Product Name: Adefovir Synonyms: 9-[2- (phosphonomethoxy) ethyl] adenine, alternate name adefovir[PMEA];[2-(6-Amino-9H-purine-9-yl)ethoxymethyl]phosphonic acid;Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- (9CI);9-[2-(6-Amino-9H-pur
Cas:106941-25-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:106941-25-7
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:106941-25-7
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryUnique advantages of Adefovir Cas 106941-25-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:cool dry place Package:25kg/drum Application:medicine
Cas:106941-25-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:106941-25-7
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:106941-25-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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Name:Adefovir CAS NO: 106941-25-7 Grade:Medical scientific research and export Molecular formula:C8H12N5O4P Molecular weight:273.18600 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da
Cas:106941-25-7
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryNow we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti
Cas:106941-25-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:106941-25-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:106941-25-7
Min.Order:10 Kilogram
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Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:106941-25-7
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiryProduct Name Adefovir CAS No. 106941-25-7 Molecular Formula C8H12N5O4P EINECS 600-789-7 Molecular Weight 273.19 Form P
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:106941-25-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:106941-25-7
Min.Order:1 Kilogram
FOB Price: $86.0 / 100.0
Type:Trading Company
inquiryAdefovir CAS:106941-25-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:106941-25-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:106941-25-7
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:106941-25-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Detail Minimum Order Qty. 10 Gram
Cas:106941-25-7
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Cas:106941-25-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Cas:106941-25-7
Min.Order:200 Milligram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:106941-25-7
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester
Adefovir
Conditions | Yield |
---|---|
With trimethylsilyl bromide | 95% |
Stage #1: [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester With trimethylsilyl bromide In acetonitrile at 20℃; for 3h; Large scale; Stage #2: With sodium hydroxide In water for 2h; Reflux; Large scale; | 86.3% |
With hydrogen bromide In water at 90℃; for 5h; Temperature; Time; | 86% |
[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid diisopropyl ester
Adefovir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 140℃; for 0.166667h; Microwave irradiation; Sealed tube; | 95% |
Multi-step reaction with 2 steps 1: acetonitrile 2: aq. NH3 View Scheme |
Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine
Adefovir
Conditions | Yield |
---|---|
With trimethylsilyl iodide; triethylamine carbonate 1) DMF, R.T., 16 h 2) 80 deg C; Yield given. Multistep reaction; |
diethyl (p-toluenesulfonyloxymethane)phosphonate
9-(2-hydroxyethyl)adenine
Adefovir
Conditions | Yield |
---|---|
With trimethylsilyl bromide; sodium t-butanolate 1.) DMF; Yield given. Multistep reaction; |
Adefovir
Conditions | Yield |
---|---|
With ammonium hydroxide Yield given; | |
With water | 33.0 g |
[2-(5-Amino-6-chloro-pyrimidin-4-ylamino)-ethoxymethyl]-phosphonic acid diethyl ester
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / 3 h / 120 °C 2: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C 3: 95 percent / TMSBr View Scheme |
O,O-diethyl((2-(6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonate
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C 2: 95 percent / TMSBr View Scheme |
9-(2-Hydroxyethyl)-N6-benzoyladenine
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) NaH 2) 0.5 mol l-1 NaOH / 1)DMF, R.T., 48 h, 2) 50 deg C, 6 h 2: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C View Scheme |
9-(2-hydroxyethyl)adenine
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 81 percent / chlorotrimethylsilane / pyridine 2: 1) NaH 2) 0.5 mol l-1 NaOH / 1)DMF, R.T., 48 h, 2) 50 deg C, 6 h 3: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C View Scheme | |
Multi-step reaction with 2 steps 1: 1) NaH, 2) 0.5 mol l-1 NaOH / 1) DMF, R.T., 48 h, 2) 50 deg C, 6 h 2: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 5 °C / Large scale 1.2: 5 h / 5 °C / Large scale 2.1: trimethylsilyl bromide / acetonitrile / 3 h / 20 °C / Large scale 2.2: 2 h / Reflux; Large scale View Scheme | |
Multi-step reaction with 2 steps 1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C 2: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 78 - 82 °C 1.2: 78 - 82 °C 2.1: trimethylsilyl bromide / 80 - 85 °C View Scheme |
Conditions | Yield |
---|---|
In dichloromethane; water; acetone |
Adefovir
Conditions | Yield |
---|---|
for 24h; Conversion of starting material; Complete medium (extra-cellular medium mimick); | |
With CEM-SS culture medium at 37℃; pH=7.4; aq. buffer; |
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphinic acid
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: pyridine; N,O-bis-(trimethylsilyl)-acetamide / 1 h / 20 °C / Inert atmosphere 1.2: 0.5 h / Inert atmosphere 1.3: Dowex 50WX2 (Na+ form) 2.1: CEM-SS culture medium / 37 °C / pH 7.4 / aq. buffer View Scheme |
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 - 85 °C 1.2: 20 h 2.1: water; hydrogen bromide / 4 h / 90 - 95 °C 2.2: 25 - 30 °C / pH 2.8 View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / acetonitrile / 14 h / 125 °C / Inert atmosphere 2: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C 3: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C View Scheme |
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction; |
adefovir dipivoxyl
Adefovir
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 1h; pH=7.5; Enzymatic reaction; |
Adefovir
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction; |
C18H30N7O6P
Adefovir
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction; |
6-Chloro-9-(β-hydroxyethylamino)purine
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 1.2: 48 h / 50 °C 2.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice View Scheme |
6-chloro-9-(ethoxycarbonylmethyl)-9H-purine
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: methanol; sodium tetrahydroborate / 0 °C 2.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 2.2: 48 h / 50 °C 3.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice View Scheme |
6-chloropurine
Adefovir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 0.17 h / 20 °C 2.1: methanol; sodium tetrahydroborate / 0 °C 3.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 3.2: 48 h / 50 °C 4.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice View Scheme |
9-(2-hydroxyethyl)adenine
Adefovir
Conditions | Yield |
---|---|
Stage #1: 9-(2-hydroxyethyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere; Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 22h; Schlenk technique; Inert atmosphere; Stage #3: With hydrogenchloride In water at 60℃; Schlenk technique; Inert atmosphere; |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In water; tert-butyl alcohol for 11h; Heating; | 96% |
Adefovir
9-(2-Phosphonylmethoxyethyl)hypoxanthine
Conditions | Yield |
---|---|
With isopentyl nitrite In acetic acid for 72h; Ambient temperature; | 93% |
Conditions | Yield |
---|---|
With water at 90℃; for 3h; | 90% |
Conditions | Yield |
---|---|
With oxalyl dichloride In dichloromethane for 4.5h; Heating / reflux; | 89% |
With oxalyl dichloride In dichloromethane for 4.5h; Heating / reflux; |
Adefovir
(Z)-4-(2-chloroethylidenyl)-2,3-dimethoxy-Δα,β-butenolide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 1h; | 88% |
1,1,1-trichloroethanol
Adefovir
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 86% |
methanol
Adefovir
Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 85% |
Conditions | Yield |
---|---|
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; | 85% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h; | 79.36% |
2-chloroethanal
Adefovir
9-(2-phosphonylmethoxyethyl)-1,N6-ethenoadenine
Conditions | Yield |
---|---|
In water at 40℃; for 24h; pH 4.5; | 78.1% |
Conditions | Yield |
---|---|
With triethylamine In 1-methyl-pyrrolidin-2-one at 50 - 55℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Large scale; | 78.1% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 25℃; for 24h; | 75% |
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 65 - 75℃; for 2h; Temperature; Reagent/catalyst; Solvent; | 57.5% |
Conditions | Yield |
---|---|
In ethanol; water at 90℃; for 3h; | 75% |
2,2,2-trifluoroethanol
Adefovir
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 74% |
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Product distribution; Ambient temperature; various hydroxylic components under different reaction conditions; | 73% |
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 73% |
Conditions | Yield |
---|---|
With water at 90℃; for 2h; | 70% |
2-(morpholin-4-yl)ethanol
Adefovir
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 68% |
2,2,2-tribromoethanol
Adefovir
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 48h; Ambient temperature; | 64% |
N,N-dimethylformamide dibenzyl acetal
Adefovir
Conditions | Yield |
---|---|
at 60℃; for 48h; | 60% |
Adefovir
ethylene glycol
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 57% |
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 56% |
Adefovir
3-Hydroxypropionitrile
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 4h; Ambient temperature; | 51% |
Adefovir
glycine ethyl ester hydrochloride
9-(bis(N,N'-(methoxycarbonylmethyl)phosphonamido)methoxyethyl)adenine
Conditions | Yield |
---|---|
With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine In pyridine at 90℃; for 24h; Mukaiyama reaction; Inert atmosphere; | 51% |
Adefovir
9-[2-(phosphonomethoxy)ethyl]adenine bis(3,6,9,12,15,18-hexaoxaeicosyl) ester
Conditions | Yield |
---|---|
Stage #1: Adefovir With tetra(n-butyl)ammonium hydroxide In methanol Stage #2: 3,6,9,12,15,1 8-hexaoxaicosyl p-toluensulfonate In N,N-dimethyl-formamide at 100℃; | 50% |
Adefovir
Conditions | Yield |
---|---|
With aq. HNO3 In water aq. soln. of org. compd. slowly added to soln. of complex (pH= 1.3 adjusted with 1 M HNO3) during 3 h, stirred for 24 h at 35°C; volatiles evapd. at room temp. in N2 stream, treated twice with MeOH (12 h, ambient temp.), foltered, elem. anal.; | 49% |
(S)-(-)-1-(3'-Chlorophenyl)-1,3-Propanediol
Adefovir
Conditions | Yield |
---|---|
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃; | A 48% B n/a |
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃; |
Adefovir
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 47% |
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature; | 46% |
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