovir

adefovir dipivoxyl
142340-99-6

adefovir dipivoxyl

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 50 - 55℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Large scale;78.1%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 25℃; for 24h;75%
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 65 - 75℃; for 2h; Temperature; Reagent/catalyst; Solvent;57.5%
Pyridine-2,6-dicarboxylic acid
499-83-2

Pyridine-2,6-dicarboxylic acid

Adefovir
106941-25-7

Adefovir

C8H12N5O4P*C7H5NO4

C8H12N5O4P*C7H5NO4

Conditions
ConditionsYield
In ethanol; water at 90℃; for 3h;75%
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

Adefovir
106941-25-7

Adefovir

9-(2-phosphonomethoxyethyl)adenine 2,2,2-trifluoroethyl ester

9-(2-phosphonomethoxyethyl)adenine 2,2,2-trifluoroethyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;74%
propan-1-ol
71-23-8

propan-1-ol

Adefovir
106941-25-7

Adefovir

9-(2-phosphonomethoxyethyl)adenine propyl ester

9-(2-phosphonomethoxyethyl)adenine propyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Product distribution; Ambient temperature; various hydroxylic components under different reaction conditions;73%
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;73%
Adefovir
106941-25-7

Adefovir

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

2C8H12N5O4P*C7H7NO2*3H2O

2C8H12N5O4P*C7H7NO2*3H2O

Conditions
ConditionsYield
With water at 90℃; for 2h;70%
2-(morpholin-4-yl)ethanol
622-40-2

2-(morpholin-4-yl)ethanol

Adefovir
106941-25-7

Adefovir

9-(2-phosphonomethoxyethyl)adenine 2-morpholinoethyl ester

9-(2-phosphonomethoxyethyl)adenine 2-morpholinoethyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;68%
2,2,2-tribromoethanol
75-80-9

2,2,2-tribromoethanol

Adefovir
106941-25-7

Adefovir

9-(2-phosphonomethoxyethyl)adenine 2,2,2-tribromoethyl ester

9-(2-phosphonomethoxyethyl)adenine 2,2,2-tribromoethyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 48h; Ambient temperature;64%
N,N-dimethylformamide dibenzyl acetal
2016-04-8

N,N-dimethylformamide dibenzyl acetal

Adefovir
106941-25-7

Adefovir

9-(2-phosphonomethoxyethyl)adenine benzyl ester

9-(2-phosphonomethoxyethyl)adenine benzyl ester

Conditions
ConditionsYield
at 60℃; for 48h;60%
Adefovir
106941-25-7

Adefovir

ethylene glycol
107-21-1

ethylene glycol

9-(2-phosphonomethoxyethyl)adenine 2-hydroxyethyl ester

9-(2-phosphonomethoxyethyl)adenine 2-hydroxyethyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;57%
Adefovir
106941-25-7

Adefovir

hexan-1-ol
111-27-3

hexan-1-ol

9-(2-phosphonomethoxyethyl)adenine hexyl ester

9-(2-phosphonomethoxyethyl)adenine hexyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;56%
Adefovir
106941-25-7

Adefovir

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

9-(2-phosphonomethoxyethyl)adenine 2-cyanoethyl ester

9-(2-phosphonomethoxyethyl)adenine 2-cyanoethyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 4h; Ambient temperature;51%
Adefovir
106941-25-7

Adefovir

glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

9-(bis(N,N'-(methoxycarbonylmethyl)phosphonamido)methoxyethyl)adenine
1041402-65-6

9-(bis(N,N'-(methoxycarbonylmethyl)phosphonamido)methoxyethyl)adenine

Conditions
ConditionsYield
With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine In pyridine at 90℃; for 24h; Mukaiyama reaction; Inert atmosphere;51%
3,6,9,12,15,1 8-hexaoxaicosyl p-toluensulfonate

3,6,9,12,15,1 8-hexaoxaicosyl p-toluensulfonate

Adefovir
106941-25-7

Adefovir

9-[2-(phosphonomethoxy)ethyl]adenine bis(3,6,9,12,15,18-hexaoxaeicosyl) ester
1313815-78-9

9-[2-(phosphonomethoxy)ethyl]adenine bis(3,6,9,12,15,18-hexaoxaeicosyl) ester

Conditions
ConditionsYield
Stage #1: Adefovir With tetra(n-butyl)ammonium hydroxide In methanol
Stage #2: 3,6,9,12,15,1 8-hexaoxaicosyl p-toluensulfonate In N,N-dimethyl-formamide at 100℃;
50%
(aqua(diethylenetriamine)platinum(II))nitrate

(aqua(diethylenetriamine)platinum(II))nitrate

Adefovir
106941-25-7

Adefovir

(diehylenetriamine)Pt(dianion of 9-[2-(phosphonomethoxy)ethyl]adenine)*HNO3*NaNO3*H2O

(diehylenetriamine)Pt(dianion of 9-[2-(phosphonomethoxy)ethyl]adenine)*HNO3*NaNO3*H2O

Conditions
ConditionsYield
With aq. HNO3 In water aq. soln. of org. compd. slowly added to soln. of complex (pH= 1.3 adjusted with 1 M HNO3) during 3 h, stirred for 24 h at 35°C; volatiles evapd. at room temp. in N2 stream, treated twice with MeOH (12 h, ambient temp.), foltered, elem. anal.;49%
Adefovir
106941-25-7

Adefovir

dimethylformamide 1,3-butylene acetal

dimethylformamide 1,3-butylene acetal

A

9-(2-phosphonomethoxyethyl)adenine 3-hydroxybutyl ester

9-(2-phosphonomethoxyethyl)adenine 3-hydroxybutyl ester

B

[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-(3-hydroxy-1-methyl-propyl) ester

[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-(3-hydroxy-1-methyl-propyl) ester

Conditions
ConditionsYield
at 70℃; for 16h;A 48%
B n/a
(S)-(-)-1-(3'-Chlorophenyl)-1,3-Propanediol
51699-45-7

(S)-(-)-1-(3'-Chlorophenyl)-1,3-Propanediol

Adefovir
106941-25-7

Adefovir

(rac)-cis-9-{2-[4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine

(rac)-cis-9-{2-[4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine

(rac)-trans-9-{2-[4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine

(rac)-trans-9-{2-[4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃;A 48%
B n/a
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃;
Adefovir
106941-25-7

Adefovir

1,2,3-tri-O-acetylthreitol

1,2,3-tri-O-acetylthreitol

9-(2-phosphonomethoxyethyl)adenine 2,3,4-trihydroxy-1-butyl ester

9-(2-phosphonomethoxyethyl)adenine 2,3,4-trihydroxy-1-butyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;47%
octanol
111-87-5

octanol

Adefovir
106941-25-7

Adefovir

9-(2-phosphonomethoxyethyl)adenine octyl ester

9-(2-phosphonomethoxyethyl)adenine octyl ester

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;46%

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