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inquiryProduct Description Product Name 4-Amino-2-chloropyridine CAS No. 14432-12-3 Appearance Yellowish to white powder Assay ≥98% Capacity 100mt/year Min.packing
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryAbout Product Details 4-Amino-2-chloropyridine Chemical Properties Melting point 90-94 °C(lit.) Boiling point 153°C 5mm density 1.2417 (rough estimate)
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inquiryProduct Name: 4-Amino-2-chloropyridine Synonyms: 4-Amino-2-Chloropyridine 98.5%;2-Chloro-4-aminopyridine ,99%;2-Chloro-4-aminopyri;2-Chloro-4-aminopyridine,97%;4-Amino-2-chloropyridine,97%;4-Amino-2-chloropyridine ,99%;4-Amino-2-chloropyridine ,
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inquiryName: 2-Chloro-4-Aminopyridine Molecular Formula:C5H5ClN2 Molecular Weight:128.56 CAS No.:14432-12-3 Appearance:Similar White To Slight Yellow Crystal Appearance:Similar White To Slight Yellow Crystal Storage:Store in cool and dry place, away fro
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2-chloro-4-nitropyridine
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With titanium for 0.25h; | 98% |
With [Zn(BH4)2(py)] In tetrahydrofuran for 2h; Heating; | 96% |
With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; chemoselective reaction; | 95% |
2-chloro-4-nitropyridine-N-oxide
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride; iron In ethanol for 3h; Reduction; Heating; | 95% |
With hydrogen; Ra-Ni In methanol | 90% |
With hydrogenchloride; iron In ethanol; water Reflux; | 85% |
2,4-dichloropyridine
A
2-Amino-4-chloropyridine
B
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With ammonium hydroxide at 170 - 180℃; | |
With ammonium hydroxide at 180℃; |
2-chloroisonicotinoyl azide
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With acetic acid |
2,4-dichloropyridine
A
2-Amino-4-chloropyridine
B
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
at 180℃; |
2-chloropyridine
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / aq. H2O2 / trifluoroacetic acid / 4 h 2: 72 percent / aq. HNO3, H2SO4 / 2 h 3: 95 percent / iron powder, aq. HCl / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 30percent aq. H2O2, AcOH / 48 h / 60 °C 2: HNO3, conc. H2SO4 / 2.5 h / 90 °C 3: 90 percent / H2 / Ra-Ni / methanol View Scheme | |
Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 2: nitric acid; sulfuric acid / 90 °C 3: iron; hydrogenchloride / ethanol; water / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 h / 25 °C 2: sulfuric acid; nitric acid / 0 - 100 °C 3: iron; hydrogenchloride / ethanol; water / Reflux View Scheme |
2-chloropyridine-N-oxide
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 72 percent / aq. HNO3, H2SO4 / 2 h 2: 95 percent / iron powder, aq. HCl / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: HNO3, conc. H2SO4 / 2.5 h / 90 °C 2: 90 percent / H2 / Ra-Ni / methanol View Scheme | |
Multi-step reaction with 2 steps 1: concentrated sulfuric acid; nitric acid 2: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 90 °C 2: iron; hydrogenchloride / ethanol; water / Reflux View Scheme |
4-nitraminopyridine N-oxide
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuryl chloride / 110 °C 2: aqueous NH3 / 180 °C View Scheme |
3-deazauracil
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosphoryl chloride / 140 °C 2: aqueous NH3 / 180 °C View Scheme |
2-chloro-4-nitropyridine-N-oxide
dibutyl ether
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With potassium hydroxide; iron; acetic acid In diethyl ether; ethanol; water; Petroleum ether |
4-Amino-2-chloropyridine
di-tert-butyl dicarbonate
tert-butyl N-tert-butoxycarbonyl-N-(2-chloro-4-pyridyl)carbamate
Conditions | Yield |
---|---|
Stage #1: 4-Amino-2-chloropyridine With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 100% |
Stage #1: 4-Amino-2-chloropyridine With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃; Inert atmosphere; | 36% |
Stage #1: 4-Amino-2-chloropyridine With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃; Inert atmosphere; | 36% |
4-Amino-2-chloropyridine
phenyl chloroformate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 2h; | 99% |
With triethylamine In dichloromethane; water | |
Stage #1: 4-Amino-2-chloropyridine With triethylamine In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: phenyl chloroformate In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere; | |
With pyridine In dichloromethane at 0 - 20℃; for 2h; |
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3h; | 99% |
Conditions | Yield |
---|---|
copper(l) iodide In methanol at 160℃; | 98% |
With copper In methanol at 160℃; | 56% |
In methanol at 140℃; for 7h; | |
In tetrahydrofuran for 16h; Heating / reflux; |
4-Amino-2-chloropyridine
phenylboronic acid
2-phenyl-pyridin-4-ylamine
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; carbon dioxide In water; acetonitrile at 70℃; under 5168.35 Torr; for 24h; Pressure; Reagent/catalyst; Suzuki Coupling; Autoclave; | 98% |
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium carbonate; palladium diacetate In water; acetonitrile at 100℃; for 13h; Suzuki-Miyaura cross-coupling; | 92% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene at 100℃; for 15h; Suzuki Coupling; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With potassium carbonate; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) In water; toluene for 12h; Suzuki-Miyaura cross-coupling; Heating; | 98% |
With potassium carbonate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In water; toluene at 100℃; Suzuki-Miyaura cross-coupling; | 98% |
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With water-d2 at 190℃; for 2h; Microwave irradiation; | 98% |
4-Amino-2-chloropyridine
2-chloro-4-bromopyridine
Conditions | Yield |
---|---|
Stage #1: 4-Amino-2-chloropyridine With hydrogen bromide; sodium nitrite In water Stage #2: With potassium bromide In water Sandmeyer bromination; | 97% |
With tert.-butylnitrite; copper(ll) bromide In acetonitrile at 0 - 20℃; for 16h; Sandmeyer Reaction; regioselective reaction; | 96% |
Stage #1: 4-Amino-2-chloropyridine With hydrogen bromide; bromine In water at 0℃; for 0.166667h; Stage #2: With sodium nitrite In water at -10 - 20℃; for 2.16667h; Stage #3: With sodium sulfite In water at 5℃; | 52% |
With sulfuric acid; copper(II) sulfate; potassium bromide; sodium nitrite at 60℃; Diazotization.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser; | |
Stage #1: 4-Amino-2-chloropyridine With hydrogen bromide; sodium nitrite In water for 1h; Sandmeyer reaction; Stage #2: With potassium bromide In water at 22℃; | 38.0 g |
4-Amino-2-chloropyridine
3-deazaC
Conditions | Yield |
---|---|
With potassium hydroxide In toluene at 170℃; for 72h; Sealed tube; | 97% |
With sodium hydroxide In ethanol at 170℃; for 15h; Substitution; | 96% |
4-Amino-2-chloropyridine
di-tert-butyl dicarbonate
A
tert-butyl N-tert-butoxycarbonyl-N-(2-chloro-4-pyridyl)carbamate
B
tert-butyl 4-(tert-butoxycarbonylamino)-2-chloropyridine-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: 4-Amino-2-chloropyridine With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 0 - 25℃; regioselective reaction; | A 3% B 96% |
Stage #1: 4-Amino-2-chloropyridine With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 25℃; for 16h; | A 66.6% B 7.3% |
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 2h; Reflux; | 96% |
Conditions | Yield |
---|---|
at 200℃; for 1h; microwave; | 95% |
at 200℃; for 1h; | 91% |
at 200℃; for 0.5h; Irradiation; | 87% |
In neat (no solvent) at 170℃; for 16h; | 1 g |
pyrrolidine
4-Amino-2-chloropyridine
2-(pyrrolidin-1-yl)pyridin-4-ylamine
Conditions | Yield |
---|---|
at 200℃; for 1h; | 94% |
at 200℃; for 0.166667h; Microwave irradiation; | 79% |
at 200℃; for 0.166667h; Microwave irradiation; | 79% |
at 200℃; for 0.166667h; Microwave irradiation; | 79% |
4-Amino-2-chloropyridine
2,5-hexanedione
1-(2-chloropyridin-4-yl)-2,5-dimethyl-1H-pyrrole
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 2h; Heating; | 93% |
With toluene-4-sulfonic acid In toluene | 93% |
With toluene-4-sulfonic acid In toluene Heating; | 93% |
4-Amino-2-chloropyridine
4-fluoroboronic acid
Conditions | Yield |
---|---|
With potassium carbonate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In water; toluene at 100℃; Suzuki-Miyaura cross-coupling; | 93% |
4-Amino-2-chloropyridine
6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)quinoline
Conditions | Yield |
---|---|
With potassium acetate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In water; butan-1-ol at 100℃; Suzuki-Miyaura cross-coupling; | 92% |
4-Amino-2-chloropyridine
4-methylphenylboronic acid
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); dicyclohexyl {2-sulfo-9-[3-(4-sulfophenyl)propyl]-9H-fluoren-9-yl}phosphonium hydrogen sulfate; potassium carbonate In water; butan-1-ol at 100℃; for 12h; Suzuki coupling; Inert atmosphere; | 92% |
With potassium carbonate; [Na2PdCl4]; (9-ethyl-2-(SO3H)-fluorenyl)dicyclohexylphosphonium HSO4 In water at 100℃; for 12h; Suzuki coupling reaction; | |
With potassium carbonate; sodium tetrachloropalladate(II); (9-ethyl-2-sulfofluorenyl)dicyclohexyl-phosphonium-tetrafluoroborate In water at 45 - 100℃; for 14h; Product distribution / selectivity; Suzuki Coupling; | >= 99 %Chromat. |
With palladium diacetate In water at 100℃; for 2h; pH=2.7 - 6.7; Suzuki Coupling; Inert atmosphere; | 100 %Chromat. |
4-Amino-2-chloropyridine
methylamine hydrochloride
N-2-methylpyridine-2,4-diamine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; sodium iodide In butan-1-ol at 120℃; for 24h; | 92% |
Stage #1: 4-Amino-2-chloropyridine; methylamine hydrochloride With N-ethyl-N,N-diisopropylamine; sodium iodide In butan-1-ol at 120℃; for 24h; Stage #2: With sodium hydrogencarbonate In water; butan-1-ol | 92% |
4-Amino-2-chloropyridine
furan-3-boronic acid
2-furan-3-ylpyridin-4-ylamine
Conditions | Yield |
---|---|
With potassium carbonate; sodium tetrachloropalladate(II) In water; butan-1-ol at 100℃; for 12h; Suzuki cross-coupling; | 92% |
4-Amino-2-chloropyridine
2-chloropyridin-4-ol
Conditions | Yield |
---|---|
Stage #1: 4-Amino-2-chloropyridine With sulfuric acid; sodium nitrite In water at 0 - 20℃; for 24h; Stage #2: With sodium hydroxide In water | 92% |
4-Amino-2-chloropyridine
3-(Trifluoromethyl)benzoyl chloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere; | 92% |
4-Amino-2-chloropyridine
1-Naphthylboronic acid
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); dicyclohexyl {2-sulfo-9-[3-(4-sulfophenyl)propyl]-9H-fluoren-9-yl}phosphonium hydrogen sulfate; potassium carbonate In water; butan-1-ol at 100℃; for 12h; Suzuki coupling; Inert atmosphere; | 91% |
With potassium hydroxide; sodium tetrachloropalladate(II) In water at 100℃; Suzuki coupling; | |
With potassium carbonate; [Na2PdCl4]; (9-ethyl-2-(SO3H)-fluorenyl)dicyclohexylphosphonium HSO4 In water at 100℃; for 12h; Suzuki coupling reaction; | |
With potassium carbonate; sodium tetrachloropalladate(II); (9-ethyl-2-sulfofluorenyl)dicyclohexyl-phosphonium-tetrafluoroborate In water at 45 - 100℃; for 14h; Product distribution / selectivity; Suzuki Coupling; | >= 99 %Chromat. |
With palladium diacetate In water at 100℃; for 2h; pH=3.3 - 7.1; Suzuki Coupling; Inert atmosphere; | 100 %Chromat. |
4-Amino-2-chloropyridine
benzoyl chloride
N-(2-chloropyridin-4-yl)benzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 90% |
With triethylamine In dichloromethane at 0 - 20℃; | 59% |
With triethylamine In dichloromethane |
4-Amino-2-chloropyridine
4-trifluoromethylphenylboronic acid
2-[4-(trifluoromethyl)phenyl]pyridin-4-amine
Conditions | Yield |
---|---|
With potassium carbonate; bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) In water; toluene for 12h; Suzuki-Miyaura cross-coupling; Heating; | 90% |
With potassium carbonate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In water; toluene at 100℃; Suzuki-Miyaura cross-coupling; | 90% |
Stage #1: 4-Amino-2-chloropyridine; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane for 0.166667h; Stage #2: 4-trifluoromethylphenylboronic acid With sodium carbonate In 1,2-dimethoxyethane; water at 90℃; for 48h; |
4-Amino-2-chloropyridine
3-pyridylboronic acid
[2,3']bipyridinyl-4-ylamine
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); dicyclohexyl {2-sulfo-9-[3-(4-sulfophenyl)propyl]-9H-fluoren-9-yl}phosphonium hydrogen sulfate; potassium carbonate In water; butan-1-ol at 100℃; for 12h; Suzuki coupling; Inert atmosphere; | 90% |
With potassium carbonate; [Na2PdCl4]; (9-ethyl-2-(SO3H)-fluorenyl)dicyclohexylphosphonium HSO4 In water at 100℃; for 20h; Suzuki coupling reaction; | |
With potassium carbonate; sodium tetrachloropalladate(II); (9-ethyl-2-sulfofluorenyl)dicyclohexyl-phosphonium-tetrafluoroborate In water at 45 - 100℃; for 22h; Product distribution / selectivity; Suzuki Coupling; | >= 99 %Chromat. |
4-Amino-2-chloropyridine
2,6-dimethoxypyridine-3-boronic acid
2',6'-dimethoxy-[2,3']bipyridinyl-4-ylamine
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); dicyclohexyl {2-sulfo-9-[3-(4-sulfophenyl)propyl]-9H-fluoren-9-yl}phosphonium hydrogen sulfate; potassium carbonate In water; butan-1-ol at 100℃; for 12h; Suzuki coupling; Inert atmosphere; | 90% |
4-Amino-2-chloropyridine
4-fluorobenzoyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; Inert atmosphere; | 89.1% |
With triethylamine In dichloromethane at 0 - 20℃; for 24h; |
pyrrolidine
4-Amino-2-chloropyridine
Conditions | Yield |
---|---|
Stage #1: 4-Amino-2-chloropyridine With sodium nitrite In sulfuric acid; water at 0℃; for 1.5h; Stage #2: pyrrolidine With potassium carbonate In water at 20℃; for 1.5h; Further stages.; | 89% |
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