DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:25kg/drum Application:medicine raw material Transportation:by courier/
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryProduct Name: Diethyl 2-propylImidazoledicarbonate Synonyms: 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL;2-Propylimidazoledicarboxylic acid diethyl ester;2-PROPYL-4,5-IMIDAZOLEDICARBOXYLIC ACID DIETHYL ESTER 98.0%;2-propyl-, diethyl e
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
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inquiryName: diethyl 2-propylimidazoledicarbonate Synonyms: 2-propyl-1h-imidazole-4,5-dicarboxylic acid diethyl ester CAS: 144689-94-1 MF: C12H18N2O4 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Appl
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryProduct Name: Diethyl 2-propylImidazoledicarbonate CAS: 144689-94-1 MF: C12H18N2O4 MW: 254.28 EINECS: 604-435-2 Mol File: 144689-94-1.mol Diethyl 2-propylImidazoledicarbonate Structure Diethyl 2-propylImidazoledicarbonate Chemical
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryDiethyl 2-propylimidazole-4,5-dicarboxylateAppearance:white powder Storage:Keep away of light, cool place Package:according to customers' requirements Application:pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) o
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:144689-94-1
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inquirySuperior quality, moderate price & quick delivery. Appearance:White Powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Tran
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
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inquiryProduct name: Diethyl 2-Propylimidazole-4,5-Dicarboxylate CAS No.:144689-94-1 Molecule Formula:C12H18N2O4 Molecule Weight:254.28 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise S
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiry2-propyl-1H-imidazole-4,5-dicarboxylic acid
ethanol
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Stage #1: 2-propyl-1H-imidazole-4,5-dicarboxylic acid; ethanol With hydrogenchloride; thionyl chloride at 5℃; for 0.166667h; Stage #2: for 1.5h; Heating; | 94% |
With hydrogenchloride Ambient temperature; | 86% |
With thionyl chloride In water at 8℃; for 6.6h; Temperature; Reflux; | 77% |
at 0℃; for 12h; Reflux; |
diethyl 2,3-dioxosuccinate
butyraldehyde
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
With ammonia In tetrahydrofuran at 30 - 70℃; for 6h; | 85.5% |
With ammonium acetate In tetrahydrofuran; acetic acid at 60℃; for 3h; Product distribution / selectivity; light-shielding conditions; |
butylamidine hydrochloride
diethyl 3-chloro-2-oxosuccinate
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
With pyridine In propan-1-ol for 6h; Reagent/catalyst; Solvent; Reflux; | 80% |
2-propylimidazole-4,5-dicarbonitrile
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
With sodium chloride; sodium hydroxide In water for 1h; Cooling with ice; |
methyl bromide
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With iodine; magnesium In dichloromethane at 15 - 25℃; for 2h; | 97.5% |
methylmagnesium bromide
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
In diethyl ether; dichloromethane at 10 - 15℃; for 1h; | 95% |
methylmagnesium chloride
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran at -10 - 0℃; for 0.166667h; Stage #2: With water; ammonium chloride In tetrahydrofuran; dichloromethane | 85% |
Stage #1: methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran; toluene for 6.5h; Inert atmosphere; Cooling with ice; Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene pH=7; | |
In tetrahydrofuran at 60℃; for 2h; | 4.81 g |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
2-propyl-1H-imidazole-4,5-dicarboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran at 50℃; for 4h; | 85% |
ethylmagnesium bromide
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
5-(1-Ethyl-1-hydroxy-propyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In diethyl ether; dichloromethane at 10 - 15℃; for 1h; | 83% |
methylene chloride
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: methylene chloride With magnesium In tetrahydrofuran for 0.5h; Reflux; Stage #2: diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran at 30℃; for 2.5h; Solvent; Temperature; | 80% |
Stage #1: methylene chloride With magnesium at 55 - 60℃; for 1h; Inert atmosphere; Stage #2: diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate at 0℃; for 8h; |
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
diethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-propylimidazole-4,5-dicarboxylate
Conditions | Yield |
---|---|
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction; |
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
2-Propyl-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazole-4,5-dicarboxylic acid diethyl ester
Conditions | Yield |
---|---|
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction; |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-isopropyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 82 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C 3: 100 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 61 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating 5: 89 percent / HCl / dioxane / 16 h / Ambient temperature 6: 94 percent / NaOH / dioxane; H2O / 5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 100 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 61 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating 5: 89 percent / HCl / dioxane / 16 h / Ambient temperature 6: 94 percent / NaOH / dioxane; H2O / 5 h / 70 °C View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 5: 82 percent / HCl / dioxane / 16 h / Ambient temperature 6: 100 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: 92 percent / HCl / dioxane / 16 h / Ambient temperature 5: 94 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 1-<(2'-carboxybiphenyl-4-yl)methyl>-4-methyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 82 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C 3: 100 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 61 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating 5: 89 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 5 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 100 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 61 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating 5: 89 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 66 percent / LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 100 percent / HCl / dioxane / 16 h / Ambient temperature 4: 100 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 82 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C 3: 93 percent / HCl / dioxane / 16 h / Ambient temperature 4: 96 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 93 percent / HCl / dioxane / 16 h / Ambient temperature 4: 96 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 96 percent / HCl / dioxane / 16 h / Ambient temperature 3: 100 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
4'-(4,5-Bis-hydroxymethyl-2-propyl-imidazol-1-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 66 percent / LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 77 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 5: 82 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: 92 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-hydroxymethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 82 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C 3: 93 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 93 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 69 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C 3: Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 87 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating 5: 96 percent / 25percent aq. AcOH / 2.5 h / 80 °C 6: 97 percent / NaOH / dioxane; H2O / 5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiAlH(O-t-Bu)3 / tetrahydrofuran / 192 h 3: Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 87 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating 5: 96 percent / 25percent aq. AcOH / 2.5 h / 80 °C 6: 97 percent / NaOH / dioxane; H2O / 5 h / 70 °C View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: 92 percent / HCl / dioxane / 16 h / Ambient temperature 4: 91 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-methyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 82 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 20 h / -5 °C 3: 100 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 61 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiAlH(O-t-Bu)3 / tetrahydrofuran / 120 h / Ambient temperature 3: 100 percent / Et3N / CH2Cl2 / 0.5 h / Ambient temperature 4: 61 percent / Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1.5 h / Heating View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 5: 93 percent / 25percent aq. AcOH / 2.5 h / 80 °C 6: 89 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: 94 percent / 25percent aq. AcOH / 2.5 h / 80 °C 5: 85 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 83 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: 92 percent / HCl / dioxane / 16 h / Ambient temperature 4: 95 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
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