Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:152628-03-0
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:152628-03-0
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inquiry
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryGood quantity 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Basic information Product Name: 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Synonyms: 4-METHYL-2-N-PROPY
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:152628-03-0
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Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:152628-03-0
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inquiryAppearance:Off-white to white powder Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china
Cas:152628-03-0
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:152628-03-0
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inquiryBeluga chemical professional supply 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic Acid CAS 152628-03-0 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capa
Cas:152628-03-0
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:152628-03-0
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inquiryCompany information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:152628-03-0
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:152628-03-0
Min.Order:10 Kilogram
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:152628-03-0
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:152628-03-0
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Type:Manufacturers
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:152628-03-0
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:152628-03-0
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:152628-03-0
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:152628-03-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:152628-03-0
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiry4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Basic information Product Name: 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Synonyms: 4-METHYL-2-N-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID;4-METHYL-2-PROPYL-1H-BENZIMIDAZOLE-6-CARBO
Cas:152628-03-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Cas:152628-03-0
Min.Order:0
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Type:Other
inquiryProduct name: 2-n-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole CAS No.: 152628-03-0 Molecule Formula:C12H14N2O2 Molecule Weight:218.25 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Ente
Cas:152628-03-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With sodium hypochlorite; sodium hydroxide In water at 16℃; for 0.5h; Temperature; | 97% |
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With sodium dithionite; water at 70 - 100℃; | 96.4% |
Multi-step reaction with 3 steps 1: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 90 percent / acetic acid / 2 h / Heating 3: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 2: glacial CH3COOH / 1.5 h / Heating 3: 5.46 g / aq. NaOH / methanol / 2 h / Heating View Scheme |
3,4-diamino-5-methylbenzoic acid
triethyl orthobutyrate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With methanesulfonic acid In N,N-dimethyl-formamide at 70℃; for 9h; Reagent/catalyst; Temperature; | 94.4% |
carbon monoxide
6-bromo-4-methyl-2-propylbenzimidazole
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With water; potassium carbonate; triphenylphosphine; palladium dichloride In 1,4-dioxane at 60 - 100℃; under 6750.68 - 10501.1 Torr; for 49.5h; Product distribution / selectivity; Autoclave; | 89% |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; oxygen; cobalt(II) 2-ethylhexanoate; acetic acid at 110℃; under 7500.75 Torr; for 2h; | 88.8% |
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide; water In methanol for 2h; Heating; | 82.3% |
With water; sodium hydroxide In methanol at 80℃; Product distribution / selectivity; | 80% |
With sodium hydroxide In methanol for 2h; Heating; | 5.46 g |
methyl 4-amino-3-methylbenzoate
butyryl chloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: methyl 4-amino-3-methylbenzoate; butyryl chloride With triethylamine In dichloromethane at 0℃; Stage #2: With sulfuric acid; nitric acid In dichloromethane at -20℃; Further stages; | 52% |
pentanal
4-amino-3-methyl-5-nitrobenzoic acid
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With sodium dithionite In ethanol; water at 70℃; for 2h; | 37% |
7-methyl-2-propyl-3H-benzimidazole-5-carbonitrile
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water In 1,4-dioxane at 100℃; for 16h; | 30% |
3-methyl-4-nitrobenzoic acid
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 74.3 percent / sulfuric acid / 2 h / Heating 2: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 3: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 4: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 5: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 6: 90 percent / acetic acid / 2 h / Heating 7: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 30 - 45 °C / 750.08 - 7500.75 Torr / Autoclave 2: bromine / methanol / 0 - 10 °C 3: triethylamine; potassium carbonate; N,N,N,N,-tetramethylethylenediamine; sodium azide; copper(l) chloride / N,N-dimethyl-formamide; water / pH Ca. 8 / Inert atmosphere; Reflux 4: N,N-dimethyl-formamide / 0 - 5 °C View Scheme |
methyl 4-amino-3-methylbenzoate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 2: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 3: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 4: 90 percent / acetic acid / 2 h / Heating 5: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: chlorobenzene / 100 °C 2: fuming HNO3, 60percent H2SO4 / 0 °C 3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 4: glacial CH3COOH / 1.5 h / Heating 5: 5.46 g / aq. NaOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 0 °C 2: sulfuric acid; nitric acid 3: hydrogen / methanol / 100 °C / 3750.38 Torr 4: acetic acid / 1 h / Reflux 5: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane 2: nitric acid / -15 °C 3: hydrazine hydrate 4: acetic acid / Reflux 5: sodium hydroxide; water / methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane 1.2: -15 °C 2.1: sodium hydroxide / water; methanol / Reflux View Scheme |
methyl 3-methyl-4-nitrobenzoate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 5: 90 percent / acetic acid / 2 h / Heating 6: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme |
methyl 4-(n-butyrylamino)-3-methylbenzoate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 2: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 3: 90 percent / acetic acid / 2 h / Heating 4: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: fuming HNO3, 60percent H2SO4 / 0 °C 2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 3: glacial CH3COOH / 1.5 h / Heating 4: 5.46 g / aq. NaOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: sulfuric acid; nitric acid 2: hydrogen / methanol / 100 °C / 3750.38 Torr 3: acetic acid / 1 h / Reflux 4: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid / -15 °C 2: hydrazine hydrate 3: acetic acid / Reflux 4: sodium hydroxide; water / methanol / 2 h / Reflux View Scheme |
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / acetic acid / 2 h / Heating 2: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating View Scheme | |
Stage #1: methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate With sodium hydroxide; water at 95 - 100℃; for 4 - 5h; Stage #2: With hydrogenchloride In water at 25 - 30℃; for 0.583333 - 0.75h; pH=4.5 - 5; Product distribution / selectivity; |
3-amino-4-butyramido-5-methylbenzoic acid
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With acetic acid at 60 - 65℃; Product distribution / selectivity; |
ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate With sodium hydroxide In ethanol; water at 90℃; Stage #2: With hydrogenchloride In water pH=6; Product distribution / selectivity; |
4-amino 3-methylbenzoic acid
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium nitrite; tartaric acid / water; ethanol / 2 h / 35 °C 2: sodium dithionite; water / methanol / 2 h / 75 - 80 °C 3: methanesulfonic acid / N,N-dimethyl-formamide / 9 h / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: bromine / methanol / 0 - 10 °C 2: triethylamine; potassium carbonate; N,N,N,N,-tetramethylethylenediamine; sodium azide; copper(l) chloride / N,N-dimethyl-formamide; water / pH Ca. 8 / Inert atmosphere; Reflux 3: N,N-dimethyl-formamide / 0 - 5 °C View Scheme |
5-nitro-m-xylene
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: nitric acid; sulfuric acid / 3 h / -10 - -5 °C 2: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 60 °C / 3750.38 Torr / Autoclave 3: polyphosphoric acid / 16 h / 120 - 125 °C 4: cobalt(II) 2-ethylhexanoate; N-hydroxyphthalimide; acetic acid; oxygen / 2 h / 110 °C / 7500.75 Torr View Scheme |
3,5-dimethyl-1,2-dinitrobenzene
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 60 °C / 3750.38 Torr / Autoclave 2: polyphosphoric acid / 16 h / 120 - 125 °C 3: cobalt(II) 2-ethylhexanoate; N-hydroxyphthalimide; acetic acid; oxygen / 2 h / 110 °C / 7500.75 Torr View Scheme |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 0 - 5℃; | 40 g |
N-methylbenzene-1,2-diamine dihydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With methanesulfonic acid In i-Amyl alcohol at 130 - 135℃; for 18h; Temperature; Solvent; Reagent/catalyst; | 93% |
Stage #1: N-methylbenzene-1,2-diamine dihydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA at 70 - 135℃; for 13.5h; Stage #2: With ammonia In water at 30 - 90℃; for 1h; pH=8.0 - 8.5; | 77.4% |
With PPA at 150℃; for 20h; | 5.86 g |
With polyphosphoric acid at 150℃; for 14h; |
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With sodium hydroxide In water; N,N-dimethyl-formamide at 0 - 5℃; for 0.5h; Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In water; N,N-dimethyl-formamide for 0.5h; | 92.1% |
N-methyl-1,2-phenylenediamine
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With methanesulfonic acid; phosphorus pentoxide at 75 - 145℃; Stage #2: With sodium hydroxide In water pH=< 3; Product distribution / selectivity; | 90% |
With polyphosphoric acid at 150 - 155℃; for 4h; Inert atmosphere; | 80% |
With PPA at 150 - 155℃; Inert atmosphere; | |
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid at 70 - 130℃; for 8.5h; Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.166667h; Stage #3: With ammonium hydroxide In methanol; water at 25℃; for 1h; Reagent/catalyst; |
2-amino-phenol
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-amino-phenol With polyphosphoric acid at 80 - 85℃; for 0.25h; Green chemistry; Stage #2: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With polyphosphoric acid at 80 - 150℃; Green chemistry; | 85% |
With polyphosphoric acid at 80 - 150℃; for 12h; | 58.7% |
With polyphosphoric acid at 80 - 150℃; for 12h; | 58.7% |
With polyphosphate at 80 - 150℃; for 12h; | 54% |
N1-methylbenzene-1,2-diamine hydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
A
desmethyl dibenzimidazole
B
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
C
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
D
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With polyphosphoric acid at 150 - 155℃; | A n/a B n/a C n/a D 84% |
N1-methylbenzene-1,2-diamine hydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With phosphorus pentoxide; phosphoric acid at 70 - 130℃; Stage #2: With ammonia In water; ethyl acetate for 3h; pH=9 - 10; Product distribution / selectivity; Cooling with ice; | 82% |
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA; Polyphosphoric acid (PPA) In water at 90 - 155℃; for 5.75 - 7h; Stage #2: With sodium hydroxide In water pH=5.5 - 6; Product distribution / selectivity; |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 2h; Stage #2: 4-chloro-N-methyl-o-phenylenediamine hydrochloride In N,N-dimethyl-formamide at 110℃; Temperature; Solvent; | 82% |
(R)-2-phenylpropylamine
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; | 71.4% |
ethanol
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 80℃; for 3h; | 71% |
2-amino-4-methylphenol hydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With PPA at 160℃; for 20h; | 67.1% |
(R)-3-amino-4-phenyl-N'-(benzyloxy)butanamide trifluoroacetate
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid ((R)-1-benzyl-2-benzyloxycarbamoylethyl)amide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 20℃; | 41% |
2-amino-3-hydroxypyridine
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
With polyphosphate at 80 - 150℃; for 12h; | 40% |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
7-methyl-2-(4-methyl-2-propyl-1H-benzo[d]imidazol-6-yl)benzo[d]oxazole
Conditions | Yield |
---|---|
With PPA at 160℃; |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: polyphosphoric acid / 160 °C 2: NaH / 1,2-dimethoxy-ethane / 20 °C View Scheme |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]-2-cyanobiphenyl
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67.1 percent / polyphosphoric acid / 20 h / 160 °C 2: 86.5 percent / NaH / 1,2-dimethoxy-ethane / 4 h / 20 °C View Scheme |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: polyphosphoric acid / 160 °C 2: NaH / 1,2-dimethoxy-ethane / 20 °C 3: NaOH; water / methanol / Heating View Scheme |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
methyl 4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67.1 percent / polyphosphoric acid / 20 h / 160 °C 2: 84.7 percent / NaH / 1,2-dimethoxy-ethane / 4 h / 20 °C View Scheme |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: polyphosphoric acid / 160 °C 2: NaH / 1,2-dimethoxy-ethane / 20 °C View Scheme |
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