Adefovir supplier | CasNO.106941-25-7

Name
Adefovir
EINECS 600-789-7
CAS No. 106941-25-7
Article Data21
CAS DataBase
Density 1.88 g/cm³
Solubility
Melting Point >260 °C
Formula C₈H₁₂N₅O₄P
Boiling Point 632.5 °C at 760 mmHg
Molecular Weight 273.188
Flash Point 336.3 °C
Transport Information
Appearance white to off-white powder
Safety 45
Risk Codes 25
Molecular Structure
Hazard Symbols T
Synonyms ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid;9-(2-Phosphorylmethoxyethyl)adenine;PMEA;Adefovir [USAN:INN];2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid;N-(2-Phophonomethoxyethyl-2,6-diaminopurine);GS 0393;GS 393;9-(2-(Phosphonomethoxy)ethyl)adenine;Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-;9-[2-Phosphonylmethoxyethyl]adenine;9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA);9-[2-phosphonyl methoxyethyl]adenine;Adefovir dipivox;9-[2-(phosphonomethoxy)ethyl]adenine;[[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphonic acid;9-(2-phosphonyl methoxyethyl)adenine;Adefovir Dipivozil;9-(2-Phosphonylmethoxyethyl)adenine;
PSA 146.19000
LogP 0.14150

Synthetic route

: 116384-53-3
[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With trimethylsilyl bromide	95%
Stage #1: [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester With trimethylsilyl bromide In acetonitrile at 20℃; for 3h; Large scale; Stage #2: With sodium hydroxide In water for 2h; Reflux; Large scale;	86.3%
With hydrogen bromide In water at 90℃; for 5h; Temperature; Time;	86%

: 142340-94-1
[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid diisopropyl ester

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With hydrogenchloride In water at 140℃; for 0.166667h; Microwave irradiation; Sealed tube;	95%
Multi-step reaction with 2 steps 1: acetonitrile 2: aq. NH3 View Scheme

: 107021-27-2
Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With trimethylsilyl iodide; triethylamine carbonate 1) DMF, R.T., 16 h 2) 80 deg C; Yield given. Multistep reaction;

: 31618-90-3
diethyl (p-toluenesulfonyloxymethane)phosphonate

: 707-99-3
9-(2-hydroxyethyl)adenine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With trimethylsilyl bromide; sodium t-butanolate 1.) DMF; Yield given. Multistep reaction;

: C14H28N5O4PSi2

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With ammonium hydroxide Yield given;
With water	33.0 g

: 212894-84-3
[2-(5-Amino-6-chloro-pyrimidin-4-ylamino)-ethoxymethyl]-phosphonic acid diethyl ester

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / 3 h / 120 °C 2: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C 3: 95 percent / TMSBr View Scheme

: 185900-69-0
O,O-diethyl((2-(6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonate

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C 2: 95 percent / TMSBr View Scheme

: 55343-28-7
9-(2-Hydroxyethyl)-N6-benzoyladenine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) NaH 2) 0.5 mol l-1 NaOH / 1)DMF, R.T., 48 h, 2) 50 deg C, 6 h 2: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C View Scheme

: 707-99-3
9-(2-hydroxyethyl)adenine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 81 percent / chlorotrimethylsilane / pyridine 2: 1) NaH 2) 0.5 mol l-1 NaOH / 1)DMF, R.T., 48 h, 2) 50 deg C, 6 h 3: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C View Scheme
Multi-step reaction with 2 steps 1: 1) NaH, 2) 0.5 mol l-1 NaOH / 1) DMF, R.T., 48 h, 2) 50 deg C, 6 h 2: 1) iodotrimethylsilane 2) 2 mol l-1 triethylammonium hydrogen carbonate / 1) DMF, R.T., 16 h 2) 80 deg C View Scheme
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 5 °C / Large scale 1.2: 5 h / 5 °C / Large scale 2.1: trimethylsilyl bromide / acetonitrile / 3 h / 20 °C / Large scale 2.2: 2 h / Reflux; Large scale View Scheme
Multi-step reaction with 2 steps 1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C 2: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C View Scheme
Multi-step reaction with 2 steps 1.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 1 h / 78 - 82 °C 1.2: 78 - 82 °C 2.1: trimethylsilyl bromide / 80 - 85 °C View Scheme

: 9-(2-Diethoxyphosphonomethoxyethyl)adenine

: 2857-97-8
trimethylsilyl bromide

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
In dichloromethane; water; acetone

: disodium {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonothioate

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
for 24h; Conversion of starting material; Complete medium (extra-cellular medium mimick);
With CEM-SS culture medium at 37℃; pH=7.4; aq. buffer;

: 159531-21-2
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphinic acid

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: pyridine; N,O-bis-(trimethylsilyl)-acetamide / 1 h / 20 °C / Inert atmosphere 1.2: 0.5 h / Inert atmosphere 1.3: Dowex 50WX2 (Na+ form) 2.1: CEM-SS culture medium / 37 °C / pH 7.4 / aq. buffer View Scheme

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 - 85 °C 1.2: 20 h 2.1: water; hydrogen bromide / 4 h / 90 - 95 °C 2.2: 25 - 30 °C / pH 2.8 View Scheme
Multi-step reaction with 3 steps 1: triethylamine / acetonitrile / 14 h / 125 °C / Inert atmosphere 2: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 12 h / 80 °C 3: chloro-trimethyl-silane / chlorobenzene / 10 h / 120 °C View Scheme

: C32H41FN7O6P

A: 106941-25-7
Adefovir

B: PMEA-F

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction;

: 142340-99-6
adefovir dipivoxyl

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 1h; pH=7.5; Enzymatic reaction;

: C32H42N7O6P

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction;

: 168537-58-4
C18H30N7O6P

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; water; magnesium chloride In aq. buffer at 37℃; for 18h; pH=7.5; Enzymatic reaction;

: 1670-62-8
6-Chloro-9-(β-hydroxyethylamino)purine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 1.2: 48 h / 50 °C 2.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice View Scheme

: 56791-59-4
6-chloro-9-(ethoxycarbonylmethyl)-9H-purine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: methanol; sodium tetrahydroborate / 0 °C 2.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 2.2: 48 h / 50 °C 3.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice View Scheme

: 87-42-3
6-chloropurine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 0.17 h / 20 °C 2.1: methanol; sodium tetrahydroborate / 0 °C 3.1: sodium hydride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere 3.2: 48 h / 50 °C 4.1: trimethylhalosilane / acetonitrile / 20 °C / Inert atmosphere; Cooling with ice View Scheme

: (di-tert-butoxyphosphoryl)methyl methanesulfonate

: 707-99-3
9-(2-hydroxyethyl)adenine

: 106941-25-7
Adefovir

Conditions

Conditions	Yield
Stage #1: 9-(2-hydroxyethyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere; Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 22h; Schlenk technique; Inert atmosphere; Stage #3: With hydrogenchloride In water at 60℃; Schlenk technique; Inert atmosphere;

: 110-91-8
morpholine

: 2303-89-1
N,N'-di-cyclohexylformamidine

: 106941-25-7
Adefovir

: 9-(2-Morpholinophosphonylmethoxyethyl)adenine N,N'-dicyclohexylcarboxamidinium salt

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In water; tert-butyl alcohol for 11h; Heating;	96%

...Expand

: 106941-25-7
Adefovir

: 113884-65-4
9-(2-Phosphonylmethoxyethyl)hypoxanthine

Conditions

Conditions	Yield
With isopentyl nitrite In acetic acid for 72h; Ambient temperature;	93%

: 99-10-5
3,5-Dihydroxybenzoic acid

: 106941-25-7
Adefovir

: C8H12N5O4P*C7H6O4*H2O

Conditions

Conditions	Yield
With water at 90℃; for 3h;	90%

: 617-84-5
N-formyldiethylamine

: 106941-25-7
Adefovir

: 1056998-35-6
C13H19Cl2N6O2P

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane for 4.5h; Heating / reflux;	89%
With oxalyl dichloride In dichloromethane for 4.5h; Heating / reflux;

: 106941-25-7
Adefovir

: 347363-99-9
(Z)-4-(2-chloroethylidenyl)-2,3-dimethoxy-Δα,β-butenolide

: [2-(6-amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-[2-(3,4-dimethoxy-5-oxo-5H-furan-2-ylidene)-ethyl] ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 1h;	88%

: 115-20-8
1,1,1-trichloroethanol

: 106941-25-7
Adefovir

: 9-<2-(phosphonomethoxy)ethyl>adenine, mono-2,2,2-trichloroethyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	86%

: 67-56-1
methanol

: 106941-25-7
Adefovir

: 107021-27-2
Methyl Ester of 9-(2-Phosphonylmethoxyethyl)adenine

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	85%

: 106941-25-7
Adefovir

: 107-15-3
ethylenediamine

: C10H18N7O3P

Conditions

Conditions	Yield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃;	85%

: 106941-25-7
Adefovir

: 895518-38-4
vitamin E

: C66H108N5O6P

Conditions

Conditions	Yield
With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h;	79.36%

: 107-20-0
2-chloroethanal

: 106941-25-7
Adefovir

: 120139-27-7
9-(2-phosphonylmethoxyethyl)-1,N6-ethenoadenine

Conditions

Conditions	Yield
In water at 40℃; for 24h; pH 4.5;	78.1%

: 18997-19-8
Chloromethyl pivalate

: 106941-25-7
Adefovir

: 142340-99-6
adefovir dipivoxyl

Conditions

Conditions	Yield
With triethylamine In 1-methyl-pyrrolidin-2-one at 50 - 55℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Large scale;	78.1%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 25℃; for 24h;	75%
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 65 - 75℃; for 2h; Temperature; Reagent/catalyst; Solvent;	57.5%

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: 106941-25-7
Adefovir

: C8H12N5O4P*C7H5NO4

Conditions

Conditions	Yield
In ethanol; water at 90℃; for 3h;	75%

: 75-89-8
2,2,2-trifluoroethanol

: 106941-25-7
Adefovir

: 9-(2-phosphonomethoxyethyl)adenine 2,2,2-trifluoroethyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	74%

: 71-23-8
propan-1-ol

: 106941-25-7
Adefovir

: 9-(2-phosphonomethoxyethyl)adenine propyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Product distribution; Ambient temperature; various hydroxylic components under different reaction conditions;	73%
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	73%

: 106941-25-7
Adefovir

: 150-13-0
4-amino-benzoic acid

: 2C8H12N5O4P*C7H7NO2*3H2O

Conditions

Conditions	Yield
With water at 90℃; for 2h;	70%

: 622-40-2
2-(morpholin-4-yl)ethanol

: 106941-25-7
Adefovir

: 9-(2-phosphonomethoxyethyl)adenine 2-morpholinoethyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	68%

: 75-80-9
2,2,2-tribromoethanol

: 106941-25-7
Adefovir

: 9-(2-phosphonomethoxyethyl)adenine 2,2,2-tribromoethyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 48h; Ambient temperature;	64%

: 2016-04-8
N,N-dimethylformamide dibenzyl acetal

: 106941-25-7
Adefovir

: 9-(2-phosphonomethoxyethyl)adenine benzyl ester

Conditions

Conditions	Yield
at 60℃; for 48h;	60%

: 106941-25-7
Adefovir

: 107-21-1
ethylene glycol

: 9-(2-phosphonomethoxyethyl)adenine 2-hydroxyethyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	57%

: 106941-25-7
Adefovir

: 111-27-3
hexan-1-ol

: 9-(2-phosphonomethoxyethyl)adenine hexyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	56%

: 106941-25-7
Adefovir

: 109-78-4
3-Hydroxypropionitrile

: 9-(2-phosphonomethoxyethyl)adenine 2-cyanoethyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 4h; Ambient temperature;	51%

: 106941-25-7
Adefovir

: 5680-79-5
glycine ethyl ester hydrochloride

: 1041402-65-6
9-(bis(N,N'-(methoxycarbonylmethyl)phosphonamido)methoxyethyl)adenine

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine In pyridine at 90℃; for 24h; Mukaiyama reaction; Inert atmosphere;	51%

: 3,6,9,12,15,1 8-hexaoxaicosyl p-toluensulfonate

: 106941-25-7
Adefovir

: 1313815-78-9
9-[2-(phosphonomethoxy)ethyl]adenine bis(3,6,9,12,15,18-hexaoxaeicosyl) ester

Conditions

Conditions	Yield
Stage #1: Adefovir With tetra(n-butyl)ammonium hydroxide In methanol Stage #2: 3,6,9,12,15,1 8-hexaoxaicosyl p-toluensulfonate In N,N-dimethyl-formamide at 100℃;	50%

: (aqua(diethylenetriamine)platinum(II))nitrate

: 106941-25-7
Adefovir

: (diehylenetriamine)Pt(dianion of 9-[2-(phosphonomethoxy)ethyl]adenine)*HNO3*NaNO3*H2O

Conditions

Conditions	Yield
With aq. HNO3 In water aq. soln. of org. compd. slowly added to soln. of complex (pH= 1.3 adjusted with 1 M HNO3) during 3 h, stirred for 24 h at 35°C; volatiles evapd. at room temp. in N2 stream, treated twice with MeOH (12 h, ambient temp.), foltered, elem. anal.;	49%

: 106941-25-7
Adefovir

: dimethylformamide 1,3-butylene acetal

A: 9-(2-phosphonomethoxyethyl)adenine 3-hydroxybutyl ester

B: [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid mono-(3-hydroxy-1-methyl-propyl) ester

Conditions

Conditions	Yield
at 70℃; for 16h;	A 48% B n/a

...Expand

: 51699-45-7
(S)-(-)-1-(3'-Chlorophenyl)-1,3-Propanediol

: 106941-25-7
Adefovir

: (rac)-cis-9-{2-[4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine

: (rac)-trans-9-{2-[4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃;	A 48% B n/a
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃;

...Expand

: 106941-25-7
Adefovir

: 1,2,3-tri-O-acetylthreitol

: 9-(2-phosphonomethoxyethyl)adenine 2,3,4-trihydroxy-1-butyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	47%

: 111-87-5
octanol

: 106941-25-7
Adefovir

: 9-(2-phosphonomethoxyethyl)adenine octyl ester

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 16h; Ambient temperature;	46%

Adefovir Chemical Properties

Molecular Structure of 9-(2-Phosphonylmethoxyethyl)adenine (CAS NO.106941-25-7):

Molecular Formula: C₈H₁₂N₅O₄P
Molecular Weight: 273.1857
IUPAC Name: 2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid
Synonyms of 9-(2-Phosphonylmethoxyethyl)adenine (CAS NO.106941-25-7): Adefovir [USAN:INN] ; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid ; 9-(2-(Phosphonomethoxy)ethyl)adenine ; Adefovir ; BRN 3561094 ; DRG-0156 ; GS 0393 ; GS 393 ; GS-0393 ; N-(2-Phophonomethoxyethyl-2,6-diaminopurine) ; N-(2-Phosphonylmethoxyethyl)adenine ; PMEA ; Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)- ; UNII-6GQP90I798
CAS NO: 106941-25-7
Classification Code: Anti-Infective Agents ; Anti-Retroviral Agents ; Antiviral ; Antiviral agents ; Enzyme Inhibitors ; Mutation data ; Nucleic Acid Synthesis Inhibitors ; Reverse Transcriptase Inhibitors
Melting point: >260°C
Index of Refraction: 1.768
Molar Refractivity: 60.14 cm³
Molar Volume: 144.9 cm³
Surface Tension: 103.8 dyne/cm
Density: 1.88 g/cm³
Flash Point: 336.3 °C
Enthalpy of Vaporization: 98.29 kJ/mol
Boiling Point: 632.5 °C at 760 mmHg
Vapour Pressure: 7.24E-17 mmHg at 25°C

Adefovir Uses

9-(2-Phosphonylmethoxyethyl)adenine (CAS NO.106941-25-7) can be used for antiviral.

Adefovir Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD	intravenous	> 1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Antimicrobial Agents and Chemotherapy. Vol. 40, Pg. 1072, 1996.
mouse	LDLo	intraperitoneal	1600mg/kg (1600mg/kg)		Antimicrobial Agents and Chemotherapy. Vol. 40, Pg. 1072, 1996.

Adefovir Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x and PO_x.

Product Name

Adefovir

Synthetic route

Adefovir Chemical Properties

Adefovir Uses

Adefovir Toxicity Data With Reference

Adefovir Safety Profile

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