Appearance:colorless liquid Storage:tightly from light Package:200kg/drum Transportation:SEA Port:Qingdao
Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
Cas:105-45-3
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inquiryWe are confident to supply you the best quality Methyl aceto acetate [Cas No.105-45-3] with competitive price,high quality and regular basis. 1. Specification of Methyl aceto acetate : Item Specific
Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct description: Product name Methyl acetoacetate CAS number 105-45-3 Assay ≥99% Appearance Colorless transparent liquid Capacity 500mt/year Application Cellulose ether e
Cas:105-45-3
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryName:Methyl acetoacetate The alias:Methyl acetoacetaten; Acetoacetic acid methyl ester; Butanoic acid, 3-oxo-, methyl ester:; methyl 3-oxobutanoate; MAA CAS NO:105-45-3 Molecular formula:C5H8O3 Molecular weight:116.1152 Product Quality 12 y
Cas:105-45-3
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inquiryProduct Name: Methyl acetoacetate Synonyms: 3-OXBUTANOIC ACID METHYL ESTER;3-OXOBUTANOIC ACID METHYL ESTER;3-OXOBUTYRIC ACID METHYL ESTER;ACETYL METHYL ACETATE;ACETOACETIC ACID METHYL ESTER;ACETOACETIC ESTER (METHYL);ACM;HYL ACETOACETATE CAS: 105
Cas:105-45-3
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName: Methyl acetoacetate Synonyms: Acetoacetic acid methyl ester CAS:105-45-3 MF: C5H8O3 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Pharmaceutical Intermediate Transp
Cas:105-45-3
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inquiryAppearance:liquid Storage:2-8°C Package:200kg/Drum Application:Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives. T
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inquiryMethyl acetoacetate CAS:105-45-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme
Cas:105-45-3
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:105-45-3
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inquiryAppearance:colorless liquid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Co
Cas:105-45-3
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
methanol
5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
for 0.0666667h; microwave irradiation; | 98% |
for 5h; Reflux; |
A
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran | A 49% B 96% |
methanol
carbon monoxide
chloroacetone
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With tributyl-amine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) at 110℃; under 11250.9 Torr; for 1h; Product distribution; Further Variations:; Reagents; Temperatures; time; | 95% |
With tributyl-amine; bis-triphenylphosphine-palladium(II) chloride at 110℃; under 7500.6 Torr; for 2h; | 80% |
methanol
2,2,6-trimethyl-4H-1,3-dioxin-4-one
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
Esterification; | 92% |
In 5,5-dimethyl-1,3-cyclohexadiene Reflux; | 77% |
at 110 - 120℃; | 72% |
In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; |
Conditions | Yield |
---|---|
With di(n-butyl)tin oxide In methanol for 12h; Heating; | 90% |
In xylene Heating; |
-essigsaeure-methylester
A
acetic acid methyl ester
B
acetic acid-(1-methoxy-vinyl ester)
C
tripropyltin chloride
D
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With acetyl chloride | A 18% B 46% C 88% D 9% |
methanol
citric acid
A
3-oxopentanedioic acid dimethyl ester
B
dimethyl 2-methoxypropene-1,3-dicarboxylate
C
trimethyl aconitate
D
trimethyl citrate
E
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: citric acid With chlorosulfonic acid In dichloromethane at 10 - 15℃; for 5 - 6h; Stage #2: methanol In dichloromethane at 3 - 35℃; for 2h; Conversion of starting material; | A 87.3% B n/a C n/a D n/a E n/a |
α-bromoacetophenone
6-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-1,3-oxazine
A
acetoacetic acid methyl ester
B
2-oxo-2-phenylethylthiocyanate
Conditions | Yield |
---|---|
With sodium methylate In methanol for 12h; Ambient temperature; | A 29% B 87% |
Conditions | Yield |
---|---|
With oxygen; nickel dichloride In methanol; water at 100℃; under 7500.75 Torr; for 12h; Reagent/catalyst; Solvent; Temperature; Autoclave; | 85.3% |
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; hexane at -45℃; 1.) 30 min, 2.) 90 min; | 84% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 20h; Heating; | 83% |
With sodium methylate at 60℃; | |
With sodium anschliessend mit Essigsaeure oder Kohlendioxyd; |
methanol
cycl-isopropylidene malonate
acetyl chloride
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: cycl-isopropylidene malonate; acetyl chloride With pyridine In dichloromethane at 20℃; for 2h; Stage #2: methanol In dichloromethane for 2h; Further stages.; | 75% |
methyl crotonate
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With methanol; water; oxygen; toluene-4-sulfonic acid; palladium dichloride In N,N-dimethyl acetamide at 80℃; under 4560.31 Torr; for 3h; Autoclave; regioselective reaction; | 73% |
With tert.-butylhydroperoxide; sodium tetrachloropalladate(II) In acetic acid; tert-butyl alcohol at 50℃; for 3h; |
Conditions | Yield |
---|---|
for 4.5h; Heating; | 72.5% |
With dmap | |
1,4-diaza-bicyclo[2.2.2]octane at 20℃; for 0.343333h; |
methanol
2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine
A
acetoacetic acid methyl ester
B
methyl carbamate
Conditions | Yield |
---|---|
With triethylamine for 24h; Heating; | A 70% B 15% |
diazomethane
tert-butyl acetoacetate
A
tert-butyl nitrate
B
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With nitric acid In dichloromethane at 0℃; for 2h; | A 60% B 20% |
Conditions | Yield |
---|---|
With sodium methylate In methanol Ambient temperature; | 57% |
A
2-methylsulfanyl-ethanethiol
B
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With water at 40℃; for 0.0833333h; | A 56% B 13% |
Conditions | Yield |
---|---|
With manganese(IV) oxide; palladium dichloride In water; acetonitrile at 60℃; for 26h; | 52% |
1-(3,5-dimethyl-1H-pyrazol-1-yl)ethanone
bromoacetic acid methyl ester
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With zinc In tetrahydrofuran for 1h; Heating; | 50% |
β-(N,N-dimethoxyamino)-isovaleric acid methyl ester
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In tetrachloromethane at 20℃; | 43.8% |
1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene
acetyl chloride
A
3,5-dioxohexanoic acid methyl ester
B
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
In diethyl ether at -78℃; for 4h; Yields of byproduct given; | A 30% B n/a |
acetic acid methyl ester
A
methyl 5-hydroxy-2-methoxycarbonyl-5-methyl-3-oxocyclohexen-1-acetate
B
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: acetic acid methyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; Stage #2: methyl (2SR,3RS)-1-benzyl-2-(indol-3-yl)piperidine-3-carboxylate In tetrahydrofuran at 0℃; for 15h; | A 27% B 24% |
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one
A
4-hydroxy-6-methyl-2-pyron
B
3,5-dioxohexanoic acid methyl ester
C
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With sodium methylate In methanol; benzene for 18h; Heating; | A 7% B 18% C 16% |
Conditions | Yield |
---|---|
sulfuric acid at 50℃; for 90h; | 13% |
methanol
ethyl (E)-2-acetyl-3-oxo-5-phenylpent-4-enoate
sodium methylate
A
acetic acid methyl ester
B
methyl 3-oxo-5-phenyl-4-pentenoate
C
Methyl cinnamate
D
acetoacetic acid methyl ester
3-hydroxybutyric acid methyl ester
A
acetoacetic acid methyl ester
B
acetone
Conditions | Yield |
---|---|
With copper at 330℃; |
Conditions | Yield |
---|---|
at 57 - 80℃; Selbstkondensation; |
cyclobutane-1,3-dione
acetoacetic acid methyl ester
Conditions | Yield |
---|---|
With methanol; sodium methylate |
Conditions | Yield |
---|---|
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In benzene at 20℃; for 2h; Inert atmosphere; | 100% |
With sulfuryl dichloride In dichloromethane for 1h; Ambient temperature; | 98% |
With ammonium cerium(IV) nitrate at 25 - 28℃; for 3h; | 85% |
With sulfuryl dichloride | |
With sulfuryl dichloride at 0℃; |
benzaldehyde
acetoacetic acid methyl ester
5-hydroxy-3-oxo-5-phenyl-valeric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 0.333333h; Stage #3: benzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 1.08333h; | 100% |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -15 - -10℃; for 0.5h; Inert atmosphere; Stage #3: benzaldehyde Further stages; | 92% |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -15 - -10℃; for 0.5h; Stage #3: benzaldehyde Further stages; | 92% |
acetoacetic acid methyl ester
prenyl bromide
methyl 7-methyl-3-oxooct-6-enoate
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; mineral oil for 0.166667h; Stage #3: prenyl bromide In tetrahydrofuran; mineral oil for 0.0833333h; | 100% |
With n-butyllithium; sodium hydride In tetrahydrofuran at 0 - 20℃; | 100% |
With n-butyllithium; sodium hydride In tetrahydrofuran at 0℃; | 79% |
Conditions | Yield |
---|---|
In methanol at 25℃; for 3h; | 100% |
Conditions | Yield |
---|---|
In methanol at 25℃; for 10h; | 100% |
benzaldehyde
acetoacetic acid methyl ester
dimethyl 4-phenyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
Conditions | Yield |
---|---|
With C23H3BF16N2O; ammonium acetate In toluene at 100℃; for 10h; Reagent/catalyst; Hantzsch Dihydropyridine Synthesis; | 100% |
With ammonium acetate In ethanol at 60℃; for 0.5h; Catalytic behavior; Hantzsch Dihydropyridine Synthesis; | 98% |
With ammonium acetate at 90℃; for 0.916667h; Hantzsch synthesis; Neat (no solvent); | 97% |
methanol
acetoacetic acid methyl ester
3,3-bismethoxybutyric acid methyl ester
Conditions | Yield |
---|---|
With RuCl2-(S)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)(benzonitrile)2; hydrogen at 50℃; under 76000.1 Torr; for 48h; | 100% |
Conditions | Yield |
---|---|
In methanol at 25℃; for 3h; | 100% |
acetoacetic acid methyl ester
(E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal
methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate
Conditions | Yield |
---|---|
With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane | 100% |
With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane | 100% |
With n-butyllithium; sodium hydride Yield given. Multistep reaction; |
acetoacetic acid methyl ester
(S)-3-hydroxybutyric acid methyl ester
Conditions | Yield |
---|---|
With cat; hydrogen In methanol; dichloromethane at 25℃; under 77572.2 Torr; for 48h; | 100% |
With (S)-BiphempRuBr2; hydrogen In methanol at 80℃; under 7600 Torr; for 1h; | 100% |
With hydrogen; [RuCl2(Sax-4,4'-bis(3-diphenylphosphineestra...)(DMF)]n In methanol at 100℃; under 76000 Torr; for 1h; Catalytic hydrogenation; | 100% |
acetoacetic acid methyl ester
A
(S)-3-hydroxybutyric acid methyl ester
B
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With Ru2Cl4-(S)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2*NEt3; hydrogen In methanol at 35℃; under 76000.1 Torr; for 48h; Title compound not separated from byproducts; | A 100% B n/a |
With <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3; hydrogen In methanol at 35℃; under 76000.1 Torr; for 48h; Title compound not separated from byproducts; | A n/a B 100% |
With hydrogen; Ru(BICP)Br2 In methanol at 40 - 65℃; under 750.075 - 3750.38 Torr; | A n/a B 95% |
Conditions | Yield |
---|---|
With cat; hydrogen In methanol; dichloromethane at 25℃; under 77572.2 Torr; for 48h; | 100% |
With (R)-MeOBiphepRuBr2; hydrogen In methanol at 50℃; under 15200 Torr; for 48h; | 100% |
With (S)-4,12-bis(diphenylphosphino)-<2.2>paracyclophane-Ru(II)bis(trifluoroacetate); hydrogen; tetra-(n-butyl)ammonium iodide In methanol; water at -5℃; under 2585.7 Torr; for 18h; | 100% |
acetoacetic acid methyl ester
(1S,3R,5R,7R)-3-Chloro-10,10-dimethyl-3-phenyl-4-oxa-3λ4-selena-tricyclo[5.2.1.01,5]decane
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 1h; Ambient temperature; | 100% |
4-methoxy-benzaldehyde
acetoacetic acid methyl ester
urea
5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
Conditions | Yield |
---|---|
With sulfuric acid; copper(l) chloride In methanol Biginelli Pyrimidone Synthesis; Reflux; Inert atmosphere; | 100% |
With ytterbium(III) triflate at 100℃; for 0.333333h; Biginelli reaction; | 99% |
With calcium chloride In ethanol for 2h; Biginelli reaction; Heating; | 98% |
acetoacetic acid methyl ester
Cysteamine
(Z)-3-(2-Mercapto-ethylamino)-but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
for 24h; Ambient temperature; | 100% |
acetoacetic acid methyl ester
rac-methylbenzylamine
(Z)-3-(1-Phenyl-ethylamino)-but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
In methanol for 12h; Heating; | 100% |
acetoacetic acid methyl ester
benzylamine
3-benzylaminobut-2-enoic acid methyl ester
Conditions | Yield |
---|---|
In methanol for 12h; Heating; | 100% |
In methanol at 20℃; for 0.5h; | 95% |
With calcium bistrifluoroacetate at 20℃; for 0.5h; chemoselective reaction; | 95% |
acetoacetic acid methyl ester
Phenylglycinol
(Z)-3-(2-Hydroxy-1-phenyl-ethylamino)-but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
In methanol for 12h; Heating; | 100% |
(2S)-2-phenylglycinol
acetoacetic acid methyl ester
(Z)-3-((S)-2-Hydroxy-1-phenyl-ethylamino)-but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
In methanol for 24h; Heating; | 100% |
heptanal
acetoacetic acid methyl ester
5-hydroxy-3-oxo-undecanoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 0.333333h; Stage #3: heptanal In tetrahydrofuran; hexane at -78 - 20℃; for 1.08333h; | 100% |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 0℃; Stage #2: With n-butyllithium In tetrahydrofuran at -78℃; Stage #3: heptanal In tetrahydrofuran Further stages.; |
acetoacetic acid methyl ester
isobutyraldehyde
5-hydroxy-6-methyl-3-oxo-heptanoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 0.333333h; Stage #3: isobutyraldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 1.08333h; | 100% |
Stage #1: acetoacetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran; hexane at -60 - 20℃; for 0.416667h; Weiler method; Inert atmosphere; Stage #2: isobutyraldehyde In tetrahydrofuran; hexane at -60 - 20℃; for 4h; Weiler method; Inert atmosphere; Stage #3: With water; ammonium chloride In tetrahydrofuran; hexane Inert atmosphere; | 95% |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 0℃; Stage #2: With n-butyllithium In tetrahydrofuran at -78℃; Stage #3: isobutyraldehyde In tetrahydrofuran Further stages.; |
(S)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamine
acetoacetic acid methyl ester
(Z)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethylamino]-but-2-enoic acid methyl ester
Conditions | Yield |
---|---|
In methanol for 24h; Heating; | 100% |
In methanol |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate at 20℃; | 100% |
Conditions | Yield |
---|---|
With silica-supported ferric hydrogensulfate/[Fe(HSO4)3*SiO2] In neat (no solvent) at 20℃; for 0.2h; regioselective reaction; | 100% |
zirconium(IV) chloride at 20℃; for 0.25h; | 95% |
With sulfated zirconia at 20℃; for 0.416667h; | 92% |
Conditions | Yield |
---|---|
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In benzene at 20℃; for 2h; Inert atmosphere; | 100% |
With N-Bromosuccinimide; toluene-4-sulfonic acid In dichloromethane at 20℃; for 0.416667h; | 94% |
With ammonium cerium(IV) nitrate at 25 - 28℃; for 2.5h; | 87% |
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 0.333333h; Stage #3: nonan-1-al In tetrahydrofuran; hexane at -78 - 20℃; for 1.08333h; | 100% |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 5℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; mineral oil at 5℃; for 0.166667h; Stage #3: nonan-1-al In tetrahydrofuran; mineral oil at 5 - 10℃; for 0.5h; |
tetrakis(triphenylphosphine) palladium(0)
trityl tetrafluoroborate
acetoacetic acid methyl ester
bis(triphenylphosphine)(methyl acetylacetato)palladium(II) tetrafluoroborate
Conditions | Yield |
---|---|
In acetone; benzene (N2); a soln. of CPh3BF4 and methyl acetoacetate in acetone was added to a soln. of the Pd complex in benzene, the soln. was agitated for 48 h; recrystn. from acetone-ether; elem. anal.; | 100% |
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 25℃; for 1h; Inert atmosphere; Stage #2: benzyl halide In tetrahydrofuran; mineral oil at 0℃; | 100% |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere; Stage #2: benzyl halide In tetrahydrofuran; mineral oil at 20 - 40℃; Inert atmosphere; | |
Stage #1: acetoacetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere; Stage #2: benzyl halide In tetrahydrofuran; mineral oil for 12h; Inert atmosphere; Reflux; |
2-aminopyridine
acetoacetic acid methyl ester
2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With bismuth(III) chloride at 100℃; for 3h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Green chemistry; | 100% |
With trichlorophosphate |
N-BOC-1,2-diaminoethane
acetoacetic acid methyl ester
(Z)-methyl 3-((2-((tert.-butoxycarbonyl)amino)ethyl)amino)but-2-enoate
Conditions | Yield |
---|---|
With silica gel at 20℃; for 16h; | 100% |
With silica gel In dichloromethane at 10 - 20℃; for 1h; | 127.9 g |
With silica gel In dichloromethane at 10 - 20℃; for 1h; | 127.9 g |
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